scholarly journals Study to Investigate the anti-inflammatory effect of Codelac® Broncho with Thymus Serpyllum (elixir) in comparison with reference drug Fenspiride (syrup) using accute Carrageenan-induced Paw Inflammation Model

2019 ◽  
Vol 5 (1) ◽  
pp. 45-52
Author(s):  
Pavel D. Kolesnichenko ◽  
Anna A. Peresypkina ◽  
Artem A. Poromov ◽  
Elena N. Kareva ◽  
Alexey N. Demidenko
Keyword(s):  
Inflammatory Activity ◽  
C Reactive Protein ◽  
Reference Drug ◽  
Reactive Protein ◽  
Model Control ◽  
Anti Inflammatory ◽  
Thymus Serpyllum ◽  
Carrageenan Inflammation ◽  
Subplantar Injection ◽  
Inflammatory Effect

Introduction: Evaluation of anti-inflammatory action of Codelac® Broncho with Thymus Serpyllum (elixir) in comparison with Fenspiride was carried out on the model of acute carrageenan inflammation of the paws in rats. Materials and methods: Edema was caused by subplantar injection of 0.1 ml of 1% λ- carrageenan gel into the hind paw. The severity of edema was assessed by using 37140 plethysmometer (UGO BASILE, Italy). The measurements were performed before edema induction and 1, 2, 4, 12, 24, 48, 72, 96 and 120 hours afterwards. Anti-inflammatory activity of the drugs was also evaluated based on the analysis of rats’ blood, C-reactive protein concentration and histological examination results. Results and discussion: A decrease in the paw volume increment was revealed in the group with the studied drug in comparison with the group with the carrageenan edema model (control) 4, 12, 24 hours after injection of carrageenan (p<0.05). As a result of plethysmometry, a more pronounced anti-inflammatory effect of the studied drug than that of Fenspiride was revealed. There was a significant decrease in the levels of leukocytes (p<0.05), lymphocytes (p<0.05), monocytes (p<0.05) and neutrophils (p<0.05) in the group with the studied drug compared to those the the control 48 hours after the initiation of edema, while in the group with Fenspiride, there was only a decrease in the levels of leukocytes (p<0.05) and lymphocytes (p<0.05). There were no differences in the concentration of C-reactive protein between the groups. Conclusion: The obtained data indicate a more pronounced anti-inflammatory activity of Codelac® Broncho with Thymus Serpyllum in comparison with Fenspiride, on the model of acute carrageenan inflammation of the paw in rats.

scholarly journals Pharmacotherapy of inflammatory process by ginger extract (Zingiber officinale) ointment

2019 ◽  
Vol 8 (2) ◽  
pp. 101-107
Author(s):  
Iryna Kravchenko ◽  
Lida Eberle ◽  
Mariia Nesterkina ◽  
Alona Kobernik
Keyword(s):  
Biochemical Parameters ◽  
Preventive Treatment ◽  
Zingiber Officinale ◽  
Subsequent Treatment ◽  
Inflammatory Activity ◽  
Ginger Extract ◽  
Reference Drug ◽  
Anti Inflammatory ◽  
Carrageenan Inflammation ◽  
Inflammatory Effect

Introduction: The anti-inflammatory activity of the ointment based on ginger extract was investigated on carrageenan-induced inflammation. Methods: Anti-inflammatory activity was investigated on the carrageenan inflammation model in rat. The animals were divided into 5 groups: first group– control (without treatment); second group– animals received preventive treatment of ointment with ginger extract two days before experiment and with subsequent treatment after administration of phlogogen; 3rd group– animals received applications of 5% ibuprofen 2 days before experiment and with subsequent treatment after induction of inflammation; fourth group – animals were treated with ginger extract ointment after one day of the phlogogen administration; fifth group – animals were treated with reference drug after one day of the phlogogen introduction. The biochemical parameters (concentration of sialic acids, seromucoids, contents of total proteins and protein fractions) of the blood of experimental animals were investigated. Results: After local application of the ointment from the ginger extract, under the conditions of its application after phlogogen inoculation, the effect was the same as anti-inflammatory effect of the ibuprofen which was used as reference drug. The preventive ointment application provided faster and more intense reduction of the inflammatory focus with returning to the background indicators on the eighth day of the experiment, and for biochemical parameters on the sixth day of therapy. Conclusion: The ointment from ginger extract shows anti-inflammatory activity by inhibiting inflammation caused by carrageenan.

scholarly journals Dietary Fiber's Effect on High Sensitivity C-reactive Protein Serum in Sedentary Workers

2021 ◽  
Vol 5 (1) ◽  
pp. 40
Author(s):  
Livia Kurniati Saputra ◽  
Dian Novita Chandra ◽  
Ninik Mudjihartini
Keyword(s):  
Body Weight ◽  
High Sensitivity ◽  
The Body ◽  
Low Grade ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Dietary Fiber Intake ◽  
Anti Inflammatory ◽  
Low Grade Inflammation ◽  
Inflammatory Effect

Low grade inflammation has been recognized of being involved in the pathogenesis of chronic disease pandemic. Individual lifestyle plays a major role in the development of low grade inflammation. Sedentary workers are at risk of low grade inflammation due to the nature of their work. Dietary habit also contributes to inflammatory status in the body. Dietary fiber intake indirectly affects the immune system. It has been hypothesized that fiber has anti-inflammatory effects, both body weight-related and body weight-unrelated This review will focus more on body weight-unrelated anti-inflammatory effect of fiber, especially through fiber’s fermentation metabolites, the short chain fatty acid (SCFA). Its anti-inflammatory effect can be seen by monitoring a biomarker of inflammation in the body, the high sensitivity C-reactive protein (hsCRP). This review’s objective is to cover the mechanisms and role of dietary fiber intake on serum hsCRP level as a marker of low grade inflammation on sedentary workers. 

scholarly journals Antiinflammatory activity of 2-, 3-, 4-carboxymethylpyridinium hexafluorosilicates on carrageenan model of inflammation

2019 ◽  
pp. 82-87
Author(s):  
B. V. Pristupa ◽  
I. O. Shyshkin ◽  
Ya. V. Rozhkovsky ◽  
V. O. Gelmboldt
Keyword(s):  
Antiinflammatory Activity ◽  
Biologically Active ◽  
Inflammatory Activity ◽  
Male Rats ◽  
Control Group ◽  
Paw Edema ◽  
Commercial Preparation ◽  
Reference Drug ◽  
Anti Inflammatory ◽  
Inflammatory Effect

In the last decade, high cariesprophylactic efficacy of ammonium hexafluorosilicates, including salts with substituted biologically active ammonium cations, has been demonstrated. Among the promising anti-caries agents are recently synthesized 2-, 3-, 4-carboxymethylpyridinium hexafluorosilicates, for whose cations anti-inflammatory activity is expected. The aim of the work is to assess the presence of anti-inflammatory activity in the series of 2-, 3-, 4-carboxymethylpyridinium hexafluorosilicates in the experiment. 2-, 3-, 4-Carboxymethylpyridinium hexafluorosilicates (I–III, respectively) were synthesized according to the previously proposed technique, carrageenan is a commercial preparation, reference drug is a indomethacin. Experiments on the anti-inflammatory activity of hexafluorosilicates were performed on 77 white Wistar male rats weighing 174–190 g using the carrageenan model of inflammation. The inflammatory reaction was reproduced by subplantary administration of 0.1 ml of a 0.2% solution of carrageenan, the studied compounds were administered orally in doses 1/10, 1/20, 1/50 from LD50 for the compound III. It was established that after administration of carrageenan, animals of the control group showed marked paw edema, which gradually increased and was maximal after 24 hours of observation. According to the data obtained, the indices for compounds I-III practically do not differ from those of the control group. This indicates that, despite the results of the PASS forecast and the presence of acetic acid residue, an anti-inflammatory pharmacofor, in compounds I-III, the compounds under study do not have an anti-inflammatory effect in the carrageenan model. 2-, 3-, 4-Carboxymethylpyridinium hexafluorosilicates do not show the expected anti-inflammatory activity in the carrageenan model of inflammation.

scholarly journals ANTI-INFLAMMATORY ACTIVITY OF THE SPRAY BASED ON IBUPROFEN AND LIQUID WORMWOOD EXTRACT

2021 ◽  
Vol 93 (3) ◽  
pp. 73-78
Author(s):  
O. A. Sushinskaya ◽  
◽  
N. S. Golyak ◽  
Keyword(s):  
Inflammatory Activity ◽  
Control Group ◽  
Average Increase ◽  
Liquid Extract ◽  
Anti Inflammatory ◽  
Carrageenan Inflammation ◽  
Inflammatory Effect

The article presents the results of determining anti-inflammatory activity of the spray based on ibuprofen and liquid wormwood extract. Anti-inflammatory activity was studied on the model of local acute carrageenan inflammation. As a result of the studies it was found that the increase in paw weight averaged 49,66% in the control group of rats, in the group of rats receiving the comparison drug «Ibuleve» - 11,26%. For the group of rats receiving combined composition and the same composition without ibuprofen, the average increase in paw weight was 7,11% and 15,07%, respectively. The index of inflammatory inhibition when using combined composition was 85,68%, the composition with liquid extract of wormwood without ibuprofen was 69,65%, the liquid extract of wormwood 1:1 was 53,00%. The index of edema suppression proves that combined composition of the spray containing ibuprofen and liquid extract of wormwood has the most pronounced anti-inflammatory effect, for which the percentage of edema suppression exceeds the value for the comparison drug on the average by 8,36%.

scholarly journals Effect of sitagliptin and glimepiride on C-reactive protein (CRP) in overweight Type-2 diabetic patients

2019 ◽  
Vol 35 (2) ◽  
Author(s):  
Mazhar Hussain ◽  
Muhammad Amir Rafique ◽  
Javed Iqbal ◽  
Lubna Akhtar
Keyword(s):  
Lipid Profile ◽  
Blood Sugar ◽  
Diabetic Patients ◽  
C Reactive Protein ◽  
Type 2 Diabetic Patients ◽  
Reactive Protein ◽  
Anti Inflammatory ◽  
Type 2 Diabetic ◽  
Inflammatory Effect

Objectives: To compare the anti-inflammatory effect of sitagliptin and glimepiride by measuring CRP in overweight Type-2 diabetic patients. Methods: This clinical trial was conducted at diabetic clinic of Islam Central Hospital, Sialkot over a period of six months from June to November 2017. A total of 110 overweight Type-2 diabetic patients were divided in to two groups. Group-A was given tablet sitagliptin 50mg while Group-B was given tablet glimepiride 2mg for a period of 12 weeks. The dose was titrated according to blood sugar level. The primary outcome was measuring changes in CRP while secondary outcomes was changes in BMI, blood sugar, HbA1C, lipid profile and CRP from baseline in both study group using SPSS 16. Results: After 12 weeks treatment, body weight increased in glimepiride but slightly reduced in sitagliptin, however comparison between them was non significant (p=0.07). Although both groups reduced blood sugar and HbA1c but comparison between them was non significant (p=0.59 and p=0.17 respectively) value. However lipid profile improved significantly in sitagliptin vs. glimepiride group i.e total cholesterol (-25±32.5 vs +1.5±45.4 P=0.02) triglycerides (-19±44.6 vs-1.8±48.7 P=0.001) LDL- cholesterol (-10±22.4 vs-0.8±18.7 P=0.001) HDL-cholesterol (-2.6±6.2 vs 1.2±5.2 P=0.03).Sitagliptin significantly reduced CRP in comparison to glimepiride (-2.3±1.8 vs0.8±1.5 P=0.001). Conclusion: Sitagliptin has strong anti inflammatory effect marked by reduction in CRP level in comparison to glimepiride in overweight type-2 diabetic patients. It also exerted beneficial effect on glycemic and lipid profiles. How to cite this:Hussain M, Rafique MA, Iqbal J, Akhtar L. Effect of sitagliptin and glimepiride on C-reactive protein (CRP) in overweight Type-2 diabetic patients. Pak J Med Sci. 2019;35(2):---------. doi: https://doi.org/10.12669/pjms.35.2.645 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

scholarly journals Anti-Inflammatory, Anti-Arthritic and Anti-Nociceptive Activities of Nigella sativa Oil in a Rat Model of Arthritis

Antioxidants ◽  
2019 ◽  
Vol 8 (9) ◽  
pp. 342 ◽  
Author(s):  
Cinzia Nasuti ◽  
Donatella Fedeli ◽  
Laura Bordoni ◽  
Marco Piangerelli ◽  
Maurizio Servili ◽  
...  
Keyword(s):  
Rat Model ◽  
Mechanical Allodynia ◽  
Nigella Sativa ◽  
C Reactive Protein ◽  
Reference Drug ◽  
Reactive Protein ◽  
Nigella Sativa Oil ◽  
Weight Growth ◽  
Preventive Efficacy ◽  
Anti Inflammatory

This study investigated the preventive efficacy of the crude oil extracted from Nigella sativa seeds in a rat model of arthritis induced by using complete Freund’s adjuvant (CFA). Nigella sativa oil at 1.82 mL/kg or 0.91 mL/kg (corresponding to 1596 and 798 mg/kg, respectively) was orally administered for 25 days from the day of immunization. One immunized group was treated orally with indomethacin (3 mg/kg) as a reference drug. Body weight growth rate, paw swelling, arthritis score, mechanical allodynia, locomotor activity and anxiety-like behavior were observed, and the levels of Interleukin 6 (IL-6), C-reactive protein, albumin and total cholesterol in plasma were measured on days 15 and 25. Nigella sativa oil showed anti-inflammatory, anti-arthritic and anti-nociceptive activities that were significant as compared to untreated arthritic rats but less than indomethacin. These results indicated that Nigella sativa oil significantly attenuated adjuvant-arthritis in rats and the higher dose (1.82 mL/kg) prevented the development of arthritis with an inhibition of 56%.

scholarly journals IN VITRO ANTI-INFLAMMATORY ACTIVITY OF BLUE-GREEN ALGAE-GEITLERINEMA SPLENDIDUM COLLECTED FROM WESTERN GHATS, SOUTH INDIA

2018 ◽  
Vol 11 (5) ◽  
pp. 407
Author(s):  
Krishnaveni J ◽  
Alarmal Mangai S ◽  
Mary Jency I
Keyword(s):  
Ethyl Acetate ◽  
Green Algae ◽  
Inflammatory Activity ◽  
Reference Drug ◽  
Minimum Concentration ◽  
Blue Green Algae ◽  
The Family ◽  
Anti Inflammatory ◽  
Inflammatory Effect

Objective: Geitlerinema splendidum is non-edible blue-green algae available in freshwater systems. It belongs to the family Pseudanabaenacae genera. In exploring the medical properties of algae, our present work aimed to analyze the anti-inflammatory effect of the algae G. Splendidum.Methods: Anti-inflammatory activity was done by human red blood cell membrane stabilization assay for ethyl acetate and ethanol crude extracts of alga and found that the ethyl acetate extract has better inhibitory property than ethanol crude extract. Diclofenac was used as the standard drug.Results: The experimental results obtained are comparable to the reference drug and are found to be dose-dependent. Even at a minimum concentration of 12.5 μg/ml, the percentage inhibition was in the range of 56.6±0.12–58.5±0.03 %, which indicated that the alga G. splendidum has a satisfactory anti-inflammatory activity.Conclusion: Our present work is supposed to be the first report in exploring the anti-inflammatory effect of the algae G. splendidum.

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