scholarly journals The latest developments in the area of therapeutic delivery excluding some diseases, such as COVID-19 and the big three (HIV/AID, malaria and tuberculosis)

2021 ◽  
Author(s):  
Catarina Pinto Reis
Keyword(s):  
Scientific Literature ◽  
Public Awareness ◽  
Research Groups ◽  
Press Releases ◽  
Drug Candidates ◽  
Therapeutic Delivery ◽  
Personal Opinion ◽  
The Face ◽  
Growth And Change ◽  
Novel Drug

Summary It is the beginning of a new decade, where COVID-19 and the ‘big three’ (HIV/AID, malaria and tuberculosis) have raised public awareness of the type of challenges researchers face every day. Beyond these diseases, there are also still many more for which scientists are working to develop new therapies and their impact in healthcare is enormous too. This industry update covers the period 1–31 August 2021, and some examples of research and approvals for many other diseases excluding COVID-19 and the ‘big three’ are presented. There is a progressive trend of approvals of novel drug candidates and the proposal of new indications for the existing ones. Some patents related to rare diseases were also published during this month. Information and analyses were sourced from scientific literature, regulatory and patent agencies, websites and press releases of the companies (and not based upon personal opinion). The main reason of leaving COVID-19 research outside the scope of this update is mainly due to the rapid growth and change in this field; some preliminary results require further research and scientists must be aware of the final impact that this research could have on public opinion. Moreover, as a result of disruptions to health care in the face of COVID-19, several research groups simply stopped their research in other diseases and, for that reason, it is imperative to sum up some important advances in other critical diseases and health areas.

An industry update: the latest developments in therapeutic delivery covering May 2020

2020 ◽  
Vol 11 (9) ◽  
pp. 541-546
Author(s):  
Oliver C Steinbach
Keyword(s):  
Scientific Literature ◽  
Press Releases ◽  
Therapeutic Delivery

The present industry update covers the period 1–31 May 2020, with information sourced from company press releases, regulatory and patent agencies as well as scientific literature.

scholarly journals Integrated network analysis identifying potential novel drug candidates and targets for Parkinson's disease

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Pusheng Quan ◽  
Kai Wang ◽  
Shi Yan ◽  
Shirong Wen ◽  
Chengqun Wei ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Drug Target ◽  
Target Genes ◽  
Enrichment Analysis ◽  
Gene Set Enrichment Analysis ◽  
Functional Enrichment ◽  
Control Group ◽  
Drug Candidates ◽  
Novel Drug

AbstractThis study aimed to identify potential novel drug candidates and targets for Parkinson’s disease. First, 970 genes that have been reported to be related to PD were collected from five databases, and functional enrichment analysis of these genes was conducted to investigate their potential mechanisms. Then, we collected drugs and related targets from DrugBank, narrowed the list by proximity scores and Inverted Gene Set Enrichment analysis of drug targets, and identified potential drug candidates for PD treatment. Finally, we compared the expression distribution of the candidate drug-target genes between the PD group and the control group in the public dataset with the largest sample size (GSE99039) in Gene Expression Omnibus. Ten drugs with an FDR < 0.1 and their corresponding targets were identified. Some target genes of the ten drugs significantly overlapped with PD-related genes or already known therapeutic targets for PD. Nine differentially expressed drug-target genes with p < 0.05 were screened. This work will facilitate further research into the possible efficacy of new drugs for PD and will provide valuable clues for drug design.

scholarly journals Missing Novelty in Drug Development

2021 ◽  
Author(s):  
Joshua Krieger ◽  
Danielle Li ◽  
Dimitris Papanikolaou
Keyword(s):  
Radical Innovation ◽  
Chemical Similarity ◽  
Net Worth ◽  
Drug Candidates ◽  
Pharmaceutical Firms ◽  
External Finance ◽  
Fda Approval ◽  
Novel Drugs ◽  
Positive Shock ◽  
Novel Drug

Abstract We provide evidence that risk aversion leads pharmaceutical firms to underinvest in radical innovation. We introduce a new measure of drug novelty based on chemical similarity and show that firms face a risk-reward trade-off: novel drug candidates are less likely to obtain FDA approval but are based on more valuable patents. Consistent with a simple model of costly external finance, we show that a positive shock to firms’ net worth leads firms to develop more novel drugs. This suggests that even large firms may behave as though they are risk averse, reducing their willingness to investment in potentially valuable radical innovation.

Developing novel chemical entities for the treatment of lysosomal storage disorders: an academic perspective

2015 ◽  
Vol 309 (12) ◽  
pp. F996-F999 ◽  
Author(s):  
James A. Shayman
Keyword(s):  
Drug Targets ◽  
Lysosomal Storage ◽  
Federal Drug Administration ◽  
Drug Candidates ◽  
Gaucher Disease Type 1 ◽  
Biotechnology Companies ◽  
Approved Drugs ◽  
Novel Drug ◽  
Early Drug

Historically, most Federal Drug Administration-approved drugs were the result of “in-house” efforts within large pharmaceutical companies. Over the last two decades, this paradigm has steadily shifted as the drug industry turned to startups, small biotechnology companies, and academia for the identification of novel drug targets and early drug candidates. This strategic pivot has created new opportunities for groups less traditionally associated with the creation of novel therapeutics, including small academic laboratories, for engagement in the drug discovery process. A recent example of the successful development of a drug that had its origins in academia is eliglustat tartrate, an oral agent for Gaucher disease type 1.

scholarly journals Harnessing the medicinal properties of Cussonia barteri Seem. (Araliaceae) in drug development. A review

2018 ◽  
Vol 64 (3) ◽  
pp. 50-61 ◽  
Author(s):  
Ighodaro Igbe ◽  
Osaze Edosuyi ◽  
Agbonlahor Okhuarobo
Keyword(s):  
Drug Development ◽  
Antioxidant Activities ◽  
Biological Activities ◽  
Stem Bark ◽  
Deciduous Tree ◽  
Drug Candidates ◽  
Medicinal Properties ◽  
Phytochemical Constituents ◽  
Anti Inflammatory ◽  
Novel Drug

Summary Cussonia barteri Seem (Araliaceae) is a deciduous tree growing in savannah of Africa. Ethnomedicinally, it is used in Africa as an analgesic, anti-malarial, anti-inflammatory, anti-anaemic, anti-diarhoea, anti-poison, ani-pyschotic and anti-epileptic agent. This review provides a brief summary on the phytochemical screenings, ethnomedicinal and pharmacological applications of various parts of C. barteri. Leaves, stem bark and seed of C. barteri have been shown to be rich in saponins, flavonoids, phenols, sugars and alkaloids. Some of these constituents have been isolated and elucidated from C. barteri. Several compounds isolated from plant include triterpenes, saponins, polyenyne and quinic esters. Phytochemical constituents are also partly responsible for biological activities of C. barteri. Extracts and components isolated from the plant have demonstrated neuropharmacological, anti-larvicidal, anti-microbial, anti-inflammatory and antioxidant activities. Overall, the insights provided by this review reinforce the potential of C. barteri for drug development and create the need for further scientific probe of constituents of the plant with the aim of developing novel drug candidates.

scholarly journals Addressing the diverging public and physician perceptions on the topic of antibiotic resistance

2016 ◽  
Vol 85 (1) ◽  
pp. 29-31
Author(s):  
Hong Yu (Andrew) Su ◽  
Matt Douglas-Vail
Keyword(s):  
Health Promotion ◽  
Antibiotic Resistance ◽  
Bacterial Infections ◽  
Public Awareness ◽  
Resistant Bacteria ◽  
Physician Perceptions ◽  
Awareness Campaigns ◽  
The Face

Antibiotics are a powerful tool in fighting bacterial infections but with overuse and misuse, resistance is emerging at an alarming rate. To better understand the root causes of resistance, studying the perceptions of both physicians and the general populace may prove beneficial from a health promotion standpoint. Research reveals that diverging views of these 2 groups remain significant, which proves concerning especially in the face of increasingly resistant bacteria and associated mortality. The issue at large, therefore, requires a better understandifrom both parties with regard to antibiotic guidelines, prescription habits and public awareness campaigns.

scholarly journals Remote Meetings in Problem-Based Learning: A Tool for Selection Research in Times of Pandemic

2021 ◽  
Author(s):  
Paloma Freire Neves Leal Cortes ◽  
Camila Delinski Bet ◽  
José Francisco dos Santos Silveira Junior ◽  
Edivaldo Rosas dos Santos Junior ◽  
Marney Pascoli Cereda
Keyword(s):  
Problem Based Learning ◽  
Research Groups ◽  
Research Topics ◽  
Analytical Methodology ◽  
Face To Face ◽  
Food Industries ◽  
The Face ◽  
Selection Research ◽  
Teaching Learning ◽  
Support Research

Abstract Active methodologies have been widely used in education to provide greater involvement in the teaching-learning process. In the face of the current pandemic scenario, remote activities are strategies to spread knowledge but require adaptations of face-to-face education. However, no records were found of its use to support research groups, which traditionally are based on personal contacts. The article reports the experience of selecting participants in the development of research in the area of starch prospecting, with an adaptation of the Problem Based Learning (PBL) technique. The proposed problem was the characterization and evaluation of cassava starch for food industries application, using a sample limited to one gram. The PBL technique used research with a qualitative approach, applied nature, descriptive objective, and action research procedures. The five members that constituted the discussion group were from different professional areas and were selected among those who made up a larger group, with starch as the central theme. The PBL technique was adapted to be completed in three videoconference meetings, with intervals of 15 days. Based on the suggestions proposed and improved during the event, it was possible to outline the solution right at the first meeting. An analytical methodology can also be established within the specified limit, capable of prospecting its food industries application. Therefore, PBL as a strategic tool to develop research topics proved effective and flexible, and suitable for remote activities. It is recommended that it be better explored as a team leader and scientific research growth.

scholarly journals PERSPECTIVE INSIGHT AND APPLICATION OF IN-SILICO TOOL AS VIRTUAL SCREENING METHOD FOR LEAD DESIGNING AND DEVELOPMENT

2021 ◽  
Vol 11 (6) ◽  
pp. 16-24
Author(s):  
Hemant U Chikhale
Keyword(s):  
In Silico ◽  
Screening Method ◽  
Lead Discovery ◽  
Environmental Technology ◽  
Lead Structure ◽  
Drug Candidates ◽  
Underlying Principle ◽  
Novel Drug ◽  
Investigative Process ◽  
Specific Illness

Humans are now in a bioinformatics and chemo informatics century, where we can foresee data across domains like as healthcare, the environmental, technology, and public health. The use of information sharing in silico methodologies has impacted sickness administration by predicting the absorption, distribution, metabolism, excretion, and toxicity (ADMET) patterns of synthetic compounds and efficient and environmentally succeeding pharmaceuticals upfront. The purpose of lead discovery and design is to create the appearance of novel drug candidates that can attach to a specific illness cause. The lead investigative process starts with the recognition of the lead structure, which is followed by the synthesis of its analogs and their estimation in order to produce a candidate for lead improvement. The finding of the proper lead exact is the fundamental and primary worked in the traditional lead discovery progression, and the use of computer (in silico) approaches is widely used in lead innovation. A medicinal chemist's passion for building lead structure is piqued by biomolecules, which are often made up of DNA, RNA, and proteins (such as enzymes, receptors, transporters, and ion channels). The underlying principle of such nuts and bolts is noteworthy to be acquainted with their pharmacological implication to the disease under examination. The motive of this review piece of writing is to emphasize several of the in silico methods that are used in lead discovery and to express the applications of these computational methods.

The Role of Financial Performance in Corporate Reputation Management: An Analysis on the Press Releases Published by Corporations During the Pandemic

2021 ◽  
Author(s):  
Deniz Akbulut ◽  
Metin Enes Dönmez
Keyword(s):  
Financial Performance ◽  
Corporate Reputation ◽  
Performance Indicator ◽  
Corporate Communication ◽  
Communication Strategy ◽  
Reputation Management ◽  
Press Releases ◽  
The Public ◽  
The Press ◽  
The Face

As with all their assets, organizations need management when it comes to their reputation. Having a successful corporate reputation is closely related to how corporations manage their existing reputation. The main components of long-term corporate reputation are categorized as appealing to emotions, product and service quality, vision and leadership, financial performance, workplace environment and social responsibility (Fombrun et al., 2013: 253). Among these components, financial performance is positioned as one of the main factors that come to the fore especially in crisis situations. Financial performance is also an effective factor in building trust in all relationships established with the target audience. Therefore, organizations should reflect their financial performance with a good corporate communication strategy in order to create a solid corporate reputation based on trust. The Covid-19 pandemic, which affected the whole world in 2019, negatively affected many corporations in Turkey economically. In the face of this situation, which can be described as a global crisis, corporations carried out corporate communication activities that support corporate reputation management in order to turn the crisis into an opportunity. It is seen that especially the financial performances of the corporations are highlighted among these activities carried out with the aim of strengthening the positive image of the corporations in the eyes of their stakeholders and the public. Within the scope of this research, the press releases published by five companies operating within the automotive sector in Turkey, among the sectors given in the Sectoral Impact of Covid 19 on the Economy report of Global Times (2020), were examined through the content analysis method in the context of financial performance indicators. The purpose of the research is to reveal how organizations reflect their strategies, which include the elements that reflect their financial performance in their press releases, to the public. As a result of the research, the financial performance indicator that took the most place in all the press releases examined was determined as “competitive advantage”.

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