scholarly journals Prevalence and outcomes of D dimer elevation among the COVID-19 patients in tertiary care hospital, Salem

2021 ◽  
Vol 10 (12) ◽  
pp. 4478
Author(s):  
Kirubhakaran Kanakaraju ◽  
MoogaambigaS Pandiyan ◽  
RangabashyamS Ranganathan ◽  
Arunkumar Asokan
Keyword(s):  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Care Hospital ◽  
D Dimer

scholarly journals Prevalence and characteristics of venous thromboembolism in severe exacerbation of chronic obstructive pulmonary disease in a tertiary care hospital in India

2021 ◽  
Author(s):  
Soibam Pahel Meitei ◽  
Sudheer Tale ◽  
Arjun Kumar Negi ◽  
Ruchi Dua ◽  
Rohit Walia ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Venous Thromboembolism ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Lower Limbs ◽  
Chronic Obstructive ◽  
Care Hospital ◽  
Obstructive Pulmonary Disease ◽  
Test Probability ◽  
D Dimer

Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) carries a high risk of venous thromboembolism (VTE). Pulmonary embolism (PE) and AECOPD increase the mortality and morbidity risk associated with each other. Racial and ethnic differences in VTE risk have been documented in multiple studies. However, there is a dearth of reliable Indian data on the same. This study was planned to find the prevalence of VTE in the setting of severe AECOPD in a tertiary care hospital in India and to identify the clinical, laboratory and radiological characteristics of VTE in severe AECOPD. A total of 156 consecutive patients admitted with severe AECOPD and meeting the specified inclusion and exclusion criteria were recruited. Thorough workup of all patients was done including ABG, serum D dimer, ECG, compression ultrasound of lower limbs and 2-D echocardiography. Patients with high pre-test probability score, or intermediate pre-test probability score at presentation with serum D dimer above the age adjusted cut-off underwent computerised tomography pulmonary angiography (CTPA).  Results were analysed using SPSS version 23.  Sixteen (10.3%) patients had VTE, 15 (93.75%) of them being cases of isolated PE. Female gender, higher cumulative past exposure to corticosteroid, higher alveolar-arterial gradient, right ventricular dysfunction, and higher mean pulmonary artery pressure were associated with increased risk for VTE. The prevalence of VTE in AECOPD in this study among an Indian population is higher than among other Asians, but lower than among the Blacks, the Caucasians and the Middle-East ethnicities. Since a vast majority of VTE presents as PE without DVT in the setting of AECOPD, the absence of deep vein thrombosis of lower limbs does not rule PE in the setting.

CORRELATION BETWEEN CT CHEST SEVERITY SCORE AND CLINICAL PARAMETERS AND BIOCHEMICAL MARKERS IN COVID 19 PATIENTS

2021 ◽  
pp. 25-28
Author(s):  
Pramodh Kumar ◽  
Konduru Aneesha ◽  
Ch. Radhika ◽  
Elaya Kumar ◽  
R. Srinivasan
Keyword(s):  
Severity Score ◽  
Biochemical Markers ◽  
Tamil Nadu ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Clinical Parameters ◽  
Care Hospital ◽  
Rt Pcr ◽  
The Relationship ◽  
D Dimer

AIM: To correlate between CT chest severity score in COVID 19 patients with Clinical [SpO2, RR, PaO2/FiO2] and Biochemical parameters [NLR ratio, CRP, D- Dimer values]. METHODS: A Retrospective, observational study was conducted in a tertiary care hospital in Kanchipuram, Tamil Nadu. 110 patients were admitted to the hospital with COVID 19 [RT PCR swab for COVID 19 positive and radiologically positive] between March 2021 to June 2021. The patient was clinically, radiologically, and biochemically evaluated. CT chest severity score was used to differentiate the patients into mild, moderate, and severe groups. The relationship between CT Severity score and Clinical parameters such as SpO2, RR, PaO2/FiO2 and Biochemical markers [ NLR ratio, CRP, D-Dimer] were studied. RESULTS: CT chest severity score was found to be positively correlated with decreased SpO2 levels, decreased PaO2/ FiO2, increased RR and elevated NLR ratio, D Dimer and CRP levels(P < 0.001). CONCLUSION: The 25 CT Severity score scores well with the Clinical parameters and biochemical markers. Our data suggest that CT Chest Severity Score correlates well with clinical parameters and biochemical markers.

scholarly journals Analysis of D-Dimer Levels among Covid -19 Positive Patients in a Tertiary Care Hospital in Bangalore

2021 ◽  
Vol 9 (2) ◽  
pp. 80-84
Author(s):  
Dr. Manasa. S ◽  
◽  
Dr. Venkatesh Vikram H. C ◽  
Keyword(s):  
Retrospective Study ◽  
Tertiary Care Hospital ◽  
Early Stage ◽  
Tertiary Care ◽  
Fibrin Clot ◽  
Coagulation Disorder ◽  
Care Hospital ◽  
Coagulation Disorders ◽  
Lab Test ◽  
D Dimer

Introduction: Pro-thrombotic changes are stimulated by Corona Virus as it has an affinity forendothelium and lung structures and this may explain its association with thrombotic events,reduction of pulmonary gas exchange, respiratory distress, and death. D-dimer is a specific markerof the breakdown of a fibrin clot and has been used as a diagnostic and prognostic marker in VTEand other coagulation disorders. Objectives: The objective of this study was to assess thecorrelation of the D-Dimer levels and disease severity among COVID-19 patients. Materials andmethods: This is a retrospective study done over 6 months from July 2020 to December 2020 in atertiary care hospital in Bangalore. All the COVID- 19 positive cases who were admitted to ourhospital were audited regarding the D-dimer levels during admission and the course of thetreatment. Results: Coagulation disorder occurred at the early stage of COVID-19 infection, with1066 (57.7%) patients having increased D-dimer levels. Out of 1846 COVID 19 patients 106(5.7%)patients died due to complications. 106 patients who deceased, all the patients had anincreased D dimer value either in the first lab test or in the consecutive tests. Among 106 patients56(52.8%) patients had increased D-dimer at the first lab test, 32 (30.1%) had D-dimer increasedat the second and 18(16.98%) in third lab tests. The increased D-dimer levels were closelyassociated with the progression of the disease and also the changes in the CT imaging. Conclusion:The increase in D-Dimer levels also increased the complications in the COVID-19 patient. So it isnecessary to continuously monitor D-dimer levels and labelled anticoagulation as management toolsfor COVID-19 disease to prevent complications and reduce interventions.

scholarly journals Clinical and Biochemical Profile of COVID-19 Patients Admitted in a Tertiary Care Hospital of Kolkata

2021 ◽  
Author(s):  
Avick Nag ◽  
Soumyadeep Ghosh ◽  
Anushree Pal ◽  
Ankan Saha ◽  
Sanjay Kumar Mandal
Keyword(s):  
Prothrombin Time ◽  
Biochemical Parameters ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Clinical Severity ◽  
Care Hospital ◽  
Biochemical Profile ◽  
Group A ◽  
Group B ◽  
D Dimer

Introduction: The disease caused by Coronavirus (COVID-19), is now pandemic all over the world including India. There are different manifestations of the disease from asymptomatic and mild to severe form. Clinical severity varies from country to country. This study was conducted to document different clinical and biochemical profiles in this Tertiary Care Hospital of Kolkata. Aim: The study was done to observe and to compare the clinical and biochemical profile in asymptomatic to mild and moderate to severe symptomatic patients. Materials and Methods: This was an observational study conducted in Medical College, Kolkata, West Bengal, India. The study was conducted from June 2019 to mid-August 2019. Total 573 Real Time Polymerase Chain Reaction (RT PCR) positive COVID patients were included in this study. All patients were examined and investigated with blood parameters. Patients were divided into two groups (Group A-asymptomatic and mild symptoms and Group B moderate and severe symptoms) clinically. Statistical calculators like Statistical Package for Social Sciences (SPSS) and Soccalculator were used and different biochemical parameters were analysed using Chi-square, unpaired T-test to find out significance among these two groups. Results: Among 573 patients, 222 were in group A and 351 were in group B. Fever was the most common presenting feature (69.6%) followed by dry cough and shortness of breath. Other features were malaise/fatigability, diarrhoea and anosmia. Among the co-morbidities hypertension and diabetes were significantly different between the two groups. Among the biochemical parameters Neutrophil-Lymphocyte Ratio (NLR), C-Reactive Protein (CPR), D-dimer, Prothrombin time, Serum Glutamic Oxaloacetic Transaminase (SGOT), Serum Glutamic Pyruvic Transaminase (SGPT) were significantly different between the two groups. Conclusion: In a tertiary care hospital of Kolkata, fever is the most common presentation followed by dry cough and fatigability in COVID patients. Diabetes and hypertension are the common co morbidities. CRP, NLR, D-dimer, prothrombin time, SGOT and SGPT should be monitored to differentiate between mild and severe cases.

scholarly journals Clinical and biomarker profile of COVID-19 patients admitted in a tertiary care hospital

Biomedicine ◽  
2021 ◽  
Vol 41 (2) ◽  
pp. 268-273
Author(s):  
Archana Bhat ◽  
Don Gregory Mascarenhas ◽  
J Manjunath ◽  
Anand Kumar R ◽  
Sucharitha Suresh ◽  
...  
Keyword(s):  
Disease Severity ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Clinical Signs ◽  
Signs And Symptoms ◽  
Care Hospital ◽  
Male Predominance ◽  
Co Morbidity ◽  
Clinical Signs And Symptoms ◽  
D Dimer

Introduction and Aim:A novel beta-coronavirus emerged in Wuhan, China during the early December 2019 and spread globally. The clinical signs and symptoms and the disease severity in people infected with COVID-19 can be varied. The present study was conducted to study the biomarker profile and their association with disease severity in COVID-19.   Materials and Methods:This was a single-centre Cohort study of data regarding epidemiological, clinical and biomarker parameters, and outcome of COVID-19 patients admitted in a tertiary care hospital in South India. CDC guidelines were followed for assessing disease severity.   Results:A total of 336 COVID-19 patients were admitted during the study period. Of these 16 were excluded and 320 cases were analysed. Mean age of patients was 44.82 years. A male predominance was observed. Diabetes mellitus was the most common co-morbidity. Asymptomatic, Mild, moderate, severe and critical disease was seen in 15%, 52.5%, 20.3%, 6.3% and 5.9% patients respectively. ICU care was required in 15.3%. Overall mortality was 5.3%. The mean NLR, ALC, CRP, LCR, LDH, Ferritin and D-dimer in the severe group vs non-severe groupwere19.03 vs 4.2, 1025cells/cumm vs 1740cells/cumm, 185.8mg/L vs 31.7mg/L, 17.1 vs 996.3, 552.8IU/L vs 252.7IU/L, 2531.9ng/ml vs 414.1ng/ml and 2245.5ng/ml vs 339.4ng/ml respectively.   Conclusion:An increased NLR, CRP, LDH, Ferritin and D-dimer and a reduced ALC and LCR are significantly associated with disease severity, need for ICU and mortality. These biomarkers will be useful adjunct to clinical assessment in better categorising and management of COVID-19 patients.

scholarly journals Prognostic significance of various biochemical markers in Corona virus disease (COVID)-19: A tertiary care hospital study in Kakinada East Godavari district, Andhra Pradesh

2021 ◽  
Vol 8 (3) ◽  
pp. 226-229
Author(s):  
G Rajeswari ◽  
P Satya Gopal ◽  
G.B.V.V.S.V Prasad
Keyword(s):  
Biochemical Markers ◽  
Inflammatory Markers ◽  
Andhra Pradesh ◽  
Liver Enzymes ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Care Hospital ◽  
Markers Of Inflammation ◽  
The Relationship ◽  
D Dimer

This study was conducted on covid 19 patients who admitted in various wards in tertiary care centre (Government general hospital, Kakinada) E.G, Dt, Andhra Pradesh, from the 1st November 2020 to 15th January 2021 before Immunization. And divided in to two groups male and female cases. This study involves estimation of Biochemical profile in all the admitted patients to predict the severity of the covid 19 disease at the time of admission in to the Hospital. To analyse and estimate the serum inflammatory markers like D dimer, Ferritin, C-Reactive Protein, LFT and RFT in Covid 19 patients and evaluate the relationship of inflammatory marker se D-Dimer with other inflammatory markers like Ferritin, CRP and biochemical markers like Creatinine and liver enzymes (OT, PT). We retrospectively analysed the Clinical features and lab parameters of 393 cases of Covid-19 admitted to tertiary care hospital GGH Kakinada. Plasma d dimer, serum CRP and ferritin were significantly raised in total covid 19 patients and more increased in males when compared with females. Biochemical parameters like creatinine and liver enzymes also elevated in total cases and more increased in males as compared with females suggest organ dysfunction and systemic inflammation. The most typical finding in patients with COVID-19 coagulopathy is an increased D dimer concentration, and the relationship between D-dimer levels and the other markers of inflammation like Ferritin, CRP in COVID-19 shows disease progression. We conclude that biochemical monitoring of Covid-19 patients helps in identifying critically ill patients even earlier, aiming to reduce mortality and improve the recovery rate.

scholarly journals Functional decline in hospitalized older patients with coronavirus disease 2019: a retrospective cohort study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Tomohiro Hosoda ◽  
Shota Hamada
Keyword(s):  
Barthel Index ◽  
Older Patients ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Functional Decline ◽  
Index Score ◽  
Sensitivity Analyses ◽  
Care Hospital ◽  
Barthel Index Score ◽  
D Dimer

Abstract Background This study aimed to determine the frequency of functional decline and to identify the factors related to a greater risk of functional decline among hospitalized older patients with coronavirus disease 2019 (COVID-19). Methods We reviewed the medical records of patients aged over 65 years who were admitted to a tertiary care hospital for COVID-19 over 1 year from February 2020. We evaluated the proportion of functional decline, which was defined as a decrease in the Barthel Index score from before the onset of COVID-19 to discharge. Multivariable logistic regression analyses were performed to evaluate the associations between the demographic and clinical characteristics of patients at admission and a greater risk of functional decline. Two sensitivity analyses with different inclusion criteria were performed: one in patients without very severe functional decline before the onset of COVID-19 (i.e., limited to those with Barthel Index score ≥ 25), and the other with a composite outcome of functional decline and death at discharge. Results The study included 132 patients with COVID-19; of these, 72 (54.5%) developed functional decline. The severity of COVID-19 did not differ between patients with functional decline and those without (P = 0.698). Factors associated with a greater risk of functional decline included female sex (adjusted odds ratio [aOR], 3.14; 95% confidence interval [CI], 1.25 to 7.94), Barthel Index score < 100 before the onset of COVID-19 (aOR, 13.73; 95% CI, 3.29 to 57.25), and elevation of plasma D-dimer level on admission (aOR, 3.19; 95% CI, 1.12 to 9.07). The sensitivity analyses yielded similar results to those of the main analysis. Conclusions Over half of the older patients who recovered from COVID-19 developed functional decline at discharge from a tertiary care hospital in Japan. Baseline activities of daily living impairment, female sex, and elevated plasma D-dimer levels at admission were associated with a greater risk of functional decline.

scholarly journals Clinical and laboratory parameters of confirmed and probable COVID-19 patients: experience from a tertiary care hospital of Bangladesh

2020 ◽  
pp. 6-11
Author(s):  
Hasna Fahmima Haque ◽  
AKM Shaheen Ahmed ◽  
Samira Humaira Habib ◽  
Maliha Sulzana ◽  
Rahul Prasad Ghosh ◽  
...  
Keyword(s):  
Urban Areas ◽  
Tertiary Care Hospital ◽  
Virus Disease ◽  
Tertiary Care ◽  
Disease Classification ◽  
Care Hospital ◽  
Laboratory Parameters ◽  
Male Predominance ◽  
Corona Virus ◽  
D Dimer

Background: Severe acute respiratory syndrome corona virus 2 (SARS-CoV-2), which was previously known as novel corona virus 2019 (2019-nCoV), causes corona virus disease 2019 (COVID-19). Since 8 March 2020, COVID -19 emerged in Dhaka city and rapidly spread throughout the country. This study evaluated the sociodemographic, clinical and laboratory parameters of confirmed and probable COVID-19 patients in a tertiary care hospital. Methods: This cross-sectional study was conducted in BIRDEM General Hospital, Dhaka, Bangladesh from May to October 2020. Adult (>18 years) patients having clinical symptoms and signs of COVID-19, irrespective of sex were included in this study. Diagnosis was confirmed by positive reverse transcriptase polymerase chain reaction (RT-PCR) for SARS-CoV-2 from nasopharyngeal samples of patients and the disease classification was done following national guidelines. Results: Total patients were 141with a mean age of 59.74±11.0 years; majority was from urban areas and there was male predominance. Diabetes mellitus (91.5%) and hypertension (75.2%) were common co-morbidities. Common clinical presentations were fever (100%), cough (97.2%), fatigue (88.7%) and shortness of breath (61.7%). Laboratory investigations revealed lymphopenia (73.8%), elevated level of C-reactive protein (94.3%) and positive D-dimer (99.4%). Chest x-ray showed bilateral shadows in 73.8% cases and 42.6% had COVID pneumonia in high-resolution computed tomography (HRCT) scan of chest. Nearly three-fifths (58.9%) of the study subjects had moderate COVID-19 and 70.92% patients were shifted to the COVID-dedicated hospitals. Conclusions: COVID-19 affects mostly the older males. Majority was diabetic and hypertensive. Common symptoms were fever, cough and respiratory distress. Common laboratory findings were lymphopenia, high CRP, positive D-dimer and bilateral shadows on lung imaging. Birdem Med J 2020; 10, COVID Supplement: 6-11

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