Histological alterations induced by heat stress and antihypertensive drug captopril in some organs of Albino rats

2009 ◽  
Vol 9 (2) ◽  
Author(s):  
RM Eldeeb
Keyword(s):  
Heat Stress ◽  
Antihypertensive Drug ◽  
Albino Rats ◽  
Histological Alterations

DEHYDROEPIANDROSTERONE-INDUCED THYROTROPHIN RELEASE DURING HEAT STRESS IN RATS

1975 ◽  
Vol 67 (1) ◽  
pp. 99-103 ◽  
Author(s):  
E. TAL ◽  
F. G. SULMAN
Keyword(s):  
Body Weight ◽  
Heat Stress ◽  
Epithelial Cell ◽  
Connective Tissue ◽  
Metabolic Rate ◽  
Albino Rats ◽  
Ambient Temperatures ◽  
Cell Height ◽  
Thyroid Epithelial Cell ◽  
Serum Tsh

SUMMARY Six groups each of 12 male albino rats were reared from day 21 of life at temperatures of 23, 34 or 37 °C. While the rats survived for unlimited periods at 23 and 34 °C, the animals reared at 37 °C succumbed within 5 days to heat stress. The latter group, when injected s.c. or i.p. with 50 mg dehydroepiandrosterone (DHA)/kg/day were no longer affected by the heat. During this treatment thyroid epithelial cell height doubled, colloid decreased by 20%, connective tissue did not change, the basic metabolic rate decreased by 10% and rectal temperatures of the treated rats increased with the ambient temperatures. Body weight increased only slightly, pituitary TSH decreased by 25%, serum TSH increased by over 50%, thyroxine and 125I uptake increased by 200%. The survival of the DHA-treated rats was apparently secured by blocking the hypothalamic thermoreceptors.

scholarly journals Histological Alterations Induced by Atorvastatin Therapeutic Doses in some Organs of Male Albino Rats

2019 ◽  
Vol 9 (1) ◽  
pp. 13-16
Author(s):  
Twana Mustafa ◽  
Hamza Abdulah
Keyword(s):  
Adult Male ◽  
Modern World ◽  
Seminiferous Tubules ◽  
Control Group ◽  
Albino Rats ◽  
Histological Structure ◽  
Albino Rat ◽  
Heart Attacks ◽  
Histological Alterations ◽  
Therapeutic Doses

Vascular disease and heart attacks are a common phenomenon in the modern world, where lipid accumulates inside blood vessels and causes plug, eventually heart stroke and death. Utilize lipidlowering drugs are the most effective factors to prevent heart disease. Atorvastatin is the most important drugs that used in this field. The aim of this study was to investigate the adverse effects of atorvastatin (20 mg/kg/b.wt/day) on some organs of albino. 12 adult male albino rats weighing 200 ± 20 g were used and divided into two groups: First group served as control group, was given 0.72 ml distilled water/rat. The second group was subjected to treatments with atorvastatin in a dose of 20 mg/kg/b.wt/day as a single daily dose (0.72 ml contained 1.44 mg of atorvastatin) orally by gastric tube for 4 weeks. Histological alterations were examined, and the results of atorvastatintreated groups showed changes in the kidney sections, which include focal tubular edema and glomerular atrophy, also liver sections revealed foci of lymphocyte accumulation, cytoplasmic vacuolization, as well as sections of the testes showed degenerative changes in the seminiferous tubules. According to this study, we can conclude that atorvastatin-induced various deleterious changes in the histological structure of the testes, kidneys and cause mild liver alteration of adult male albino rat.

Does garlic ameliorates histological alterations of induced mucositis in Albino rats subjected to gamma radiation?

2020 ◽  
Vol 175 (9-10) ◽  
pp. 938-951
Author(s):  
Reham M. Amin ◽  
Randa H. Mokhtar ◽  
Nabil A. El-Faramawy
Keyword(s):  
Gamma Radiation ◽  
Albino Rats ◽  
Histological Alterations

scholarly journals EFFECT OF VITAMIN E AGAINST HEAT STRESS INDUCED TESTICULAR DAMAGE IN WISTAR ALBINO RATS

2017 ◽  
Vol 5 (2.2) ◽  
pp. 3800-3804
Author(s):  
Yadav G ◽  
◽  
Awasthi J R ◽  
Pandey N ◽  
Shrestha S ◽  
...  
Keyword(s):  
Heat Stress ◽  
Vitamin E ◽  
Albino Rats ◽  
Testicular Damage ◽  
Wistar Albino Rats

scholarly journals Effect of Lycopene on Histological Alterations of Basement Membrane & Fibrosis in Renal Interstitial Tissue of Celebrex Induced Albino Rats; An Experimental Study

2021 ◽  
pp. 555-563
Author(s):  
Sadia Sundus ◽  
Ashok Kumar ◽  
Anjum Rehman ◽  
. Ata-Ur-Rehman ◽  
Sara Naqvi ◽  
...  
Keyword(s):  
Experimental Study ◽  
Basement Membrane ◽  
Brush Border ◽  
Research Work ◽  
Albino Rats ◽  
Interstitial Tissue ◽  
Histological Alterations ◽  
Renal Interstitium ◽  
Proximal Tubular ◽  
Animal House

Objective: To assess the histological alterations in basement membrane and fibrosis in renal interstitium of albino rats due to celebrex with enhancement by lycopene.  Study Design: Experimental study. Abode of Study: Animal House of Jinnah Postgraduate institute, Karachi, Materials and Methods: COX-2 inhibitor and antioxidant medicines were used in this research work. These medications were orally administered in 40 male albino rats weighing 200-220gm for experimentation. Rats were housed in separate pens at 23ºC. Rats were arranged into 4 groups including control horde and three experimental hordes. The medications were dose up orally by gastric tube daily for one month.  At completion of experiment, animals were dissected and tissues were well-preserved for staining. Results: In second horde PAS stained kidney segments showed disrupted basement membrane of distended proximal convoluted tubules & ill-defined brush border and fibrosis in renal interstitium, but 3rd horde had intact basement membrane & well-define brush border at the luminal surface of proximal tubular epithelium and there was mild fibrosis in renal interstitium. Conclusion: This study divulges that lycopene convalesce the disrupted basement membrane and fibrosis in second horde.

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