scholarly journals Comparison of Medicinally Important Natural Products versus Synthetic Drugs-A Short Commentary

2018 ◽  
Vol 06 (02) ◽  
Author(s):  
Bushra Nisar ◽  
Aeysha Sultan ◽  
Syeda Laila Rubab
Keyword(s):  
Natural Products ◽  
Synthetic Drugs ◽  
Short Commentary

A chemoinformatic analysis of atoms, scaffolds and functional groups in natural products

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Joelle Ngo Hanna ◽  
Boris D. Bekono ◽  
Luc C. O. Owono ◽  
Flavien A. A. Toze ◽  
James A. Mbah ◽  
...  
Keyword(s):  
Natural Products ◽  
Drug Discovery ◽  
Physicochemical Properties ◽  
Functional Groups ◽  
Atomic Composition ◽  
Synthetic Compounds ◽  
Chemical Libraries ◽  
Synthetic Drugs ◽  
Drugs Analysis ◽  
Chemical Class

Abstract In the quest to know why natural products (NPs) have often been considered as privileged scaffolds for drug discovery purposes, many investigations into the differences between NPs and synthetic compounds have been carried out. Several attempts to answer this question have led to the investigation of the atomic composition, scaffolds and functional groups (FGs) of NPs, in comparison with synthetic drugs analysis. This chapter briefly describes an atomic enumeration method for chemical libraries that has been applied for the analysis of NP libraries, followed by a description of the main differences between NPs of marine and terrestrial origin in terms of their general physicochemical properties, most common scaffolds and “drug-likeness” properties. The last parts of the work describe an analysis of scaffolds and FGs common in NP libraries, focusing on huge NP databases, e.g. those in the Dictionary of Natural Products (DNP), NPs from cyanobacteria and the largest chemical class of NP – terpenoids.

Characteristics of known drug space. Natural products, their derivatives and synthetic drugs

2010 ◽  
Vol 45 (12) ◽  
pp. 5646-5652 ◽  
Author(s):  
Richard Bade ◽  
Ho-Fung Chan ◽  
Jóhannes Reynisson
Keyword(s):  
Natural Products ◽  
Synthetic Drugs

Fitoterapia i suplementacja diety w chorobach górnego odcinka przewodu pokarmowego

2019 ◽  
Vol 20 (2) ◽  
Author(s):  
Krzysztof Błecha
Keyword(s):  
Natural Products ◽  
Gastrointestinal Tract ◽  
Digestive System ◽  
Raw Materials ◽  
Main Role ◽  
Plant Raw Materials ◽  
Synthetic Drugs ◽  
Physiological Processes ◽  
Anti Inflammatory ◽  
Materials Used

Prevention and therapy of gastrointestinal tract diseases should take into account as minimal as possible intervention physiological processes which take place in digestive system. Digestive disorders, which are often caused by synthetic drugs, can generate more complicated diseases. Herbs should be a preventive or complementary way of action. They can also play the main role in therapy of less complicated diseases. Natural products are used in therapy of gastrointestinal tract diseases because they have anti-inflammatory, antibacterial, coating, digestion improving and relaxative properties. They are helpful in gastro-oesophageal reflux, dyspepsia, gastritis and ulcers. Natural products, especially plant raw materials, used in the therapy of digestive system diseases, according to their leading activity, can be divided into the following groups: anti-inflammatory and protective, facilitating digestion, sedative and antimicrobial. It should be emphasized that plant raw materials act in multidirectional way and therefore not always may be classified strictly within such groups of curing activity.

Anti-Malarial Drug Resistance

2022 ◽  
pp. 233-250
Author(s):  
Manish Kumar Dwivedi ◽  
Prashant Kumar Singh
Keyword(s):  
Natural Products ◽  
Protozoan Parasite ◽  
Mechanisms Of Action ◽  
New Drugs ◽  
Efficacy And Safety ◽  
Infected Female ◽  
Traditional Medicines ◽  
Anopheles Mosquitoes ◽  
Synthetic Drugs ◽  
Life Threatening

Malaria is a life-threatening infectious disease caused by a protozoan parasite of the genus Plasmodium. It is transmitted through the bites of infected female Anopheles mosquitoes. The global burden is estimated to be around 219 million cases in 87 countries. Natural compounds have been used primarily in the traditional medicine for thousands of years. For the treatment of malaria, natural products were used until the development of synthetic drugs, and most of the currently available anti-malarial drugs have been derived based on the compounds from these traditional medicinal plants. The current chapter tries to briefly indicate the emerging resistance against anti-malarial drugs and to discuss the recent research on natural products that have been evaluated for anti-malarial activity. Rigorous evaluation of the efficacy and safety of traditional medicines is required along with identification of active constituents in order to develop new drugs with novel mechanisms of action.

scholarly journals In-Silico Analysis of Natural Products That Modulates Enzymes of Diabetic Target

2020 ◽  
Author(s):  
Babita Aryal ◽  
Saroj Basnet ◽  
Bishnu P. Marasini ◽  
Karan Khadayat ◽  
Darbin Kumar Poudel ◽  
...  
Keyword(s):  
Natural Products ◽  
Secondary Metabolites ◽  
Aldose Reductase ◽  
In Silico ◽  
Metabolic Diseases ◽  
In Silico Analysis ◽  
Metabolic Enzymes ◽  
Alpha Amylase ◽  
Synthetic Drugs ◽  
Alpha Glucosidase

Metabolic enzymes are often targeted for drug development programs of metabolic diseases such as diabetes and its complications. Many secondary metabolites isolated from natural products have shown therapeutic action against these enzymes. However, some commercially available synthetic drugs have shown unfriendly impacts with various side effects. Thus, this research has focused on a comprehensive study of secondary metabolites showing better inhibitory activities towards metabolic enzymes such as α-amylase, α-glucosidase, aldose reductase, and lipase. Further receptor-based virtual screening was performed against the various secondary metabolites database designed in-silico. Using Gold combined with subsequent post-docking analyses, the score was obtained as methyl xestospongic ester (Gold score 65.83), 2,″4″-O-diacetylquercitrin (Gold score 65.15), kaempferol-3-O-neohesperidoside (Gold score 53.37) and isosalvianolic acid C methyl ester (Gold score 53.44) for lipase, aldol reductase, α-amylase, and α-glucosidase, respectively. Besides, vitexin and isovitexin for α-amylase; N-trans-Caffeoyl-tyramin for α-glucosidase; purpurolide F and schaftoside for lipase; acteoside and orientin for aldose reductase could be potential drugs for respective enzymes based on in-silico analyses, supported by experimental IC50 values reported. They could bind to the competitive sites of the various targets of metabolic enzymes, and finally, toxicity analysis using ProTox-II was also performed.

Is orbitrap quantitative? Critical aspects of its potential using natural products and synthetic drugs as models

Planta Medica ◽  
2012 ◽  
Vol 78 (11) ◽  
Author(s):  
E Gikas ◽  
A Termentzi ◽  
J Tchoumtchoua ◽  
E Kouloura ◽  
N Lemonakis ◽  
...  
Keyword(s):  
Natural Products ◽  
Synthetic Drugs ◽  
Critical Aspects

Fastidious Anatomization of Biota Procured Compounds on Cancer Drug Discovery

2020 ◽  
Vol 21 (5) ◽  
pp. 354-363
Author(s):  
Anand Thirupathi ◽  
Chandra M. Shanmugavadivelu ◽  
Sampathkumar Natarajan
Keyword(s):  
Natural Products ◽  
Side Effects ◽  
Cancer Therapy ◽  
Biological Activities ◽  
Drug Approval ◽  
Current Treatment ◽  
New Drugs ◽  
Cancer Drug ◽  
Synthetic Drugs ◽  
Wide Range

Background: Natural products are the rootstock for identifying new drugs since ancient times. In comparison with synthetic drugs, they have abounding beneficial effects in bestowing protection against many diseases, including cancer. Cancer has been observed as a major threat in recent decades, and its prevalence is expected to increase over the next decades. Also, current treatment methods in cancer therapy such as radiation therapy and chemotherapy cause severe adverse side effects among the cancer population. Therefore, it is exigent to find a remedy without any side effects. Methods: In recent years, research has focused on obtaining naturally derived products to encounter this complication. The current pace of investigations, such as gene identification and advancement in combinatorial chemistry, leads to the aberrant access to a wide range of new synthetic drugs. In fact, natural products act as templates in structure predictions and synthesis of new compounds with enhanced biological activities. Results: Recent developments in genomics have established the importance of polymorphism, which implies that patients require different drugs for their treatment. This demands the discovery of a large number of drugs, but limited sources restrict the pharmaceutical industry to overcome these major obstacles. The use of natural products and their semisynthetic and synthetic analogues could alleviate these problems. However, the lack of standardization in terms of developing methods for evaluating the chemical composition, efficacy, isolation and international approval is still a major limitation in this field. In the past few years, several drug-approval authorities, including the FDA and WHO have allowed using these naturally derived compounds in humans. Conclusion: In this review, we described the use of some natural products from plant and marine sources in cancer treatment and shed some light on semi-synthetic and synthetic compounds derived from natural sources used in cancer therapy.

Neutralization of Bothrops asper venom by antibodies, natural products and synthetic drugs: Contributions to understanding snakebite envenomings and their treatment

Toxicon ◽  
2009 ◽  
Vol 54 (7) ◽  
pp. 1012-1028 ◽  
Author(s):  
Bruno Lomonte ◽  
Guillermo León ◽  
Yamileth Angulo ◽  
Alexandra Rucavado ◽  
Vitelbina Núñez
Keyword(s):  
Natural Products ◽  
Synthetic Drugs ◽  
Bothrops Asper

scholarly journals Plant-Based Drugs as an Adjuvant to Cancer Chemotherapy

2020 ◽  
Author(s):  
Lakshmi Mohan
Keyword(s):  
Natural Products ◽  
Cancer Chemotherapy ◽  
Herbal Medicines ◽  
Modern Medicine ◽  
Aquatic Life ◽  
Traditional Medicines ◽  
Synthetic Drugs ◽  
History Of ◽  
Drug Leads

Humans have turned to natural products, obtained from plants, animals and aquatic life for treating diseases since time immemorial. Modern medicine is based on ancient wisdom transferred over generations. Drug development relies mainly on natural sources. Herbal medicines are making a comeback due to lower side effects, and positive results in the long term when compared to synthetic drugs. The current drug discovery process relies on identifying traditional medicines followed by Bioactivity-guided fractionation to isolate significant lead molecules. Plants have a history of long-term use by humans and hence it can be presumed that the bioactive compounds obtained from plants will have low human toxicity. There exists a huge potential for discovering new antitumor drug leads by screening natural products either in the form of crude extracts purified phytochemicals which have already been described in the literature. The fact that phytochemicals like paclitaxel, vinblastine, vincristine and camptothecin are being successfully used in clinical practice and several others like combretastatin and noscapine are in different stages of clinical trials implies the importance of plants in cancer chemotherapy.

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