scholarly journals Microfracture Arthroscopy Efficacy In Treatment Of Articular Cartilage Insult Of Knee

2018 ◽  
Vol 14 (1) ◽  
pp. 24-28
Author(s):  
Mohamed Baqir Alshara
Keyword(s):  
Articular Cartilage ◽  
Arthroscopic Surgery ◽  
Biomechanical Properties ◽  
Cross Sectional Study ◽  
Cartilage Defects ◽  
Sectional Study ◽  
Degenerative Arthritis ◽  
Cross Sectional ◽  
Orthopedic Surgeons ◽  
Articular Cartilage Defects

Background: The treatment of articular cartilage defects is one of the most clinical challeng for orthopedic surgeons. Articular cartilage is a highly organized tissue with complex biomechanical properties and substantial durability. However, it has a poor ability for healing, and damage from trauma or degeneration can result in morbidity and functional impairment. debilitating joint pain, dysfunction, and degenerative arthritis                                                                           Objectives: The purpose of study is to show effectiveness of micro fracture arthroscopy as a method of treatment for such problem . Type of the study: Cross-sectional study.                     Methods: Arthroscopic surgery was done to 52 patients who complain of knee pain limping and show clinical or radiological evidence of cartilaginous injury and we used arthroscopic micro fracture technique for those patient who have injury of no more than4cm2 then we instruct patient to not put any weight over knee  for 2-3 months and followed clinically according to Lyshlom scor and by MRI and some of them by second look arthroscopy to assess the healing. Results: Fifty two patients under go micro fracture arthroscopy . Thirty four patients (65.4%) reported good or excellent subjective results  , thirteen patients (25%) had fair knee function, and only five patients  (9.6%) reported poor result Conclusions: Micro fracture arthroscopy is a   cheap effective method for repairing cartilaginous lesion .                                            

scholarly journals A composite scaffold of Wharton’s jelly and chondroitin sulphate loaded with human umbilical cord mesenchymal stem cells repairs articular cartilage defects in rat knee

2021 ◽  
Vol 32 (4) ◽  
Author(s):  
Zhong Li ◽  
Yikang Bi ◽  
Qi Wu ◽  
Chao Chen ◽  
Lu Zhou ◽  
...  
Keyword(s):  
Stem Cells ◽  
Articular Cartilage ◽  
Composite Scaffold ◽  
Biomechanical Properties ◽  
Cartilage Defects ◽  
Human Umbilical Cord ◽  
Composite Scaffolds ◽  
Articular Cartilage Defects

AbstractTo evaluate the performance of a composite scaffold of Wharton’s jelly (WJ) and chondroitin sulfate (CS) and the effect of the composite scaffold loaded with human umbilical cord mesenchymal stem cells (hUCMSCs) in repairing articular cartilage defects, two experiments were carried out. The in vitro experiments involved identification of the hUCMSCs, construction of the biomimetic composite scaffolds by the physical and chemical crosslinking of WJ and CS, and testing of the biomechanical properties of both the composite scaffold and the WJ scaffold. In the in vivo experiments, composite scaffolds loaded with hUCMSCs and WJ scaffolds loaded with hUCMSCs were applied to repair articular cartilage defects in the rat knee. Moreover, their repair effects were evaluated by the unaided eye, histological observations, and the immunogenicity of scaffolds and hUCMSCs. We found that in vitro, the Young’s modulus of the composite scaffold (WJ-CS) was higher than that of the WJ scaffold. In vivo, the composite scaffold loaded with hUCMSCs repaired rat cartilage defects better than did the WJ scaffold loaded with hUCMSCs. Both the scaffold and hUCMSCs showed low immunogenicity. These results demonstrate that the in vitro construction of a human-derived WJ-CS composite scaffold enhances the biomechanical properties of WJ and that the repair of knee cartilage defects in rats is better with the composite scaffold than with the single WJ scaffold if the scaffold is loaded with hUCMSCs.

Study on Polyvinyl Alcohol Hydrogel Materials for Improving the Performance of Artificial Articular Cartilage

2013 ◽  
Vol 703 ◽  
pp. 29-32 ◽  
Author(s):  
Hou Jiang Yuan ◽  
Zhou Jian Wei ◽  
Xia Zhen Yu
Keyword(s):  
Articular Cartilage ◽  
Polyvinyl Alcohol ◽  
Impact Force ◽  
Biomechanical Properties ◽  
Research Progress ◽  
Cartilage Defects ◽  
Human Articular Cartilage ◽  
The Impact ◽  
Articular Cartilage Defects

Polyvinyl alcohol hydrogel has compatibility and biomechanical properties of human articular cartilage similar and good biological. The implantation in the human body can replace part of articular cartilage, which plays the role of bearing and alleviate the impact force. It has the prospect of clinical application. This paper introduces the research progress of polyvinyl alcohol hydro-gel materials. And compared with the characteristics of articular cartilage, clarify the possibility of repair of articular cartilage defects of the materials.

scholarly journals Orthopedic Surgeons’ Views of Hyaluronic Acid Formulations in the Management of Knee Osteoarthritis: A Questionnaire-Based Cross-Sectional Study

Medicina ◽  
2021 ◽  
Vol 57 (9) ◽  
pp. 990
Author(s):  
Shahd Alnasser ◽  
Fatima AlHussain ◽  
Hassan Asiri ◽  
Abdullah Almutairi ◽  
Hisham Alsanawi ◽  
...  
Keyword(s):  
Saudi Arabia ◽  
Hyaluronic Acid ◽  
Cross Sectional Study ◽  
Years Of Experience ◽  
Sectional Study ◽  
Cross Sectional ◽  
Local Skin ◽  
Knee Oa ◽  
Orthopedic Surgeons ◽  
Therapeutic Value

Multiple hyaluronic acid (HA) products were approved and marketed to manage osteoarthritis (OA). Although these products are widely prescribed by orthopedic surgeons to manage OA, especially knee OA, the therapeutic value of these products is highly uncertain. Few studies with significant limitations in their designs have indicated positive outcomes among OA patients treated with HA; however, their results were inconclusive. Thus, we aimed to explore the therapeutic value of different HA products in alleviating knee OA pain and improving patients’ physical function from the orthopedic surgeons’ perspective. Methods: This was a questionnaire-based cross-sectional study in which practicing orthopedic surgeons in two countries (e.g., Saudi Arabia and Jordan) were invited to participate. The 10-item, newly developed questionnaire inquired about the respondents’ sociodemographic characteristics (e.g., age, gender, country, years of experience), and their opinions regarding the efficacy of HA products in the management of OA (e.g., efficacy in improving mobility and alleviating pain). Results: Out of the 200 orthopedic surgeons who were invited to participate, 122 (61%) filled out the questionnaire. Most of the respondents were from Saudi Arabia (58%), aged 35 to 55 years (68%), had at least 10 years of experience (69%), and male (98%). About 80% of the respondents reported prescribing HA, such as Hyalgan®, Orthovisc®, Hyalubrix®, and Crespine Gel®. About 66% of the respondents believed that HA was moderately to highly effective in managing knee OA, and 34% believed that HA was either ineffective or mildly effective. Pain at the site of injection (44.3%) and rash or local skin reactions (22.1%) were the most commonly reported adverse events. Conclusions: The variations in the formulation of different HA brands (e.g., molecular weight and cross-linking) did not seem to offer any therapeutic advantage. HA might have value in the management of knee OA; however, its value is highly uncertain and necessitates more well-designed studies to further examine its therapeutic value.

scholarly journals Perception of complications by spine surgeons

2020 ◽  
Vol 11 ◽  
pp. 88
Author(s):  
Asdrubal Falavigna ◽  
Jefferson Dedea ◽  
Alfredo Guiroy ◽  
Giovanni Barbanti Brodano
Keyword(s):  
Cross Sectional Study ◽  
Years Of Experience ◽  
Surgery Complications ◽  
Sectional Study ◽  
Cross Sectional ◽  
Orthopedic Surgeons ◽  
Clinical Scenarios ◽  
Different Types ◽  
Clinical Cases

Background: The perception of major versus minor complications may vary according to surgeons, institutions, and different specialties. Here, we analyzed the geographic distribution of the different types/severities of the most frequent complications in spinal surgery, and assessed how the perception of spine surgeons about postoperative complications differed. Methods: We performed a cross-sectional study using a questionnaire, we developed to encompass different clinical scenarios of surgeons’ perceptions of spine surgery complications. The survey involved the members of AOSpine Latin America (LA) (January 28, 2017–March 15, 2017). The main variables studied included: specialty, age, years of experience, country, individual surgeon’s perception of different clinical scenarios, and the surgeon’s classification of complications for each scenario (e.g., major, minor, or none). Our results from LA were then analyzed and compared to North American (NA) responses. Results: Orthopedic surgeons represented about 58.2% (n = 412) of the 708 questionnaires answered. Of interest, 45.6% (n = 323) of those responding had >10 years of experience. The countries analyzed included Brazil (31.5%), Mexico (17.5%), Argentina (14.4%), Colombia (8.0%), and Venezuela (7.6%). Four of the 11 scenarios showed consensus in the results (e.g., average being over 82.5%). A tendency toward consensus was present in 45.4% of the clinical cases, while two out of 11 clinical cases did not present a consensus among surgeons. Of interest, the perception of complications was similar between cohorts (LA 85% vs. NA 80%). Conclusion: Significant consensus in the perception of complications was observed in most of the analyzed scenarios for both LA and NA. However, within the LA data, responses to different clinical scenarios varied.

scholarly journals Study of the Head of Human Dry Radii in a Medical College of Nepal: A Descriptive Cross-sectional Study

2020 ◽  
Vol 58 (223) ◽  
pp. 141-143
Author(s):  
Muna Kadel ◽  
Trilok Pati Thapa
Keyword(s):  
Radial Head ◽  
Cross Sectional Study ◽  
Transverse Diameter ◽  
Sectional Study ◽  
Cross Sectional ◽  
Medical College ◽  
Orthopedic Surgeons ◽  
Ethical Approval ◽  
Convenience Sampling ◽  
Common Shape

Introduction: Radius is a lateral bone of forearm. Its proximal end forms a part of elbow joint and superior radioulnar joint. Knowledge of the shape and size of radial head is essential for construction of radial head prosthesis. The objective of this study is to study the morphology of head of human dry radii. Methods: A descriptive cross-sectional study was conducted in human dry radii in the Dissection hall of Nepalese Army Institute of Health Sciences, Sanobharyang, Kathmandu, Nepal from September to October 2019. Ethical approval was taken. Altogether, 68 dry bones were enrolled in the study by convenience sampling method. Radial head was studied in respect to anteroposterior and transverse diameter, height at medial and distal end and shape. Mean and standard deviations of the parameters were obtained by using Statistical Package for Social Sciences version 20. Results: Mean height of radial head at medial and lateral end was 0.91cm and 0.76cm respectively.  Mean anteroposterior and transverse diameter of radial head were 2.09 cm and 2.02 cm respectively. Most common shape of radial head in this study was circular in 40 radii (59%) followed by elliptical in 23 (34%). Mean depth of the superior articular facet of the radial head was 0.19 mm. Conclusions: The most common shape of radial head is elliptical but it was found to be circular  in this study. This study will be useful for orthopedic surgeons in making prosthesis of radial head.    

Correlates of Hip Cartilage Defects: A Cross-sectional Study in Older Adults

2016 ◽  
Vol 43 (7) ◽  
pp. 1406-1412 ◽  
Author(s):  
Harbeer G. Ahedi ◽  
Dawn A. Aitken ◽  
Leigh C. Blizzard ◽  
Chang-hai H. Ding ◽  
Flavia M. Cicuttini ◽  
...  
Keyword(s):  
Structural Changes ◽  
Prevalence Ratio ◽  
Cross Sectional Study ◽  
Hip Pain ◽  
Cartilage Defects ◽  
Structural Factors ◽  
Sectional Study ◽  
Cross Sectional ◽  
Leg Strength ◽  
Hip Cartilage

Objective.Knee cartilage defects are a key feature of osteoarthritis (OA) but correlates of hip defects remain unexplored. The aims of this cross-sectional study were to describe the correlates of hip cartilage defects.Methods.The study included 194 subjects from the Tasmanian Older Adult Cohort who had right hip short-tau inversion recovery magnetic resonance imaging (MRI). Hip cartilage defects were assessed and categorized as grade 0 = no defects, grade 1 = focal blistering or irregularities on cartilage or partial thickness defect, and grade 2 = full thickness defect. Hip pain was determined by Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). Hip structural changes were measured on MRI, and hip radiographic OA (ROA) was assessed. Leg strength and physical activity were assessed using dynamometer and pedometers, respectively. Data were analyzed using log binomial and linear regression.Results.Of 194 subjects, 24% (n = 48) had no defects, 34% (n = 66) had grade 1, and 41% (n = 80) had grade 2. In multivariable analyses, any hip defects were associated with greater hip pain [prevalence ratio (PR) 1.20, 95% CI 1.02–1.35] and lower mean leg strength (men; mean ratio 0.83, 95% CI 0.67–0.98). Grade 1 defects were associated with hip bone marrow lesions (BML; PR 1.42, 95% CI 1.03–1.96) and high cartilage signal (men; PR 1.84, 95% CI 1.27–2.70), but not with hip pain or other structural findings. Grade 2 defects were associated with greater hip pain (PR 1.40, 95% CI 1.09–1.80), hip BML (PR 1.45, 95% CI 1.15–1.85), hip effusion cross-sectional area (PR 1.14, 95% CI 1.01–1.30), hip ROA (men; PR 1.60, 95% CI 1.13–2.25), and steps/day (PR 0.97, 95% CI 0.96–0.99).Conclusion.Grade 2 defects in both sexes and grade 1 defects (mostly in men) are associated with clinical, demographic, and structural factors relevant for OA. Damage to the hip cartilage could be one of the major causes of rapid disease progression and pathophysiology of hip defects. The topic needs further study.

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