Bile acid-permeation enhancement for inner ear cochlear drug – pharmacological uptake: bio-nanotechnologies in chemotherapy-induced hearing loss

2021 ◽  
Author(s):  
Louise Carey ◽  
Daniel Walker ◽  
Melissa Jones ◽  
Corina Ionescu ◽  
Susbin Wagle ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Hearing Loss ◽  
Inner Ear ◽  
Bile Acids ◽  
Biological Effects ◽  
Drug Stability ◽  
Drug Induced ◽  
Physiochemical Properties ◽  
Hair Cell Death ◽  
Sensory Epithelia

Ototoxicity is the damage to inner ear sensory epithelia due to exposure to certain medications and chemicals. This occurs when toxins enter the tightly controlled inner ear environment inducing hair cell death, resulting in hearing loss. Recent studies have explored hydrogel-based bio-nanotechnologies and new drug delivery formulations to prevent drug-induced hearing loss, with much attention given to administration of antioxidant drugs. Bile acids have been recognized as promising excipients due to their biocompatibility and unique physiochemical properties. As yet bile acids have not been explored in improving drug delivery to the inner ear despite improving drug stability and delivery in other systems and demonstrating positive biological effects in their own right.

Drug Delivery to the Inner Ear: Strategies and Their Therapeutic Implications for Sensorineural Hearing Loss

2012 ◽  
Vol 9 (3) ◽  
pp. 231-242 ◽  
Author(s):  
Teresa Rivera ◽  
Lorena Sanz ◽  
Guadalupe Camarero ◽  
Isabel Varela-Nieto
Keyword(s):  
Drug Delivery ◽  
Hearing Loss ◽  
Sensorineural Hearing Loss ◽  
Inner Ear ◽  
Sensorineural Hearing ◽  
Therapeutic Implications

scholarly journals Promising Applications of Nanoparticles in the Treatment of Hearing Loss

2021 ◽  
Vol 9 ◽  
Author(s):  
Zilin Huang ◽  
Qiang Xie ◽  
Shuang Li ◽  
Yuhao Zhou ◽  
Zuhong He ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Hearing Loss ◽  
Inner Ear ◽  
Drug Delivery System ◽  
Clinical Application ◽  
Delivery System ◽  
Diagnosis And Treatment ◽  
Biological Research ◽  
Medical Applications ◽  
Traditional Treatment

Hearing loss is one of the most common disabilities affecting both children and adults worldwide. However, traditional treatment of hearing loss has some limitations, particularly in terms of drug delivery system as well as diagnosis of ear imaging. The blood–labyrinth barrier (BLB), the barrier between the vasculature and fluids of the inner ear, restricts entry of most blood-borne compounds into inner ear tissues. Nanoparticles (NPs) have been demonstrated to have high biocompatibility, good degradation, and simple synthesis in the process of diagnosis and treatment, which are promising for medical applications in hearing loss. Although previous studies have shown that NPs have promising applications in the field of inner ear diseases, there is still a gap between biological research and clinical application. In this paper, we aim to summarize developments and challenges of NPs in diagnostics and treatment of hearing loss in recent years. This review may be useful to raise otology researchers’ awareness of effect of NPs on hearing diagnosis and treatment.

Local Drug Delivery to Inner Ear for Treatment of Hearing Loss

2008 ◽  
Vol 3 (2) ◽  
pp. 143-147 ◽  
Author(s):  
Takayuki Nakagawa ◽  
Juichi Ito
Keyword(s):  
Drug Delivery ◽  
Hearing Loss ◽  
Inner Ear ◽  
Local Drug Delivery

scholarly journals Delivery of therapeutics to the inner ear: The challenge of the blood-labyrinth barrier

2019 ◽  
Vol 11 (482) ◽  
pp. eaao0935 ◽  
Author(s):  
Sophie Nyberg ◽  
N. Joan Abbott ◽  
Xiaorui Shi ◽  
Peter S. Steyger ◽  
Alain Dabdoub
Keyword(s):  
Drug Delivery ◽  
Hearing Loss ◽  
Inner Ear ◽  
Blood Brain Barrier ◽  
Vestibular System ◽  
Brain Barrier ◽  
Luminal Surface ◽  
Delivery Methods ◽  
Blood Brain

Permanent hearing loss affects more than 5% of the world’s population, yet there are no nondevice therapies that can protect or restore hearing. Delivery of therapeutics to the cochlea and vestibular system of the inner ear is complicated by their inaccessible location. Drug delivery to the inner ear via the vasculature is an attractive noninvasive strategy, yet the blood-labyrinth barrier at the luminal surface of inner ear capillaries restricts entry of most blood-borne compounds into inner ear tissues. Here, we compare the blood-labyrinth barrier to the blood-brain barrier, discuss invasive intratympanic and intracochlear drug delivery methods, and evaluate noninvasive strategies for drug delivery to the inner ear.

Novel drug delivery systems for inner ear protection and regeneration after hearing loss

2008 ◽  
Vol 5 (10) ◽  
pp. 1059-1076 ◽  
Author(s):  
Rachael T Richardson ◽  
Andrew K Wise ◽  
Jacqueline K Andrew ◽  
Stephen J O'Leary
Keyword(s):  
Drug Delivery ◽  
Hearing Loss ◽  
Inner Ear ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Novel Drug

scholarly journals Pharmacologic Manipulation of the Labyrinth with Novel and Traditional Agents Delivered to the Inner Ear

2003 ◽  
Vol 82 (4) ◽  
pp. 276-300 ◽  
Author(s):  
Michael D. Seidman ◽  
Thomas R. Van De Water
Keyword(s):  
Drug Delivery ◽  
Hearing Loss ◽  
Inner Ear ◽  
Blood Brain Barrier ◽  
Auditory System ◽  
Middle Ear ◽  
Great Risk ◽  
Vestibular Function ◽  
Protective Mechanism ◽  
The Past

We describe the methodology and rationale behind the delivery of therapeutic medicines to the inner ear. The inner ear has long been impervious to pharmacologic manipulation. This is most likely the result of a protective mechanism called the blood-labyrinth barrier, whose function closely resembles that of the blood-brain barrier. This protective barrier impedes the clinician's ability to treat inner ear diseases with systemically administered medications. Since 1935, otolaryngologists have attempted to manipulate the inner ear with transtympanically injected medicines. Success has varied widely, but medicinal ablation of vestibular function can be achieved in this manner. Unfortunately, the auditory system is also at great risk from any medicine that is delivered to the inner ear via the middle ear. Over the past 10 years, significant improvements in drug delivery have allowed for more “titratable” treatment, which has reduced (but not eliminated) the risk of permanent hearing loss. In this article, we discuss both novel and time-tested methods of delivering medicines to the inner ear. We also review the classes of medications that alter inner ear function and the attendant risks of such treatments.

Development of nanoparticle drug-delivery systems for the inner ear

Nanomedicine ◽  
2020 ◽  
Vol 15 (20) ◽  
pp. 1981-1993
Author(s):  
Xiaogang An ◽  
Dingjun Zha
Keyword(s):  
Drug Delivery ◽  
Hearing Loss ◽  
Inner Ear ◽  
Drug Delivery Systems ◽  
Sensory Nerve ◽  
Delivery Systems ◽  
Functional Surface ◽  
Advantages And Disadvantages ◽  
Therapeutic Drugs ◽  
Effective Delivery

Hearing loss has become the most common sensory nerve disorder worldwide, with no effective treatment strategy. Low-permeability and limited blood supply to the blood–labyrinth barrier limit the effective delivery and efficacy of therapeutic drugs in the inner ear. Nanoparticle (NP)-based drugs have shown benefits of stable controlled release and functional surface modification, and NP-based delivery systems have become a research hotspot. In this review, we discuss the development of new targeted drug-delivery systems based on the biocompatibility and safety of different NPs in the cochlea, as well as the advantages and disadvantages of their prescription methods and approaches. We believe that targeted NP-based drug-delivery systems will be effective treatments for hearing loss.

Drug-induced Defibrinogenation as New Treatment Approach of Acute Hearing Loss in an Animal Model for Inner Ear Vascular Impairment

2017 ◽  
Vol 38 (5) ◽  
pp. 648-654 ◽  
Author(s):  
Bernhard G. Weiss ◽  
Mattis Bertlich ◽  
Stephan A. Bettag ◽  
Hendrik Desinger ◽  
Friedrich Ihler ◽  
...  
Keyword(s):  
Animal Model ◽  
Hearing Loss ◽  
Inner Ear ◽  
Treatment Approach ◽  
Drug Induced ◽  
New Treatment ◽  
Acute Hearing Loss
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