scholarly journals A study of insulin resistance and its clinico-metabolic associations among apparently healthy individuals attending a tertiary care hospital

2014 ◽  
Vol 4 (5) ◽  
pp. 823 ◽  
Author(s):  
S Bhattacherjee ◽  
S Guha ◽  
I Banerjee ◽  
I Nath ◽  
R Banerjee ◽  
...  





Author(s):  
Irm Yasmeen ◽  
Supinder Kour ◽  
Imran Khurshid ◽  
Aasifa Malik

 Background: Transfusion transmitted infections (TTIs) can be caused by various microorganisms present in the blood of apparently healthy donors. The recipient may get infected after being transfused with the unsafe blood. It is mandatory to screen the blood for HIV 1 and 2, HBV, HCV, Syphilis and Malaria. This study was undertaken to investigate the seroprevalance of Transfusion transmitted infections among blood donors at our tertiary care centre and to compare our study with other studies conducted at different hospitals of the country as well as outside.Methods: A retrospective review of blood donor records was made over a period of 5 years with effect from January 2014 to December 2018 at blood bank, department of Blood Transfusion and Immunohaematology, SKIMS, Soura, Srinagar. Both voluntary and replacement blood donors were selected after taking proper history and examination were included in the study. Serum samples were screened for HIV 1 & 2, HBV (HBsAg) and HCV using ELISA with 3rd generation kits.Results: A total of 56325 blood donors were screened. Out of total 55346 (98.2%) were males and 979 (1.73%) were females. Among them 38969 (69.1%) were replacement donors and 17356 (30.8%) were voluntary donors. The seroprevalance of HBV (HBsAg), HCV and HIV 1and 2 was 0.24%, 0.17% and 0.01% respectively and overall seroprevalance of TTIs was 0.43%.Conclusions: Continuous improvement and implementation of newer techniques like NAT and chemilumenescence for testing of blood for TTIs will reduce the risk of acquiring these infections.lance



Author(s):  
Nayana Deb ◽  
Sharmistha Chatterjee ◽  
Mousumi Mukhopadhyay ◽  
Biswajit Majumder ◽  
Swati Bhattacharyya

Background: Insulin Resistance is of paramount importance in the pathophysiology of Type 2 Diabetes Mellitus along with endothelial dysfunction is mediated by Nitric Oxide (NO). Central to this endothelial dysfunction is the action of Insulin on the Nitric oxide synthase enzyme. Since NO cannot be measured because of its short half-life, metabolites of NO (namely nitrite and nitrate) are measured towards assessing their relationship along with different direct and surrogate markers of insulin resistance in patients of Diabetes Mellitus attending a tertiary care hospital in Eastern India. Aim of the study was to assess the level of Insulin resistance with the direct and surrogate markers of insulin resistance in patients of Diabetes Mellitus attending a tertiary care hospital in Eastern India.Methods: Blood samples from newly diagnosed Type 2 Diabetic patients were assayed for fasting and postprandial sugar and insulin, lipid profile and serum nitrate and nitrite and different anthropological parameters were measured. After that, HOMA-IR and QUICKI’ index were measured.Results: Values of anthropological parameters and the direct and surrogate markers of insulin resistance showed statistically significant difference between cases and controls. Bivariate analysis of post-prandial blood glucose showed strong co-relation with HOMA-IR while serum total nitrate-nitrite ratio showed a strong co-relation with QUICKI.Conclusions: Serum nitrate-nitrite ratio showed a strong co-relation with HOMA-IR and QUICKI. The significance of this study lies in the fact that measurement of the serum nitrate-nitrite may give an idea of the level of insulin resistance of a diabetic patient.





2016 ◽  
Vol 3 (2) ◽  
pp. 162
Author(s):  
Sunil Sonu Hatkar ◽  
Santosh Arvind Kotgire ◽  
Alka Ramchandrasingh Thakur


2016 ◽  
Vol 3 (2) ◽  
pp. 140-145
Author(s):  
◽  
Vijay Loknath Badge ◽  
Arun Y Humne ◽  
Kalpana M Kale ◽  
Pushpa Lokare


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