scholarly journals Can chest radiographic findings determine disease severity in Covid-19-positive patients? A single-center study

2021 ◽  
Vol 19 ◽  
pp. 205873922110644
Author(s):  
Ruza Stevic ◽  
Nikola Colic ◽  
Branislava Milenkovic ◽  
Dragan Masulovic
Keyword(s):  
Disease Severity ◽  
University Hospital ◽  
Common Finding ◽  
Duration Of Symptoms ◽  
Radiographic Findings ◽  
Single Center Study ◽  
Radiographic Score ◽  
Time Courses ◽  
The University ◽  
Present On Admission

Objectives The purpose of this study was to describe the severity of the radiographic findings of COVID-19 over time and to assess their correlation with the duration of symptoms prior to admission, CT scores, and disease severity. Methods A retrospective analysis of patients with COVID-19 confirmed by reverse transcription polymerase chain reaction (RT-PCR) and CXR who were admitted at the university hospital was performed between March 25 and 30 April 2020. Baseline and serial CXRs were reviewed, along with onset and disease time courses. Correlations between CXR scores and CT scores, durations of symptoms and disease severity were evaluated; and also between regression times and disease severity. Results Of 208 total patients, there were 33 mild (15.9%), 103 moderate (49.5%), and 72 severe-critical (34.6%) cases. The most frequent symptoms were fever, cough, fatigue, and dyspnea. Dyspnea was more frequent in patients with severe and critical disease ( p < 0.001). The duration of symptoms experienced prior to admission was longer in patients with severe and critical disease than in moderate cases ( p < 0.05). Abnormalities on CXR were present on admission in 83.2% patients, with reticulations being the most common finding. CXR scores correlated with duration of symptoms prior to admission and CT scores ( p < 0.05 and p < 0.001, respectively). The median radiographic score of the severe-critical-type group was significantly higher than the moderate type ( p <  0.001) and regression time correlated with disease severity ( p < 0.001). Conclusion Our study showed that despite the limitations, CXR remains a very important tool for diagnosing and managing patients with COVID-19.

scholarly journals Is there an association between Anti-Citrullinated Peptide Antibodies and the Severity of Rheumatoid Arthritis Parameters in Algerian Patients?

2020 ◽  
Vol 10 (4) ◽  
pp. 17-24
Author(s):  
Siheme OUALI ◽  
Khalida ZEMRI ◽  
Ferial SELLAM ◽  
Noria HARIR ◽  
Zahira BENIASSA ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Disease Activity ◽  
Disease Severity ◽  
Disease Duration ◽  
University Hospital ◽  
Laboratory Assessment ◽  
Functional Rehabilitation ◽  
Strong Relation ◽  
The University ◽  
Citrullinated Peptide

Objectives: The aim of this study was to demonstrate the relationships between anti-citrullinated peptide/protein antibodies status and clinical characteristics, disease severity, radiological damages and laboratory assessment in Algerian patients with Rheumatoid arthritis, as well as their importance like a predictive factor for the diagnosis of Rheumatoid arthritis (RA). Methods: 281 patients diagnosed with RA according to ACR 1987 criteria in the  internal medicine and Functional Rehabilitation departments (the University Hospital of Sidi Bel Abbes) were enrolled in the study based on medical records including age, gender, disease duration, disease activity score (DAS28), joint damages, laboratory tests and treatment. All data were processed and analyzed via SPSS 22.0. Results: 86.5% of patients were females with a mean age and disease duration of respectively 52.665±12.3477, 4.19±4.050.  Patients with Anti-CCP positive (79.7%) presented a high disease activity (p<0.0001), a long disease duration (p=0.016) and a erosion damages (p<0.0001). we did not found any significant relation between gender, hands damages and CRP..A logistic regression showed that the presence of Anti-CCP was associated with Erosion, disease activity, age and RF presence. Conclusion: There was a strong relation between Anti-CCP antibodies status and the development of RA in Algerian patients. It could be considered as a useful predictor of disease severity.  

scholarly journals Web-based, rapid and contactless management of ambulatory patients for SARS-CoV-2-testing

2020 ◽  
Author(s):  
Jannik Stemler ◽  
Oliver A. Cornely ◽  
Torsten Noack-Schönborn ◽  
Corinna Forholz ◽  
Sofie Schumacher ◽  
...  
Keyword(s):  
Mass Casualty Incident ◽  
Mass Casualty ◽  
University Hospital ◽  
Test Results ◽  
Web Based ◽  
Duration Of Symptoms ◽  
Efficient Management ◽  
Ambulatory Patients ◽  
The University ◽  
Outpatient Appointments

Abstract BackgroundDuring the SARS-CoV-2 pandemic a mass casualty incident of ambulatory patients occurred at the COVID-19 rapid response infrastructure (CRRI) facility at the University Hospital of Cologne (UHC). We report the development of a patient-centred mobile-device solution to support efficient management of the facility, triage of patients and rapid delivery of test results.MethodsThe UHC-Corona Web Tool (CWT) was developed as a web-based application useable on each patient's smartphone. It provides, among others, a self-reported medical history including type and duration of symptoms and potential risk contacts and links all retrieved information to the digital patient chart via a QR code. It provides scheduling of outpatient appointments and automated transmission of SARS-CoV-2 test results.ResultsThe UHC-CWT was launched on April 9th, 2020. It was used by 28652 patients until August 31st,2020. Of those, 15245 (53,2%) consulted the CRRI, representing 43,1% of all CRRI patients during the observed period.There were 8304 (29,0%) specifications concerning travel history and 17145 (59,8%) indications of ≥1 symptom of SARS-CoV-2 infection. The most frequently indicated symptoms were sore throat (60,0%), headache (50,7%), common cold (45,1%) and cough (42,6%) while 11057 (40,2%) patients did not report any symptoms. After implementation of the UHC-CWT, the number of patient contacts per physician rose from 38 to 98,7 per day. The personnel for communication of test results was reduced from four on seven days to one on five days.ConclusionThe UHC-CWT is an effective digital solution for management of large numbers of outpatients for SARS-CoV-2 testing.

scholarly journals Similar Rates of AKI during the First Two Waves of COVID-19 in Northern Italy: a single-center study

2021 ◽  
Author(s):  
Gaetano Alfano ◽  
Silvia Giovanella ◽  
Francesco Fontana ◽  
Jovana Milic ◽  
Giulia Ligabue ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Diuretic Therapy ◽  
Kidney Injury ◽  
University Hospital ◽  
Respiratory Impairment ◽  
Steady Rate ◽  
Single Center Study ◽  
Incidence Risk ◽  
The University

Introduction: Two waves of COVID-19 cases have overwhelmed most European countries during 2020. It is unclear if the incidence of acute kidney injury (AKI) has changed during the COVID-19 outbreaks. This study aims to evaluate the differences in incidence, risk factors and outcome of AKI in patients with SARS-CoV-2 infection during the first and second wave of COVID-19. Method: We reviewed the health medical records of 792 consecutive patients with COVID-19 hospitalized at the University Hospital of Modena, Italy, from February 25 to December 14, 2020. Results: AKI was diagnosed in 122 (15.4%) patients. Incidence of AKI remained steady rate during wave-1 (15.9%) and wave-2 (14.7%) (P=0.89). AKI patients were older (P=<0.001) and had a more severe respiratory impairment (PO2/FO2) (P=≤0.001) than their non-AKI counterparts. AKI led to a longer hospital stay (P=0.001), complicated with a higher rate of ICU admission. COVID-19-related AKI was associate with 59.7% of deaths during wave-1 and 70.6% during wave-2. At the end of the period of observation, 24% (wave-1) and 46.7% (wave-2) of survivors were discharged with a not fully recovered kidney function. Risk factors for AKI in patients with COVID-19 were diuretics (HR=5.3; 95%CI, 1.2-23.3; P=0.025) and cardiovascular disease (HR, 2.23; 95%CI, 1.05-5.1; P=0.036). Conclusion: The incidence of AKI (about 15%) remained unchanged during 2020, regardless of the trend of COVID-19. AKI occurred in patients with severe COVID-19 symptoms and was associated with a higher incidence of deaths than non-AKI patients. The risk factors of COVID-19-related AKI were diuretic therapy and cardiovascular disease.

scholarly journals A Novel Severity Scoring Derived from Chest Radiographic Findings in COVID 19 Patients Admitted to a COVID Care University Hospital in India

2021 ◽  
pp. 17-25
Author(s):  
Abhijit Mahavir Patil ◽  
Meenakshi Bhakare ◽  
Sundeep Salvi
Keyword(s):  
Oxygen Saturation ◽  
Clinical Severity ◽  
Host Cells ◽  
University Hospital ◽  
Disease Spread ◽  
Blood Oxygen ◽  
The Novel ◽  
Blood Oxygen Saturation ◽  
Radiographic Findings ◽  
Radiographic Score

Coronavirus (COVID 19) disease predominantly affects the Respiratory system and cause by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-COV2). It enters into the host cells via angiotensin-converting enzyme-2 (ACE-2), a part of the renin-angiotensin system (RAS) found in the epithelium of the nasal, lungs. Aim: Chest Radiographic findings in COVID-19 patients detected for COVID care. Applying the novel chest radiographic scoring in disease-spread patients is admitted to the COVID care center and its correlation with blood oxygen saturation (SpO2) and clinical severity. Objective: 1) To apply the novel chest radiographic scoring in patients of COVID 19 infection are admitted to our Covid Care Centre and 2) To apply its correlation with blood oxygen saturation (SpO2) and clinical severity. Results: 1) We found a moderate negative correlation between the chest radiographic score and SpO2. 2) Weak positive correlation between Clinical grading and CxR score. Conclusion: Chest radiographic score taking into account the nature of opacities and extent is useful in classifying the patients into mild-moderate, severe, and critical grades. Take-home Message: A chest radiograph can be used as a baseline radiological investigation in COVID 19 patients as it can help to triage them according to the severity and treat them accordingly.

scholarly journals In-hospital Mortality Among Neurological Patients over the Period of 5 years — a Retrospective, Single-center Study

2020 ◽  
Vol 9 (1) ◽  
pp. 20-26
Author(s):  
Adam Wiśniewski ◽  
Keyword(s):  
Mortality Rate ◽  
Hospital Mortality ◽  
Neurological Disorders ◽  
Hemorrhagic Stroke ◽  
University Hospital ◽  
Hospital Death ◽  
Single Center Study ◽  
Neurological Patients ◽  
Neurology Clinic ◽  
The University

Introduction. Neurological disorders have been considered for many years dangerous and are associated with higher risk of in-hospital death. Brain vascular disorders are widely considered as the most severe and related to the highest mortality rate. Aim. The aim of the study was to assess the mortality rate in subjects hospitalized in the Neurology ward within 5 years, in particular the etiology, direct cause and predictability of deaths. Material and Methods. This study is retrospective. The documentation analysis concerned the last 5 years, i.e. from 2015 to 2019. From among the entire database of 8247 patients hospitalized in the Neurology Clinic of the University Hospital No. 1 in Bydgoszcz, 429 deaths were reported and analyzed. Results. The mortality rate was 5.2% among all subjects, 6.6% among all vascular patients and 1.16% among non-vascular subjects. The highest mortality was reported among hemorrhagic stroke (28.4%) and it was significantly higher compared to ischemic stroke (OR = 6.25, 95% CI 4.9–7.8, p < 0.0001). Patients with stroke had significantly higher mortality compared to other neurological disorders (OR = 11.08 95% CI 7.7–15.9, p < 0.0001). The main direct reason of death (80%) was primary cerebral as a result of baseline disease. 7% of deaths were considered as sudden, unexpected and 10.7% were related to complications developed during hospitalization. Conclusions. Stroke, especially hemorrhagic subtype, still remains the cause of the highest in-hospital mortality rate in the Neurology Ward. It is worth to notice that special attention should be paid to patients with coexisting infectious diseases, that contribute to higher mortality risk. (JNNN 2020;9(1):20–26) Key Words: in-hospital mortality, neurological disorders, stroke, prognosis

scholarly journals Thirty Years of Kawasaki Disease: A Single-Center Study at the University Hospital of Lausanne

2019 ◽  
Vol 7 ◽  
Author(s):  
Marion de La Harpe ◽  
Stefano di Bernardo ◽  
Michaël Hofer ◽  
Nicole Sekarski
Keyword(s):  
Kawasaki Disease ◽  
University Hospital ◽  
Single Center ◽  
Single Center Study ◽  
The University ◽  
Center Study

scholarly journals Web-based, rapid and contactless management of ambulatory patients for SARS-CoV-2-testing

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Jannik Stemler ◽  
Oliver A. Cornely ◽  
Torsten Noack-Schönborn ◽  
Corinna Fohrholz ◽  
Sofie Schumacher ◽  
...  
Keyword(s):  
Mass Casualty Incident ◽  
Mass Casualty ◽  
University Hospital ◽  
Test Results ◽  
Web Based ◽  
Duration Of Symptoms ◽  
Efficient Management ◽  
Ambulatory Patients ◽  
The University ◽  
Outpatient Appointments

Abstract Background During the SARS-CoV-2 pandemic a mass casualty incident of ambulatory patients occurred at the COVID-19 rapid response infrastructure (CRRI) facility at the University Hospital of Cologne (UHC). We report the development of a patient-centred mobile-device solution to support efficient management of the facility, triage of patients and rapid delivery of test results. Methods The UHC-Corona Web Tool (CWT) was developed as a web-based software useable on each patient’s smartphone. It provides, among others, a self-reported medical history including type and duration of symptoms and potential risk contacts and links all retrieved information to the digital patient chart via a QR code. It provides scheduling of outpatient appointments and automated transmission of SARS-CoV-2 test results. Results The UHC-CWT was launched on 9 April 2020. It was used by 28,652 patients until 31 August 2020. Of those, 15,245 (53,2%) consulted the CRRI, representing 43,1% of all CRRI patients during the observed period. There were 8304 (29,0%) specifications concerning travel history and 17,145 (59,8%) indications of ≥1 symptom of SARS-CoV-2 infection. The most frequently indicated symptoms were sore throat (60,0%), headache (50,7%), common cold (45,1%) and cough (42,6%) while 11,057 (40,2%) patients did not report any symptoms. After implementation of the UHC-CWT, the amount of patient contacts per physician rose from 38 to 98,7 per day. The personnel for communication of test results were reduced from four on seven days to one on five days. Conclusion The UHC-CWT is an effective digital solution for management of large numbers of outpatients for SARS-CoV-2 testing.

Symptomatic vascular complications after vascular closure device use following diagnostic and interventional catheterisation

VASA ◽  
2004 ◽  
Vol 33 (2) ◽  
pp. 78-81 ◽  
Author(s):  
Thalhammer ◽  
Aschwanden ◽  
Jeanneret ◽  
Labs ◽  
Jäger
Keyword(s):  
Current Literature ◽  
Vascular Complications ◽  
University Hospital ◽  
Closure Device ◽  
Ultrasound Guided ◽  
Vascular Closure Device ◽  
Device Use ◽  
Arterial Stenoses ◽  
The University ◽  
Stenotic Lesions

Background: Haemostatic puncture closure devices for rapid and effective hemostasis after arterial catheterisation are a comfortable alternative to manual compression. Implanting a collagen plug against the vessel wall may become responsible for other kind of vascular injuries i.e. thrombotic or stenotic lesions and peripheral embolisation. The aim of this paper is to report our clinically relevant vascular complications after Angio-Seal® and to discuss the results in the light of the current literature. Patients and methods: We report the symptomatic vascular complications in 17 of 7376 patients undergoing diagnostic or therapeutic catheterisation between May 2000 and March 2003 at the University Hospital Basel. Results: Most patients presented with ischaemic symptoms, arterial stenoses or occlusions and thrombotic lesions (n = 14), whereas pseudoaneurysms were extremely rare (n = 3). Most patients with ischaemic lesions underwent vascular surgery and all patients with a pseudoaneurysm were successfully treated by ultrasound-guided compression. Conclusions: Severe vascular complications after Angio-Seal® are rare, consistent with the current literature. There may be a shift from pseudoaneurysms to ischaemic lesions.

User Evaluation of an Integrated Medical Workstation for Clinical Data Analysis

1993 ◽  
Vol 32 (05) ◽  
pp. 365-372 ◽  
Author(s):  
T. Timmeis ◽  
J. H. van Bemmel ◽  
E. M. van Mulligen
Keyword(s):  
Data Analysis ◽  
Clinical Research ◽  
Clinical Data ◽  
University Hospital ◽  
User Evaluation ◽  
Scientific Staff ◽  
Medical Institutions ◽  
Clinical Data Analysis ◽  
Research Problems ◽  
The University

AbstractResults are presented of the user evaluation of an integrated medical workstation for support of clinical research. Twenty-seven users were recruited from medical and scientific staff of the University Hospital Dijkzigt, the Faculty of Medicine of the Erasmus University Rotterdam, and from other Dutch medical institutions; and all were given a written, self-contained tutorial. Subsequently, an experiment was done in which six clinical data analysis problems had to be solved and an evaluation form was filled out. The aim of this user evaluation was to obtain insight in the benefits of integration for support of clinical data analysis for clinicians and biomedical researchers. The problems were divided into two sets, with gradually more complex problems. In the first set users were guided in a stepwise fashion to solve the problems. In the second set each stepwise problem had an open counterpart. During the evaluation, the workstation continuously recorded the user’s actions. From these results significant differences became apparent between clinicians and non-clinicians for the correctness (means 54% and 81%, respectively, p = 0.04), completeness (means 64% and 88%, respectively, p = 0.01), and number of problems solved (means 67% and 90%, respectively, p = 0.02). These differences were absent for the stepwise problems. Physicians tend to skip more problems than biomedical researchers. No statistically significant differences were found between users with and without clinical data analysis experience, for correctness (means 74% and 72%, respectively, p = 0.95), and completeness (means 82% and 79%, respectively, p = 0.40). It appeared that various clinical research problems can be solved easily with support of the workstation; the results of this experiment can be used as guidance for the development of the successor of this prototype workstation and serve as a reference for the assessment of next versions.

Sign in / Sign up

Export Citation Format

Share Document