Do Maternal Blood Parameters Affect Fetal Birth Weight?

Abstract Background The aim of the study was to evaluate the ultrasound-derived measurements of the fetal soft-tissue, heart, liver and umbilical cord in pregnancies complicated by gestational (GDM) and type 1 diabetes mellitus (T1DM), and further to assess their applicability in the estimation of the fetal birth-weight and prediction of fetal macrosomia. Methods Measurements were obtained from diet-controlled GDM (GDMG1) (n = 40), insulin-controlled GDM (GDMG2) (n = 40), T1DM (n = 24) and healthy control (n = 40) patients. The following parameters were selected for analysis: fetal sub-scapular fat mass (SSFM), abdominal fat mass (AFM), mid-thigh fat/lean mass (MTFM/MTLM) and inter-ventricular septum (IVS) thicknesses, heart and thorax circumference and area (HeC/HeA; ThC/ThA), liver length (LL), umbilical cord/vein/arteries circumference and area (UmC/UmA; UvC/UvA; UaC/UaA) together with total umbilical vessels (UveA) and Wharton's jelly area (WjA). Regression models were created in order to assess the contribution of selected parameters to fetal birth-weight (FBW) and risk of fetal macrosomia. Results Measurements of the fetal SSFM, AFM, MTFM, MTFM/MTLM ratio, HeC, HeA, IVS, LL, UmC, UmA, UaC, UaA, UveA and WjA were significantly increased among patients with GDMG2/T1DM as compared to GDMG1 and/or control groups (p < .05). The regression analysis revealed that maternal height as well as fetal biparietal diameter, abdominal circumference (AC), AFM and LL measurements were independent predictors of the FBW (p < .05). In addition, increase in the fetal AFM, AC and femur length (FL) was associated with a significant risk of fetal macrosomia occurrence (p < .05). The equation developed for the FBW estimation [FBW(g) = − 2254,942 + 17,204 * FL (mm) + 105,531 * AC (cm) + 131,347 * AFM (mm)] provided significantly lower mean absolute percent error than standard formula in the sub-group of women with T1DM (5.7% vs 9.4%, p < .05). Moreover, new equation including AC, FL and AFM parameters yielded sensitivity of 93.8%, specificity 77.7%, positive predictive value 54.5% and negative predictive value of 97.8% in the prediction of fetal macrosomia. Conclusions Ultrasound measurements of the fetal soft tissue, heart, liver and umbilical cord are significantly increased among women with GDM treated with insulin and T1DM. In addition to standard biometric measurements, parameters, such as AFM, may find application in the management of diabetes-complicated pregnancies.

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The Egyptian formula a New Formula for Prediction of Fetal Birth Weight using Liver Volume Measured by Three-Dimensional Ultrasound (VOCAL System)

Women s Health ◽

10.15406/mojwh.2017.04.00078 ◽

2017 ◽

Vol 4 (2) ◽

Author(s):

Haitham Torky

Keyword(s):

Birth Weight ◽

Liver Volume ◽

Three Dimensional ◽

Vocal System ◽

Fetal Birth Weight ◽

New Formula

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Pregnancy Dating in the Rat: Placental Morphology and Maternal Blood Parameters

Toxicologic Pathology ◽

10.1080/019262302753559614 ◽

2002 ◽

Vol 30 (2) ◽

pp. 271-282 ◽

Cited By ~ 70

Author(s):

Eveline P.C.T. De Rijk ◽

Eric Van Esch ◽

Gert Flik

Keyword(s):

Maternal Blood ◽

Blood Parameters ◽

Pregnancy Dating

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miR-27b-3p is highly expressed in serum of patients with preeclampsia and has clinical significance

Endocrine Metabolic & Immune Disorders - Drug Targets ◽

10.2174/1871530321666211208152709 ◽

2021 ◽

Vol 21 ◽

Author(s):

Yang Yang ◽

Fang Tang ◽

Xuezhi Zhao

Keyword(s):

Blood Pressure ◽

Birth Weight ◽

Serum Creatinine ◽

Pregnant Women ◽

Clinical Significance ◽

Roc Curve ◽

Late Pregnancy ◽

Healthy Controls ◽

Urine Protein ◽

Fetal Birth Weight

Background: Preeclampsia (PE) is defined as a salient complication of late pregnancy. microRNAs (miRNAs) have emerged as critical biological regulators in PE. This study determined miR-27b-3p expression in serum of PE patients and investigated its clinical significance in PE. Methods: Totally 130 pregnant women including 90 PE patients (51 mild PE and 39 severe PE) and 40 healthy controls were enrolled in this study. miR-27b-3p expression in the serum of PE patients and healthy controls was detected using RT-qPCR. The correlation among miR-27b-3p expression and 24-h urine protein, systolic blood pressure (SBP), diastolic blood pressure (DBP), serum creatinine, and fetal birth weight was analyzed using Pearson's correlation coefficient. The targeting relationship between miR-27b-3p and PPARG was verified. PPARG protein level in PE patients was detected using ELISA kits. The predictive efficiency of miR-27b-3p and PPARG in PE was analyzed using the receiver operating characteristic (ROC) curve. Results: Compared to normal pregnant women, PE pregnant women, especially severe PE patients had higher miR-27b-3p expression. miR-27b-3p was positively correlated with 24-h urine protein, SBP, DBP, and serum creatinine, but negatively correlated with fetal birth weight. PPARG was poorly expressed in PE patients and negatively correlated with miR-27b-3p. ROC curve showed that both miR-27b-3p and PPARG had good predictive efficacy on PE. Conclusion: miR-27b-3p expression in serum of pregnant women with PE was positively correlated with the severity of PE symptoms, suggesting the involvement of miR-27b-3p in PE occurrence.

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ESTIMATION OF FETAL WEIGHT BY CLINICAL METHODS AND ULTRASOUND AND CORRELATING ITS ACCURACY WITH ACTUAL BIRTH WEIGHT IN TERM PREGNANCIES AT ANMMCH, GAYA, BIHAR

10.36106/2332504 ◽

2021 ◽

pp. 17-19

Author(s):

Kumari Ragini ◽

Amit Kumar ◽

Reena Kumari ◽

Debarshi Jana

Keyword(s):

Birth Weight ◽

Prospective Study ◽

Fetal Weight ◽

Term Pregnancy ◽

Abdominal Girth ◽

Medical College ◽

Obstetrics And Gynaecology ◽

Clinical Methods ◽

Fetal Birth Weight ◽

A Prospective Study

Objective:This study was to estimate the fetal weight in term pregnancy by clinical methods and ultrasound and to compare the results with actual birth weight (ABW). Material and Methods:This study was conducted at Department of Obstetrics and Gynaecology, Anugrah Narayan Magadh Medical College and Hospital, Gaya, Bihar from December 2019 to May 2020. It was a prospective study covering 200 pregnant women at term gestation. Results: Estimated birth weight by abdominal girth × symphysis fundal height (AG × SFH) formula was closest to the ABW (P = 0.060), as compared to the estimated birth weight by Johnson's formula (P = 0.000) and Hadlock's formula (P = 0.000). Therefore, of the three formulae studied, AG × SFH formula had better predictive value as compared to Johnson's and Hadlock's formulae. The accuracy of AG × SFH (Insler's formula) for estimating the fetal weight at term was found to be comparable to Hadlock's formula (P= 0.104). Conclusion: Clinical estimation of birth weight denitely has a role in the management of labor and delivery. AG × SFH is a simple, easy, costeffective, and universally applicable method to predict fetal birth weight which can be used even by paramedics like midwives and also in centers where ultrasound is not available.

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Fetal Birth Weight Estimation in High-Risk Pregnancies Through Machine Learning Techniques

ICC 2019 - 2019 IEEE International Conference on Communications (ICC) ◽

10.1109/icc.2019.8761985 ◽

2019 ◽

Cited By ~ 1

Author(s):

Mario W. L. Moreira ◽

Joel J. P. C. Rodrigues ◽

Vasco Furtado ◽

Constandinos X. Mavromoustakis ◽

Neeraj Kumar ◽

...

Keyword(s):

Machine Learning ◽

Birth Weight ◽

High Risk ◽

Machine Learning Techniques ◽

Weight Estimation ◽

Learning Techniques ◽

Fetal Birth Weight

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Happiness feelings at 12 weeks can predict fetal birth weight

European Journal of Obstetrics & Gynecology and Reproductive Biology ◽

10.1016/j.ejogrb.2018.08.361 ◽

2019 ◽

Vol 234 ◽

pp. e92-e93

Author(s):

Ernesto S. González-Mesa ◽

Marta Blasco-Alonso ◽

Nadia Ibrahim-Diez ◽

Teresa García-Campano

Keyword(s):

Birth Weight ◽

Fetal Birth Weight

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Comparison of Maternal and Perinatal Outcome in Pregnant Women with Hypothyroidism Diagnosed before Conception with Hypothyroidism Diagnosed during Pregnancy

Journal of Universal College of Medical Sciences ◽

10.3126/jucms.v2i2.11170 ◽

2014 ◽

Vol 2 (2) ◽

pp. 21-27

Author(s):

P Basnet ◽

N Aggrawal ◽

V Suri ◽

P Dutta ◽

K Mukhopadhyay

Keyword(s):

Birth Weight ◽

Pregnant Women ◽

Thyroid Function ◽

Early Pregnancy ◽

Perinatal Outcome ◽

Fetal Outcome ◽

Endocrine Disorder ◽

Fetal Birth Weight ◽

Group A ◽

Group B

BACKGROUND: Thyroid disorder is one of commonest endocrine disorder in women and hence constitutes a common endocrine disorder complicating pregnancy. Diagnosing and treating hypothyroidism preconceptionally and during early pregnancy appears to be a useful strategy to improve maternal and fetal outcome. OBJECTIVE: To compare the maternal and perinatal outcome in pregnant women with hypothyroidism diagnosed preconceptionally with hypothyroidism diagnosed during pregnancy. METHODS: A prospective study. One hundred pregnant women with hypothyroidism at less than 20 weeks Period of Gestation (POG) were recruited for the study and grouped into two groups: Group A-hypothyroidism diagnosed and on treatment before conception, Group B-hypothyroidism diagnosed and started on treatment during pregnancy. Both groups were intensively monitored during pregnancy with serial Thyroid Function Test (TFT) and thyroxine replacement doses were adjusted accordingly. Various maternal, perinatal and fetal outcome measures were studied in both groups prospectively till delivery. RESULTS: The maternal and fetal complications were comparable in the two groups, however the fetal birth weight was significantly higher in Group A versus Group B (2.89±0.485kg vs. 2.70±0.453kg; p=0.039). All the new born babies had normal thyroid function. CONCLUSION: Hypothyroidism diagnosed preconceptionally or during early pregnancy and treated appropriately has beneficial effect on fetal birth weight, and hence the total pregnancy outcome. Screening for thyroid dysfunction should be judiciously performed in all high risk women prior to a planned conception or during their first antenatal visit. DOI: http://dx.doi.org/10.3126/jucms.v2i2.11170 Journal of Universal College of Medical Sciences (2014) Vol.2(2): 21-27

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Can Placental Thickness predict Fetal Weight?

QJM ◽

10.1093/qjmed/hcaa056.012 ◽

2020 ◽

Vol 113 (Supplement_1) ◽

Author(s):

M A El-Kady ◽

A M Mansour ◽

M H Ismail

Keyword(s):

Birth Weight ◽

Prospective Observational Study ◽

Antenatal Clinic ◽

Maternity Hospital ◽

Fetal Weight ◽

Principal Influence ◽

Fetal Birth Weight ◽

New Formula ◽

Placental Thickness ◽

Predictive Rule

Abstract Background The placenta is the principal influence on fetal birth weight, and it is thought that abnormalities of placental growth may precede abnormalities in fetal growth. Because the placenta may be the first organ to manifest changes of disease in pregnancy, placental features may have a role in screening for pregnancy complications. Aim of the Work The aim this study is to assess the accuracy of placental thickness (estimated by ultrasonography) in predicting fetal weight. Patients and Methods This prospective observational study was conducted at Ain Shams University Maternity Hospital November, 15th, 2016 to November, 1st, 2017. 100 Normal antenatal pregnant women at 24-28 weeks of pregnancy who attended antenatal clinic at the department of obstetrics and gynecology, Ain Shams University Maternity Hospital were recruited, after fulfilling the inclusion and exclusion criteria. Results The predictive rule could estimate actual birth weight with an accuracy of ± 0.450 kg (SEest = 0.450 kg). In visits 1 and 2; ± 0.448 kg (SEest = 0.448 kg) in visit 3. Conclusion The actual birth weight was regressed on the placental thickness using simple linear regression to obtain a predictive rule. There is very weak correlation between the actual neonatal weight and placental thickness. The current study deduced a new formula for correction of EFW using placental thickness which has a promising role to offer in the prediction of birth weight.

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