scholarly journals Prospects of Vaccination Against COVID-19 and Road to DNA-based Vaccine: A Review

2022 ◽  
Vol 1 (10) ◽  
pp. 1-8
Keyword(s):  
Immune Response ◽  
Immune System ◽  
Dna Vaccines ◽  
Global Scale ◽  
Live Virus ◽  
The Public ◽  
Great Possibility ◽  
The Way

Covid-19 made the countries develop and adopt significant measures to control the spread of disease. For this purpose, firstly countries ordered the public to follow precautions, like, wearing a mask, sanitizer usage, and home quarantine. Then, countries endeavor for the preparation of vaccination started to not only stop the spread but to control and end the coronavirus. These efforts of vaccination started giving benefits in late 2020 and by the end of February 2021, many vaccines were approved conditionally and ready to use, while more were on the way to approval. Apparent from this, there is a great possibility that more clinically proven vaccines will be available on the market in the coming few years. Now, when there is the solution, "The Vaccine", the main point is how to meet the need for the vaccine on a global scale and capital generation for the purchase of vaccine. Till so far, mRNA vaccines are market-available, while DNA-type vaccines are under improvement, being experimented and tested. Because DNA vaccines usually only encode one protein from a pathogen; those may not be as effective if individuals need to mount an immune response to numerous proteins to gain protection, but this can be achieved by combining multiple vaccines. While mRNA vaccines guide the immune system to make a protein that will trigger an immune response without using a live virus and generate longer immunity.

scholarly journals Respon Imun Pada Penderita Asma Selama Kehamilan

2017 ◽  
Vol 4 (1) ◽  
pp. 58
Author(s):  
Wiwik Agustina
Keyword(s):  
Immune Response ◽  
Immune System ◽  
Pregnant Women ◽  
Influenza A ◽  
Detrimental Effect ◽  
Scientific Work ◽  
Premature Delivery ◽  
Literature Study ◽  
The Public ◽  
Children With Asthma

The immune system of a woman while pregnant it would be more sensitive than usual. Therefore, pregnant women are particularly vulnerable to some diseases, particularly influenza. A new study suggests that women who often experience flu during pregnancy, would be at risk of having children with asthma. In addition, asthma and allergies can also be inheritable. If both parents have allergies, the child has an allergy risk 75 percent. If only one parent with allergies, or if a near of kin has an allergy, the child will have a 30 to 40 percent risk of experiencing various types of allergies. However, if the parents do not have allergies at all, the risk of allergies in children only 10 to 15 percent. This scientific work aimed to determine the immune response in pregnant women with a asthma. This scientific work methods using literature study. Effect of pregnancy on the incidence of asthma attacks in each patient are not the same, even attacks are not common in a first pregnancy and subsequent pregnancies. Usually the attack will arise from the age of 24 weeks to 36 weeks, and will be reduced by the end of pregnancy. Effect of asthma in mother and the fetus is very dependent on the frequency and severity of asthma attacks, because of the mother and the fetus will experience hypoxia. Hypoxia if not addressed would have a detrimental effect on the fetus, such as miscarriage, premature delivery, and fetal weight were not in accordance with gestational age. It is expected the public to give more attention and be aware in patients with asthma, especially in during pregnancy.;Keywords : immune system , pregnant women , asthma

scholarly journals Impact of Zinc, Glutathione, and Polyphenols as Antioxidants in the Immune Response against SARS-CoV-2

Processes ◽  
2021 ◽  
Vol 9 (3) ◽  
pp. 506
Author(s):  
José Manuel Pérez de la Lastra ◽  
Celia Andrés-Juan ◽  
Francisco J. Plou ◽  
Eduardo Pérez-Lebeña
Keyword(s):  
Immune Response ◽  
Immune System ◽  
Immune Responses ◽  
Rational Design ◽  
Global Scale ◽  
Key Factors ◽  
Central Function ◽  
Antiviral Immune Response ◽  
The Relationship

SARS-CoV-2, the coronavirus triggering the disease COVID-19, has a catastrophic health and socioeconomic impact at a global scale. Three key factors contribute to the pathogenesis of COVID-19: excessive inflammation, immune system depression/inhibition, and a set of proinflammatory cytokines. Common to these factors, a central function of oxidative stress has been highlighted. A diversity of clinical trials focused predominantly on antioxidants are being implemented as potential therapies for COVID-19. In this study, we look at the role of zinc, glutathione, and polyphenols, as key antioxidants of possible medicinal or nutritional significance, and examine their role in the antiviral immune response induced by SARS-Cov-2. An unresolved question is why some people experience chronic COVID and others do not. Understanding the relationship between SARS-CoV-2 and the immune system, as well as the role of defective immune responses to disease development, would be essential to recognize the pathogenesis of COVID-19, the risk factors that affect the harmful consequences of the disease, and the rational design of successful therapies and vaccinations. We expect that our research will provide a novel perspective that contributes to the design of clinical or nutritional targets for the prevention of this pandemic.

scholarly journals Alloantigen–induced specific immunological unresponsiveness

2001 ◽  
Vol 356 (1409) ◽  
pp. 665-680 ◽  
Author(s):  
Kathryn J. Wood ◽  
Nick D. Jones ◽  
Andrew R. Bushell ◽  
Peter J. Morris
Keyword(s):  
Immune Response ◽  
Immune System ◽  
Environmental Conditions ◽  
Functional Activity ◽  
Molecular Mechanisms ◽  
Tolerance Induction ◽  
Therapeutic Agents ◽  
The Future ◽  
The Way

When the immune system encounters alloantigen it can respond in any one of a number of different ways. The choice that is made will take into account factors such as where, when and how the contact with the alloantigen takes place, as well as the environmental conditions that prevail at the time the alloantigen is encountered. Alloantigen administration before transplantation either alone or in combination with therapeutic agents that modulate the functional activity of the responding leucocytes can be a powerful way of inducing specific unresponsiveness to alloantigens in vivo .The molecular mechanisms that influence the way the outcome of the immune response to alloantigen develops, either activation or unresponsiveness to the triggering antigen, hold the key to our ability to manipulate the immune system effectively by exposing it to donor antigen for therapeutic purposes. This review will focus on alloantigen–induced immunological unresponsiveness and how insights into the mechanisms of unresponsiveness have driven the development of novel tolerance–induction strategies that show promise for translation into the clinic in the future.

scholarly journals Exploring Patterns of Socio-spatial Interaction in the Public Spaces of City through Big Data.

2017 ◽  
Author(s):  
Aminreza Iranmanesh ◽  
Resmiye Alpar Atun
Keyword(s):  
Social Media ◽  
Big Data ◽  
Spatial Interaction ◽  
Public Spaces ◽  
Global Scale ◽  
Urban Life ◽  
The Public ◽  
Spatial Aspect ◽  
The City ◽  
The Way

Research on socio-spatial aspect of cities has never been so vibrant and exciting. The form of urban life is changing and evolving with new advancements in communication and technology.  Digital communication and social media has reshaped the way people as the actors of society interact with each other and with the network of city. New social networks and widespread of mobile devises can be used to create and reinforce existing social ties. Mobile devises also change the role of citizens from consumers into producers of data; they are the new reporters, photographers, videographers of everyday life. This production creates large quantities of data known as the “Big Data”. Big data has opened up many doors for researchers to investigate new aspects of cities.  This paper aims to explore how people access urban public spaces through social media by taking the parameter of distance and physical proximity into account. We tried to investigate if different levels of accessibility effects the way people interact with space through social media. Through this process the study explored different socio-spatial patterns in the city that are being affected by social media.  The research data was collect in two layers of Nicosia in Northern Cyprus: first, the geo-tagged social media data was collected from the target group, and it was located on the map. Twitter as a microblogging medium was selected for data collection due to its public nature, geo-tagged abilities, and manageable short content. Second, degrees of accessibility in local and global scale were calculated using Space Syntax. The data was analyzed using regression analysis, scatter plot, and outlier detention. The result shows various patterns in correlation of interactions between society and space; it illustrates the importance of exploring the outliers when reading big data on the city. The result shows clear importance of local accessibility even when social media is the effective variable.

Heritage

2018 ◽  
Author(s):  
Omar Shaikh ◽  
Stefano Bonino
Keyword(s):  
Facial Expressions ◽  
South Asian ◽  
Online Video ◽  
The South ◽  
Men And Women ◽  
The Public ◽  
Video Footage ◽  
Community Heritage ◽  
Personal Accounts ◽  
The Way

The Colourful Heritage Project (CHP) is the first community heritage focused charitable initiative in Scotland aiming to preserve and to celebrate the contributions of early South Asian and Muslim migrants to Scotland. It has successfully collated a considerable number of oral stories to create an online video archive, providing first-hand accounts of the personal journeys and emotions of the arrival of the earliest generation of these migrants in Scotland and highlighting the inspiring lessons that can be learnt from them. The CHP’s aims are first to capture these stories, second to celebrate the community’s achievements, and third to inspire present and future South Asian, Muslim and Scottish generations. It is a community-led charitable project that has been actively documenting a collection of inspirational stories and personal accounts, uniquely told by the protagonists themselves, describing at first hand their stories and adventures. These range all the way from the time of partition itself to resettling in Pakistan, and then to their final accounts of arriving in Scotland. The video footage enables the public to see their facial expressions, feel their emotions and hear their voices, creating poignant memories of these great men and women, and helping to gain a better understanding of the South Asian and Muslim community’s earliest days in Scotland.

The End of History Museums: What's Plan B??

2008 ◽  
Vol 30 (4) ◽  
pp. 9-27 ◽  
Author(s):  
Cary Carson
Keyword(s):  
Historic Sites ◽  
The Public ◽  
End Of History ◽  
House Museums ◽  
The Past ◽  
History Museums ◽  
Plan B ◽  
The End Of History ◽  
The Way

Abstract Are historic sites and house museums destined to go the way of Oldsmobiles and floppy disks?? Visitation has trended downwards for thirty years. Theories abound, but no one really knows why. To launch a discussion of the problem in the pages of The Public Historian, Cary Carson cautions against the pessimistic view that the past is simply passéé. Instead he offers a ““Plan B”” that takes account of the new way that learners today organize information to make history meaningful.

Rewritten or Reused? Originality, Intertextuality, and Reuse in the Writings of a Buddhist Visionary in Contemporary Tibet

2017 ◽  
Vol 33 (1-2) ◽  
pp. 203-231
Author(s):  
Antonio Terrone
Keyword(s):  
Public Domain ◽  
The Public ◽  
The Way

The study of Buddhist texts can inform us of the way scriptures were composed, as well as illuminate the reasons behind their production. This study examines the phenomenon of borrowing and reusing portions of texts without attributing them to their ‘legitimate authors’ within the Buddhist world of contemporary Tibet. It shows that not only is such a practice not at all infrequent and is often socially accepted, but that it is used in this case as a platform to advance specific claims and promote an explicit agenda. Therefore, rather than considering these as instances of plagiarism, this essay looks at the practice of copying and borrowing as an exercise in intertextuality, intended as the faithful retransmission of ancient truths, and as an indication of the public domain of texts in Tibet.

scholarly journals Secondary haemophagocytic lymphohistiocytosis in COVID-19: correlation of the autopsy findings of bone marrow haemophagocytosis with HScore

2021 ◽  
pp. jclinpath-2020-207337
Author(s):  
Claudia Núñez-Torrón ◽  
Ana Ferrer-Gómez ◽  
Esther Moreno Moreno ◽  
Belen Pérez-Mies ◽  
Jesús Villarrubia ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Immune Response ◽  
Immune System ◽  
Multiorgan Failure ◽  
Histological Findings ◽  
Haemophagocytic Lymphohistiocytosis ◽  
Bone Marrow Tissue ◽  
Autopsy Findings ◽  
Specific Finding ◽  
Clinical Records

BackgroundSecondary haemophagocytic lymphohistiocytosis (sHLH) is characterised by a hyper activation of immune system that leads to multiorgan failure. It is suggested that excessive immune response in patients with COVID-19 could mimic this syndrome. Some COVID-19 autopsy studies have revealed the presence of haemophagocytosis images in bone marrow, raising the possibility, along with HScore parameters, of sHLH.AimOur objective is to ascertain the existence of sHLH in some patients with severe COVID-19.MethodsWe report the autopsy histological findings of 16 patients with COVID-19, focusing on the presence of haemophagocytosis in bone marrow, obtained from rib squeeze and integrating these findings with HScore parameters. CD68 immunohistochemical stains were used to highlight histiocytes and haemophagocytic cells. Clinical evolution and laboratory parameters of patients were collected from electronic clinical records.ResultsEleven patients (68.7%) displayed moderate histiocytic hyperplasia with haemophagocytosis (HHH) in bone marrow, three patients (18.7%) displayed severe HHH and the remainder were mild. All HScore parameters were collected in 10 patients (62.5%). Among the patients in which all parameters were evaluable, eight patients (80%) had an HScore >169. sHLH was not clinically suspected in any case.ConclusionsOur results support the recommendation of some authors to use the HScore in patients with severe COVID-19 in order to identify those who could benefit from immunosuppressive therapies. The presence of haemophagocytosis in bone marrow tissue, despite not being a specific finding, has proved to be a very useful tool in our study to identify these patients.

scholarly journals The immune response of T cells and therapeutic targets related to regulating the levels of T helper cells after ischaemic stroke

2021 ◽  
Vol 18 (1) ◽  
Author(s):  
Tian-Yu Lei ◽  
Ying-Ze Ye ◽  
Xi-Qun Zhu ◽  
Daniel Smerin ◽  
Li-Juan Gu ◽  
...  
Keyword(s):  
Immune Response ◽  
T Cells ◽  
Immune System ◽  
Immune Responses ◽  
Ischaemic Stroke ◽  
Immune Cells ◽  
Tissue Injury ◽  
Recovery Period ◽  
Vital Functions ◽  
Anti Inflammatory

AbstractThrough considerable effort in research and clinical studies, the immune system has been identified as a participant in the onset and progression of brain injury after ischaemic stroke. Due to the involvement of all types of immune cells, the roles of the immune system in stroke pathology and associated effects are complicated. Past research concentrated on the functions of monocytes and neutrophils in the pathogenesis of ischaemic stroke and tried to demonstrate the mechanisms of tissue injury and protection involving these immune cells. Within the past several years, an increasing number of studies have elucidated the vital functions of T cells in the innate and adaptive immune responses in both the acute and chronic phases of ischaemic stroke. Recently, the phenotypes of T cells with proinflammatory or anti-inflammatory function have been demonstrated in detail. T cells with distinctive phenotypes can also influence cerebral inflammation through various pathways, such as regulating the immune response, interacting with brain-resident immune cells and modulating neurogenesis and angiogenesis during different phases following stroke. In view of the limited treatment options available following stroke other than tissue plasminogen activator therapy, understanding the function of immune responses, especially T cell responses, in the post-stroke recovery period can provide a new therapeutic direction. Here, we discuss the different functions and temporal evolution of T cells with different phenotypes during the acute and chronic phases of ischaemic stroke. We suggest that modulating the balance between the proinflammatory and anti-inflammatory functions of T cells with distinct phenotypes may become a potential therapeutic approach that reduces the mortality and improves the functional outcomes and prognosis of patients suffering from ischaemic stroke.

scholarly journals Why Does SARS-CoV-2 Infection Induce Autoantibody Production?

Pathogens ◽  
2021 ◽  
Vol 10 (3) ◽  
pp. 380
Author(s):  
Ales Macela ◽  
Klara Kubelkova
Keyword(s):  
Immune Response ◽  
Immune System ◽  
Host Cell ◽  
Critical Role ◽  
Cell Interaction ◽  
Immune Recognition ◽  
Autoantibody Production ◽  
Host Cell Interaction ◽  
Primary Virus

SARS-CoV-2 infection induces the production of autoantibodies, which is significantly associated with complications during hospitalization and a more severe prognosis in COVID-19 patients. Such a response of the patient’s immune system may reflect (1) the dysregulation of the immune response or (2) it may be an attempt to regulate itself in situations where the non-infectious self poses a greater threat than the infectious non-self. Of significance may be the primary virus-host cell interaction where the surface-bound ACE2 ectoenzyme plays a critical role. Here, we present a brief analysis of recent findings concerning the immune recognition of SARS-CoV-2, which, we believe, favors the second possibility as the underlying reason for the production of autoantibodies during COVID-19.

Sign in / Sign up

Export Citation Format

Share Document