and stored, such that they can be defrosted and grown on again later. This is cloning and storage of human cells in exactly the same way that cloning and storage of human embryos is. In many ways they are separated by a distinction without a difference and I would not like to be the person that had to tell a seriously, or even terminally, ill individual that it is not possible to treat them because the only way is to produce immunologically sound material which they will not reject by cloning – and that this is not allowed. It was decided on 15 November 2001 that cloning of embryos for therapeutic research should no longer be licensed, but cloning one for birth apparently is and there are medical practitioners who seem to think that this is a good and practical idea. It is suspected that the incredibly high failure rate of cloned foetuses will mitigate against pursuing human clones. To put numbers on this, of 277 attempts only one sheep, Dolly, was born and further successful examples of animal cloning have been just as hard won. However, failure in this context is not a simple, clear, non-viable embryo; it includes gross malformations and developmental problems. These would not be an acceptable outcome in human cloning. This problem of not thinking about questions on a ‘what if?’ basis before the practical necessity arises is exactly the same situation that seems to have occurred with DNA profiling and genetic testing for disease genes. We have simply not been ready as a society to address questions that are going to have profound effects for future generations. This, sadly, is a general failing. Statements such as ‘think of the children’, have very little power to motivate; what does motivate seems to be political will and commerce. It is true, as discussed earlier, that large numbers are not easily conceived of. What is also true is that long periods of time are not easily comprehended either. So, to take an example from a different science, but one which is very real now and can therefore give us pointers to the future of our ethical problems in genetics, let us consider the question of nuclear waste. We can visualise this not just as a physical problem but an ethical one which is dependent upon society and the good will of society as well. The long term control of nuclear waste is a problem. No matter how it is stored or dealt with it needs to be looked after for a very long time. Given the half-life of some of this material – that is the length of time it takes to reduce its radioactivity by half – the storage times are prodigiously long. It is not unrealistic to say that storage should be in excess of 10,000 years, but no civilisation has been around that long and it would require a great leap of faith to suggest that the current nuclear powers would remain intact, politically stable and financially able to look after such a potential problem for so long. It is to be hoped that humanity is going to out-last nuclear waste, but the questions regarding political stability remain. We simply do not know what sort of a government we will have 1,000 years hence; we do not know what sort of data they will hold about our genes, so now is the time to question their perceived right to hold such information. Now is the time to challenge the perceived right of testers to take samples to find out whatever they like about an individual and possibly pass it on.

1995 ◽  
Vol 09 (16) ◽  
pp. 985-988 ◽  
Author(s):  
A.M. JAYANNAVAR

We have solved analytically a simple model of evolution of particles driven by identical noise. We show that the trajectories of all particles collapse into a single trajectory at long time. This synchronization also leads to violation of the law of large numbers.


2018 ◽  
Vol 18 (3) ◽  
pp. 421-446
Author(s):  
István Temesi

Some EU member states have been migrant destinations for a long time, while others have lost a considerable part of their population since their accession to the EU. Hungary belongs to the latter. Large numbers of immigrants have not been arriving here since the end of the war in former Yugoslavia. However, in 2015 Hungary was suddenly strongly affected by mass migration, mainly because of the country’s geographical location. Mass migration has strongly influenced politics as the decision-maker and public administration as the executor of political decisions. Both the decisions and the policy-makers have been strongly criticised for taking a different approach to the situation compared with many other European countries. The Hungarian government’s priority was to reduce or stop mass migration and it used political, legal, and physical instruments selected for this purpose. This study does not aim to judge whether they are right or wrong. Hungarian public administration has had to adapt to the situation and it has done so by way of implementing new and modified legal rules. However, due to the political decisions described above, it has developed and changed at the same time.


2019 ◽  
Vol 322 (3) ◽  
pp. 1833-1839 ◽  
Author(s):  
Szabolcs Osváth ◽  
Jixin Qiao ◽  
Xiaolin Hou

Abstract 93Mo is an important long-lived radionuclide in nuclear waste, and is required to be measured during the characterization of decommissioning waste. However, no commercial 93Mo solution is available to be calibrated and used as standard in the analysis of nuclear waste. This work presents a method for separation of 93Mo from Nb metal used in cyclotron as a target holder and irradiated with protons for long time. The separation of 93Mo from Nb matrix was implemented by combination of precipitation and chromatographic separation. The Nb matrix was first removed by precipitating oxides-hydroxides of Nb (e.g. Nb2O5) and then by Fe(OH)3 co-precipitation; Mo in the solution was purified using an alumina (Al2O3) column. A decontamination factor of ca. 105 was achieved for Nb. A pure carrier-free 93Mo solution was successfully prepared, and the 93Mo purity was verified by liquid scintillation spectrometry.


2019 ◽  
Vol 43 (6) ◽  
pp. 329-338 ◽  
Author(s):  
Ronny Baber ◽  
Michael Kiehntopf

Abstract Biobanks are important infrastructures to support clinical research and developments in personalized medicine. Although biobanking is not a new invention it has gained importance in the last few years due to increased quality requirements for biological samples in biomedical research and new high resolution Omics-technologies. Moreover, quality-assured collection, processing and storage of biological samples with defined pre-analytical history plays a key role for reproducibility in scientific research and paves the path towards precision medicine. Due to the increasing need for large numbers of samples, both in basic as well as in translational research, particular attention must be paid to sample acquisition and preparation in order to guarantee the highest possible sample quality. This can be achieved by following best practices or implementation and operation of specific biobank quality management systems that are compliant with the new DIN EN ISO 20387. Moreover, automation of critical process steps in biobanking can help to reach the highest quality standard and consistent sample quality. The following article will present and discuss currently available solutions for process automation in biobanking.


2002 ◽  
Vol 37 (4) ◽  
pp. 425-441 ◽  
Author(s):  
Sergio R. Vaudagna ◽  
Guillermo Sanchez ◽  
Maria S. Neira ◽  
Ester M. Insani ◽  
Alyandra B. Picallo ◽  
...  

1986 ◽  
Vol 84 ◽  
Author(s):  
Rodney C. Ewing ◽  
Michael J. Jercinovic

AbstractOne of the unique and scientifically most difficult aspects of nuclear waste isolation is the extrapolation ofshot-term laboratory data (hours to years) to the long time periods (103-105 years) required by regulatory agencies for performance assessment. The direct verification of these extrapolations is not possible, but methods must be developed to demonstrate compliance with government regulations and to satisfy the lay public that there is a demonstrable and reasonable basis for accepting the long-term extrapolations. Natural analogues of both the repository environment (e.g. radionuclide migration at Oklo) and nuclear waste form behavior (e.g. alteration of basaltic glasses and radiation damage in minerals) have been used to demonstrate the long-term behavior of large scale geologic systems and, on a smaller scale, waste form durability. This paper reviews the use of natural analogues to predict the long-term behavior of nuclear waste form glasses. Particular emphasis is placed on the inherent limitations of any conclusions that are based on “proof” by analogy. An example -- corrosion of borosilicate glass -- is discussed in detail with specific attention to the proper and successful use of natural analogues (basaltic glass) in understanding the long-term corrosion behavior of borosilicate glass.


Blood ◽  
1982 ◽  
Vol 59 (4) ◽  
pp. 822-827 ◽  
Author(s):  
LC Lasky ◽  
RC Ash ◽  
JH Kersey ◽  
ED Zanjani ◽  
J McCullough

Abstract Successful complete hematopoietic reconstitution (CHR) using nonleukemic peripheral stem cells (PSC) after marrow ablation has been reported in animals but not man. Previous studies of cytapheresis products from humans, as a prelude to use for CHR, have documented the presence of committed myeloid (CFU-GM) and erythroid (BFU-E) precursors. We have examined mononuclear cell (MNC) products collected on the Fenwal CS3000 Blood Cell Separator for these plus the more primitive mixed (granulo-, erythro-, mono-, and megakaryocytic) cell colony-forming units (CFU-GEMM) and for various lymphocytic subpopulations (LSP). One to two-hour products contained 36 +/- 7 CFU- GEMM/10(6) MNC (mean +/- SE, n = 8) or 490 +/- 131/ml product. This compared favorably with blood (23 +/- .4/10(6) MNC or 46 +/- 8/ml, n = 14) and bone marrow (146 +/- 58/10(6) MNC, n = 12). Collection efficiency for E-rosette-positive cells approximated that for total lymphocytes and was variable for other LSP. Recovery of CFU-GEMM after freezing in 10% dimethylsulfoxide at a controlled rate and storage in liquid N2 was 54% +/- 8% (n = 8). Cytapheresis collection of large numbers of pluripotent hematopoietic precursors and demonstration of adequate recovery of these after cryopreservation, both previously unreported, are significant steps toward eventual CHR using nonleukemic PSC.


1997 ◽  
Vol 4 (4) ◽  
pp. 294-302 ◽  
Author(s):  
Glenda Strachan

Deciding to take industrial action or go on strike has been an issue of great concern for nurses. While it is typical for most groups of workers to undertake industrial action in the pursuit of better wages and working conditions or improved quality of services, historically, nurses have found this a difficult course to pursue. Frequently, nurses have been caught between acceptance of themselves as ordinary workers and a professional model, which has carried with it the implication that a profession does not engage in industrial action (although, in reality, professions, including medical practitioners, have undertaken industrial action). Nurses in Australia have gone on strike, although widespread industrial action was not undertaken until the 1980s, when lengthy industrial campaigns, including strikes, were used in an effort to achieve enhanced status for the profession, improved career paths and increased salaries. While debate remains about the efficacy of this course of action, large numbers of nurses have been involved in these campaigns. Significant changes in salaries and status were achieved in the 1980s.


1975 ◽  
Vol 65 (2) ◽  
pp. 324-334 ◽  
Author(s):  
P M Leuenberger ◽  
A B Novikoff

The pigment epithelial cell of the retina actively participates in two aspects of lipid metabolism: (a) the fatty acid esterification of vitamin A and its storage and transport to the photoreceptors, and (b) the phagocytosis and degradation of the lipoprotein membrane disks shed from the photoreceptor cells. Study of the pigment epithelial cells of adult albino and pigmented rodents has revealed the abundance of an organelle, microperoxisomes, not previously known to exist in this cell type. The metabolism, transport, and storage of lipids are major functions of other cell types which possess large numbers of microperoxisomes associated with a highly developed smooth endoplasmic reticulum. Microperoxisomes were encountered, but relatively rarely, in Müller cells and vascular endothelial cells. A tubular system in photoreceptor terminals is reactive in the cytochemical procedure used to visualize microperoxisomes.


Sign in / Sign up

Export Citation Format

Share Document