scholarly journals Comparison of Maternal and Perinatal Outcome in Pregnant Women with Hypothyroidism Diagnosed before Conception with Hypothyroidism Diagnosed during Pregnancy

2014 ◽  
Vol 2 (2) ◽  
pp. 21-27
Author(s):  
P Basnet ◽  
N Aggrawal ◽  
V Suri ◽  
P Dutta ◽  
K Mukhopadhyay
Keyword(s):  
Birth Weight ◽  
Pregnant Women ◽  
Thyroid Function ◽  
Early Pregnancy ◽  
Perinatal Outcome ◽  
Fetal Outcome ◽  
Endocrine Disorder ◽  
Fetal Birth Weight ◽  
Group A ◽  
Group B

BACKGROUND: Thyroid disorder is one of commonest endocrine disorder in women and hence constitutes a common endocrine disorder complicating pregnancy. Diagnosing and treating hypothyroidism preconceptionally and during early pregnancy appears to be a useful strategy to improve maternal and fetal outcome. OBJECTIVE: To compare the maternal and perinatal outcome in pregnant women with hypothyroidism diagnosed preconceptionally with hypothyroidism diagnosed during pregnancy. METHODS: A prospective study. One hundred pregnant women with hypothyroidism at less than 20 weeks Period of Gestation (POG) were recruited for the study and grouped into two groups: Group A-hypothyroidism diagnosed and on treatment before conception, Group B-hypothyroidism diagnosed and started on treatment during pregnancy. Both groups were intensively monitored during pregnancy with serial Thyroid Function Test (TFT) and thyroxine replacement doses were adjusted accordingly. Various maternal, perinatal and fetal outcome measures were studied in both groups prospectively till delivery. RESULTS: The maternal and fetal complications were comparable in the two groups, however the fetal birth weight was significantly higher in Group A versus Group B (2.89±0.485kg vs. 2.70±0.453kg; p=0.039). All the new born babies had normal thyroid function. CONCLUSION: Hypothyroidism diagnosed preconceptionally or during early pregnancy and treated appropriately has beneficial effect on fetal birth weight, and hence the total pregnancy outcome. Screening for thyroid dysfunction should be judiciously performed in all high risk women prior to a planned conception or during their first antenatal visit. DOI: http://dx.doi.org/10.3126/jucms.v2i2.11170   Journal of Universal College of Medical Sciences (2014) Vol.2(2): 21-27

Fetal and Maternal Outcome Asymptomatic vs. Symptomatic Covid Positive Pregnant Women

2021 ◽  
Vol 15 (10) ◽  
pp. 3423-3425
Author(s):  
Amna Najam ◽  
Samreen Fakeer Muhammad ◽  
Samia Saifullah ◽  
Maryam Shoaib ◽  
Maria Anwar
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Cesarean Section ◽  
Pregnant Women ◽  
Apgar Score ◽  
Adverse Outcomes ◽  
Maternal Outcomes ◽  
Group A ◽  
Nicu Admission ◽  
Group B

Objective: The aim of this study is to compare the fetal and maternal outcomes in between asymptomatic and symptomatic COVID positive pregnant women. Study Design: Retrospective cohort study Place and Duration: The study was conducted at Gynae and Obs department of Sandeman Provincial Hospital, Quetta for duration of six months from November 2020 to April 2021. Methods: One hundred and ten pregnant women with ages 18-45 years had corona virus disease were presented. Informed written consent was taken from all patients for detailed demographics. COVID -19 was diagnosed by PCR. 55 patients had symptoms of coronavirus were included in group A and 55 patients did not show symptoms were included in group B. Frequency of pre-eclampsia, gestational diabetes mellitus and post-partum haemorrhage were calculated. Maternal adverse outcomes (cesarean section, instrumental delivery, induction of labor and prolong labor, hypertensive disorder) were calculated among both groups. Fetal outcomes perinatal mortality, Low birth weight, Low Apgar score and NICU admission were observed. SPSS 20.0 version was used to analyze all data. Results: Mean age of the patients in group A was 28.47±3.18 years with mean BMI 24.03±5.24 Kg/m2 and in group B mean age was 27.99±4.17 years with mean BMI 24.44±6.41 Kg/m2. Maternal outcomes (cesarean section, instrumental delivery, induction of labor and prolong labor,) in symptomatic group were significantly higher than that of asymptomatic group. Fetal outcomes, perinatal mortality in group A 9 (16.4%) and in group B was 5 (9.1%), low birth weight in group A was among 21 (38.2%) and in group B was 10 (18.2%), low apgar score in group A was 11 (20%) and in group B was 8 (14.4%), 15 (27.3%) in group A went to NICU admission and 3 (5.5%) patient in group II admitted to NICU. Conclusion: In this study we concluded that adverse outcomes among symptomatic COVID pregnant women were higher than that of asymptomatic coronavirus pregnant women in terms maternal and perinatal outcomes. Keywords: Pregnant women, Coronavirus, Symptomatic, Asymptomatic, Adverse Outcomes

scholarly journals Comparison of Maternal and Fetal Outcomes in Pregnancies with Preterm Premature Rupture of Membrane (PPROM) Terminating in 34th or 36th Gestational Weeks: A Clinical Trial

2017 ◽  
Vol 5 (2) ◽  
pp. 3
Author(s):  
Shamsi Abbasalizadeh ◽  
Rana Bagherifard ◽  
Farshad Mahdavi ◽  
Fatemeh Abbasaizadeh ◽  
Shiva Raouf
Keyword(s):  
Birth Weight ◽  
Pregnant Women ◽  
Pregnancy Termination ◽  
Neonatal Outcomes ◽  
Birth Complications ◽  
Significant Difference ◽  
Group A ◽  
Maternal And Neonatal Outcomes ◽  
Nicu Admission ◽  
Group B

present  study,  we aimed at studying maternal  and  neonatal  outcomes  in  patients with terminated pregnancy in 34th  and  36th  gestational  weeks. Materials and methods: 40 pregnant women, with PPROM who underwent pregnancy termination at 34 group (A) or 36 group (B) gestational weeks, were included to be evaluated and compared for maternal and neonatal outcomes. Type of delivery, birth complications, chorioamnoionitis, endometritis, sepsis, maternal mortality, infant gender, birth weight, Apgar scores, respiratory distress syndrome, Meconium-stained amniotic fluid, NICU admission, abruption, umbilical cord prolapse, maternal and neonatal outcomes were compared between the two groups.  Results: There was no statistically significant difference between the two groups regarding maternal age, level of education, or gravity. The percentage of cases with birth weight between 1500 and 2500 g was significantly higher in group A P<0.001). Frequency of NICU admission in group A was significantly more than group B (P<0.001). In conclusion: Termination of pregnancy at 36 weeks compared to 34 weeks in pregnant women with PPROM is preferred in terms of neonatal outcomes and it is recommended; also, there might be no preference in terms of  maternal outcomes. 

scholarly journals THE IMPACT OF ISOLATED OLIGOHYDRAMNIAS AT TERM ON PERINATAL OUTCOME: A COMPARATIVE STUDY

2021 ◽  
Vol 71 (4) ◽  
pp. 1274-77
Author(s):  
Bushra Zafar ◽  
Nadia Arif ◽  
Ayesha Arif ◽  
Raja Qaseem Ahmed ◽  
Farrukh Shahzad
Keyword(s):  
Birth Weight ◽  
Comparative Study ◽  
Amniotic Fluid ◽  
Perinatal Outcome ◽  
Mode Of Delivery ◽  
Fetal Demise ◽  
Intrauterine Fetal Demise ◽  
Group A ◽  
Group B ◽  
The Impact

Objective: To study the impact of isolated oligohydramnios at term on mode of delivery and perinatal outcome. Study Design: Prospective comparative study. Place and Duration of Study: Combined Military Hospital Okara, from Aug 2019 to Aug 2020. Methodology: A total of 250 patients were recruited in the study. They were divided in 2 groups. In group A there was 123 patients, with isolated oligohydramnias at term, amniotic fluid index of ≤5cm, while in group B 127 patients, with normal liquor volume were included through lottery method. Demographic parameters, Intrauterine fetal demise, mode of delivery, perinatal out comes like meconium stained amniotic fluid, low birth weight, APGAR score at 1 and 5 minutes, of two groups were compared. Results: A total of 57 (46.3%) patients in group A delivered through cesarean section and 27 (21.3%) in group B. Meconium staining of liquor was in 56 (45.5%) in group A versus 13 (10.2%) in group B. As compared to group B the patients in group A lower birth weight babies 2.6 ± 0.34 kg versus 3.0 ± 0.33 kg were delivered. Mortality in group A, intrauterine fetal demise was 4 (3.3%) and still birth was 2.3%. There were no perinatal mortality in controlled group B. Conclusion: Isolated oligohydramnias at term is not associated with adverse perinatal outcome. Umbilical cord compression, potential utero-placental insuffiency and increased incidence of meconium stained liquor possibly explains the increased perinatal morbidity. The delivery should be routinely advocated as in otherwise uncomplicated pregnancy with appropriately grown fetus.

Analysis of Perinatal Outcome of Normal Pregnant Women with Diabetes Mellitus

2021 ◽  
Vol 7 (5) ◽  
pp. 1378-1382
Author(s):  
Sitong Lin ◽  
Yushan Guo
Keyword(s):  
Quality Of Life ◽  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Pregnant Women ◽  
Perinatal Outcome ◽  
Adverse Pregnancy Outcome ◽  
Perinatal Complications ◽  
Group A ◽  
Group B

The perinatal outcome of normal pregnant women with gestational diabetes mellitus was analyzed. Methods: The subjects were 50 pregnant women admitted to our hospital from September 2018 to 2019. According to the control of blood glucose level, they were divided into two groups: group A and group B. 32 pregnant women in group A had ideal control of blood glucose and 18 in group B had unsatisfactory control of blood glucose. The adverse pregnancy outcome, comparison of blood lipid and lipoprotein, quality of life score, perinatal complications and other relevant conditions were observed. Result: The adverse pregnancy outcome of group A was significantly lower than that of group B (P < 0.05); the lipid and lipid protein of group A was significantly better than that of group B (P < 0.05); the quality-of-life score of group A was significantly better than that of group B (P < 0.05); the perinatal complications of group A was significantly lower than that of group B (P < 0.05). Conclusion: The control of blood bottle level of pregnant women with gestational diabetes mellitus is beneficial to the perinatal outcome, reduce the incidence of complications of pregnant women and newborns, and significantly improve the quality of life of pregnant women.

scholarly journals Effects of Hyperuricemia on Fetal Outcome in Preeclamptic Patients

2019 ◽  
Vol 9 (2) ◽  
pp. 117-120
Author(s):  
Nusrat Mahjabeen ◽  
Sk Zinnat Ara Nasreen ◽  
Ferdousi Begum ◽  
Faryl Mustary
Keyword(s):  
Uric Acid ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Serum Uric Acid ◽  
Uric Acid Level ◽  
Acid Level ◽  
Serum Uric Acid Level ◽  
Fetal Outcome ◽  
Group A ◽  
Group B

Background: A raised serum uric acid is recognized as an unfavourable fetal outcome of pre-eclampsia. The objective of this study was to determine the relationship between hyperuricemia and fetal outcome in preeclamptic patients. Methods: This observational study was carried out in the Department of Gynecology and Obstetrics of BIRDEM General Hospital from July 2015 to June 2016. Fifty pre eclamptic pregnant women with hyperuricemia (group A) and 50 preeclamptic pregnant women with normal serum uric acid level (group B) were taken as study subjects. Data were analyzed by SPSS where p value less than 0.05 was considered significant. Results: Mean age of the patients was 25.88 ± 4.52 years and 24.30 ± 5.09 years in group A and group B respectively. Mean serum uric acid level was 7.19±0.62 mg/dl in group A and 4.83±0.73 mg/dl in group B. Maximum (66%) patients were primigravida in group A and 34% in group B. In this study, intra-uterine death (IUD) occurred in 4 (8%) cases in group A and in 1 (2%) case in group B, intra-uterine growth retardation (IUGR) was 20 (40%) cases in group A and 4 (8%) cases in group B, low birth weight was in 38 (76%) cases in group A and 21(42%) cases in group B. Occurrence of IUGR and low birth weight was significantly higher in group A than group B. APGAR score was significantly lower in group A (5.10±1.61) than that of group B (6.36±1.32). Neonatal intensive care unit (NICU) referral was more in group A (60%) than group B (20%). Conclusion: It can be concluded that hyperuricemia is a predictor of poor fetal outcome in pre-eclamptic women. Birdem Med J 2019; 9(2): 117-120

Comparison of Perinatal Outcome (Low Birth Weight, Preterm Delivery) in Women with <6 Month Versus 12-17 Months of IBI

2021 ◽  
Vol 15 (10) ◽  
pp. 2742-2745
Author(s):  
Andleeb Arshad ◽  
Misbah Kausar Javaid ◽  
Abida Rehman
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Preterm Delivery ◽  
Perinatal Outcome ◽  
Short Interval ◽  
Singleton Pregnancy ◽  
Optimal Interval ◽  
Low Birth Weight Babies ◽  
Group B ◽  
Inter Pregnancy Interval

Objectives: To compare the perinatal outcome (low birth weight, preterm delivery) in women with <6 month versus 12-17 months of interpregnancy birth interval. Material and methods: This Cohort study was conducted at Department of Obstetrics and Gynecology, Lahore General Hospital Lahore from March 2020 to September 2020. Total 420 patients with age range 18-40 years, singleton pregnancy, women with previous live birth, parity 1-4 and Gestational age > 28 weeks assessed on LMP were selected for this study. Patients were divided into two groups (A & B) according to their inter-pregnancy interval i.e. <6 months group labelled as A group and 12-17 months group labelled as B group. All patients in both groups will be followed till delivery and the perinatal outcome i.e. preterm delivery (birth occurred before completion of 37 weeks of gestation) and low birth weight (those babies whose weight less than 2.5 Kg at the time of birth) were noted. Results: The mean age of women in group A was 26.73 ± 6.56 years and in group B was 26.73 ± 6.56 years. The perinatal outcome was preterm delivery in 189 (90.0%) and low birth weight babies in 143 (68.10%) women of <6 months while in 12-17 months interpregnancy interval, it was noted in 111 (52.86%) and 102 (48.57%) women respectively Conclusion: Our study concluded that appropriate inter pregnancy interval could reduce the rate of preterm delivery and low birth weight babies and optimal interval associated with the lowest risk of adverse perinatal outcome was 12-17 months. Keywords: Birth spacing, short interval, preterm delivery, low birth weight.

Prevention of Hepatitis B Infection in Newborns Through Mass Screening and Delayed Vaccination of All Infants of Mothers With Hepatitis B Surface Antigen

PEDIATRICS ◽  
1989 ◽  
Vol 83 (6) ◽  
pp. 1041-1048
Author(s):  
Solko W. Schalm ◽  
J. Adriaan Mazel ◽  
Gijsbert C. de Gast ◽  
Rudolf A. Heijtink ◽  
Meindert J. Botman ◽  
...  
Keyword(s):  
Hepatitis B ◽  
Pregnant Women ◽  
Rural Area ◽  
Surface Antigen ◽  
Hepatitis B Surface Antigen ◽  
Large City ◽  
Hepatitis B Infection ◽  
Active Vaccination ◽  
Group A ◽  
Group B

Beginning in 1982 all pregnant women undergoing prenatal routine blood analysis in three large city hospitals and one large rural area were tested for hepatitis B surface antigen (HBsAg). Infants of all HBsAg-positive mothers received hepatitis B immunoglobulin (HBIg), 0.5 mL/kg of body weight within two hours of birth and, after randomization, 10 µg of hepatitis B vaccine either at 0, 1, 2, and 11 months of age (schedule A) or at 3, 4, 5, and 11 months of age (schedule B). A second injection of HBIg (1 mL) was given to infants on schedule B at 3 months of age. Blood samples were obtained at 3, 6, 11, 12, 24, and 36 months. In a two-year period, 28,412 pregnant women were tested for HBsAg; screening efficiency varied between 85% and 98%. The overall prevalence of HBsAg was 0.8%, with a marked variation between urban centers (2.2%) and the rural area (0.3%). Vaccinations were received by 180 of 193 infants of HBsAg-positive mothers (90 on schedule A and 90 on schedule B). Concentrations of hepatitis B surface antibody less than 10 IU/L were observed in nine instances in five children from group A and in seven instances in six children from group B. Four hepatitis B viral infections (two HBsAg carriers, two who underwent antihepatitis B core seroconversions) were recorded in group A v one infection (antihepatitis B core seroconversion) in group B. The protective efficacy of the program (screening plus passive immunization and delayed vaccination) was 94%. The estimated cost of preventing one case of hepatitis B infection in neonates was $3,000 (US currency). It is concluded that screening all pregnant women for HBsAg can be introduced effectively at reasonable costs in a country with a low prevalence of HBsAg and a high proportion of home deliveries. Delayed active vaccination starting at 3 months of age may be an effective and, for reasons of high compliance and low cost, attractive alternative to early active vaccination.

Perinatal Outcome of Monochorionic Twins With Selective IUGR Compared With Uncomplicated Monochorionic Twins

2011 ◽  
Vol 14 (5) ◽  
pp. 457-462 ◽  
Author(s):  
Boaz Weisz ◽  
Liat Hogen ◽  
Yoav Yinon ◽  
Liat Gindes ◽  
Alon Shrim ◽  
...  
Keyword(s):  
Perinatal Outcome ◽  
Umbilical Artery ◽  
Perinatal Outcomes ◽  
Monochorionic Twins ◽  
Group A ◽  
Umbilical Artery Doppler ◽  
Group B ◽  
A Prospective Study ◽  
Gestational Age At Birth ◽  
Twin Pregnancies

Objective: To evaluate the perinatal outcome of MC twins with selective IUGR (sIUGR).Study design: A prospective study, which included three groups of MC twins: Group A, uncomplicated MC twin pregnancies (n = 91); group B, sIUGR with normal umbilical artery Doppler (n = 19); and group C, sIUGR with abnormal (absence or reversed EDV) umbilical artery Doppler (n = 18). The latter were routinely hospitalized in the high-risk ward under strict surveillance.Results: Neonatal outcome of fetuses complicated with sIUGR and normal Doppler was similar to controls. Neonates born to pregnancies complicated by sIUGR and abnormal Doppler had significantly increased incidence of CNS findings, RDS, NEC, sepsis, and neonatal death compared to controls. Adverse outcome in this group was independently associated only with gestational age at birth.Conclusion: The perinatal outcomes of MC twins complicated with sIUGR and normal Doppler are similar to uncomplicated MC pregnancies. MC twins with sIUGR and abnormal Doppler have reasonable outcomes, yet significantly more neonatal complications compared to non-complicated MC twins.

scholarly journals Manual Vacuum Aspiration (M.V.A) Versus Conventional Evacuation and Curettage in Early Pregnancy Loss

2021 ◽  
Vol 15 (8) ◽  
pp. 2213-2215
Author(s):  
Uzma Shaheen ◽  
Sumaira Yasmin ◽  
Nazia Liaqat ◽  
Sonia Rafique
Keyword(s):  
Early Pregnancy ◽  
Gestational Age ◽  
Pregnancy Loss ◽  
Cervical Ripening ◽  
Early Pregnancy Loss ◽  
Vacuum Aspiration ◽  
Manual Vacuum Aspiration ◽  
Group A ◽  
Randomized Control ◽  
Group B

Objective: The aim of this study is to compare the efficacy of manual vacuum aspiration and conventional evacuation and curettage in early pregnancy loss Study Design: Randomized control trial Place and Duration: Study was conducted at department of obstetrics and gynecology Lady Reading Hospital Peshawar from 1st January 2019 to 31st August 2020. Methods Patients were early pregnancy loss (12 weeks or lesser gestational age) were enrolled. Patients were divided into two groups by lottery method. Group A were the patients who had conventional evacuation and curettage treatment. Group B were patient in which MVA was used. Patients’ demographics were recorded after taking written consent. Gestational age was calculated from first day of last menstrual cycle and by ultrasound. Cervical ripening was done by (misoprostol 400mcg) two hours before procedure. Procedure was carried out under aseptic measures. Complete uterine evacuation by either procedure was assessed by ultrasound after procedure and complications were noted. Data was analyzed by SPSS 24.0. Results: mean age in Group A was 29 years with SD ± 8.65 while mean age in Group B mean age was 30 years with SD ±7.62. Group B (Manual Vacuum Aspiration) was effective in 96% patients while Group A(Conventional Evacuation and Curettage) was effective in 89% patients. Complications were fewer in MVA as compared to conventional evacuation and curettage Keywords: MVA, Evacuation and curettage , Early pregnancy loss.

scholarly journals Amino acid infusion in oligohydromnios and increase in AFI and impact on perinatal outcome

2019 ◽  
Vol 8 (2) ◽  
pp. 617
Author(s):  
Isha Sunil ◽  
Chejerla Sunitha ◽  
Harkirat Kaur
Keyword(s):  
Amino Acid ◽  
Perinatal Outcome ◽  
Perinatal Outcomes ◽  
Apgar Scores ◽  
Acid Infusion ◽  
Amino Acid Infusion ◽  
Vaginal Deliveries ◽  
Group A ◽  
One Year ◽  
Group B

Background: Decreased amniotic fluid is related to adverse maternal and perinatal outcomes. The purpose of this study was to evaluate the role of amino acid infusion in patients of oligohydromnios and compare the perinatal outcome in the two groups.Methods: This study was conducted in the Department of Obstetrics and Gynaecology, ASCOMS Hospital, Jammu for a period of one year from October 2017 to September 2018. A total of 50 women with AFI <8 cm were enrolled in the study . They were divided into two groups of 25 each. Group A were given amino acid infusion and Group B were not given any intervention. These were compared for increase in AFI and perinatal outcome.Results: In the present study, the gain in AFI in Group A was 2.32 ± 0.67 and in group B was 1.32 ± 1.03 which was statistically significant. The perinatal outcome was better Group A compared to Group B with decreased incidence of meconium stained liquor, low birth weight, low APGAR scores and NICU admissions and increase in vaginal deliveries as compared to caesarean sections.Conclusions: The present study suggests that parentral transfusion of amino acid in cases of oligohydromnios significantly increases the AFI of the patient and decreases the incidence of caesarean sections, meconium stained liquor, low APGAR scores and NICU admissions.

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