scholarly journals Frequency of Cutaneous Fungal Infections and Azole Resistance of the Isolates in Patients with Diabetes Mellitus

2017 ◽  
Vol 6 (1) ◽  
pp. 71 ◽  
Author(s):  
Parvin Dehghan ◽  
Omid Raiesi ◽  
Mansour Siavash ◽  
Faezeh Mohammadi ◽  
Javaher Chabavizadeh ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Fungal Infections ◽  
Azole Resistance ◽  
Patients With Diabetes

CASE SERIES: A SPECTRUM OF FUNGAL INFECTIONS IN COVID-19

2021 ◽  
pp. 29-30
Author(s):  
Venkatesh B. C. ◽  
Rajendra Rao K. M. ◽  
K. N. Mohan Rao
Keyword(s):  
Diabetes Mellitus ◽  
Fungal Infections ◽  
Virus Disease ◽  
Case Series ◽  
Health Crisis ◽  
Major Health ◽  
Corona Virus ◽  
Patients With Diabetes ◽  
Causative Agents

Corona virus Disease 2019 (COVID-19) pandemic is causing a major health crisis across the globe. With the increasing number of fungal infections associated with COVID-19 being reported, it is imperative to understand the spectrum of such infections. Most documented cases have been reported in patients with diabetes mellitus or treatment with immunomodulators. The most common causative agents are Aspergillus, Candida or Mucorales. This series aims to portray the spectrum of fungal infections associated with COVID-19.

scholarly journals Assessment of Candidal carriage in patients with Type II Diabetes Mellitus

2015 ◽  
Vol 5 (9) ◽  
pp. 733-738 ◽  
Author(s):  
RS Lamichhane ◽  
K Boaz ◽  
S Natarajan ◽  
M Shrestha
Keyword(s):  
Diabetes Mellitus ◽  
Fungal Infections ◽  
Surrogate Marker ◽  
Salivary Flow ◽  
Type Ii Diabetes Mellitus ◽  
Serum Glucose ◽  
Denture Stomatitis ◽  
Oral Rinse ◽  
Increased Risk ◽  
Patients With Diabetes

Background: It is generally acknowledged that patients with diabetes mellitus are more susceptible to fungal infections, particularly with Candida albicans. Oral infection by Candida can result in a number of clinical lesions, including median rhomboid glossitis (central papillary atrophy), denture stomatitis, squamous cell carcinoma, Radiation therapy, immunocompromised status, etc. Different studies have shown that patients with diabetes mellitus have increased frequency of oral candidal carriage and increased risk of candidiasis, which is related to poor metabolic control, neutrophil dysfunction, reduced salivary flow, high glucose concentration in blood and saliva and in medications.Materials and Methods: Subjects of both the groups were given 10 ml of sterile normal saline and asked to rinse the mouth for one minute. The subjects were then asked to return the oral rinse in a sterile clean, broad-mouthed container which was capped, labelled and taken to the laboratory. The samples were then inoculated onto the culture medium (Sabouraud’s dextrose agar with Chloramphenicol) with minimal delay (within 6-8 hours of collection of oral rinse). Candidal colonies were counted and compared with non-diabetics.Results: Statistically significant increase in colony forming units (p=0.0324) were obtainedin patients with diabetes mellitus.Conclusion: The results indicate significant increase in colonization and carriage of candida in the oral cavity among diabetics when compared with non-diabetics. However, further research using larger samples is required which may lend credibility to the suggestion of increased candidal CFUs in diabetics serving as a surrogate marker of serum glucose levels.Journal of Pathology of Nepal (2015) Vol. 5, 733-738

scholarly journals Fusarium-Induced Cellulitis in an Immunocompetent Patient With Sickle Cell Disease: A Case Report

2020 ◽  
Vol 8 ◽  
pp. 232470962093430
Author(s):  
Shaher Samrah ◽  
Aroob Sweidan ◽  
Abdelwahab Aleshawi ◽  
Mahmoud Ayesh
Keyword(s):  
Diabetes Mellitus ◽  
Sickle Cell Disease ◽  
Lower Extremity ◽  
Sickle Cell ◽  
Fungal Infections ◽  
Fusarium Species ◽  
Immunocompetent Patient ◽  
Minor Trauma ◽  
Cell Disease ◽  
Patients With Diabetes

Fungal infections due to Fusarium species are mostly present in immunocompromised and patients with poorly controlled diabetes mellitus. We report a case of lower extremity skin infection caused by Fusarium species in a 61-year-old woman diagnosed with sickle cell disease. Single skin ulceration caused by Fusarium species can result from fungal inoculation into damaged tissue, so any condition that damages the skin can be considered as a risk factor for inoculation. Long-standing sickle cell disease may develop vaso-occlusion in the skin that can produce lower extremity ulcers and myofascial syndromes. The mechanism is not completely characterized, but compromised blood flow, endothelial dysfunction, thrombosis, inflammation, and delayed healing are thought to contribute to locally compromised tissue that may eventually lead to opportunistic infection such as in our case. Other factors contribute to the pathophysiology of lower extremity ulcers such as diabetes mellitus, with the resulting peripheral vascular ischemia causing poor circulation to the lower extremity, and peripheral neuropathy, which can make patients with diabetes unaware of minor trauma leading to the development of skin infections.

scholarly journals Candida sp. Infections in Patients with Diabetes Mellitus

2019 ◽  
Vol 8 (1) ◽  
pp. 76 ◽  
Author(s):  
Célia Rodrigues ◽  
Maria Rodrigues ◽  
Mariana Henriques
Keyword(s):  
Diabetes Mellitus ◽  
Medical Devices ◽  
Fungal Infections ◽  
Review Of The Literature ◽  
Exclusion Criteria ◽  
Comprehensive Review ◽  
Candida Sp ◽  
Search Terms ◽  
Patients With Diabetes ◽  
Increased Susceptibility

Candidiasis has increased substantially worldwide over recent decades and is a significant cause of morbidity and mortality, especially among critically ill patients. Diabetes mellitus (DM) is a metabolic disorder that predisposes individuals to fungal infections, including those related to Candida sp., due to a immunosuppressive effect on the patient. This review aims to discuss the latest studies regarding the occurrence of candidiasis on DM patients and the pathophysiology and etiology associated with these co-morbidities. A comprehensive review of the literature was undertaken. PubMed, Scopus, Elsevier’s ScienceDirect, and Springer’s SpringerLink databases were searched using well-defined search terms. Predefined inclusion and exclusion criteria were applied to classify relevant manuscripts. Results of the review show that DM patients have an increased susceptibility to Candida sp. infections which aggravates in the cases of uncontrolled hyperglycemia. The conclusion is that, for these patients, the hospitalization periods have increased and are commonly associated with the prolonged use of indwelling medical devices, which also increase the costs associated with disease management.

scholarly journals Candida species oral detection and infection in patients with diabetes mellitus: a meta-analysis

2021 ◽  
Vol 3 (2) ◽  
pp. 115-121
Author(s):  
Alberto Rodríguez-Archilla ◽  
◽  
Claudia Piedra-Rosales ◽  
Keyword(s):  
Diabetes Mellitus ◽  
Candida Species ◽  
Fungal Infections ◽  
Meta Analysis ◽  
Oral Candidiasis ◽  
Cochrane Library ◽  
Diabetic Patients ◽  
Oral Infections ◽  
Glucose Levels ◽  
Patients With Diabetes

Introduction: Diabetes mellitus is a chronic metabolic disorder that induces elevated plasma glucose levels. Diabetic patients are more susceptible to infections, especially fungal infections. There is a direct relationship between increased blood glucose levels and the number of Candida hyphae in the oral mucosa. This study aimed to evaluate oral candidiasis and the different Candida species found in patients with and without diabetes mellitus. Methods: A search for studies on oral candidiasis and diabetes mellitus was carried out in the following databases: PubMed (MEDLINE, Cochrane Library), Web of Science (WoS) and Google Scholar. For dichotomous outcomes, the estimates of effects of an intervention were expressed as odds ratios (OR) using the Mantel-Haenszel (M-H) method with 95% confidence intervals. Results: 25 studies were included in this meta-analysis. Diabetes Mellitus patients tripled the probability of being infected by Candida species (OR:3.16, p<0.001). Likewise, Candida species infections were more likely in patients with poor glycemic control (OR:2.94, p<0.001) and with dentures (OR:2.22, p<0.001). In contrast, neither gender nor diabetes mellitus type of diabetes conditioned fungal infections (p>0.05). The most prevalent Candida species in both diabetics and controls were C. albicans and C. tropicalis. Diabetics had significantly fewer C. non-albicans species oral infections than non-diabetics (p=0.04). Conclusions: Diabetics are more prone to oral candidiasis, especially C. albicans infections.

scholarly journals A study of cutaneous manifestations in diabetes mellitus patients in tertiary care centre

2019 ◽  
Vol 5 (3) ◽  
pp. 571
Author(s):  
Kirankanth Vudayana ◽  
K. Sudheer ◽  
Dilipchandra Chintada
Keyword(s):  
Diabetes Mellitus ◽  
Bacterial Infections ◽  
Fungal Infections ◽  
Tertiary Care ◽  
Tertiary Care Centre ◽  
Cutaneous Lesions ◽  
Cutaneous Manifestations ◽  
Cutaneous Infections ◽  
Patients With Diabetes ◽  
Medical Wards

<p class="abstract"><strong>Background:</strong> Diabetes is the most common metabolic disorder with increased prevalence in developing countries like India. It affects almost all organs among which skin is affected by the acute metabolic derangments as well as by chronic degenerative complications. The aims were to study the pattern of cutaneous lesions in patients with diabetes mellitus and to determine the incidence of skin manifestations specific to and associated with diabetics.</p><p class="abstract"><strong>Methods:</strong> Hundred cases of diabetes mellitus with cutaneous manifestations attending skin outpatient department and other patients admitted in medical wards were included in the study.<strong></strong></p><p class="abstract"><strong>Results:</strong> The common skin disorders were cutaneous manifestations (67%), dermatosis more commonly associated with diabetes (36%), neuropathic and ischemic diabetic skin disease (11%).</p><p class="abstract"><strong>Conclusions:</strong> Most common cutaneous manifestation was cutaneous infections followed by dermatosis more commonly associated with diabetes. Among cutaneous infections fungal infections were more common followed by bacterial infections. Cutaneous infections were more common in patients with poor glycaemic control and the association was found to be statistically significant.</p>

Intramuscular Nerve and Neuromuscular Junction Alteration In Extraocular Muscles of Diabetic Mice

1985 ◽  
Vol 43 ◽  
pp. 682-683
Author(s):  
Bruce R. Pachter
Keyword(s):  
Diabetes Mellitus ◽  
Peripheral Nerves ◽  
Sudden Onset ◽  
Extraocular Muscles ◽  
Diabetic Patients ◽  
Oculomotor Palsy ◽  
Third Nerve Palsy ◽  
Patients With Diabetes ◽  
Intramuscular Nerve ◽  
Oculomotor Nerves

Diabetes mellitus is one of the commonest causes of neuropathy. Diabetic neuropathy is a heterogeneous group of neuropathic disorders to which patients with diabetes mellitus are susceptible; more than one kind of neuropathy can frequently occur in the same individual. Abnormalities are also known to occur in nearly every anatomic subdivision of the eye in diabetic patients. Oculomotor palsy appears to be common in diabetes mellitus for their occurrence in isolation to suggest diabetes. Nerves to the external ocular muscles are most commonly affected, particularly the oculomotor or third cranial nerve. The third nerve palsy of diabetes is characteristic, being of sudden onset, accompanied by orbital and retro-orbital pain, often associated with complete involvement of the external ocular muscles innervated by the nerve. While the human and experimental animal literature is replete with studies on the peripheral nerves in diabetes mellitus, there is but a paucity of reported studies dealing with the oculomotor nerves and their associated extraocular muscles (EOMs).

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