Impact of chronic cigarette smoking on platelet aggregation and coagulation profile in apparently healthy male smokers

2015 ◽  
Vol 2 (2) ◽  
pp. 128 ◽  
Author(s):  
DoddamaniR Basalingappa ◽  
Metta Sandhya ◽  
Uppala Satyanarayana ◽  
Shruti Mohanty
Keyword(s):  
Platelet Aggregation ◽  
Cigarette Smoking ◽  
Healthy Male ◽  
Coagulation Profile ◽  
Apparently Healthy

scholarly journals Acute impact of cigarette smoking on power spectral measures of HRV

2018 ◽  
Vol 13 (1) ◽  
pp. 8-12 ◽  
Author(s):  
Mehboba Ferdous ◽  
Sultana Ferdousi
Keyword(s):  
Myocardial Infarction ◽  
Cigarette Smoking ◽  
Sympathetic Activity ◽  
Cigarette Smoker ◽  
Healthy Male ◽  
Spectral Measures ◽  
Cardiac Events ◽  
Paired Sample ◽  
Power Spectral ◽  
Apparently Healthy

Background: Cigarette smoking is associated with various forms of acute cardiac events such as myocardial infarction and ventricular fibrillation etc.Objective: To observe immediate impact of cigarette smoking on power spectral measures of heart rate variability (HRV) in current apparently healthy male regular cigarette smokers.Methods: This study was carried out on 120 apparently healthy male current regular cigarette smoker aged 20-55 years. To watch the intense impacts, data were recorded 5 and 30 min after completing a full stick of cigarette. Power spectral measures of HRV were recorded by a RMS digital polyrite D. Statistical analysis was done by paired sample t test.Results: LF power, LF nu & LF/HF ratio were significantly increased and HF power & HF nu were significantly decreased from their corresponding baseline value just 5 minutes after smoking and returned close to their baseline value after 30 minutes of smoking.Conclusion: The result of the study concludes that acceleration of sympathetic activity with simultaneous withdrawn of cardiovascular vagal adjustment happens quickly in the wake of smoking a cigarette.J Bangladesh Soc Physiol. 2018, June; 13(1): 8-12

scholarly journals The Effects of Cigarette Smoking on Serum Carboxyhemoglobin and Calcium Levels in Apparently Healthy Male Smokers in Benin City, Nigeria

2022 ◽  
Vol 15 (01) ◽  
pp. 26-35
Author(s):  
Grace Umahi-Ottah ◽  
Babatunde Ishola Gabriel Adejumo ◽  
Elvis Osamede Godwins ◽  
Uchechukwu Dimkpa ◽  
Simon Uzor ◽  
...  
Keyword(s):  
Cigarette Smoking ◽  
Healthy Male ◽  
Benin City ◽  
Apparently Healthy

scholarly journals Acute Effect of Cigarette Smoking on HRV in Current Cigarette Smokers

2015 ◽  
Vol 9 (2) ◽  
pp. 59-64 ◽  
Author(s):  
Mehboba Ferdous ◽  
Sultana Ferdousi
Keyword(s):  
Cigarette Smoking ◽  
Time Domain ◽  
Acute Effect ◽  
T Test ◽  
Total Power ◽  
Vagal Activity ◽  
Cigarette Smoker ◽  
Acute Effects ◽  
Healthy Male ◽  
Apparently Healthy

Background:Cigarette smoking induced increased sympathetic activity is one of the major independent risk factor for cardiac morbidity and mortality. Objective:To assess acute effects of smoking on neuro cardiovascular regulation by analysis of time domain measures of HRV in current regular healthy male cigarette smoker. Methods:This comparative analytical study was conducted in the Department of Physiology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Shahbag, Dhaka from July 2011 to June 2012. 120 apparently healthy male current regular cigarette smoker aged 20-55 years were participated in the study group. Age and BMI matched 70 apparently healthy male non smoker subjects were studied as control. To observe the acute effects data were recorded 5 and 30 min after finishing a cigarette. Time domain measures of HRV were recorded by a RMS digital polyrite D. Statistical analysis was done by independent sample t test and paired sample t test. Results: Resting pulse rate, SBP, DBP, mean heart rate were significantly higher (p<0.001) and mean R-R interval, SDNN, RMSSD and total power were significantly lower (p<0.001) in all smokers in comparison to those of healthy control.In addition, all time domain parameters were significantly decreased from their corresponding baseline value just 5 minutes after smoking and returned close to their baseline value after 30 minutes of smoking but it remained significantly lower than control value. Conclusion: The result of this study concludes that cigarette smoking had acute effect on cardiac autonomic function causing depressed vagal activity and overbalance of sympathetic function. DOI: http://dx.doi.org/10.3329/jbsp.v9i2.22798 Bangladesh Soc Physiol. 2014, December; 9(2): 59-64

Evaluation of Renal Function of Apparently Healthy Male Cannabis Smokers of College of Health Sciences, Nnewi Campus, Anambra State, Nigeria

2018 ◽  
Vol 4 (01) ◽  
Author(s):  
Analike Rosemary Adamma ◽  
Emekwue Loveth ◽  
Ogbodo Emmanuel Chukwuemeka ◽  
Ezeugwunne Ifeoma Priscilla ◽  
Onoh Joy Obioma ◽  
...  
Keyword(s):  
Uric Acid ◽  
Cannabis Sativa ◽  
Demographic Data ◽  
Cannabis Use ◽  
Total Carbon ◽  
Total Calcium ◽  
Healthy Male ◽  
Anambra State ◽  
Control Subjects ◽  
Apparently Healthy

The use of Cannabis sativa is on the increase worldwide especially among adolescents and youths. This study investigated the effect of cannabis smoking on renal functions in young and apparently healthy male students of Nnamdi Azikiwe University, Nnewi campus, Anambra state, Nigeria. A total of 60 male (40 cannabis smokers and 20 controls) subjects participated in this study. A well-structured questionnaire was used to obtain the demographic data and anthropometric of subjects. Thereafter, 5mls of fasting blood sample was collected from the subjects into plain container for the estimation of biochemical parameters (creatinine, urea, uric acid, electrolytes). Renal parameters were estimated using standard methods. Data obtained were statistically analyzed using paired student t-test and pearson r correlation. Result showed that the mean serum levels of urea, creatinine, K+, Na+, Cl-, ionized calcium, total calcium, total carbon dioxide, anion gap, and pH were not significantly different in both smokers and control subjects(p>0.05). However, there was significantly higher mean serum level of uric acid (2.42 ± 38.54 vs 1.92 ± 41.61; p<0.05) and total calcium (16.0 ± 0.30 vs 10.24 ± 0.18; p<0.05) in smokers compared with control subjects. Again, BMI was significantly higher in smokers compared with non-smokers (23.96 ± 3.15; p<0.05 Vs 21.95 ± 2.17; p<0.05). Therefore, cannabis use had no deleterious effect on the kidneys, but the significantly higher uric acid levels in the smokers may provide some anti-oxidant protection. However, further studies are necessary to further unravel the full potentials of cannabis use.

scholarly journals Effect of cigarette smoking on platelet aggregation in arteriosclerosis

1977 ◽  
Vol 8 (4) ◽  
pp. 524-528
Author(s):  
Yuzo NAGAKAWA ◽  
Toshio OZAWA ◽  
Masaki YOSHIKAWA
Keyword(s):  
Platelet Aggregation ◽  
Cigarette Smoking

Abstract 3473: The Effect of Cigarette Smoking on the Antiplatelet Effect of Clopidogrel: The Smokers Paradox

Circulation ◽  
2007 ◽  
Vol 116 (suppl_16) ◽  
Author(s):  
Paul Gurbel ◽  
Joseph Dichiara ◽  
Kevin P Bliden ◽  
Mark J Antonino ◽  
Lawal Lookman
Keyword(s):  
Platelet Aggregation ◽  
Cigarette Smoking ◽  
Metabolic Activation ◽  
Adenosine Diphosphate ◽  
Platelet Inhibition ◽  
Response Variability ◽  
Light Transmittance ◽  
Prior History ◽  
Platelet Response ◽  
Clopidogrel Therapy

Background: Wide response variability to clopidogrel therapy has been reported. Clopidogrel is a prodrug that requires metabolic activation by hepatic cytochromes (CYP). Cigarette smoking is an inducer of CYP1A2 and may, therefore, enhance the metabolism of clopidogrel. We sought to examine the effect of cigarette smoking on the platelet response to clopidogrel. Methods: Three hundred thirteen consecutive patients undergoing elective coronary stenting were studied. Platelet aggregation (PA) was assessed by light transmittance aggregometry (LTA) stimulated by 5 and 20μ M adenosine diphosphate. One hundred fourteen patients were on chronic clopidogrel therapy, were not reloaded, and had pre-stenting PA measurements. Pre-and post-stenting PA was measured in 199 patients: 60 were loaded with 300mg and 139 were loaded with 600mg. There were 120 current smokers (smoking within 2 weeks of PCI) and 193 non-smokers (no prior history of smoking). Low PA was defined as the lowest two quartiles of 5μM ADP-induced platelet aggregation (≤ 40%). Results: PA was significantly lower (p ≤ 0.008) in smokers on long term chronic clopidogrel treatment (Table ). Relative platelet inhibition (RPI) was higher in smokers treated with either 300mg or 600mg clopidogrel measured by 5 and 20μM ADP-induced PA. In a multivariate analysis, cigarette smoking was an independent predictor of low PA in patients on chronic clopidogrel therapy and in patients loaded with clopidogrel (r=0.3, p=0.0001). Conclusion: Clopidogrel therapy in smokers is associated with increased platelet inhibition and lower aggregation as compared to non-smokers. The mechanism of the smoking effect deserves further study and may be another cause of response variability to clopidogrel. RPI = 100 x ((baseline aggregation-post-treatment aggregation)/(baseline aggregation))

scholarly journals Effect of Cigarette Smoking on Plasma Fibrinogen and Platelet Count

2012 ◽  
Vol 2 (3) ◽  
pp. 181-184 ◽  
Author(s):  
Rashmi Narayanrao Gitte
Keyword(s):  
Platelet Count ◽  
Cigarette Smoking ◽  
Coagulation Factor ◽  
Plasma Fibrinogen ◽  
Fibrinogen Concentration ◽  
Human Beings ◽  
Healthy Male ◽  
The Mean ◽  
Surrounding Areas ◽  
Two Parameters

Objective: Cigarette smoking is one of the major lifestyle factors influencing the health of human beings. Fibrinogen is the major plasma protein coagulation factor. Higher plasma fibrinogen concentrations are associated with cardiovascular diseases. Material & Methods: One hundred twenty healthy male smokers and one hundred twenty healthy male non-smokers among hospital employees and people from surrounding areas of Narayana Medical College, Nellore (India) were studied. The platelet count was done using Beckman Coulter Automatic Analyzer; AcT 5diffCP.Assay for plasma fibrinogen was performed using turbido-metric immunoassay. Results: The mean plasma fibrinogen concentration for smokers is 3.78 gms/L and for non-smokers 3.02 gms/L. The mean platelet count for smokers is 257325 per mm3 and for non-smokers 215483.3 per mm3. The difference between mean plasma fibrinogen and platelet count of smokers and non-smokers was statistically significant (p<0.0001). Conclusion: Thus we concluded that in smokers plasma fibrinogen concentration and platelet count increase significantly. Regular monitoring of these two parameters in smokers is advised DOI: http://dx.doi.org/10.3126/ajms.v2i3.4261 Asian Journal of Medical Sciences 2 (2011) 181-184  

scholarly journals Circulating Platelet Aggregates During Emotional Stress and Cigarette Smoking

1977 ◽  
Author(s):  
G.F. Gensini ◽  
R. Abbate ◽  
D. Prisco ◽  
G.G. Neri Serneri
Keyword(s):  
Platelet Aggregation ◽  
Medical Students ◽  
Cigarette Smoking ◽  
Cigarette Smoke ◽  
Emotional Stress ◽  
Predictive Value ◽  
Normal Values ◽  
Circulating Platelet Aggregates ◽  
Platelet Aggregates ◽  
Clinically Significant

Increased platelet aggregation has been observed in various hypercoagulable states, but its predictive value for thrombosis is so far uncertain. We studied the effect of emotional stress and of cigarette smoking on circulating platelets by platelet aggregates ratio (PAR) according to Wu and Hoak (1974.) in medical students aged 20-22 years. The emotional stress was undergoing a University examination.PAR was measured immediately before the examination, at the end and 15 and 30 min after the examination.PAR was significantly lowered in all the subjects at the end (P<0.0l) and after 15 min (P<0.0l) but returned toward normal values after 30 min. The decrease of PAR suggests the production of reversible circulating platelet aggregates. The effect of smo=king a cigarette has been investigated in 8 students. PAR has been determined before smoking, at the end and after 2,5 and 10 min. Smoking lasted 4 min. In 5 subjects we observed a decrease of PAR at 2 min (P< 0. 01), whereas at 5 and 10 min PAR value became normal. Lettuce cigarette smoke did not affect PAR value. Our results indicate that: 1) – Platelet aggregates are very easily produced in circulating blood; 2)- A low value of PAR does not necessarily indicate a platelet hy=peraggregability clinically significant.

scholarly journals Total Count of White Blood Cells in Adult Male Smokers

1970 ◽  
Vol 2 ◽  
pp. 49-53 ◽  
Author(s):  
Mohammed Montasir Islam ◽  
Md Ruhul Amin ◽  
Shameema Begum ◽  
Dilruba Akther ◽  
Abedur Rahman
Keyword(s):  
Cigarette Smoking ◽  
Adult Male ◽  
White Blood Cells ◽  
Total Count ◽  
Cigarette Smokers ◽  
History Of ◽  
Study Population ◽  
One Year ◽  
Wbc Count ◽  
Apparently Healthy

The present study was carried out to observe the changes in total count in WBC in cigarette smokers. The study population consisted of 105 adult male smokers and non-smokers, aged 20~40 years, from different socio-economic classes. Among them, 30 apparently healthy non-smokers were taken as control. 75 apparently healthy smokers, who had the history of smoking of one or more cigarette per day, regularly for at least last one year, were taken as the study group. Smokers were again subdivided into three categories according to the number of cigarettes they consumed per day. For statistical analysis unpaired ‘t' test was used for comparison. Mean ± SD of Total count of WBC in non smokers and smokers were 7501.66 ± 929.4 /mm3 and 9171.3 ± 1037.7/mm3 respectively. Smokers had significantly (P<0.001) higher WBC counts than non-smokers. In addition, WBC count was found increased with intensity of smoking. The smokers who were smoking e 20 cigarettes per day had the higher total WBC count than those who were smoking lesser. The findings of the present study suggest that cigarette smoking may cause increased the total count of WBC, which may predict high risk for some fatal diseases. Key words: Cigarette Smoking; White Blood Cell; Adult Male DOI:10.3329/jbsp.v2i0.985 J Bangladesh Soc Physiol. 2007 Dec;(2): 49-53

scholarly journals Generation of human induced pluripotent stem cell line UNIGEi003-A from skin fibroblasts of an apparently healthy male donor

2020 ◽  
Vol 48 ◽  
pp. 101928 ◽  
Author(s):  
Erika Cosset ◽  
Tieng Vannary ◽  
Frédérique Sloan-Béna ◽  
Stefania Gimelli ◽  
Eric Gerstel ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cell Line ◽  
Pluripotent Stem Cell ◽  
Induced Pluripotent Stem Cell ◽  
Skin Fibroblasts ◽  
Healthy Male ◽  
Stem Cell Line ◽  
Male Donor ◽  
Induced Pluripotent ◽  
Apparently Healthy
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