Prevalence and family history of recurrent aphthous stomatitis among the students of a dental institution in south India

Background: Recurrent Aphthous Stomatitis (RAS) is inflammation in oral mucosa characterized by recurrent single or multiple ulcers that usually affected in non keratinized mucosa. Etiology RAS is unknown but psychological stress, allergy, and gastrointestinal disease can be predisposing factors Case Management: A 23rd years old complained recurrent oral ulcer with free ulcer period for 3-5 days. The patient had a history of food allergy, GERD and psychological stress. Intraoral examination showed recurrent multiple ulcers in variation site of the mouth. DASS 42 screening showed high stress and high anxiety. Skin Prick Test showed positive allergy to kapok, beef, chicken, cow milk, white egg, duck egg, shrimp, cob fish, milkfish, chocolate, and peanut. Ulcers treated with nonsteroid antiinflammation Aloe Vera gel and stress management by reading assignment method.Discussion: Psychological stress altered the immune system so oral mucosa prone to inflammation, and make the history of GERD getting worse. Stress causes cortisol secretion that changes the imbalance of proinflammatory and antiinflammatory cytokines. Oral mucosa becomes more susceptible to hypersensitivity. In addition, stress decreased oral and esophageal mucosa resistance to GERDConclusion: RAS triggered by psychological stress, allergy, and GERD. Treatment of RAS is by elimination predisposing factors to prevent recurrence.

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POS1326 FAMILIAL PERIODIC FEVER, APHTHOUS STOMATITIS, PHARYNGITIS AND ADENITIS (PFAPA)SYNDROME; IS IT A SEPARATE DISEASE?

Annals of the Rheumatic Diseases ◽

10.1136/annrheumdis-2021-eular.3458 ◽

2021 ◽

Vol 80 (Suppl 1) ◽

pp. 945.2-945

Author(s):

Y. Butbul

Keyword(s):

Family History ◽

Pediatric Population ◽

Periodic Fever ◽

Positive Family History ◽

Aphthous Stomatitis ◽

M694v Mutation ◽

Fever Syndromes ◽

History Of ◽

Pfapa Syndrome ◽

Sporadic Disease

Background:Periodic fever, aphthous stomatitis, pharyngitis, and adenitis syndrome (PFAPA) is the most common periodic fever syndrome in the pediatric population. Unlike other periodic fever syndromes, the pathogenesis and genetics of PFAPA is unknown. Until recently, PFAPA was believed to be a sporadic disease, yet family clustering has been widely observed and current research indicates that heredity is likely.Objectives:To identify demographic and clinical differences between patients with PFAPA who have a positive family history (FH+) compared to those with PFAPA with no family history (FH-) that can reveal if heritable and sporadic subtypes of this disorder exist.Methods:In a database comprising demographic and clinical data of 273 pediatric PFAPA patients treated at two tertiary centers in Israel, 31(14.3%) of patients were PFAPA FH+. Data from patients with FH+ for PFAPA was compared to data from those with FH- of the disorder. Furthermore, family members (FMs) of those with FH+ were contacted via telephone for more demography and clinical details.Results:FH+ group had more headaches (32% vs.2%; p= 0.016), myalgia (56% vs. 19%; p= 0.001), higher carrier frequency of M694V mutation (54% vs. 25%; p=0.053), greater family history of FMF (30% vs. 15%; p=0.096) and better outcomes with colchicine (82% vs. 52%; p=0.096) compared to those with FH-. FMs displayed almost identical characteristics to the FH+ group except for greater arthralgia during flares (64% vs. 23%; p=0.008) and compared to the FH- group, more oral aphthae (68% vs. 43%; p=0.002), myalgia/arthralgia (64% vs. 19%/16%; p<0.0001), and higher rates of FH of FMF (45% vs.15%; p=0.003).Conclusion:Our findings suggest that FH+ had probably different subset of disease with higher frequency of family history of FMF arthralgia, myalgia and better response to colchicine. Colchicine prophylaxis for PFAPA should be considered in FH+.Disclosure of Interests:None declared

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Detection of HSV1 and HSV2 viruses among Iraqi patients with recurrent Stomatitis Aphthous

Iraqi Dental Journal ◽

10.46466/idj.v40i1.134 ◽

2018 ◽

Vol 40 (1) ◽

pp. 19-24

Author(s):

Eman A Al-Hasnawi

Keyword(s):

Family History ◽

Recurrent Aphthous Stomatitis ◽

Aphthous Stomatitis ◽

Control Group ◽

Study Group ◽

Elisa Method ◽

Healthy Control ◽

Simplex Virus ◽

Positive Results ◽

Hsv 1

Background: Recurrent aphthous stomatitis (RAS) is a global oral case that stay incompletely understood yet. It was classified into three main types of minor, major or herpetiform, based on clinical features, but the exact causative agent is unknown, therefore treatments are primarily should be experimental and aimed at decrease symptoms rather than remedy or prevention. The aim of study is to detection of Herpes simplex virus-1 and Herpes simplex virus-2 in saliva of patients with recurrent aphthous stomatitis (RAS) as a causative agents of the disease by the enzyme-linked immunosorbent assay (ELISA) assay, and correlation between positive results and finding of age, gender, and family history. Materials and Methods: Study group of (40) saliva samples were taken from 40 patients with RAS lesions included 15 male and 25 female, with mean age at (34) years, at range about (18-55) years , and healthy control group were (20) healthy volunteers were suffered from oral traumatic ulcers, consist women (13), men (7), mean age (33) years in range (18-55). for detection of HSV viruses types that may causes this disease, and healthy control group were (20) healthy volunteers were suffered from oral traumatic ulcers, ELISA method used for diagnosis HSV-1 and HSV-2, from saliva samples of the patients with (RAS) with correlation between positive results and finding of age, gender, and family history. Results: Diagnostic specimens were consisted of two groups, study group of (40) saliva samples taken from 40 patients with RAS lesions. The results of ELISA to detect HSV had high significant (17): 42.5% from (40) patients with (RAS), HSV-1: (13)32.5%, and HSV-2: (4)10%. Conclusion: This high number of RAS cases by HSV, and presence of HSV-2 in patients saliva in this study acted important cause of prevalence of this disease in Iraq, were in age group (18-25) mostly in female especially in those with family history of infection. Keywords: Recurrent Aphthous Stomatitis (RAS), Aphthous ulcer, HSV-1&2 viruses, ELISA method

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Could recurrent aphthous stomatitis be linked to cancer development?

Dentistry 3000 ◽

10.5195/d3000.2017.66 ◽

2017 ◽

Vol 5 (1) ◽

Author(s):

Emily Norton

Keyword(s):

Ovarian Cancer ◽

Recurrent Aphthous Stomatitis ◽

Aphthous Stomatitis ◽

Cancer Case ◽

Brca Mutations ◽

Ovarian Cancer Case ◽

The Family ◽

History Of ◽

Oral Cancer Screening ◽

Practical Implications

Background: Recurrent aphthous stomatitis is a common multifactorial oral mucosal disorder. Genetic and local factors causing RAS may contribute to the development of cancer. This study aims to explore this connection by examining a family with a history of RAS and ovarian cancer. Case Description: The family described in the case exhibits a history of minor recurrent aphthous stomatitis. The severity of this condition increases with each generation. One member of the family has no history of RAS but was diagnosed with ovarian cancer. Genetic testing for BRCA mutations was negative indicating a different genetic cause of the cancer. All affected members of the family indicate high levels of stress or difficulty responding to stressful situations. No treatment for RAS was performed due to its self-limiting nature. Practical Implications: Further research is needed before dentists begin to tell their patients with RAS they may be at higher risk of developing cancer. Diligent oral cancer screening and stress management counseling can decrease the risk to the patient.

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A Clinic Trial Evaluating the Effects of Aloe Vera Fermentation Gel on Recurrent Aphthous Stomatitis

Canadian Journal of Infectious Diseases and Medical Microbiology ◽

10.1155/2020/8867548 ◽

2020 ◽

Vol 2020 ◽

pp. 1-9

Author(s):

Yan Shi ◽

Kehong Wei ◽

Jiachen Lu ◽

Jing Wei ◽

Xiaojing Hu ◽

...

Keyword(s):

High Throughput Sequencing ◽

Aloe Vera ◽

Specific Treatment ◽

Healing Time ◽

Oral Bacteria ◽

Recurrent Aphthous Stomatitis ◽

Aphthous Stomatitis ◽

History Of ◽

Potential Benefits

Recurrent aphthous stomatitis (RAS) is the most common disorder in the oral mucosa that affects the daily quality of life of patients, and there is currently no specific treatment. In the present study, we developed aloe vera fermentation gel under the action of probiotics on aloe vera. In total, 35 patients with the history of aphthous stomatitis were enrolled to explore the potential benefits of aloe vera fermentation gel to treat RAS, and the healing-promotion effects were recorded and compared; microbial compositions in different groups were tested by high-throughput sequencing. Our results indicated that the duration of healing time of the aloe group showed potentially better effects because of the higher proportion of 4–6 day healing time (35% vs. 20%) and lower proportion of 7–10 day healing time (65% vs. 80%) compared with that of the chitosan group. Also, the use of aloe vera fermentation gel could return oral bacteria to normal levels and reduce the abundance of harmful oral bacteria including Actinomyces, Granulicatella, and Peptostreptococcus. These results suggest that aloe vera fermentation gel has the ability to treat patients with RAS and has positive prospects in clinical applications.

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PREVALENCE AND PSYCHOLOGICAL STRESS IN RECURRENT APHTHOUS STOMATITIS AMONG FEMALE DENTAL STUDENTS IN SAUDI ARABIA

Medicine and Pharmacy Reports ◽

10.15386/cjmed-840 ◽

2018 ◽

Vol 91 (2) ◽

pp. 216-221 ◽

Cited By ~ 3

Author(s):

Muhammed Ajmal ◽

Lujain Ibrahim ◽

Nada Mohammed ◽

Heba Al-Qarni

Keyword(s):

Psychological Stress ◽

Depression Scale ◽

Strong Relationship ◽

Dental Students ◽

Recurrent Aphthous Stomatitis ◽

Aphthous Stomatitis ◽

Medical Problems ◽

Exact Etiology ◽

History Of ◽

Had Scale

Introduction. Recurrent Aphthous Stomatitis (RAS) is a common oral mucosal disorder which is characterized by recurrent ulcerations mainly confined to non-keratinized oral mucosa. Though the exact etiology is imprecise, stress and anxiety were found to be linked with the onset of RAS. The present study was directed to know the prevalence of RAS among female dental students in King Khalid University, to find out the association between RAS and psychological stress and the effectiveness of Hospital Anxiety and Depression scale (HADS) in finding out the psychological profile of RAS patients.Method. 122 female dental students of age group 17 to 25 years were selected for the study. Subjects with relevant medical problems and deleterious habits were excluded. A questionnaire comprising general stress related questions and HAD scale were used to assess stress. Those who were giving history of ulcer were diagnosed as RAS based on the clinical features. The questionnaire results were used for statistical analysis and processed.Result. 14% of the total students were having RAS. 70% could correlate the onset of ulcer with certain specific factors; stress being the major causative agent (91%). In HAD scale, 88% of students were having anxiety and 65% had depression; all patients with depression had anxiety.Conclusion. The prevalence of RAS in female dental students in KKU was around 14%. There is a strong relationship between psychological stress and RAS, as in most of the other studies. HAD scale alone can be used for detecting the psychological factor in RAS.

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LncRNA NEAT1 is upregulated in recurrent aphthous stomatitis (RAS) and has predictive values

BMC Oral Health ◽

10.1186/s12903-021-01909-1 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Yaolun Han ◽

Lu Wang ◽

Qingfu Li ◽

Hongli Chen ◽

Xin Ma

Keyword(s):

Plasma Levels ◽

Inflammatory Responses ◽

Recurrent Aphthous Stomatitis ◽

Aphthous Stomatitis ◽

Control Group ◽

Predictive Values ◽

Tnf Α ◽

History Of ◽

Lncrna Neat1 ◽

Proinflammatory Factors

Abstract Background LncRNA NEAT1 promotes inflammatory responses, which contribute to recurrent aphthous stomatitis (RAS). This study focused on the involvement of NEAT1 in RAS. Methods RT-qPCR and ELISA were performed to determine the expression of NEAT1 and proinflammatory factors (IL-2, IL-1β, and TNF-α) in plasma from patients with a history of RAS and showing symptom (n = 80, S-RAS group), people with a history of RAS but showing no symptom (n = 80, NS-RAS group), and controls without a history of RAS (n = 80, Control group). Correlation analysis was performed with Pearson’s correlation coefficient. S-RAS group received treatmen,t and plasma levels of NEAT1 and proinflammatory factors were compared before and after treatment. S-RAS group was followed up for 12 months, and the recurrence was recorded. Results Plasma NEAT1, IL-2, IL-1β, and TNF-α levels were the highest in the S-RAS group, followed in turn by NS-RAS and control groups. NEAT1 was positively and significantly correlated with IL-2, IL-1β, and TNF-α across S-RAS and NS-RAS samples, but not control samples. After treatment, plasma levels of NEAT1, IL-2, IL-1β, and TNF-α decreased significantly. Moreover, a higher recurrence rate was observed during the follow-up in patients with high plasma NEAT1 levels. Conclusion NEAT1 is upregulated in RAS and correlated with multiple proinflammatory factors. Moreover, NEAT1 has predictive values for RAS.

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Honorrhoid stomatitis

Kazan medical journal ◽

10.17816/kazmj52947 ◽

2020 ◽

Vol 22 (2) ◽

pp. 248

Author(s):

Y. Pechnikov

Keyword(s):

Oral Mucosa ◽

Severe Pain ◽

Interesting Case ◽

Recurrent Aphthous Stomatitis ◽

Aphthous Stomatitis ◽

Hospital Nurse ◽

Severe Inflammation ◽

History Of ◽

Usual Process ◽

Tip Of The Tongue

Klepper (Derm. Woch., 1925, no. 39) describes an interesting case of gonorrhoid stomatitis in a hospital nurse with a history of recurrent aphthous stomatitis. 4 days after the usual relapse, the patient began to care for the child suffering from gonoblenorrhea, and after the next 4 days, she had a sudden deterioration of the usual process in the mouth: severe pain while eating, swelling of the tongue, fever, sores near the tip of the tongue, in the corner of the mouth and along the edge of the lower gum, with severe inflammation. Gonococci were found in smears and cultures of ulcer discharge. This case is interesting, as it contradicts the old ideas about the immunity of the oral mucosa of adults in relation to gonorrhoid infection.

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The Impact of DNA Methylation on IL6 mRNA Levels in Hematinic Deficiency and Atopy-Associated Recurrent Aphthous Stomatitis Patients

International Journal of Dentistry ◽

10.1155/2021/5560695 ◽

2021 ◽

Vol 2021 ◽

pp. 1-11

Author(s):

Nanan Nur’aeny ◽

Dida Akhmad Gurnida ◽

Oki Suwarsa ◽

Irna Sufiawati

Keyword(s):

Dna Methylation ◽

Recurrent Aphthous Stomatitis ◽

Aphthous Stomatitis ◽

Control Group ◽

Mrna Levels ◽

Modified Dna ◽

Increased Risk ◽

History Of ◽

The Impact ◽

Il6 Gene

Objective. To investigate the DNA methylation using pyrosequencing and its effects on the upregulation of IL6 mRNA in patients with recurrent aphthous stomatitis (RAS) in connection with hematinic deficiency and atopy. Material and Methods. This cross-sectional study was conducted at Dr. Hasan Sadikin Hospital, Bandung, from January–March 2019 and was approved by the Health Research Ethics Committee of Universitas Padjadjaran (Ethics No. 990/UN6.KEP/EC/2018). Furthermore, the subjects had RAS ulcers with a history of at least twice a year along with atopy and dietary imbalance with no history of recurrent intraoral herpes or any systemic diseases. This study was performed on 23 RAS patients and 21 healthy subjects, and the sampling was carried out consecutively. The blood samples were collected from all the subjects, and then, the DNA and RNA were extracted from the peripheral blood mononuclear cells (PBMCs). Consequently, the bisulfite-modified DNA was used to confirm the methylation status of the IL6 gene promoter through the pyrosequencing method. The methylation levels of the IL6 promoter were assessed by a reverse transcriptase-polymerase chain reaction technique. The gene expression of RAS and the control group was analyzed by the 2−ΔΔCT method. The statistical analysis using the Mann–Whitney U test was conducted to evaluate IL6 mRNA levels and DNA methylation with p value <0.05 considered to be statistically significant. Result. The IL6 mRNA levels were approximately 1.88-fold in RAS patients, and there was a significant relationship between the expression of the IL6 gene and the increased risk of RAS p < 0.001 . It was reported that four out of six sites in the cytosine phosphate guanine (CpG) island IL6 promoter had a lower degree of methylation, and two other sites in patients with RAS had greater methylation compared with control, but not statistically significant. Conclusion. This study showed the upregulation of IL6 mRNA levels in RAS patients compared to control. DNA methylation in the present study is at sites 566–658, whereas the location of the IL6 promoter is at sites 1–1684. Thus, it would be necessary conducting some research at other CpG sites of IL6 promoter islands to determine the status of DNA methylation.

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Language Onset and Concomitant Speech and Language Problems in Subgroups of Stutterers and Their Siblings

Journal of Speech Language and Hearing Research ◽

10.1044/jshr.2504.482 ◽

1982 ◽

Vol 25 (4) ◽

pp. 482-486 ◽

Cited By ~ 12

Author(s):

Robin A. Seider ◽

Keith L. Gladstien ◽

Kenneth K. Kidd

Keyword(s):

Family History ◽

Same Sex ◽

Speech And Language ◽

Negative Family History ◽

Late Talkers ◽

Language Problems ◽

History Of ◽

Language Onset

Time of language onset and frequencies of speech and language problems were examined in stutterers and their nonstuttering siblings. These families were grouped according to six characteristics of the index stutterer: sex, recovery or persistence of stuttering, and positive or negative family history of stuttering. Stutterers and their nonstuttering same-sex siblings were found to be distributed identically in early, average, and late categories of language onset. Comparisons of six subgroups of stutterers and their respective nonstuttering siblings showed no significant differences in the number of their reported articulation problems. Stutterers who were reported to be late talkers did not differ from their nonstuttering siblings in the frequency of their articulation problems, but these two groups had significantly higher frequencies of articulation problems than did stutterers who were early or average talkers and their siblings.

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