scholarly journals AYURVEDIC HERBAL MEDICINES ON BURN WOUND: A REVIEW

2021 ◽  
pp. 35-40
Author(s):  
Anusha P ◽  
Jyolsna G Krishna
Keyword(s):  
Wound Healing ◽  
Burn Injury ◽  
Herbal Medicines ◽  
Medical Attention ◽  
Burn Wound ◽  
Scientific Methods ◽  
Burn Wounds ◽  
Burn Wound Healing ◽  
Natural Remedies ◽  
Based Medicine

Burn injuries are under-appreciated injuries that are associated with substantial morbidity and mortality. Burn wound healing is a complicated process that includes inflammation, re-epithelialization, granulation, neovascularization, and wound contraction. Initial treatment of burn wounds aims at preventing infection and early wound healing. Properties like antioxidant, anti-inflammatory, antimicrobial, antibacterial are also helps in wound healing. The level of severity of the burn is of the utmost importance. Third degree burns require immediate medical attention while studies suggest that a number of natural remedies may aid in the treatment of first- and second-degree burns. The basic concepts and principles of management of burn injury is described in Ayurveda are very much relevant and useful in this era of modern surgery. There are so many herbs mentioned in Ayurveda classics are found to have properties like Dagdhahara, Vrana prasamana, Pittahara, Varnaprasadana, Twacya etc which contributes to burn wound healing. More recently, scientists increasingly rely on modern scientific methods and evidence based medicine to prove efficacy of herbal medicine and focus on better understanding of mechanisms of their action. The purpose of this article is to review the evidence supporting the use of some of the Ayurvedic herbal drugs and formulations as effective and affordable treatments for burn wounds.

556 The Use of a Concentrated Surfactant Based Gel to Promote Burn Wound Healing

2021 ◽  
Vol 42 (Supplement_1) ◽  
pp. S126-S127
Author(s):  
Rebecca Coffey ◽  
Rachel Penny
Keyword(s):  
Wound Healing ◽  
New Product ◽  
Ease Of Use ◽  
Burn Injuries ◽  
Full Thickness ◽  
Burn Wound ◽  
Burn Wounds ◽  
Burn Care ◽  
Product Trial ◽  
Burn Wound Healing

Abstract Introduction Strategies to remove necrotic tissue from burn wounds include excisional and non-excisional debridement. Alternative treatments could promote burn wound healing while minimizing patient discomfort and the need for surgery. We evaluated the usage of a concentrated surfactant gel (CSG) to promote burn wound healing in those with indeterminate depth and full thickness burn injuries. Methods An IRB approved retrospective study was conducted during a 10-patient new product trial period with enrollment between September and October 2019. Patients included in this study had indeterminate or full thickness burn wounds and were treated with a concentrated surfactant-based gel. Patients with non-burn diagnoses were excluded. Data collected included demographic information, injury descriptors, and additional burn wound characteristics. Results A total of 10 patients were included in this study as part of a new product trial. The subjects were 80% male with an average TBSA of 7.5%. 40% had indeterminate and 60% had full thickness burn wounds. Prior to initiation of the CSG, the burn wounds had been open for an average of 41 days. There were no infections or complications with usage of the CSG. 90% of patients reported less pain than the standard of care topical agents for burns. Average duration of treatment with the CSG until healing was 28 days. After usage of the CSG, no patients required surgery. Conclusions Our findings support the usage of a concentrated surfactant-based gel in patients with burn wounds. Patients reported decreased pain during dressing changes and ease of use compared to the standard topical agent in burn care. It also prevented surgical debridement in those with indeterminate and full thickness burn injuries.

scholarly journals Sufficient therapeutic effect of cryopreserved frozen adipose-derived regenerative cells on burn wounds

2018 ◽  
Author(s):  
Yasuhiko Kaita ◽  
Takehiko Tarui ◽  
Hideaki Yoshino ◽  
Takeaki Matsuda ◽  
Yoshihiro Yamaguchi ◽  
...  
Keyword(s):  
Wound Healing ◽  
Therapeutic Effect ◽  
Healing Process ◽  
Control Group ◽  
Type I ◽  
Burn Wound ◽  
Burn Wounds ◽  
Burn Wound Healing ◽  
Significant Difference ◽  
Regenerative Cells

AbstractThe purpose of this study was to evaluate whether cryopreserved (frozen) adipose-derived regenerative cells (ADRCs) have a therapeutic effect on burn wound healing as well as freshly isolated (fresh) ADRCs.Full thickness burns were created on dorsum of nude mice and burn wound was excised. The wound was covered by artificial dermis with; (i) fresh ADRCs, (ii) frozen ADRCs, and (iii) PBS (control). The assessment for wound healing was performed by morphological, histopathological and immunohistochemical analyses.In vivo analyses exhibited the significant therapeutic effect of frozen ADRCs on burn wound healing up to the similar or higher level of fresh ADRCs. There were significant differences of wound closure, epithelized tissue thickness, and neovascularization between the treatment groups and control group. Although there was no significant difference of therapeutic efficacy between fresh ADRC group and frozen ADRC group, frozen ADRCs improved burn wound healing process in dermal regeneration with increased great type I collagen synthesis compared with fresh ADRCs.These findings indicate that frozen ADRCs allow us to apply not only quickly but also for multiple times, and the cryopreserved ADRCs could therefore be useful for the treatment of burn wounds in clinical settings.

scholarly journals Plant Mediated Green Synthesis of Zinc Oxide Nanoparticles for Burn Wound Therapy

2020 ◽  
Author(s):  
Mohd Riyaz Beg ◽  
Shital Ghodinde ◽  
Vidhi Gupta
Keyword(s):  
Antimicrobial Activity ◽  
Wound Healing ◽  
Zinc Oxide ◽  
Green Synthesis ◽  
Zinc Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Burn Wound ◽  
Zno Nps ◽  
Burn Wounds ◽  
Burn Wound Healing

In this changing world, we all are surrounded by the surmountable risk of getting injured. Amongst various risk factors, major burns are the most distressing and catastrophic. Burn wounds are not easy to heal via natural healing process and ultimately ended up with scar formation. If the degree of burn is high then the loss of tissue and its function is very common. To fasten-up the natural burn wound healing; zinc, an essential trace element is found to be very much effective. But due to its’ particle size limitation, less contact with wounded cells and tissues, and high inherent toxicity restrict its use. Needlessly, zinc is an element with dual action i.e. both antimicrobial and wound healing it is a prime choice to apply its aptitude in burn wound healing. To overcome the documented limitations zinc has converted to nanoparticle form. Zinc oxide nanoparticles, in particular, have attained ample of interest due to their unique properties and potential antimicrobial activity along with wound healing activity which makes it promising for the healing of topical burn wounds. Plant mediated green synthesis of nano-metal oxide particles is gaining a lot of significance due to its simplicity, eco-friendliness and extensive antimicrobial activity and recommended as an appealing substitute to not only physical methods but also chemical methods avoiding the use of the high rate of toxic chemicals and extreme surroundings. This study includes ZnO NPs role in burn wound healing with Phyto-mediated synthesis methods to provide evidence of their potential applications. Additionally, it provides an overview of traditional methods used for the synthesis of ZnO nanoparticles and characterization techniques to obtain information concerning the size, shape and optical properties along with toxicity and safety concern of ZnO NPs and its biomedical applications.

scholarly journals The Use of Stem Cells in Burn Wound Healing: A Review

2015 ◽  
Vol 2015 ◽  
pp. 1-9 ◽  
Author(s):  
Fadi Ghieh ◽  
Rosalyn Jurjus ◽  
Amir Ibrahim ◽  
Alice Gerges Geagea ◽  
Hisham Daouk ◽  
...  
Keyword(s):  
Stem Cells ◽  
Wound Healing ◽  
Therapeutic Effect ◽  
Healing Time ◽  
Burn Injuries ◽  
Burn Wound ◽  
Burn Wounds ◽  
Complex Processes ◽  
Burn Wound Healing

Burn wound healing involves a series of complex processes which are subject to intensive investigations to improve the outcomes, in particular, the healing time and the quality of the scar. Burn injuries, especially severe ones, are proving to have devastating effects on the affected patients. Stem cells have been recently applied in the field to promote superior healing of the wounds. Not only have stem cells been shown to promote better and faster healing of the burn wounds, but also they have decreased the inflammation levels with less scar progression and fibrosis. This review aims to highlight the beneficial therapeutic effect of stem cells in burn wound healing and to discuss the involved pathways and signaling molecules. The review covers various types of burn wound healing like skin and corneal burns, along with the alternative recent therapies being studied in the field of burn wound healing. The current reflection of the attitudes of people regarding the use of stem cells in burn wound healing is also stated.

scholarly journals The Effect of Educated Platelets on the Healing Process of Burn Wounds in Rats: Educated Platelets in Rat Burn Wound Healing

2021 ◽  
Vol 8 ◽  
Author(s):  
Orkun Ilgen ◽  
Sefa Kurt ◽  
Osman Yilmaz ◽  
Murat Celiloglu
Keyword(s):  
Wound Healing ◽  
Burn Injury ◽  
Healing Process ◽  
Recovery Period ◽  
Control Group ◽  
Study Group ◽  
Second Line ◽  
Burn Wound ◽  
Wound Area ◽  
Burn Wound Healing

Burns are serious life-threatening health problems. This study was performed to determine the effect of educated platelets on burn wound healing process. 28 female wistar albino 200-220 gr rats were randomly divided into four groups. Group A1 rats(n:7) were the first-line burnt group from which blood samples are extracted to develop platelet-rich plasma(PRP) with the educated platelets that have a response to burn injury. Group B1 rats(n:7) were the unburnt group with ordinary platelets. Group A2 rats(n:8) were the second-line burnt group which was given PRP with educated platelets. Group B2 rats(n:6), as control group, were the second-line burnt group which was given PRP with ordinary platelets. Photos of rats' dorsum were taken by digital camera on the first day and 21st day of the study. Wound healing was determined by scar surface area. In the study group (Group A2) mean wound area was  53±37 mm², in the control group (Group B2) mean wound area was 114±55 mm² on the last day of the experiment. The sizes of the wounded areas were significantly lower in the study group compared with the control group (p: 0.039). Educated platelets seem to facilitate the recovery period of burn wound healing in rats.

scholarly journals Evaluation of the Healing Effects of Hypericum perforatum and Curcumin on Burn Wounds in Rats

2020 ◽  
Vol 2020 ◽  
pp. 1-5
Author(s):  
Nevra Seyhan
Keyword(s):  
Wound Healing ◽  
Hypericum Perforatum ◽  
Control Group ◽  
Sprague Dawley ◽  
Burn Wound ◽  
Burn Wounds ◽  
Burn Wound Healing ◽  
Significant Difference ◽  
Group A ◽  
Second Degree

Background. For centuries, medicinal plants have been extensively used in wound healing of burn injuries. The aim of this study is to analyze comparatively the effects of curcumin and Hypericum perforatum (HP) on second-degree burn wounds in rats. Materials and Methods. This experimental study was conducted on 24 male Sprague-Dawley rats with second-degree burns. The animals were randomly divided into three groups. The burns were treated with curcumin (Group B) and Hypericum perforatum (Group C) with daily application. Group A was considered as the control group and received no medication. Histological parameters, reepithelization, granulation tissue formation, inflammation, and angiogenesis were assessed after the scar biopsy at the end of research. Results. All histological parameters of the control group showed statistically significant difference than the other groups (p<0.05). There was no statistically significant difference between Groups B and C in terms of reepithelization and inflammation (p=0.351, p=0.067). In the curcumin group compared with the HP group, a significant difference was observed for two parameters of fibrosis and angiogenesis (p<0.05). Conclusion. Both curcumin and Hypericum perforatum oil are effective in burn wound healing. Our findings showed a better quality of healing in curcumin-treated rats.

Assortment of human amniotic membrane and curcumin: a potential therapeutic strategy for burn wound healing

2020 ◽  
Vol 15 ◽  
Author(s):  
Ayesha Siddika ◽  
Md. Arifuzzaman ◽  
Liakat Hossain ◽  
Md. Hasib Adnan ◽  
Farzana Diba ◽  
...  
Keyword(s):  
Wound Healing ◽  
Amniotic Membrane ◽  
Therapeutic Strategy ◽  
Burn Injury ◽  
Cost Effective ◽  
Human Amniotic Membrane ◽  
Microbial Infection ◽  
Burn Wound ◽  
Burn Wound Healing ◽  
Potential Source

: Burn wound associated injury management is one of the major unresolved clinical concerns. Most of the drugs and dressing materials found in the market cause dose escalation and even exert side effects. Besides, a severe burn injury is susceptible to microbial infection that leads to prolonged hospital stay which ultimately causes a financial crisis to the victims. To get rid of this problem, researchers are being interested in developing such materials that are cost-effective, easily available and accelerate faster healing. Human amniotic membrane (AM) and various herbal extracts like curcumin are a potential source of burn wound healing. AM has various healing properties and is being used as a best burn wound dressing material for centuries. Similarly, curcumin has been proven as faster dressing material for the treatment of burn injury. Since both AM and curcumin are a potential source of burn and wound healing, if a gel/agent could be formulated by mixing these two things, this combination may be a potential therapeutic strategy to treat burn wound healing.

Burn injury: Challenges and advances in burn wound healing, infection, pain and scarring

2018 ◽  
Vol 123 ◽  
pp. 3-17 ◽  
Author(s):  
Yiwei Wang ◽  
Joanneke Beekman ◽  
Jonathan Hew ◽  
Stuart Jackson ◽  
Andrea C. Issler-Fisher ◽  
...  
Keyword(s):  
Wound Healing ◽  
Burn Injury ◽  
Burn Wound ◽  
Burn Wound Healing

scholarly journals The plasminogen receptor, Plg-RKT, plays a role in inflammation and fibrinolysis during cutaneous wound healing in mice

2020 ◽  
Vol 11 (12) ◽  
Author(s):  
Lina Ny ◽  
Robert J. Parmer ◽  
Yue Shen ◽  
Sandra Holmberg ◽  
Nagyung Baik ◽  
...  
Keyword(s):  
Wound Healing ◽  
Wound Closure ◽  
Cytokine Expression ◽  
Epidermal Differentiation ◽  
Epidermal Thickness ◽  
Burn Wound ◽  
Burn Wounds ◽  
Burn Wound Healing ◽  
Key Steps ◽  
Wound Tissue

AbstractWound healing is a complex physiologic process that proceeds in overlapping, sequential steps. Plasminogen promotes fibrinolysis and potentiates the inflammatory response during wound healing. We have tested the hypothesis that the novel plasminogen receptor, Plg-RKT, regulates key steps in wound healing. Standardized burn wounds were induced in mice and time dependence of wound closure was quantified. Healing in Plg-RKT−/− mice was significantly delayed during the proliferation phase. Expression of inflammatory cytokines was dysregulated in Plg-RKT−/− wound tissue. Consistent with dysregulated cytokine expression, a significant delay in wound healing during the proliferation phase was observed in mice in which Plg-RKT was specifically deleted in myeloid cells. Following wound closure, the epidermal thickness was less in Plg-RKT−/− wound tissue. Paradoxically, deletion of Plg-RKT, specifically in keratinocytes, significantly accelerated the rate of healing during the proliferation phase. Mechanistically, only two genes were upregulated in Plg-RKT−/− compared with Plg-RKT+/+ wound tissue, filaggrin, and caspase 14. Both filaggrin and caspase 14 promote epidermal differentiation and decrease proliferation, consistent with more rapid wound closure and decreased epidermal thickness during the remodeling phase. Fibrin clearance was significantly impaired in Plg-RKT−/− wound tissue. Genetic reduction of fibrinogen levels to 50% completely abrogated the effect of Plg-RKT deletion on the healing of burn wounds. Remarkably, the effects of Plg-RKT deletion on cytokine expression were modulated by reducing fibrinogen levels. In summary, Plg-RKT is a new regulator participating in different phases of cutaneous burn wound healing, which coordinately plays a role in the interrelated responses of inflammation, keratinocyte migration, and fibrinolysis.

scholarly journals Topical treatment of standardised burns with herbal remedies in model rats

2005 ◽  
Vol 5 (4) ◽  
pp. 50-57 ◽  
Author(s):  
Fahir Bečić ◽  
Nedžad Mulabegović ◽  
Zakira Mornjaković ◽  
Elvedina Kapić ◽  
Senad Prašović ◽  
...  
Keyword(s):  
Wound Healing ◽  
Healing Process ◽  
Silver Sulfadiazine ◽  
Herbal Remedies ◽  
Control Group ◽  
Therapeutic Effects ◽  
Skin Area ◽  
Burn Wound ◽  
Burn Wounds ◽  
Burn Wound Healing

Experimental studies of burns require the use of different animal models. The aim of this work was to establish experimental model of thermal injuries and to evaluate the effects of topical agents on healing of the burn wounds. Forty female Wistar rats were randomly classified in 4 groups and isolated for 2 weeks before the onset of experiment. Animals were primarily anaesthetized with pentobarbital-sodium and then shaved (skin area of their back with diameters 5 cm x 5 cm). A round metal stamp with contact area of 5 cm2 and total weight of 100 g was heated up to 80°C and then applied without additional pressure on the depilated skin of the back for 14 seconds. This procedure produced a standardized burn wound. Induced burn wounds were immediately drowned in the 4°C-water for 3 s in order to maintain microcirculation. After the inducement of thermal injures, all rats were treated with 1% silver sulfadiazine cream, herbal topical preparations or were not treated at all. Burn wounds were treated twice a day until the healing completion. The result of treatment application was a significant reduction of burn wound diameters. Herbal topical preparations expressed positive therapeutic effects on the parameters of burn wounds. The efficiency of silver sulfadiazine cream in burn wound healing was significantly more expressed in comparison to healing process in control group of animals (p<0,001). We conclude that herbal topical preparations efficiently caused the completion of burn wound healing process without scar formation.

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