Assortment of human amniotic membrane and curcumin: a potential therapeutic strategy for burn wound healing

2020 ◽  
Vol 15 ◽  
Author(s):  
Ayesha Siddika ◽  
Md. Arifuzzaman ◽  
Liakat Hossain ◽  
Md. Hasib Adnan ◽  
Farzana Diba ◽  
...  
Keyword(s):  
Wound Healing ◽  
Amniotic Membrane ◽  
Therapeutic Strategy ◽  
Burn Injury ◽  
Cost Effective ◽  
Human Amniotic Membrane ◽  
Microbial Infection ◽  
Burn Wound ◽  
Burn Wound Healing ◽  
Potential Source

: Burn wound associated injury management is one of the major unresolved clinical concerns. Most of the drugs and dressing materials found in the market cause dose escalation and even exert side effects. Besides, a severe burn injury is susceptible to microbial infection that leads to prolonged hospital stay which ultimately causes a financial crisis to the victims. To get rid of this problem, researchers are being interested in developing such materials that are cost-effective, easily available and accelerate faster healing. Human amniotic membrane (AM) and various herbal extracts like curcumin are a potential source of burn wound healing. AM has various healing properties and is being used as a best burn wound dressing material for centuries. Similarly, curcumin has been proven as faster dressing material for the treatment of burn injury. Since both AM and curcumin are a potential source of burn and wound healing, if a gel/agent could be formulated by mixing these two things, this combination may be a potential therapeutic strategy to treat burn wound healing.

scholarly journals Characterization of burn wound healing gel prepared from human amniotic membrane and Aloe vera extract

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Md Shaifur Rahman ◽  
Rashedul Islam ◽  
Md Masud Rana ◽  
Lucas-Sebastian Spitzhorn ◽  
Mohammad Shahedur Rahman ◽  
...  
Keyword(s):  
Wound Healing ◽  
Amniotic Membrane ◽  
Aloe Vera ◽  
Human Amniotic Membrane ◽  
Burn Wound ◽  
Burn Wound Healing

scholarly journals The Effect of Educated Platelets on the Healing Process of Burn Wounds in Rats: Educated Platelets in Rat Burn Wound Healing

2021 ◽  
Vol 8 ◽  
Author(s):  
Orkun Ilgen ◽  
Sefa Kurt ◽  
Osman Yilmaz ◽  
Murat Celiloglu
Keyword(s):  
Wound Healing ◽  
Burn Injury ◽  
Healing Process ◽  
Recovery Period ◽  
Control Group ◽  
Study Group ◽  
Second Line ◽  
Burn Wound ◽  
Wound Area ◽  
Burn Wound Healing

Burns are serious life-threatening health problems. This study was performed to determine the effect of educated platelets on burn wound healing process. 28 female wistar albino 200-220 gr rats were randomly divided into four groups. Group A1 rats(n:7) were the first-line burnt group from which blood samples are extracted to develop platelet-rich plasma(PRP) with the educated platelets that have a response to burn injury. Group B1 rats(n:7) were the unburnt group with ordinary platelets. Group A2 rats(n:8) were the second-line burnt group which was given PRP with educated platelets. Group B2 rats(n:6), as control group, were the second-line burnt group which was given PRP with ordinary platelets. Photos of rats' dorsum were taken by digital camera on the first day and 21st day of the study. Wound healing was determined by scar surface area. In the study group (Group A2) mean wound area was  53±37 mm², in the control group (Group B2) mean wound area was 114±55 mm² on the last day of the experiment. The sizes of the wounded areas were significantly lower in the study group compared with the control group (p: 0.039). Educated platelets seem to facilitate the recovery period of burn wound healing in rats.

Burn injury: Challenges and advances in burn wound healing, infection, pain and scarring

2018 ◽  
Vol 123 ◽  
pp. 3-17 ◽  
Author(s):  
Yiwei Wang ◽  
Joanneke Beekman ◽  
Jonathan Hew ◽  
Stuart Jackson ◽  
Andrea C. Issler-Fisher ◽  
...  
Keyword(s):  
Wound Healing ◽  
Burn Injury ◽  
Burn Wound ◽  
Burn Wound Healing

scholarly journals Human amniotic membrane: A biological cost effective dressing in chronic wounds.

2020 ◽  
Vol 27 (06) ◽  
pp. 1249-1254
Author(s):  
Ibrahim Yamin ◽  
Ayesha ◽  
Ramla ◽  
Muhammad Ajmal
Keyword(s):  
Wound Healing ◽  
Amniotic Membrane ◽  
Chronic Wounds ◽  
Biological Membrane ◽  
Case Series ◽  
Cost Effective ◽  
Complete Healing ◽  
Lower Limbs ◽  
Human Amniotic Membrane ◽  
Healing Wound

Objectives: The use of human amniotic membrane is essential new concept in wound healing which functions as a biodegradable scaffold on wound surface, as it is a rich hub of stem cells which play an important role in wound healing. Study Design: Randomized Control Trial. Setting: Department of Surgery THQ Hospital Gojra. Period: 1st January 2019 to 30 September 2019. Material & Methods: Experimental study using clinical trial. A case series of 50 patient cases were picked from surgical OPD. Who fall in criteria of chronic non-healing wound with at least three months duration comprising of diabetic, venous ulcers and traumatic non healing wound and neuropathic ulcers. All located on lower limbs. Results: All 50 patient were treated with standard protocol by applying freshly prepared amniotic membrane out of which 4 chronic wounds more than 4 year duration were not healed and 2 cases escaped from the study. HAM dressing was changed after every 7 days and its effect were studied by seeing measuring the reduction in wound size and improvement in pain, swelling and mental stress. Success rate was found about 90% with complete healing. Conclusion: There is a dire need in developing countries to promote the use of HAM, in chronic non healing wounds which is a biological membrane, readily available (free if fresh) with simple sterilization techniques, easy storage and easy application with ultimate goal in achieving speedy cost effective wound healing.

72 Parent Behavioral Responses to Children’s Itching following Unintentional Burns: Persevering Through Devastation. A Mixed-Methods Study

2021 ◽  
Vol 42 (Supplement_1) ◽  
pp. S50-S50
Author(s):  
Yuting Lin
Keyword(s):  
Wound Healing ◽  
Young Children ◽  
Lived Experience ◽  
Burn Injury ◽  
Behavioral Responses ◽  
Self Report ◽  
Symptom Experience ◽  
Structured Interviews ◽  
Burn Wound ◽  
Burn Wound Healing

Abstract Introduction Postburn itch is one of the disturbing symptoms that persist throughout the burn wound healing period. Parents often assume the responsibility to respond to their child’s symptoms; consequently, their responses to their child’s symptoms contributed to the child’s symptom experience and long-term outcomes. To date, literature examining parental behaviors in response to symptoms has been limited to children with pain. This study examined parents’ behavioral responses to itching in young children with burns. Methods:: This analysis was part of a larger descriptive study that examined parental behavioral and psychological responses to children’s itch following the child’s unintentional burn injury. Parents of young children with deep second or third-degree burns were recruited. Semi-structured interviews were conducted with parents to learn about parental behavioral responses to the child’s itching. The Adult Responses to Children’s Symptoms (ARCS) scale was used to evaluate parental responses as part of the interview. The ARCS scale consists of 29 items that allow parents to self-report their responses to children’s itch. However, four items were excluded: three items were not appropriate to the study sample; one item related to sleep because children’s sleep pattern has been dramatically disturbed. We used the inductive content analysis that adapted from Grounded Theory to analyze the data. Results Twenty parents of children 34 (±11.5) months with moderate to severe burns 11.2% (±8.7%) total burn surface area (TBSA) participated in the interview. The mean length of time since burn injury was 6.4 (±3.1) months. Persevering through Devastation was the core construct that captured the lived experience of parental itching management. Parental behavioral responses to their child’s itch involved shifting their children’s attention, touching the scar, and tending to the itching scar. Data triangulation revealed that the ARCS scale captured parent behaviors in response to their child’s itch that was not reported in the interview. Conclusions Parents were devastated when they struggled on their own to relieve their child’s incessant itching during the prolonged wound healing stage. They cared for children with perseverance in the face of traumatic burn event; however, some parents responded to their child’s distress and call for comfort with anger or reactive behavior.

scholarly journals Hydrogel with silver nanoparticles synthesized by Mimosa tenuiflora for second-degree burns treatment

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Aaron Martínez-Higuera ◽  
César Rodríguez-Beas ◽  
Jesús Mauro Adolfo Villalobos-Noriega ◽  
Abraham Arizmendi-Grijalva ◽  
Carlos Ochoa-Sánchez ◽  
...  
Keyword(s):  
Wound Healing ◽  
Silver Nanoparticles ◽  
Photoelectron Spectroscopy ◽  
Burn Injury ◽  
Histopathological Analysis ◽  
Burn Wound ◽  
X Ray ◽  
Burn Wound Healing ◽  
Mimosa Tenuiflora ◽  
Second Degree

AbstractIn this work we use Mimosa tenuiflora (MtE) extracts as reducing agents to synthesize silver nanoparticles (AgMt NPs) which were characterized by DPPH and Total Polyphenols Assays, UV–visible, X-ray diffractometer (XRD), high-resolution transmission electron microscopy (HRTEM), X-ray photoelectron spectroscopy (XPS) and Thermogravimetric analysis (TGA). AgMt NPs possess average sizes of 21 nm and fcc crystalline structure, it was also confirmed that the MtE is present in the AgMt NPs even after the cleaning protocol applied. Subsequently, carbopol hydrogels were made and the MtE and the synthesized AgMt NPs were dispersed in different gels (MtE-G and AgMt NPs-G, respectively) at 100 µg/g concentration. The gels were characterized by UV–Vis, IR, and rheology. Antimicrobial tests were performed using Staphylococcus aureus and Escherichia coli. Burn wound healing was evaluated in a second-degree burn injury on a Wistar rats model for 14 days and additional skin biopsies were examined with histopathological analysis. Gel with commercial silver nanoparticles (Ag NPs) was prepared and employed as a control on the biological assays. Hydrogel system containing silver nanoparticles synthesized with Mimosa tenuiflora (AgMt NPs-G) is a promising therapeutic strategy for burn wound healing, this due to bactericidal and anti-inflammatory effects, which promotes a more effective recovery (in percentage terms) by damaged area.

scholarly journals AYURVEDIC HERBAL MEDICINES ON BURN WOUND: A REVIEW

2021 ◽  
pp. 35-40
Author(s):  
Anusha P ◽  
Jyolsna G Krishna
Keyword(s):  
Wound Healing ◽  
Burn Injury ◽  
Herbal Medicines ◽  
Medical Attention ◽  
Burn Wound ◽  
Scientific Methods ◽  
Burn Wounds ◽  
Burn Wound Healing ◽  
Natural Remedies ◽  
Based Medicine

Burn injuries are under-appreciated injuries that are associated with substantial morbidity and mortality. Burn wound healing is a complicated process that includes inflammation, re-epithelialization, granulation, neovascularization, and wound contraction. Initial treatment of burn wounds aims at preventing infection and early wound healing. Properties like antioxidant, anti-inflammatory, antimicrobial, antibacterial are also helps in wound healing. The level of severity of the burn is of the utmost importance. Third degree burns require immediate medical attention while studies suggest that a number of natural remedies may aid in the treatment of first- and second-degree burns. The basic concepts and principles of management of burn injury is described in Ayurveda are very much relevant and useful in this era of modern surgery. There are so many herbs mentioned in Ayurveda classics are found to have properties like Dagdhahara, Vrana prasamana, Pittahara, Varnaprasadana, Twacya etc which contributes to burn wound healing. More recently, scientists increasingly rely on modern scientific methods and evidence based medicine to prove efficacy of herbal medicine and focus on better understanding of mechanisms of their action. The purpose of this article is to review the evidence supporting the use of some of the Ayurvedic herbal drugs and formulations as effective and affordable treatments for burn wounds.

Effects of Topical Application of Royal Jelly on Second-Degree Burn Wound Healing in Male Rats

2020 ◽  
Author(s):  
Zeinab Mahdian ◽  
Fereshteh Amiri ◽  
Zohreh Mohammadi ◽  
Parviz Farzadinia ◽  
Fahimeh Safizadeh ◽  
...  
Keyword(s):  
Wound Healing ◽  
Royal Jelly ◽  
Burn Injury ◽  
Male Rats ◽  
Control Group ◽  
Therapeutic Effects ◽  
Burn Wound ◽  
Treatment Groups ◽  
Burn Wound Healing ◽  
Second Degree

Background and Aims: Burn injury remain as a major medical problem throughout the world. This injury is accompanied with inflammatory and wound healing responses. Since royal jelly (RJ) has anti-inflammatory and wound healing activity therefore, the aim of this study was to evaluate the repairing effects of RJ on skin burn- damage. Materials and Methods: In an experimental study, 40 male Wistar rats (8 weeks old) were engaged. The animals were divided into five equal groups. Group 1 was considered healthy control. Group 2 (positive control) was treated topically with Silver Sulfadiazine Cream, group 3 received Eucerin as negative control, and group 4, 5 treated with RJ (10 and 30%). Sampling was performed after observing the second-degree burns on the first, seventh and fourteenth days. Then after 28 days, rats were sacrificed and their skin tissues were used for morphological and morphometric assessments. Results: The results of this study showed that the amount and arrangement of collagen type 1 protein was higher in the RJ treatment groups versus control group. Reconstruction and thickening of the epithelium in RJ treated groups confirmed therapeutic effects of RJ. In addition, RJ increased angiogenesis compared to the control group. The woundchr('39')s surface area was reduced in the RJ treatment groups compared to the control group. In addition, fibroblast cell proliferation was increased in the groups receiving RJ versus control. Conclusions: It could be concluded that, RJ induce wound healing effects and might be considered as potential treatment option to improve the burn wound healing.

scholarly journals Identification of Major Active Ingredients Responsible for Burn Wound Healing ofCentella asiaticaHerbs

2012 ◽  
Vol 2012 ◽  
pp. 1-13 ◽  
Author(s):  
Fang Wu ◽  
Difei Bian ◽  
Yufeng Xia ◽  
Zhunan Gong ◽  
Qian Tan ◽  
...  
Keyword(s):  
Wound Healing ◽  
Burn Injury ◽  
Centella Asiatica ◽  
Asiatic Acid ◽  
Burn Wound ◽  
Active Constituent ◽  
Healthy Human ◽  
Burn Wound Healing

Centella asiaticaherbs have been prescribed as a traditional medicine for wound healing in China and Southeast Asia for a long time. They contain many kinds of triterpenoid compounds, mainly including glycosides (asiaticoside and madecassoside) and corresponding aglycones (asiatic acid and madecassic acid). To identify which is the major active constituent, a comprehensive and comparative study of these compounds was performed.In vitro, primary human skin fibroblasts, originating from healthy human foreskin samples, were treated with various concentrations of asiaticoside, madecassoside, asiatic acid, and madecassic acid, respectively. Cell proliferation, collagen synthesis, MMP-1/TIMP-1 balance, and TGF-β/Smad signaling pathway were investigated.In vivo, mice were orally administered with the four compounds mentioned above for two weeks after burn injury. The speed and quality of wound healing, as well as TGF-β1levels in skin tissues, were examined. Interestingly, in contrast to prevalent postulations, asiaticoside and madecassoside themselves, rather than their corresponding metabolites asiatic acid and madecassic acid, are recognized as the main active constituents ofC. asiaticaherbs responsible for burn wound healing. Furthermore, madecassoside is more effective than asiaticoside (P=0.0446for procollagen type III synthesisin vitro,P=0.0057for wound healing speed, andP=0.0491for wound healing patternin vivo, correspondingly).

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