scholarly journals Effect of dietary incorporation of Vernonia colorata (Willd) leaves on blood lipid profile of albino rats

Author(s):  
II Ijeh ◽  
AC Egedigwe
Author(s):  
Kayode A. Arowora ◽  
Chinedu Imo ◽  
Chukwuma S. Ezeonu ◽  
Zuhairah I. Muhammad

<p class="abstract"><strong>Background:</strong> This study was carried out to investigate the effects of <em>Datura metel (</em>leaf, seed and fruit<em>)</em> on blood lipid profile of male albino rats.</p><p class="abstract"><strong>Methods:</strong> Thirty-five albino rats (8 weeks old) weighing between 66g and 84g were purchased and randomly allotted into 7 groups. The normal control (group 1) received normal saline, while groups 2 to 7 received extracts of <em>Datura metel</em> at low (300 mg/kg body weight) and high doses (600 mg/kg body weight). The extracts were administered orally for seven consecutive days, while the animals were sacrificed on the 8th day; blood samples were collected, allowed to stand for fifteen minutes and then centrifuged.  </p><p class="abstract"><strong>Results:</strong> There was a general decreasing trend in the mean values of low density lipoprotein levels across  the groups, however, group 7 (with lowest value) was found to be significantly lower (p &lt;0.05) than other groups when compared with the normal control. Also, there was a general decreasing trend in the values of high density lipoprotein compared with normal control group, however lowest value was recorded to be 1.35±0.06 mmol/l for group 5. There were no significant differences (p &gt;0.05) in triglyceride levels across the groups, while total cholesterol in groups 5 and 6 had significant differences with values of 2.05±0.06 mmol/l and 2.13±0.10 mmol/l respectively when compared with the normal control.</p><p><strong>Conclusions:</strong> This study suggests that ethanolic extracts of<em> Datura metel </em>have active ingredients that are capable of improving blood lipid profile and this might be useful in the management of cardiovascular diseases. </p>


Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 732-P
Author(s):  
NAN LI ◽  
YANRU WANG ◽  
BING ZHU ◽  
HANG SUN ◽  
PENG YANG ◽  
...  

Molecules ◽  
2021 ◽  
Vol 26 (16) ◽  
pp. 4720
Author(s):  
Arlindo César Matias Pereira ◽  
Helison de Oliveira Carvalho ◽  
Danna Emanuelle Santos Gonçalves ◽  
Karyny Roberta Tavares Picanço ◽  
Abrahão Victor Tavares de Lima Teixeira dos dos Santos ◽  
...  

This study aimed to evaluate and compare the effects of co-treatment with purified annatto oil (PAO) or its granules (GRA, Chronic®) with that of testosterone on the orchiectomy-induced osteoporosis in Wistar rats. After surgery, rats were treated from day 7 until day 45 with testosterone only (TES, 7 mg/kg, IM) or TES + PAO or GRA (200 mg/kg, p.o.). The following parameters were evaluated: food/water intake, weight, HDL, LDL, glucose, triglycerides (TG), total cholesterol (TC), alkaline phosphatase levels, blood phosphorus and calcium contents, femur weight, structure (through scanning electron microscopy), and calcium content (through atomic absorption spectrophotometry). Our results show that orchiectomy could significantly change the blood lipid profile and decrease bone integrity parameters. Testosterone reposition alone could improve some endpoints, including LDL, TC, bone weight, and bone calcium concentration. However, other parameters were not significantly improved. Co-treatment with PAO or GRA improved the blood lipid profile and bone integrity more significantly and improved some endpoints not affected by testosterone reposition alone (such as TG levels and trabeculae sizes). The results suggest that co-treatment with annatto products improved the blood lipid profile and the anti-osteoporosis effects of testosterone. Overall, GRA had better results than PAO.


2012 ◽  
Vol 5 (1) ◽  
Author(s):  
Ana Elisa Madalena Rinaldi ◽  
Erick Prado de Oliveira ◽  
Fernando Moreto ◽  
Gleice Fernanda Costa Pinto Gabriel ◽  
José Eduardo Corrente ◽  
...  

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