scholarly journals Effect of Butea monosperma leaf extracts on cyclophosphamide induced clastogenicity and oxidative stress in mice

2015 ◽  
Vol 7 (1) ◽  
pp. 85 ◽  
Author(s):  
Bimlesh Kumar ◽  
Amarjeet Singh ◽  
Mohanjit Kaur ◽  
Adarsh Choudhary
Keyword(s):  
Oxidative Stress ◽  
Leaf Extracts ◽  
Butea Monosperma ◽  
And Oxidative Stress

scholarly journals Mulberry Leaf Extracts prevent obesity-induced NAFLD with regulating adipocytokines, inflammation and oxidative stress

2018 ◽  
Vol 26 (2) ◽  
pp. 778-787 ◽  
Author(s):  
Chiung-Huei Peng ◽  
Huei-Ting Lin ◽  
Dai-Jung Chung ◽  
Chien-Ning Huang ◽  
Chau-Jong Wang
Keyword(s):  
Oxidative Stress ◽  
Leaf Extracts ◽  
Mulberry Leaf ◽  
And Oxidative Stress

scholarly journals Phenolic Rich Extract fromClinacanthus nutansAttenuates Hyperlipidemia-Associated Oxidative Stress in Rats

2016 ◽  
Vol 2016 ◽  
pp. 1-16 ◽  
Author(s):  
Nadarajan Sarega ◽  
Mustapha Umar Imam ◽  
Der-Jiun Ooi ◽  
Kim Wei Chan ◽  
Norhaizan Md Esa ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
High Fat Diet ◽  
Protocatechuic Acid ◽  
Synergistic Effects ◽  
Leaf Extracts ◽  
Antioxidant Genes ◽  
Stress Markers ◽  
Antioxidant Capacities ◽  
Clinacanthus Nutans ◽  
And Oxidative Stress

Clinacanthus nutansis used as traditional medicine in Asia but there are limited scientific studies to support its use. In this study, the stem and leaf ofC. nutanswere extracted using solvents of differing polarities, and their antioxidant capacities were determined using multiple antioxidant assays. The water and aqueous methanolic leaf extracts were further fractionated and their antioxidant capacities and phenolic compositions were tested. Furthermore, the efficacies of the water and aqueous methanolic leaf extracts were tested against hyperlipidemia-induced oxidative stress in rats. Serum and hepatic antioxidant and oxidative stress markers were tested after feeding the rats with high fat diet together with the extracts or simvastatin for 7 weeks. The results indicated that both leaf extracts attenuated oxidative stress through increasing serum antioxidant enzymes activity and upregulating the expression of hepatic antioxidant genes. Multiple phenolic compounds were detected in the extracts and fractions ofC. nutans, although protocatechuic acid was one of the most abundant and may have contributed significantly towards the bioactivities of the extracts. However, synergistic effects of different phenolics may have contributed to the overall bioactivities.C. nutanscan be a good source of functional ingredients for the management of oxidative stress-related diseases.

scholarly journals The Effect of Thaumatococcus danielli Leaf Extracts on Immunological and Oxidative Stress Markers in Rat

2021 ◽  
pp. 6-14
Author(s):  
O. B. Adu ◽  
G. A. Adeyemo ◽  
O. B. Falua ◽  
O. O. Fajana ◽  
O. O. Ogunrinola ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Blood Cell ◽  
Petroleum Ether ◽  
Negative Control Group ◽  
Negative Control ◽  
Control Group ◽  
Leaf Extracts ◽  
Antioxidant Parameters ◽  
Plasma Antioxidant ◽  
And Oxidative Stress

This work demonstrated the immunological and antioxidant activities of Thaumatococcus daniellii leaf extracts and their potential as the pharmaceutical factor for the treatment of some pathological disorders such as cancer, leucopenia, cells inflammation, dietary, atherosclerosis, neurodegenerative disease and other immunological and oxidative stress disorders.36 albino rats of average weight 140 ± 5 g were randomly grouped into 6 with six rats per group. The rats in group A (positive control) received only 0.1% DMSO. The rats in the negative control (group B) received pyrogallol (immunosuppressor) + 0.1% DMSO for 7 days and challenged with 0.1ml Sheep Red Blood Cell (SRBC). The test groups (C to F) also received pyrogallol + 0.1% DMSO for 7 days and were also challenged with SRBC for a period of 72hours after which they were treated with High and Low doses of either petroleum ether or water extracts of Thaumatococcus danielii for 21days. The assessment of immunomodulatory activity was carried out using Carbon Clearance Test. Haematological/ immunological parameters, Spleen and Plasma antioxidant parameters like Catalase (CAT), Superoxide dismutase (SOD), Glutathione Peroxidase (GPX) Activities, Lipid Peroxidation (LPO) and Malonaldehyde (MDA) concentrations were also determined. Result unveiled a significant (p<0.05) increase in the phagocytic index of both high doses of water and petroleum ether extracts compared to the negative control group. There were no significant (p<0.05) changes in the Heamatological parameters and plasma catalase, but there was a significant change in the white blood cell (WBC) count and also an improvement in the spleen and plasma antioxidant parameters. Further study is required to understand the mechanism of action of both extracts in order to exploit it in immunomodulation.

scholarly journals Olive-Leaf Extracts Modulate Inflammation and Oxidative Stress Associated with Human H. pylori Infection

Antioxidants ◽  
2021 ◽  
Vol 10 (12) ◽  
pp. 2030
Author(s):  
Jose Manuel Silvan ◽  
Esperanza Guerrero-Hurtado ◽  
Alba Gutiérrez-Docio ◽  
Teresa Alarcón-Cavero ◽  
Marin Prodanov ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Inflammatory Response ◽  
Ros Production ◽  
Human Pathogens ◽  
Olive Leaf ◽  
Leaf Extracts ◽  
Ags Cells ◽  
Hydrophilic Compounds ◽  
H Pylori ◽  
And Oxidative Stress

Helicobacter pylori (H. pylori) is one of the major human pathogens and the main cause of pathological damages that can progress from chronic gastritis to gastric cancer. During the colonization of gastric mucosa, this bacterium provokes a strong inflammatory response and subsequent oxidative process, which are associated with tissue damage. Therefore, the objective of this research was to evaluate the ability of two olive-leaf extracts (E1 and E2) to modulate the inflammatory response and oxidative stress in H. pylori-infected human gastric AGS cells. The obtained results showed that both extracts significantly decreased interleukin-8 (IL-8) secretion and reactive oxygen species (ROS) production in human gastric AGS cells. Both extracts also showed antibacterial activity against different H. pylori strains. HPLC-PAD-MS characterization demonstrated that extract E1 was mainly composed of highly hydrophilic compounds, such as hydroxytyrosol (HT) and its glucosides, and it was the most effective extract as an antibacterial agent. In contrast, extract E2 was composed mostly of moderately hydrophilic compounds, such as oleuropein (OLE), and it was more effective than extract E1 as an anti-inflammatory agent. Both extracts exhibited similar potential to decrease ROS production. These results show the importance of standardizing the extract composition according to the bioactive properties that should be potentiated.

Association between calcitriol and paricalcitol with oxidative stress in patients with hemodialysis

2020 ◽  
pp. 1-8
Author(s):  
Hasan Haci Yeter ◽  
Berfu Korucu ◽  
Elif Burcu Bali ◽  
Ulver Derici
Keyword(s):  
Oxidative Stress ◽  
Vitamin D ◽  
Antioxidant Status ◽  
Total Antioxidant Status ◽  
Stress Index ◽  
Total Oxidant Status ◽  
Vitamin D Analog ◽  
Total Antioxidant ◽  
Oxidant Status ◽  
And Oxidative Stress

Abstract. Background: The pathophysiological basis of chronic kidney disease and its complications, including cardiovascular disease, are associated with chronic inflammation and oxidative stress. We investigated the effects of active vitamin D (calcitriol) and synthetic vitamin D analog (paricalcitol) on oxidative stress in hemodialysis patients. Methods: This cross-sectional study was composed of 83 patients with a minimum hemodialysis vintage of one year. Patients with a history of any infection, malignancy, and chronic inflammatory disease were excluded. Oxidative markers (total oxidant and antioxidant status) and inflammation markers (C-reactive protein and interleukin-6) were analyzed. Results: A total of 47% (39/83) patients were using active or analog vitamin D. Total antioxidant status was significantly higher in patients with using active or analog vitamin D than those who did not use (p = 0.006). Whereas, total oxidant status and oxidative stress index were significantly higher in patients with not using vitamin D when compared with the patients who were using vitamin D preparation (p = 0.005 and p = 0.004, respectively). On the other hand, total antioxidant status, total oxidant status, and oxidative stress index were similar between patients who used active vitamin D or vitamin D analog (p = 0.6; p = 0.4 and p = 0.7, respectively). Conclusion: The use of active or selective vitamin D analog in these patients decreases total oxidant status and increases total antioxidant status. Also, paricalcitol is as effective as calcitriol in decreasing total oxidant status and increasing total antioxidant status in patients with chronic kidney disease.

Sign in / Sign up

Export Citation Format

Share Document