The Status of Vitamin D Among Children Aged 0 to 18 Years

Over the past two decades, the understanding of the roles of vitamin D has expanded to include many nonskeletal effects such as reduced risk of acute respiratory tract infections, autoimmune diseases, cancer, cardiovascular disease, diabetes mellitus, neurological diseases, and adverse pregnancy and birth outcomes. The role of vitamin D for optimal health is well known in Western developed countries but less so in Central Asian countries. This narrative review compares the status of vitamin D between Central Asian countries and Northern European countries. The analysis also summarizes the evidence for the beneficial effects of vitamin D and recommendations for Central Asian countries.

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SUN-P249: Update on the Status of Vitamin D in Children with Cerebral Palsy (CP)

Clinical Nutrition ◽

10.1016/s0261-5614(16)30592-1 ◽

2016 ◽

Vol 35 ◽

pp. S136-S137

Author(s):

E. Kasapidou ◽

O.A. Gomez Santamaria ◽

M. Chourdakis

Keyword(s):

Vitamin D ◽

Cerebral Palsy ◽

Children With Cerebral Palsy ◽

The Status

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Vitamin D and Diabetic Foot

10.5772/intechopen.97115 ◽

2021 ◽

Author(s):

Antony Macido

Keyword(s):

Vitamin D ◽

Diabetic Foot ◽

Large Scale ◽

Negative Relationship ◽

Hydroxyvitamin D ◽

Diabetic Foot Infections ◽

Randomized Controlled Studies ◽

Patients With Diabetes ◽

The Status ◽

25 Hydroxyvitamin D

Approximately 15% of patients with diabetes mellitus (DM) are prone to developing diabetic foot ulcers (DFU) in their lifetime. The term vitamin D status or 25-hydroxyvitamin D [25(OH)D] levels are used interchangeably to represent the status of vitamin D in individuals throughout this paper. Evidence suggests a relationship between 25(OH)D levels and DFU. However, very minimal data is available on the association between DFU and vitamin D deficiency. After a careful review of the literature, it was inferred that vitamin D could be associated with DFU and diabetic foot infections. Available evidence on vitamin D and DFU suggests a negative correlation between 25(OH)D levels and the presence of DFU. Evidence also supports a negative relationship between 25(OH)D levels and diabetic foot infections. Further large-scale randomized controlled studies need to be done to confirm the relationship between 25(OH)D levels and DFU including the use of vitamin D in the management of DFU and diabetic foot infections.

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Geographic and Seasonal Variation of Vitamin D: A Retrospective Study in Two Centers of Nepal

Journal of Nepal Health Research Council ◽

10.33314/jnhrc.v18i1.1873 ◽

2020 ◽

Vol 18 (1) ◽

pp. 103-107

Author(s):

Arun Sedhain ◽

Gandhi R Bhattarai ◽

Sanjaya Raya Yadav ◽

Bhupendra Raj Pandey ◽

Thakur Prasad Pant

Keyword(s):

Vitamin D ◽

Vitamin D Deficiency ◽

Winter Season ◽

Hypovitaminosis D ◽

Cross Sectional Study ◽

Reproductive Age ◽

Age Group ◽

Cross Sectional ◽

Study Results ◽

The Status

Background: Vitamin D deficiency is a common problem in many countries throughout the world. This study aimed at understanding the status of vitamin D deficiency in relation to age, gender, geography and season among relatively bigger numbers of population residing in central and western regions of Nepal.Methods: This retrospective cross-sectional study was carried out by reviewing the records of vitamin D tests in two centers of Nepal- namely united reference laboratories at Pokhara and Chitwan Medical College at Chitwan. A total of 3320 individuals who were tested for clinical suspicion of vitamin D deficiency over a period of one year were included in the study. Results: Mean vitamin D level was 18.7 ng/mL. Majority of subjects tested for vitamin D were females (71.36 %) with female to male ratio of 2.49:1. Hypovitaminosis D (? 30 ng/mL) was found in 84.5% subjects and was moderate to severely deficit (<10 ng/mL) in 25.9% of subjects. Status of hypovitaminosis D was found to be less in ?50 years (79.9%) than the younger subjects (89.9% in ?18 years and 87.0% in 19-49 years age group). Vitamin D deficiency was found lower in hills districts (80.8% vs 89.7% in the plains), which was found to be more pronounced during winter through summer seasons as compared to fall season.Conclusions: Population residing in plain areas and summer, spring and winter season are found to have increased problem of Hypovitaminosis D. It is also found to be common among younger children and female of reproductive age group. We have also found out the increased problem of hypovitaminosis D among population residing in the plain areas than in the hills especially in the summer, spring and winter season.Keywords: Geographic variation; hypovitaminosis D; Nepal

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The status of serum vitamin D in the population of the United Arab Emirates

Eastern Mediterranean Health Journal ◽

10.26719/2016.22.9.682 ◽

2016 ◽

Vol 22 (9) ◽

pp. 682-686 ◽

Cited By ~ 7

Author(s):

Kaissar Yammine ◽

Hamdi Al Adham

Keyword(s):

Vitamin D ◽

United Arab Emirates ◽

Serum Vitamin ◽

Serum Vitamin D ◽

The Status

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Normal or Arthritic: Is 25-hydroxy Vitamin D status significant?

Journal of Gandaki Medical College-Nepal ◽

10.3126/jgmcn.v10i1.17908 ◽

2017 ◽

Vol 10 (1) ◽

pp. 21-24

Author(s):

Krishna Bahadur Bista ◽

PP Lamichhane ◽

SM Regmi ◽

A Naglla ◽

S Shrestha

Keyword(s):

Vitamin D ◽

Skeletal Development ◽

Serum Vitamin ◽

Normal Subjects ◽

Medical College ◽

Serum Vitamin D ◽

Disease Condition ◽

The Status ◽

25 Hydroxy Vitamin D ◽

And Function

Background: Vitamin D is required for proper skeletal development and function. However, the status of vitamin D in healthy subjects and those suffering from arthritis in Nepal is largely unknown.Objective: This study measured vitamin D level in healthy and arthritic individuals of Western Nepal.Methods: Vitamin D level in healthy and arthritic subjects were measured by using LIASION 25-hydroxy Vitamin D assay, a direct competitive chemiluminescence immunoassay (CLIA).Results: Our result suggested that most of the subjects, irrespective of age and disease condition, have subnormal/normal level of vitamin D (≥16ng/mL). Also, the data suggested that serum vitamin D level is significantly higher in males than in females. Moreover, the vitamin D level is higher in healthy individuals when compared with those suffering from arthritis. However, vitamin D level in normal subjects and arthritic patients could not be correlated.Conclusion: Vitamin D level is higher in normal subjects compared to arthritic individuals. However, the level could not be correlated suggesting need of a pilot study to determine vitamin D level and its association with arthritis in Nepalese.Journal of Gandaki Medical College Vol. 10, No. 1, 2017, Page: 21-24

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Vitamin K & D Deficiency Are Independently Associated With Covid-19 Disease Severity

Open Forum Infectious Diseases ◽

10.1093/ofid/ofab408 ◽

2021 ◽

Author(s):

Ankita P Desai ◽

Sahera Dirajlal-Fargo ◽

Jared C Durieux ◽

Heather Tribout ◽

Danielle Labbato ◽

...

Keyword(s):

Vitamin D ◽

Disease Severity ◽

Vitamin K ◽

Matrix Gla Protein ◽

Vitamin D Status ◽

Hydroxyvitamin D ◽

Moderate Disease ◽

Unit Increase ◽

The Status ◽

25 Hydroxyvitamin D

Abstract Background We investigated the status of vitamin K and vitamin D and association to COVID-19 outcomes. Methods Levels of inactive vitamin K-dependent dephosphorylated uncarboxylated matrix Gla protein (dp-ucMGP; marker of vitamin K status) and 25-hydroxyvitamin D levels (25(OH)D; vitamin D status) were measured in plasma samples from participants with confirmed acute COVID-19 and were age and sex matched to healthy controls. Unadjusted (UOR) and adjusted odds ratios (AOR) with 95% confidence intervals (CI) were computed using cumulative logistic regression. Results 150 subjects were included, 100 COVID-19+ and 50 controls. Median agewas 55 (IQR: 48, 63), 50% were females. 34% had mild COVID-19 disease, 51% moderate disease, and 15% severe. Dp-ucMGP levels were higher (i.e. worse K status) in COVID-19+ vs controls (776.5 ng/mL vs 549.8 ng/mL, p <0.0001) with similar 25(OH)D between groups (25.8 vs 21.9 ng/mL, p=0.09). Participants who were vitamin D deficient (<20ng/mL) had the worse vitamin K status (dp-ucMGP >780ng/mL) and experienced the most severe COVID-19 outcomes. In adjusted models, every one-unit increase in the log2 dp-ucMGP nearly doubled the odds of acute critical disease or death [AOR 95%CI: 1.84 (1.01, 3.45)] and every one-unit decrease in the natural log 25(OH)D was associated with more than three times the likelihood of COVID-19 disease severity [AOR 95%CI: 0.29 (0.11, 0.67)]. Conclusion Early in acute COVID-19, both vitamin K and vitamin D deficiency were independently associated with worse COVID-19 disease severity, suggesting a potential synergistic interplay between these two vitamins in COVID-19.

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CALCIFICATION OF THE AORTIC VALVE IN PATIENTS ON PROGRAM HEMODIALYSIS

Nephrology (Saint-Petersburg) ◽

10.24884/1561-6274-2018-22-4-90-95 ◽

2018 ◽

Vol 22 (4) ◽

pp. 90-95 ◽

Cited By ~ 3

Author(s):

A. Sh. Rumyantcev ◽

H. Rafrafi ◽

O. V. Galkina

Keyword(s):

Risk Factors ◽

Vitamin D ◽

Aortic Valve ◽

Average Concentration ◽

Echocardiographic Study ◽

Increased Risk ◽

Traditional Age ◽

The Status ◽

Traditional Risk Factors

THE AIM: to determine the relationship between non-traditional risk factors and calcification of the aortic valve in patients with CKD C5D.PATIENTS AND METHODS. We examined 103 patients receiving treatment with program hemodialysis (53 men and 50 women, mean age 54.8 ± 15.2 years). A traditional nephrological examination was carried out, including the determination of synchronous 24-hour ECG and AD monitoring, an echocardiographic study evaluating the thickness of the carotid arteries intima-media complex. In 79 patients, the status of vitamin D was determined by the enzyme immunoassay.RESULTS.Traditional (age over 50, male and dyslipidemic) and non- traditional (duration of hemodialysis more than 5 years, calcitriol level less than 10 pmol/L) risk factors for the calcification of the aortic valve were revealed. The average concentration of calcifediol in serum was 33.3 ± 13.8 nmol /L, calcitriol – 11.5 ± 6.9 pmol /L. Calcification of the aortic valve was detected in 48 patients, 2 times more often in men. Stenosis of the aortic valve was found in 28% of men and 22% of women. During the first five years of HD, the prevalence of aortic valve calcification increased 1,5 times and continued to increase later, however, not to the degree of stenosis. The risk of stenosis increased by age over 50 years (3,6 times), whereas the use of alfacalcidol was accompanied by a 70% decrease of stenosis risk. Deficiency of calcitriol (but not calcifediol) increased the risk of calcification (but not stenosis) of the aortic valve in 2 times.CONCLUSION.Vitamin D deficiency is associated with an increased risk of developing extraosteal calcification, including aortic valve. A decrease in the concentration of calcitriol in the blood serum is a predictor for a specific lesion of the aortic valve. Adequate correction of phosphoric calcium exchange can serve as one of the methods for its prevention.

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