Calibrator material selection: a key criteria during biomarker assay method development

Bioanalysis ◽  
2021 ◽  
Author(s):  
Sai P Thankamony ◽  
Rong Liu ◽  
Jon E Peterson ◽  
Rasa Santockyte ◽  
Timothy Olah ◽  
...  
Keyword(s):  
Decision Making ◽  
Case Studies ◽  
Method Development ◽  
Material Selection ◽  
Assay Method ◽  
Context Of Use ◽  
The Impact ◽  
Selection Of

Biomarker assay method development is a multistep rigorous process and calibrant material selection is integral to ensuring the quality of such assays. However, the impact of selection of calibrator material may often get overlooked. In this article, we highlight three case studies where biomarker calibrant material selection was deemed an essential criterion for consideration. Through these case studies we highlight challenges faced, steps taken and discuss the impact on assay-related decision-making. We also provide additional perspectives for selection and characterization of calibrant proteins in the setting of an evolving biomarker context of use.

scholarly journals Scar Resurfacing

2020 ◽  
pp. 311-316
Author(s):  
Fiona M. Wood
Keyword(s):  
Decision Making ◽  
Clinical Decision Making ◽  
Healing Process ◽  
Clinical Decision ◽  
Skin Surface ◽  
History Of ◽  
Secondary Healing ◽  
The Impact ◽  
Selection Of

AbstractScar resurfacing is focused on the improvement in the quality of a scar by disruption of the skin surface and reducing the bulk of the scar by control of the secondary healing process. The prerequisite is knowledge of the wound healing and scarring process such that the intervention can be designed to reduce the risk of increasing the scarring.The clinical examination and assessment of the scar will guide the selection of the technique addressing the specific aspects of the scar, such as the pigment restoration and volume reduction, with the aim of blending the scar with the surrounding uninjured skin.Understanding the natural history of the scar, the impact it has on the patient, and the techniques available for improvement provides the clinical decision-making matrix to drive an improved scar outcome. Resurfacing is one opportunity for scar modulation which needs to be taken into context relative to the range of conservative and surgical therapeutic opportunities explored within the chapters of the book.

scholarly journals The impact of culture and relational quality in the cooperation between export companies and local distributors

2018 ◽  
Vol 1 (2) ◽  
pp. 1-19
Author(s):  
Gisela Alves
Keyword(s):  
Qualitative Analysis ◽  
Case Studies ◽  
Relationship Marketing ◽  
Relational Quality ◽  
Research Questions ◽  
Similarities And Differences ◽  
Relationship Structures ◽  
The Impact ◽  
Selection Of

This study covers the main concepts of international marketing and relationship marketing to understand the role played by culture and the quality of cooperation relations between Portuguese exporting companies and their distributors in Angola. The aim of this research is to understand how the culture and the quality of the relations affect the established cooperation between companies, in the context of the internationalization of the business. It should be emphasized that relationships characterized by trust and commitment in international contexts have been sparsely studied, as well as the impact of cultural similarities and differences in relationship structures. In methodological terms, we opted for a qualitative analysis: five case studies of Portuguese exporting companies and five case studies of Angolan distributors were analyzed. Interviews were conducted with the managers of the Portuguese exporting companies and with the collaborators responsible for export activities, as well as with the Angolan distributors, to obtain answers to the research questions. The selection of Portuguese companies was based on a list of the fifty largest Portuguese exporting companies to Angola, made available by the Portuguese Investment and Foreign Trade Agency, EPE (AICEP), in August 2011. The results show that culture, trust and commitment have an impact on the cooperation of commercial relations between Portuguese exporting companies and their Angolan distributors.

scholarly journals Characterization of Carrier Phase-Based Positioning in Real-World Jamming Conditions

2021 ◽  
Vol 13 (14) ◽  
pp. 2680
Author(s):  
Søren Skaarup Larsen ◽  
Anna B. O. Jensen ◽  
Daniel H. Olesen
Keyword(s):  
Real World ◽  
Carrier Phase ◽  
Reference Station ◽  
Baseline Length ◽  
Dual Frequency ◽  
Positioning Accuracy ◽  
The Impact ◽  
Single Versus ◽  
Selection Of

GNSS signals arriving at receivers at the surface of the Earth are weak and easily susceptible to interference and jamming. In this paper, the impact of jamming on the reference station in carrier phase-based relative baseline solutions is examined. Several scenarios are investigated in order to assess the robustness of carrier phase-based positioning towards jamming. Among others, these scenarios include a varying baseline length, the use of single- versus dual-frequency observations, and the inclusion of the Galileo and GLONASS constellations to a GPS only solution. The investigations are based on observations recorded at physical reference stations in the Danish TAPAS network during actual jamming incidents, in order to realistically evaluate the impact of real-world jamming on carrier phase-based positioning accuracy. The analyses performed show that, while there are benefits of using observations from several frequencies and constellations in positioning solutions, special care must be taken in solution processing. The selection of which GNSS constellations and observations to include, as well as when they are included, is essential, as blindly adding more jamming-affected observations may lead to worse positioning accuracy.

scholarly journals Lessons Learned From an Early Hotspot During the COVID-19 Pandemic

2021 ◽  
pp. 000313482199475
Author(s):  
Brett M. Chapman ◽  
George M. Fuhrman
Keyword(s):  
Decision Making ◽  
Surgical Education ◽  
Clinical Care ◽  
Well Being ◽  
Educational Environment ◽  
Lessons Learned ◽  
Residency Programs ◽  
Surgical Residency ◽  
The Impact

The Covid-19 pandemic has provided challenges for surgical residency programs demanding fluid decision making focused on providing care for our patients, maintaining an educational environment, and protecting the well-being of our residents. This brief report summarizes the impact of the impact on our residency programs clinical care and education. We have identified opportunities to improve our program using videoconferencing, managing recruitment, and maintaining a satisfactory caseload to ensure the highest possible quality of surgical education.

Optimizing patient adherence to stroke rehabilitation: A mixed method telerehabilitation trial (Preprint)

2021 ◽  
Author(s):  
Isabelle Gaboury ◽  
Michel Tousignant ◽  
Hélène Corriveau ◽  
Matthew Menear ◽  
Guylaine Le Dorze ◽  
...  
Keyword(s):  
Decision Making ◽  
Shared Decision Making ◽  
Stroke Rehabilitation ◽  
Patient Adherence ◽  
Interprofessional Collaboration ◽  
Interdisciplinary Collaboration ◽  
Control Group ◽  
Shared Decision ◽  
The Impact

BACKGROUND Strong evidence supports beginning stroke rehabilitation as soon as the patient’s medical status has stabilized and continuing following discharge from acute care. However, adherence to rehabilitation treatments over the rehabilitation phase has been shown to be suboptimal. OBJECTIVE Objective: The aim of this study is to assess the impact of a telerehabilitation platform on stroke patients’ adherence to a rehabilitation plan and on their level of reintegration to normal social activities, in comparison with usual care. The primary outcome is patient adherence to stroke rehabilitation (up to 12 weeks), which is hypothesized to influence reintegration to normal living. Secondary outcomes for patients include functional recovery and independence, depression, adverse events related to telerehabilitation, use of services (up to 6 months), perception of interprofessional shared decision making, and quality of services received. Interprofessional collaboration as well as quality of interprofessional shared decision making will be measured on clinicians. METHODS In this interrupted time series with a convergent qualitative component, rehabilitation teams will be trained to develop rehabilitation treatment plans that engage the patient and family, while taking advantage of a telerehabilitation platform to deliver the treatment. The intervention will entail 220 patients to receive stroke telerehabilitation with an interdisciplinary group of clinicians (telerehabilitation) versus face-to-face, standard of care (n = 110 patients). RESULTS Results: Our Research Ethics Board has approved the study in June 2020. Data collection for the control group is underway, with another year planned before we begin the intervention phase. CONCLUSIONS This study will contribute to minimize both knowledge and practice gaps, while producing robust, in-depth data on the factors related to the effectiveness of telerehabilitation in a stroke rehabilitation continuum. Findings will inform best practices guidelines regarding telecare services and the provision of telerehabilitation, including recommendations regarding effective interdisciplinary collaboration regarding stroke rehabilitation. CLINICALTRIAL ClinicalTrials.gov NCT04440215

The Impact of Conflict- Generating Techniques on Student Reactions and Decision Quality

1995 ◽  
Vol 58 (4) ◽  
pp. 39-45
Author(s):  
Granger Macy ◽  
Joan C. Neal
Keyword(s):  
Decision Making ◽  
Business Students ◽  
Decision Quality ◽  
Structured Decision Making ◽  
Constructive Conflict ◽  
Significant Difference ◽  
Student Reactions ◽  
Graduate Business Students ◽  
The Impact

This study examined the effectiveness of conflict-generating decision-making techniques in the college classroom. Utiliz ing constructive conflict in classroom exercises may affect decision-making quality and student reactions. This study of undergraduate and graduate business students found significant difference in both the quality of the decisions and in student reactions to the techniques. The findings and discussion indicate the potential for appropriate use of structured decision-making techniques in the classroom.

scholarly journals Wine preferences based on intrinsic attributes: A tasting experiment in Alto Adige/Südtirol province

2021 ◽  
pp. 129-134
Author(s):  
Luigi Fabbris ◽  
Alfonso Piscitelli
Keyword(s):  
Food Product ◽  
Fractional Factorial ◽  
Region Of Origin ◽  
Double Blind ◽  
White Wines ◽  
Grape Varieties ◽  
The Impact ◽  
Administration Procedure ◽  
Selection Of

Different methods have been developed by researchers in modelling wine consumers purchase behaviour. The quality of a food product is described by a set of characteristics ascribable to the intrinsic and extrinsic product attributes (Olson and Jacoby, 1972). Price, brand, region of origin, grapes and gained awards are the key extrinsic attributes and physical characteristics of the wine such as taste and flavour are intrinsic attributes. This paper addresses the problem of measuring the intrinsic attributes that characterise the wine, based on specific characteristics and the impact on consumers in terms of preferences. To this end, a fractional factorial experiment held on a selection of white wines of the Alto Adige/Südtirol province in Italy. The sensorial experiment involved a voluntary sample of 33 mild wine consumers and concerned 6 grape varieties typical of that territory. For each variety, two producing cellars were selected for a total of 12 evaluated wines. The experiment followed a double-blind administration procedure to the sample and a paper questionnaire was used to elicit the consumers’ opinions on the tasted wines. The results show that intrinsic attributes, such as taste-olfactory intensity, harmony and olfactory complexity, are the drivers used in combination by consumers to rank wines in order of preference.

scholarly journals Evaluación del bloque de tierra mediante un Estudio De Viabilidad Constructiva (EVC)

2020 ◽  
Vol 10 (2) ◽  
pp. 54-69
Author(s):  
Ana Romero-Girón ◽  
Jacinto Canivell ◽  
María Reyes Rodríguez-García ◽  
Ana González-Serrano
Keyword(s):  
Decision Making ◽  
Case Studies ◽  
Case Analysis ◽  
Technical Training ◽  
External Conditions ◽  
Block Construction ◽  
Earth Block ◽  
Common Situation ◽  
Technical Safety

Although earth block construction (EB) is supported by numerous scientific works, there is a lack of confidence in its constructive viability, aggravated by the lack of specific technical training. In view of this uncertainty, which is widespread in Spain, it is necessary to provide well-founded technical responses. This article, considering these aspects, presents the design and validation of a tool to assess the constructive viability of EB. For this purpose, 29 case studies are chosen in Spain, which establish the constructive use determinations and indicators to assess a degree of technical suitability. This parameter, as a result of the proposed tool, acts as a support for decision-making, the improvement of the design and, the efficiency of the solutions that use EB. It concludes by validating the tool, demonstrating its reliability and adaptability to any situation. Finally, the case analysis shows how the quality of the product combined with adverse external conditions, even with correct construction designs, defines a common situation where the degree of suitability of the solution is reduced. Therefore, it is also necessary to demand products with guarantees and prescriptions that ensure and offer sufficient technical safety.

scholarly journals Energy and Exergy Analyses of Stirling Engine using CFD Approach

2020 ◽  
Vol 77 (1) ◽  
pp. 100-123
Author(s):  
Sherihan El- Ghafour ◽  
Nady Mikhael ◽  
Mohamed El- Ghandour
Keyword(s):  
Energy Analysis ◽  
Stirling Engine ◽  
Recovery Processes ◽  
Energy And Exergy ◽  
Main Driver ◽  
The Impact ◽  
Exergy Analyses ◽  
Comprehensive Characterization

A comprehensive characterization of the GPU-3 Stirling engine losses with the aid of the CFD approach is presented. Firstly, a detailed description of the losses-related phenomena along with the method of calculating each type of loss are addressed. Secondly, an energy analysis of the engine is carried out in order to specify the impact of each type of losses on the performance. Finally, the design effectivity of each component of the engine is investigated using an exergy analysis. The results reveal that the hysteresis loss occurs mainly within the working spaces due to the flow jetting during the first part of the expansion strokes. Additionally, the pressure difference between the working spaces is the main driver for the flow leakage through the appendix gap. The exposure of the displacer top wall to the jet of hot gas flowing into the expansion space during expansion stroke essentially increases the shuttle heat loss. A new definition for the regenerator effectiveness is presented to assess the quality of the heat storage and recovery processes. The energy analysis shows that regenerator thermal loss and pumping power represent the largest part of the engine losses by about 9.2% and 7.5% of the heat input, respectively. The exergy losses within regenerator and cold space are the highest values among the components, consequently, they need to be redesigned.

Spousal Attitude Towards Exerting Conflict Resolution Strategies in Decision Making

Paradigm ◽  
2017 ◽  
Vol 21 (1) ◽  
pp. 75-90
Author(s):  
Shivendra Singh ◽  
Atul Dhyani
Keyword(s):  
Decision Making ◽  
Negative Impact ◽  
Marital Power ◽  
Consumption Decisions ◽  
Northern India ◽  
The Family ◽  
Conflict Resolution Strategies ◽  
Decision Satisfaction ◽  
The Impact ◽  
Selection Of

Family is one entity that has complex variables underplaying the consumption decisions, and marketers must understand how couples behave in concert to resolve conflict across major decisions. In this study, the family aspects are investigated to shed more light on spouse attitude towards family decision-making for selection of car and school/college for their ward and assess the impact of attitudinal factor on decision satisfaction. The drop-off/pick-up method was used to collect the data from Northern India. The result reveals that spousal attitude is formed by marital power, assertiveness, subtle manipulation, love, bargaining and being submissive. Results of multiple regression analysis show that subtle manipulation is most and marital power has a negative impact on spouses’ decision satisfaction. Thus, when targeting a family for a significant trades assay, the salesperson should focus on both husband and wife and stimulate a conversation between them to appeal to their conjoint kinship.

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