Correlation of chest radiographic findings and coagulation abnormality with disease severity in COVID-19 positive patients

Shruti Chandak; Yogender Aggarwal; Ankur Malhotra; Deepti Arora; Ashutosh Kumar; Vivek Bhandari

doi:10.4103/amit.amit_27_21

Clinical presentation of different severities of hemorrhagic fever with renal syndrome: How to recognize it

Vojnosanitetski pregled ◽

10.2298/vsp1207604l ◽

2012 ◽

Vol 69 (7) ◽

pp. 604-609

Author(s):

Mirjana Lausevic ◽

Zeljko Lausevic ◽

Biljana Stojimirovic

Keyword(s):

Disease Severity ◽

Clinical Presentation ◽

Clinical Laboratory ◽

Hemorrhagic Fever ◽

Clinical Findings ◽

Severe Form ◽

Careful Consideration ◽

Phosphorus Concentration ◽

Radiographic Findings ◽

Severe Clinical Picture

Background/Aim. Besides viral serotype, HLA haplotype and cytokine genes polymorphism are associated with clinical presentation of hemorrhagic fever with renal syndrome. Since these analyses are unavailable in routine clinical practice, the aim of this study was to assess clinical, laboratory and radiographic findings associated with clinical presentation of disease severity. Methods. A total of 30 patients (27 men and 3 women), average age 40 ? 14.9 years, treated for hemorrhagic fever with renal syndrome from January 1, 1999 to December 31, 2009 in Clinical Center of Serbia, were included in the study. Nine patients (30%) had mild, 14 (46.7%) moderate and 7 (23.3%) severe form of the disease; 24 (80%) recovered, 6 (20%) died in the acute phase of the illness, and 19 patients (63.3%) required hemodialysis. Results. The average titer of antiviral antibodies in patients infected with Belgrade serotype virus were significantly higher in those with severe clinical presentation. Hypotension, anuria, macrohaematuria, pulmonary infiltration, pleural effusion, hepatomegalia and positive meningeal signs were more frequent in the patients with severe form of the disease. Statistically significant differences between groups with mild, moderate and severe clinical picture were found in serum total protein, albumin, calcium, glutamate pyruvate and glutamate oxaloacetate transaminase on admittance; serum creatinine and phosphorus concentration on day 14 and day 21; serum sodium and calciums on day 14; hemoglobine concentration on day 21. A statistically significant correlation was found between clinical presentation of the disease severity and platelet count, white blood cell count, hemoglobine concentration, serum calcium and serum transaminases on admittance. Multivariate analysis identified variables` combinations associated with clinical presentation of the disease. Conclusion. Our study confirmed that we can distinguish patients who will manifest different severities of the disease on the basis of careful consideration of laboratory and clinical findings on admission.

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Can chest radiographic findings determine disease severity in Covid-19-positive patients? A single-center study

European Journal of Inflammation ◽

10.1177/20587392211064461 ◽

2021 ◽

Vol 19 ◽

pp. 205873922110644

Author(s):

Ruza Stevic ◽

Nikola Colic ◽

Branislava Milenkovic ◽

Dragan Masulovic

Keyword(s):

Disease Severity ◽

University Hospital ◽

Common Finding ◽

Duration Of Symptoms ◽

Radiographic Findings ◽

Single Center Study ◽

Radiographic Score ◽

Time Courses ◽

The University ◽

Present On Admission

Objectives The purpose of this study was to describe the severity of the radiographic findings of COVID-19 over time and to assess their correlation with the duration of symptoms prior to admission, CT scores, and disease severity. Methods A retrospective analysis of patients with COVID-19 confirmed by reverse transcription polymerase chain reaction (RT-PCR) and CXR who were admitted at the university hospital was performed between March 25 and 30 April 2020. Baseline and serial CXRs were reviewed, along with onset and disease time courses. Correlations between CXR scores and CT scores, durations of symptoms and disease severity were evaluated; and also between regression times and disease severity. Results Of 208 total patients, there were 33 mild (15.9%), 103 moderate (49.5%), and 72 severe-critical (34.6%) cases. The most frequent symptoms were fever, cough, fatigue, and dyspnea. Dyspnea was more frequent in patients with severe and critical disease ( p < 0.001). The duration of symptoms experienced prior to admission was longer in patients with severe and critical disease than in moderate cases ( p < 0.05). Abnormalities on CXR were present on admission in 83.2% patients, with reticulations being the most common finding. CXR scores correlated with duration of symptoms prior to admission and CT scores ( p < 0.05 and p < 0.001, respectively). The median radiographic score of the severe-critical-type group was significantly higher than the moderate type ( p < 0.001) and regression time correlated with disease severity ( p < 0.001). Conclusion Our study showed that despite the limitations, CXR remains a very important tool for diagnosing and managing patients with COVID-19.

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Case Example: Adjacent Segment Disease: What Is It, and How Is It Rated?

Guides Newsletter ◽

10.1001/amaguidesnewsletters.2011.marapr02 ◽

2011 ◽

Vol 16 (2) ◽

pp. 8-9

Author(s):

Marjorie Eskay-Auerbach

Keyword(s):

Clinical Symptoms ◽

Lumbar Fusion ◽

Adjacent Segment Degeneration ◽

Adjacent Segment Disease ◽

Adjacent Segment ◽

Disc Space Narrowing ◽

Disc Disease ◽

Disc Space ◽

Radiographic Findings ◽

Asymptomatic Patients

Abstract The incidence of cervical and lumbar fusion surgery has increased in the past twenty years, and during follow-up some of these patients develop changes at the adjacent segment. Recognizing that adjacent segment degeneration and disease may occur in the future does not alter the rating for a cervical or lumbar fusion at the time the patient's condition is determined to be at maximum medical improvement (MMI). The term adjacent segment degeneration refers to the presence of radiographic findings of degenerative disc disease, including disc space narrowing, instability, and so on at the motion segment above or below a cervical or lumbar fusion. Adjacent segment disease refers to the development of new clinical symptoms that correspond to these changes on imaging. The biomechanics of adjacent segment degeneration have been studied, and, although the exact mechanism is uncertain, genetics may play a role. Findings associated with adjacent segment degeneration include degeneration of the facet joints with hypertrophy and thickening of the ligamentum flavum, disc space collapse, and translation—but the clinical significance of these radiographic degenerative changes remains unclear, particularly in light of the known presence of abnormal findings in asymptomatic patients. Evaluators should not rate an individual in anticipation of the development of changes at the level above a fusion, although such a development is a recognized possibility.

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Disease severity predicts bone loss: A longitudinal study in inflammatory bowel disease patients

Gastroenterology ◽

10.1016/s0016-5085(01)83124-3 ◽

2001 ◽

Vol 120 (5) ◽

pp. A628-A628

Author(s):

S HENDERSON ◽

S DHALIWAL ◽

N HOFFMAN ◽

R PRINCE

Keyword(s):

Inflammatory Bowel Disease ◽

Longitudinal Study ◽

Bone Loss ◽

Disease Severity ◽

Bowel Disease ◽

Inflammatory Bowel

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Psoriasis Lessens Quality of Life Regardless of Disease Severity

Skin & Allergy News ◽

10.1016/s0037-6337(06)71449-8 ◽

2006 ◽

Vol 37 (8) ◽

pp. 13

Author(s):

KERRI WACHTER

Keyword(s):

Quality Of Life ◽

Disease Severity

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361 The intrinsic mitochondrial oxidative capacity of human failing hearts is depressed and relates to disease severity but keeps normal regulatory properties

European Journal of Heart Failure Supplements ◽

10.1016/s1567-4215(03)90218-9 ◽

2003 ◽

Vol 2 (1) ◽

pp. 70

Author(s):

B METTAUER ◽

J ZOLL ◽

B NGUESSAN ◽

F RIBERA ◽

E LAMPERT ◽

...

Keyword(s):

Disease Severity ◽

Oxidative Capacity ◽

Mitochondrial Oxidative Capacity ◽

Regulatory Properties

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Vitamin D levels are not associated with non-alcoholic fatty liver disease severity in a Brazilian population

International Journal for Vitamin and Nutrition Research ◽

10.1024/0300-9831/a000667 ◽

2020 ◽

pp. 1-8

Author(s):

Jeniffer Danielle M. Dutra ◽

Quelson Coelho Lisboa ◽

Silvia Marinho Ferolla ◽

Carolina Martinelli M. L. Carvalho ◽

Camila Costa M. Mendes ◽

...

Keyword(s):

Vitamin D ◽

Liver Disease ◽

Fatty Liver ◽

Disease Severity ◽

Fatty Liver Disease ◽

Hypovitaminosis D ◽

Alcoholic Fatty Liver ◽

Vitamin D Levels ◽

The Mean ◽

Alcoholic Fatty Liver Disease

Abstract. Some epidemiological evidence suggests an inverse correlation between non-alcoholic fatty liver disease (NAFLD) frequency and vitamin D levels. Likewise, a beneficial effect of vitamin D on diabetes mellitus (DM) and insulin resistance has been observed, but this is an unsolved issue. Thus, we aimed to investigate the prevalence of hypovitaminosis D in a NAFLD Brazilian population and its association with disease severity and presence of comorbidities. In a cross-sectional study, the clinical, biochemical and histological parameters of 139 NAFLD patients were evaluated according to two different cut-off points of serum 25-hydroxyvitamin D levels (20 ng/mL and 30 ng/mL). The mean age of the population was 56 ± 16 years, most patients were female (83%), 72% had hypertension, 88% dyslipidemia, 46% DM, 98% central obesity, and 82% metabolic syndrome. Serum vitamin D levels were < 30 ng/mL in 78% of the patients, and < 20 ng/mL in 35%. The mean vitamin D level was 24.3 ± 6.8 ng/mL. The comparison between the clinical, biochemical and histological characteristics of the patients according to the levels of vitamin D showed no significant difference. Most patients with NAFLD had hypovitaminosis D, but low vitamin D levels were not related to disease severity and the presence of comorbidities.

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