PENTINGNYA PENGATURAN DIET HIPERTENSI DALAM PENCEGAHAN KEKAMBUHAN HIPERTENSI

2021 ◽  
Vol 3 (1) ◽  
pp. 150-155
Author(s):  
Rizki Sari Utami Muchtar ◽  
Fenisia Prawita ◽  
Abdul Rahim ◽  
Neni Triana ◽  
Istini Istini ◽  
...  
Keyword(s):  
Direct Delivery

Hipertensi adalah salah satu penyakit terbanyak yang dijumpai pada lansia, dan secara khusus di Kampung KB dan Paya Lebar Kelurahan Tanjung Uban Kota Hipertensi juga merupakan penyakit yang mendominasi di kalangan usia dewasa akhir dan lansia. Seseorang dikatakan menderita hipertensi apabila memiliki tekanan darah sistolik lebih dari 140 mmHg dan diastolik lebih dari 90 mmHg. Berdasarkan penelusuran awal diketahui sebanyak 60% penderita hipertensi di Kampung KB dan Paya Lebar memiliki tekanan darah yang tidak terkontrol  Kendala yang sering dialami oleh Lansia dalam mengontrol tekanan darah yaitu 60% mengatakan makanan yang sulit tanpa garam, 20% mengatakan tidak ada yang mengantar ke puskesmas sehingga kadang putus obat dan 20% mengatakan bosan dengan mengkomsumsi obat terus menerus. Tujuan dari penyuluhan ini adalah untuk memberikan pengetahuan tentang diet hipertensi agar peserta dapat melakukan pencegahan dan perawatan pada penderita hipertensi dengan benar dengan bahan yang mdah didapatkan. Metode yang dilakukan adalah “direct delivery” atau penyampaian secara langsung dengan tetap protocol kesehatan Covid-19. Peserta berjumlah 15 orang yang terdiri dari lansia dan kader daerah Kampung KB dan Paya Lebar Kelurahan Tanjung Uban Kota. Hasil dari penyuluhan ini adalah bertambahnya ilmu pengetahuan para peserta mengenai pencegahan dan perawatan pada penderita hipertensi yang ditandai dengan 15 peserta (100%) dapat menjawab pertanyaan tentang diet hipertensi. Kesimpulannya adalah pengetahuan peserta tentang diet Hipertensi menunjukkan peningkatan sangat baik.

Intratumoral and Oncoviral Immunotherapy

2021 ◽  
Author(s):  
Rahul A. Sheth
Keyword(s):  
Treatment Strategy ◽  
Cancer Care ◽  
Therapeutic Agent ◽  
Checkpoint Inhibitor ◽  
Objective Response ◽  
Combination Immunotherapy ◽  
Image Guided ◽  
Checkpoint Inhibitor Therapy ◽  
Direct Delivery ◽  
Paradigm Shifting

AbstractImmunotherapy is a paradigm-shifting advance in cancer care, but despite their success, contemporary immunotherapy strategies are limited by several factors. The objective response rates to checkpoint inhibitor therapy remain below 50%, and the toxicities associated with systemically administered immunotherapies, particularly combination immunotherapy regimens, can be devastating. Intratumoral immunotherapies represent a burgeoning paradigm in immuno-oncology designed to address these limitations. The direct delivery of intratumoral immunotherapies can result in concentrations of the therapeutic agent at levels that would likely be far too toxic if administered systemically. In this review, I summarize the sound biological framework underlying intratumoral immunotherapies as well as provide an overview of the major categories of intratumoral agents currently under investigation. I also emphasize the components of this treatment strategy that are relevant for image-guided interventionalists based on existing clinical experience.

scholarly journals Adenoviral mediated overexpression of human β2 adrenergic receptor after direct delivery into canine myocardium

1996 ◽  
Vol 27 (2) ◽  
pp. 289
Author(s):  
Scott C. Silvestry ◽  
Karsten Peppel ◽  
R.Eric Lilly ◽  
Greg Heintz ◽  
Walther J. Koch ◽  
...  
Keyword(s):  
Adrenergic Receptor ◽  
Β2 Adrenergic Receptor ◽  
Direct Delivery ◽  
Canine Myocardium

Mucosal vaccines to prevent porcine reproductive and respiratory syndrome: a new perspective

2012 ◽  
Vol 13 (1) ◽  
pp. 21-37 ◽  
Author(s):  
Gourapura J. Renukaradhya ◽  
Varun Dwivedi ◽  
Cordelia Manickam ◽  
Basavaraj Binjawadagi ◽  
David Benfield
Keyword(s):  
Mucosal Immunity ◽  
Protective Immunity ◽  
Mucosal Immune Response ◽  
Respiratory Pathogens ◽  
Swine Industry ◽  
Prrs Virus ◽  
Mucosal Vaccines ◽  
Direct Delivery ◽  
New Perspective ◽  
Swine Herds

AbstractPorcine reproductive and respiratory syndrome (PRRS) is an economically important infectious disease of swine. Constant emergence of variant strains of PRRS virus (PPRSV) and virus-mediated immune evasion followed by viral persistence result in increased incidence and recurrence of PRRS in swine herds. Current live and killed PRRSV vaccines administered by a parenteral route are ineffective in inducing complete protection. Thus, new approaches in design and delivery of PRRSV vaccines are needed to reduce the disease burden of the swine industry. Induction of an effective mucosal immunity to several respiratory pathogens by direct delivery of a vaccine to mucosal sites has proven to be effective in a mouse model. However, there are challenges in eliciting mucosal immunity to PRRS due to our limited understanding of safe and potent mucosal adjuvants, which could potentiate the mucosal immune response to PRRSV. The purpose of this review is to discuss methods for induction of protective mucosal immune responses in the respiratory tract of pigs. The manuscript also discusses how PRRSV modulates innate, adaptive and immunoregulatory responses at both mucosal and systemic sites of infected and/or vaccinated pigs. This information may help in the design of innovative mucosal vaccines to elicit superior cross-protective immunity against divergent field strains of PRRSV.

NgCAM and VAMP2 Reveal that Direct Delivery and Dendritic Degradation Maintain Axonal Polarity

2021 ◽  
Author(s):  
Alec T. Nabb ◽  
Marvin Bentley
Keyword(s):  
Membrane Proteins ◽  
Molecular Mechanisms ◽  
Minor Role ◽  
Axonal Membrane ◽  
Quantitative Analyses ◽  
Direct Delivery ◽  
Novel Strategy ◽  
Extreme Scale ◽  
A Minor

Neurons are polarized cells of extreme scale and compartmentalization. To fulfill their role in electrochemical signaling, axons must maintain a specific complement of membrane proteins. Despite being subject of considerable attention, the trafficking pathway of axonal membrane proteins is not well understood. Two pathways, direct delivery and transcytosis, have been proposed. Previous studies reached contradictory conclusions about which of these mediates delivery of axonal membrane proteins to their destination, in part because they evaluated long-term distribution changes and not vesicle transport. We developed a novel strategy to selectively label vesicles in different trafficking pathways and determined the trafficking of two canonical axonal membrane proteins, NgCAM and VAMP2. Results from detailed quantitative analyses of transporting vesicles differed substantially from previous studies and found that axonal membrane proteins overwhelmingly undergo direct delivery. Transcytosis plays only a minor role in axonal delivery of these proteins. In addition, we identified a novel pathway by which wayward axonal proteins that reach the dendritic plasma membrane are targeted to lysosomes. These results redefine how axonal proteins achieve their polarized distribution, a crucial requirement for elucidating the underlying molecular mechanisms. [Media: see text] [Media: see text] [Media: see text] [Media: see text]

Brokerage and Boots on the Ground: Complements or Substitutes in the Manufacturing Extension Partnerships?

2018 ◽  
Vol 32 (4) ◽  
pp. 288-299 ◽  
Author(s):  
Philipp Brandt ◽  
Andrew Schrank ◽  
Josh Whitford
Keyword(s):  
Optimal Design ◽  
Service Delivery ◽  
Administrative Data ◽  
Third Party ◽  
Advisory Services ◽  
Street Level ◽  
Direct Delivery ◽  
Network Failures ◽  
Street Level Bureaucrats

There is more agreement on the need for advisory services to help small and midsized manufacturers keep up with the latest managerial techniques and technologies than there is on the optimal design of those services. This study reconfigures and reanalyzes administrative data from the American Manufacturing Extension Partnership, and draws on extensive interviews with “street-level bureaucrats” at Manufacturing Extension Partnership centers, to identify and compare variation in centers’ approaches to service delivery. Centers and clients who rely on third-party providers tend to have more rather than less enduring ties, suggesting that it’s direct delivery, rather than brokerage, that is associated with one-shot deals. There is evidence also that projects generate the most impact when they help “get the relationships right” and mitigate network failures.

scholarly journals Abramchik and Ostrovsky: the struggle for leadership among the Belarusian post-war emigration

2021 ◽  
pp. 272-290
Author(s):  
Evgenii V. Kodin
Keyword(s):  
Cold War ◽  
The United States ◽  
Intelligence Agency ◽  
Communist System ◽  
Close Cooperation ◽  
Direct Delivery ◽  
Post War ◽  
The Right ◽  
The Cold War ◽  
To Receive

The post-war Belarusian emigration, both in Europe and in the United States, was divided into two main groups: the supporters of the President of the Belarusian Central Rada R. K. Ostrowski (Astrouski) and the Chairman of the BNR Rada N. S. Abramchyk. The declassified CIA documents indicate that this was not just a rivalry for the right to speak and act on behalf of the entire Belarusian emigration, but also to receive substantial dividends from close cooperation with the American intelligence agency in the implementation of plans to destabilize the situation in Belarus through the preparation of various kinds of espionage and subversive operations, up to the direct delivery of agents to the territory of the BSSR in the 1950s, as well as in information and propaganda work against the Soviet Belarus. This confrontation took various forms: from accusations of direct collaboration with the Nazis during the war (Ostrowski) to the self-appointment as the head of the Belarusian Folk Republic (Abramchyk). The visions of the future of free Belarus and its foreign policy between these actors differed, as well as the means and methods of struggle for the liberation of the Belarusian people from the communist system. At the same time, both Abramchyk and Ostrowski understood well that in order to strengthen their positions among the Belarusian emigration, close relations with those who built and financed the anti-Soviet policy of the West during the Cold War were important. First of all, it was about the American intelligent services. And here Abramchyk won an obvious victory, and Ostrowski’s main former comrades-in-arms were soon going to move to his camp.

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