scholarly journals Hepatoprotective Potential of Mimusops elengi L leaf Extracts against Paracetamol Induced Hepatotoxicity in Rats

2021 ◽  
Vol 69 (2) ◽  
Author(s):  
B. Edwin Jose ◽  
S. Manikandan ◽  
S. Jebaseelan ◽  
Dr.R. Meera ◽  
Dr.R. Kalirajan
Keyword(s):  
Aqueous Extract ◽  
Biochemical Parameters ◽  
Hepatoprotective Activity ◽  
Leaf Extracts ◽  
Standard Drug ◽  
Herbal Plants ◽  
Serum Glutamate Pyruvate Transaminase ◽  
Glutamate Pyruvate ◽  
Mimusops Elengi ◽  
Serum Glutamate

Many traditional systems of medicines employ herbal drugs for the hepatoprotection. The aim of the study is to investigate the hepatoprotective activity of Mimusopselengi L leaf extracts extracts against paracetamol induced hepatotoxicity. However, herbal plants are the windfall for the humankind providing solution for most of the wellness breakdowns. Mimusopselengi L is one of such plants with enormous therapeutic and nutraceutical potencies. The main aspiration of the current investigation is to evaluate the hepatoprotective ability of methanolic and aqueous extract of Mimusopselengi L leaves against paracetamol induced hepatotoxicity using wistar rats through biochemical parameters and histopathological findings. The phytochemical screening was carried on the leaves extracts of Mimusopselengi L revealed the presence of some active ingredients such as Alkaloids, Tannins, Sponginess, Phenols, glycosides, steroids, terpenoids and flavonoids. Leaves of Mimusopselengi L was successively ethylacetate fraction with methanolic and aqueous extract against paracetamol (2 ml/kg.p.o) induced hepatotoxicity using Standard drug Liv 52 (5 ml/kg). There was a significant changes in biochemical parameters (increases in serum glutamate pyruvate transaminase (SGPT), Serum glutamate oxaloacetate transaminase (SGOT), alanine phosphatase (ALP), serum bilirubin in paracetamol treated rats, which were restored towards normalization in Mimusopselengi L methanolic and aqueous extract (200 mg/kg and 200 mg/kg) treated animals. Thus, the present study ascertains that the leaf extract of Mimusopselengi L possesses significant hepatoprotective activity.

Evaluation of Hepatoprotective and In-vitro Cytotoxic Activity of Leaves of Premna serratifolia Linn

2008 ◽  
Vol 1 (1) ◽  
pp. 145-152 ◽  
Author(s):  
Rajendran Vadivu ◽  
A. Jerad Suresh ◽  
K Girinath ◽  
P. Boopathi Kannan ◽  
R Vimala ◽  
...  
Keyword(s):  
Cytotoxic Activity ◽  
Hepatoprotective Activity ◽  
Alcoholic Extract ◽  
Standard Drug ◽  
Degree Of Protection ◽  
Serum Glutamate Pyruvate Transaminase ◽  
Glutamate Pyruvate ◽  
Traditional Practitioners ◽  
Serum Glutamate

Premna serratifolia is used by the traditional practitioners as cardiotonic, antibiotic, anti-coagulant, stomachic, carminative, hepatoprotective, antitumor etc. The present study aims in the evaluation of hepatoprotective and in-vitro cytotoxic activity of alcoholic extract of leaves of Premna serratifolia Linn. Hepatoprotective activity is studied by carbon tetrachloride induced hepato-toxicity in rats and the in-vitro cytotoxic activity is carried out by tryphane blue exclusion method using EAC cell lines. The degree of protection in hepatoprotective activity has been measured by using biochemical parameters such as serum glutamate oxalate transaminase (SGOT) and serum glutamate pyruvate transaminase (SGPT), alkaline phosphatase (ALP), bilirubin and total protein. The results suggest that the alcoholic extract at the dose level of 250mg/kg has produced significant  (p < 0.001) hepatoprotection by decreasing the activity of serum enzymes, bilirubin, and lipid peroxidation which is comparable to that of standard drug silymarin. The alcoholic extract also does exhibit the IC50 value of 75µg/ml which indicates the significant in-vitro cytotoxic activity of the extract. It is concluded that alcoholic extract of leaves of Premna serratifolia Linn is not only an effective hepatoprotective agent, but also possesses significant antitumor activity.  Keywords: Premna serratifolia Linn; Alcoholic extract hepatoprotective; In-vitro cytotoxic activity.  © 2009 JSR Publications. ISSN: 2070-0237 (Print); 2070-0245 (Online). All rights reserved. DOI: 10.3329/jsr.v1i1.1046 

scholarly journals Hepatoprotective activity of Adina cordifolia against ethanol induce hepatotoxicity in rats

2012 ◽  
Vol 1 (9) ◽  
pp. 279-284 ◽  
Author(s):  
A Sharma ◽  
B Sangameswaran ◽  
V Jain ◽  
M S Saluja
Keyword(s):  
Pharmaceutical Journal ◽  
Hepatoprotective Activity ◽  
Serum Markers ◽  
Hepatocellular Injury ◽  
Standard Drug ◽  
Blood Samples ◽  
Hepatic Cells ◽  
Serum Glutamate Pyruvate Transaminase ◽  
Histopathological Studies ◽  
Serum Glutamate

The acetone (AEAC) and aqueous extracts (AQEAC) of Adina cordifolia, belonging to the family Rubiaceae, were studied for hepatoprotective activity against Wister rats with liver damage induced by ethanol. It was found that AEAC and AQEAC, at a dose of 500 mg/kg body weight exhibited hepatoprotective effect by lowering the Serum Glutamate Pyruvate Transaminase (SGPT), Serum Glutamate Oxaloacetate Transaminase (SGOT), alkaline phosphate and total bilirubin to a significant extent and also significantly increased the levels of total protein. The hepatoprotective activity was also supported by histopathological studies of liver tissue. Since results of biochemical studies of blood samples of ethanol treated rats showed significant increase in the levels of serum enzyme activities, reflecting the liver injury caused by ethanol and blood samples from the animals treated with AEAC and AQEAC showed significant decrease in the levels of serum markers, indicating the protection of hepatic cells against ethanol induced hepatocellular injury. The effects of AEAC and AQEAC were comparable with standard drug silymarin.DOI: http://dx.doi.org/10.3329/icpj.v1i9.11619 International Current Pharmaceutical Journal 2012, 1(9): 279-284 

scholarly journals EVALUATION OF ANTI-HYPERTROPHIC POTENTIAL OF CAMELLIA SINENSIS IN ISOPROTERENOL INDUCED CARDIAC HYPERTROPHY

2018 ◽  
Vol 10 (10) ◽  
pp. 119
Author(s):  
Doss V. A. ◽  
Jeevitha Parthibhan ◽  
Dharaniyambigai Kuberapandian
Keyword(s):  
Lactate Dehydrogenase ◽  
Cardiac Hypertrophy ◽  
Aqueous Extract ◽  
Marker Enzymes ◽  
Glutamate Oxaloacetate Transaminase ◽  
Glutamate Pyruvate Transaminase ◽  
Cardiac Marker ◽  
Serum Glutamate Pyruvate Transaminase ◽  
Glutamate Pyruvate ◽  
Serum Glutamate

Objective: Camellia sinensis (C. sinensis family-Theaceae) has potent antioxidant activity used in the treatment of cardiovascular disease. The present study evaluates the cardioprotective (anti-hypertrophic) effect of aqueous extract of C. sinensis in isoproterenol (ISO) induced cardiac hypertrophic rats.Methods: The beneficial effect of the green tea extract was examined by the administration of the aqueous extract of the leaves of C. sinensis (100 mg/kg b.w., oral., 7 d) in ISO (10 mg/kg b.w., subcutaneous.,7 d) induced cardiac hypertrophic rats with reference to the standard drug, losartan (50 mg/kg b.w., oral.,7 d) followed by biochemical estimations of glucose, protein, cholesterol, cardiac marker enzymes namely serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT) and lactate dehydrogenase (LDH) in serum and heart tissues thus collected at the end of 7 d.Results: The biochemical assays revealed significantly (P<0.05) increased glucose, protein, cholesterol, cardiac marker enzymes namely serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT) lactate dehydrogenase (LDH) and significantly (P<0.05) decreased in ISO induced cardiac hypertrophic rats that were reciprocated by the effect of plant extract.Conclusion: Thus, this study showed that the aqueous leaf extract of C. sinensis possesses potent effect against cardiac hypertrophy. This potential is hypothesized to be due to the phytochemical, Catechin present in the plant that requires further isolation and characterization with respect to anti-hypertrophic therapeutics.

scholarly journals Effect of rhizomes of Curculigo orchioides on Thioacetamide induced hepatotoxicity

2014 ◽  
Vol 15 (1&2) ◽  
pp. 55-60
Author(s):  
Somesh Thapliyal ◽  
Vijay Juyal ◽  
Anil Bhandari
Keyword(s):  
Total Bilirubin ◽  
Serum Alkaline Phosphatase ◽  
Hepatoprotective Activity ◽  
Glutamate Oxaloacetate Transaminase ◽  
Glutamate Pyruvate Transaminase ◽  
Once Daily ◽  
Curculigo Orchioides ◽  
Serum Glutamate Pyruvate Transaminase ◽  
Glutamate Pyruvate ◽  
Serum Glutamate

The hepatoprotective activity of methanolic rhizome extract of Curculigo orchioides (MECO) were evaluated against Thioacetamide-induced hepatic damage in rats. The MECO at dose of 100, 200 and 400 mg/kg were administered orally once daily for 21 days and simultaneously administered TAA 100 mg/kg b.w. s.c. 1 h after the respective assigned treatments every 72 h.  Serum enzymatic levels of serum glutamate oxaloacetate transaminase (AST), serum glutamate pyruvate transaminase (ALT), serum alkaline phosphatase (ALP) and total bilirubin were estimated along with estimation of superoxide dismutase (SOD) and malondialdehyde (MDA) levels in liver tissues.  

Anti-Inflammatory and Hepatoprotective Activity of Peh-Hue-Juwa-Chi-Cao in Male Rats

2002 ◽  
Vol 30 (02n03) ◽  
pp. 225-234 ◽  
Author(s):  
Chun-Ching Lin ◽  
Lean-Teik Ng ◽  
Jenq-Jer Yang ◽  
Yu-Fang Hsu
Keyword(s):  
Intraperitoneal Administration ◽  
Hepatoprotective Activity ◽  
Herbal Extract ◽  
Male Rats ◽  
Study Results ◽  
Acute Elevation ◽  
Serum Glutamate Pyruvate Transaminase ◽  
Glutamate Pyruvate ◽  
Anti Inflammatory ◽  
Serum Glutamate

Peh-Hue-Juwa-Chi-Cao (PHJCC) is a common commercial name for the herbal extract of either Hedyotis diffusa (HD), H. corymbosa (HC), or Mollugo pentaphylla (MP). The present study was carried out to investigate the anti-inflammatory and hepatoprotective effects of these three extracts in rats. The results indicated that extracts of HC, HD and MP possess anti-inflammatory activity, and that MP has the greatest inhibition against carrageenan-induced paw edema. In the hepatoprotective study, results indicated that the three plant extracts significantly reduced the acute elevation of serum glutamate oxalate transaminase (sGOT) and serum glutamate pyruvate transaminase (sGPT) concentration, and alleviated the degree of liver damage 24 hours after the intraperitoneal administration of hepatotoxins.

scholarly journals Hepatoprotective Effects of Thespesia lampas Dalz & Gibs in CCl4 Induced Liver Injury in Rats

1970 ◽  
Vol 7 (1) ◽  
pp. 11-13 ◽  
Author(s):  
B Sangameswaran ◽  
Chumbhale Deshraj ◽  
BR Balakrishnan ◽  
B Jayakar
Keyword(s):  
Carbon Tetrachloride ◽  
Tween 80 ◽  
Treated Group ◽  
Hepatoprotective Activity ◽  
Glutamate Oxaloacetate Transaminase ◽  
Glutamate Pyruvate Transaminase ◽  
Chronic Liver Damage ◽  
Serum Glutamate Pyruvate Transaminase ◽  
Glutamate Pyruvate ◽  
Serum Glutamate

The extracts of the roots of Thespesia lampas (Malvaceae) were evaluated for hepatoprotective activity in rats by inducing chronic liver damage by subcutaneous injection of 50% v/v carbon tetrachloride in Tween 80 at a dose of 3ml/kg for a period of 4 weeks. The biochemical parameters like serum glutamate pyruvate transaminase (SGPT), serum glutamate oxaloacetate transaminase (SGOT), alkaline phosphatase (ALP), serum bilirubin and total proteins were estimated to assess the liver function. Hepatic steatosis, centrilobular necrosis, and often swelling of the hepatic cytoplasm were observed in carbontetra chloride treated group, while these were completely absent in the extracts of T. lampas (300 mg/kg b.wt) treated groups (p < 0.01). The present investigation established pharmacological evidence to support the folkloric claim of hepatoprotective activity of T. lampas.Key words: Thespesia lampas, Carbon tetrachloride, Hepatoprotective, Rats, Root extracts  DOI = 10.3329/dujps.v7i1.1201Dhaka Univ. J. Pharm. Sci. 7(1): 11-13, 2008 (June)

scholarly journals IN VITRO HEPATOPROTECTIVE ACTIVITY OF YELLOW LEAF EXTRACTS OF THESPESIA POPULNEA AGAINST CARBON TETRACHLORIDE INDUCED TOXICITY

2019 ◽  
pp. 21-23
Author(s):  
UMADEVI A. ◽  
P. AJITH KUMAR
Keyword(s):  
Carbon Tetrachloride ◽  
Methanolic Extract ◽  
Rat Hepatocytes ◽  
Hepatoprotective Activity ◽  
Yellow Leaf ◽  
Leaf Extracts ◽  
Isolated Rat Hepatocytes ◽  
Standard Drug ◽  
Serum Glutamate

Objective: The study was aimed to evaluate in vitro hepatoprotective activity of yellow leaf extracts of Thespesiapopulnea. Methods: Hepatoprotective activity is studied by carbon tetrachloride-induced hepato-toxicity in isolated rat hepatocytes. The biochemical parameters observed in serum were serum glutamate oxaloacetate transaminase (SGOT/AST), serum glutamate pyruvate transaminase (SGPT/ALT) levels. The extracts exhibited a dose-dependent reduction in AST, ALT levels. Results: Methanolic extract was found to exhibit higher hepatoprotection. T. populnea extract was found to be antihepatotoxic at a concentration of 125 mcg with a significant decrease in ALT (P<0.001) and AST (P<0.0001). Conclusion: The results suggest that the methanolic extract has produced significant (p<0.001) hepatoprotection by decreasing the activity of serum enzymes which is comparable to that of standard drug silymarin.

scholarly journals Antidiabetics in combination with hydroxychloroquine improve antioxidant and hepatoprotective activities in alloxan-induced diabetic rats

2015 ◽  
Vol 18 (1) ◽  
pp. 72-77
Author(s):  
Shaheda Zannah ◽  
Monirul Islam ◽  
Yusuf Ali ◽  
Md Asaduzzaman ◽  
Md Shahid Sarwar ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Pharmaceutical Journal ◽  
Diabetic Rats ◽  
Hepatoprotective Effect ◽  
Sod Activity ◽  
Pancreatic Cells ◽  
Additional Protection ◽  
Serum Glutamate Pyruvate Transaminase ◽  
Glutamate Pyruvate ◽  
Serum Glutamate

Hyperglycemia exerts toxic effects on the pancreatic ?-cells. This study investigated the hypothesis that the antidiabetic drugs glibenclamide and metformin, in combination with hydroxychloroquine (HCQ) offer additional protection for the pancreas against oxidative stress and produce hepatoprotective effect in alloxan-induced diabetic rats. Diabetes was induced in male Long-Evans rats by a single dose of alloxan (120 mg/kg; i.p.). Different groups of diabetic animals were treated with glibenclamide (10 mg/70 kg, i.p.), metformin (850 mg/70 kg, i.p.), HCQ (300 mg/70 kg, i.p.) and combination of both glibenclamide and metformin with HCQ, separately for a period of 28 days. Diabetic rats had significantly elevated levels of serum glutamate oxaloacetate transaminase (SGOT) and serum glutamate pyruvate transaminase (SGPT), while catalase (CAT) and superoxide dismutase (SOD) activity were significantly reduced. Glibenclamide and metformin produced no significant effects on antioxidant enzymes but both showed significant (p<0.05) result in reducing SGOT and SGPT level in diabetic rats. In contrast, the combination of glibenclamide or metformin with HCQ showed better effect on up-regulation of CAT and SOD activity and down-regulation of SGOT and SGPT activity in comparison with the antidiabetic drug alone. These findings suggest that, HCQ potentiates the effect of glibenclamide and metformin to protect pancreas against oxidative stress and produce hepatoprotective effect in diabetic rats.Bangladesh Pharmaceutical Journal 18(1): 72-77, 2015

scholarly journals Evaluation of Hepatoprotective and in vivo Antioxidant Potentials of Methanol Extract of Tephrosia pumila against Thioacetamide Induced Liver Toxicity in Wistar Rats

2021 ◽  
Vol 70 (2) ◽  
Author(s):  
Ramesh C ◽  
Pinkey Rawal ◽  
Soma Pramanik ◽  
Shabana S
Keyword(s):  
Biochemical Parameters ◽  
Methanol Extract ◽  
Liver Toxicity ◽  
Antioxidant Properties ◽  
Total Duration ◽  
Hepatoprotective Activity ◽  
Oral Toxicity ◽  
Standard Drug ◽  
Protein Ions

The objective of the current investigation was performed to assess the hepatoprotective potentials and in vivo antioxidant properties of methanol extract of Tephrosia pumila against thioacetamide induced liver damage in rats. The acute oral toxicity study of methanol extract was determined as per OECD guidelines and the extract was proved to be safe up to the dose of 2000mg/kg. The total duration of the study was 21 days and animals were divided into six groups. Hepatotoxicity was induced in the animals of all groups except normal control by single dose administration of Thioacetamide(100mg/kg) at first day of the study followed by animals were treated daily with standard drug sylimarin and methanol extract of Tephrosia pumila (100mg/kg, 200mg/kg and 400mg/kg) to respective groups for 21 days. Variations in biochemical parameters like alanine transferase (ALT), aspartate transferase (AST), alkaline phosphatase (ALP), total bilirubin, direct bilirubin, albumin, total protein, ions and others parameters like clotting time and weight of the liver were considered to determine beneficial effect of the extract. At the end of the study liver samples were collected and subjected to histopathological evaluation. There were significant variations in the above mentioned biochemical parameters in toxic control animals treated with Thioacetamide alone while in the animals treated with methanol extract and standard drug silymarin, all the parameters were normal possibly due to their beneficial property in protecting the liver against thioacetamide induced hepatotoxicity. The results obtained in the above study suggesting that, the methanol extract of Tephrosia pumila possess significant hepatoprotective activity.

scholarly journals Evaluation of hepatoprotective potential of aqueous extract of Withania somnifera in albino rats

2021 ◽  
Vol 10 (3) ◽  
pp. 255
Author(s):  
Monica Sharma ◽  
Anand Gaur ◽  
Pinki Vishwakarma ◽  
Raj Kumar Goel ◽  
K. K. Saxena
Keyword(s):  
Aqueous Extract ◽  
Withania Somnifera ◽  
Work Force ◽  
Hepatoprotective Activity ◽  
Albino Rats ◽  
Standard Drug ◽  
Hepatic Diseases ◽  
Organ Systems ◽  
Herbal Plant ◽  
Biochemical Examination

Background: Hepatic diseases are a major cause of morbidity and disability of work force throughout the world. The treatment of hepatic diseases with standard drugs poses the risk of toxicity on various organ systems. Withania somnifera, a herbal plant has been claimed to be effective in the treatment of various types of hepatic conditions. The present study was undertaken to explore the hepatoprotective activity of aqueous extract of Withania somnifera (AEWS) in experimentally induced hepatotoxicity in albino rats.Methods: The study was commenced after obtaining approval from institutional animal ethical committee using AEWS leaves in Albino wistar rats (150-200 gm) of either sex. The hepatoprotective activity was evaluated using biochemical examination. The animals were divided into five groups of six animals each. In each experiment, first group was given normal saline (1 ml/kg/day), second group was injected with toxin CCl4 (1 ml/kg) i.p only once to produce hepatotoxicity, third and fourth groups were given Withania somnifera orally (500 mg/kg and 1000 mg/kg) (respectively), as a single dose per orally every morning and fifthgroup was given standard drug Liv-52 (1 mg/kg).Results: Aqueous extract of Withania somnifera leaves in oral dose exhibited significant hepatoprotective effect in all models used in this study.Conclusions: It can be concluded from our study that aqueous extract of Withania somnifera leaves possesses hepatoprotective activity.

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