scholarly journals Photodynamic Therapy in Endodontics

2017 ◽  
Vol 18 (6) ◽  
pp. 534-538 ◽  
Author(s):  
Zahed Mohammadi ◽  
Sousan Shalavi ◽  
Jun-Ichiro Kinoshita ◽  
Hamid Jafarzadeh
Keyword(s):  
Photodynamic Therapy ◽  
Antimicrobial Agents ◽  
Oral Candidiasis ◽  
Periodontal Pocket ◽  
Canal System ◽  
Denture Stomatitis ◽  
Root Canals ◽  
Infected Root ◽  
Infected Area ◽  
Root Canal System

ABSTRACT Commonly used irrigants do not always eradicate the entire microbial flora in infected root canals. Therefore, several other strategies, such as photodynamic therapy (PDT) have been developed. Photoactivated disinfection is based on the interaction of a photosensitive antibacterial agent and a light source. It uses a nontoxic dye named photosensitizer (PS) and lowintensity visible light. In oxygen presentation, these combine to produce some cytotoxic species. The PS molecules attach to bacteria membrane. Irradiation with a specific wavelength of the light may lead to the production of singlet oxygen, resulting in rupture of the microbial cell wall. There are several applications for PDT in dentistry. A successful periodontal treatment is based on elimination of bacteria from the infected area. Phenothiazinium PSs have been shown to be highly effective and safe for this purpose. However, scaling/root planing should be performed before the PDT. While performing the PDT, PS should be first injected in the periodontal pocket and allowed to pigment. Then, the special fiber should be inserted 1 mm short of the pocket base and lased. Photodynamic therapy has also been used to disinfect caries dentin before restoration, disinfecting oral tissues before or during surgical procedures, treating denture stomatitis, and treating oral candidiasis in immunocompromised patients. Photodynamic therapy can be used in combination with mechanical instrumentation and chemical antimicrobial agents, such as sodium hypochlorite, too. The purpose of this study was to review historical perspective, mechanism of action, and applications of PDT in dentistry and especially in endodontics was reviewed. Furthermore, the effects of PDT on dentin bonding and endotoxin are discussed. Clinical significance Photodynamic therapy has been advocated to increase the disinfection level of the root canal system. How to cite this article Mohammadi Z, Jafarzadeh H, Shalavi S, Kinoshita JI. Photodynamic Therapy in Endodontics. J Contemp Dent Pract 2017;18(6):534-538.

scholarly journals Antimicrobial and Antibiofilm Properties of Bioceramic Materials in Endodontics

Materials ◽  
2021 ◽  
Vol 14 (24) ◽  
pp. 7594
Author(s):  
Zhejun Wang ◽  
Ya Shen ◽  
Markus Haapasalo
Keyword(s):  
Root Canal ◽  
Antimicrobial Agents ◽  
Chemical Properties ◽  
Canal System ◽  
Root Canals ◽  
Physico Chemical ◽  
Infected Root ◽  
Root Canal System ◽  
Dental Applications ◽  
Infected Root Canal

Microbes are prevalent in the root canals of necrotic teeth, and they are the cause of primary and post-treatment apical periodontitis. Bacteria can dwell within the infected root canal system as surface-adherent biofilm structures, which exhibit high resistance to antimicrobial agents. Bioceramic materials, with their biocompatible nature and excellent physico-chemical properties, have been widely used in dental applications, including endodontics. This review focuses on the application of bioceramic technology in endodontic disinfection and the antibiofilm effects of endodontic bioceramic materials. Different bioceramic materials have shown different levels of antibiofilm effects. New supplements have emerged to potentially enhance the antibiofilm properties of bioceramics aiming to achieve the goal of microbial elimination in the root canal system.

Controversies in Endodontics

2004 ◽  
Vol 15 (2) ◽  
pp. 99-114 ◽  
Author(s):  
G. Bergenholtz ◽  
L. Spångberg
Keyword(s):  
Root Canal ◽  
Randomized Clinical Trials ◽  
Canal System ◽  
Efficient Treatment ◽  
Scientific Methods ◽  
Root Canals ◽  
Infectious Origin ◽  
Infected Root ◽  
Root Canal System

Diseases of the dental pulp often have an infectious origin, and treatments are aimed to control infections of the root canal system. Endodontic treatment principles originally evolved on the basis of trial and error, and only in recent decades have scientific methods been adopted to support clinical strategies. Yet, relevant research on the disease processes, their diagnoses, and efficient treatment are rare in the endodontic literature. Hence, the advancement of biologically based knowledge significant to clinical endodontics has been slow. Therefore, many differences of opinion still prevail in this field of dentistry. This review highlights and analyzes the background of some of the more heavily debated issues in recent years. Specifically, it deals with disagreements regarding the clinical management of pulpal exposures by caries in the adult dentition, definitions of success and failure of endodontic therapy, and causes of and measures to control infections of the root canal system. Clearly, a most apparent gap in the published endodontic literature is the lack of randomized clinical trials that address the more significant controversial matters relating to the management of pulpal wounds, medication, and the number of appointments required for the treatment of infected root canals. However, trials in endodontics require extremely long follow-up periods if valid conclusions are to be generated. Therefore, it is not to be expected that there will be rapid solutions to these issues in the foreseeable future.

scholarly journals Advancing Photodynamic Therapy for Endodontic Disinfection with Nanoparticles: Present Evidence and Upcoming Approaches

2021 ◽  
Vol 11 (11) ◽  
pp. 4759
Author(s):  
Rayyan A. Alfirdous ◽  
Isadora M. Garcia ◽  
Abdulrahman A. Balhaddad ◽  
Fabrício M. Collares ◽  
Frederico C. Martinho ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Root Canal ◽  
Bacterial Resistance ◽  
In Vivo Studies ◽  
Canal System ◽  
Root Canals ◽  
Clinical Literature ◽  
Root Canal System ◽  
And Performance

The persistence of microorganisms in the root canal system is one of the leading causes of root canal treatment failure. Root canal anatomy is complex, and it is often a challenge to obtain optimal disinfection. Biofilms of putative pathogens hidden inside dentin tubules and other root canal ramifications may limit current disinfection protocols. The search for additional disinfection of the root canal has been intensely carried out over the last twenty years. Antimicrobial photodynamic therapy (aPDT) is an adjunctive, conservative, non-selective bacterial kill approach. aPDT has been used to improve root canals disinfection without inducing bacterial resistance. This review focuses on the up-to-date aPDT performance and upcoming promising strategies for disinfection of the root canal system. First, we summarized the barriers encountered by photosensitizer (PS) and light delivery applied to root canal disinfection. Second, we compile the most updated clinical literature. A systematic search for scientific articles was conducted in PubMed, MEDLINE, SCOPUS, and EMBASE to screen the related in vivo studies about this theme. Third, we summarized and critically analyzed the current developments to overcome the aPDT limitations, and we revealed upcoming perspectives in this scoping literature review. We present a timely and opportune review article focusing on the significant potential of aPDT in endodontic disinfection. aPDT offers multiple capabilities that may be considered toward the root canal system’s disinfection with future outlooks in nanosized-platforms’ design and performance.

scholarly journals Application of High-Power Diode Laser and Photodynamic Therapy in Endodontic Treatment - Review of the Literature

2015 ◽  
Vol 19 (2) ◽  
pp. 71-74 ◽  
Author(s):  
Dejan Marković ◽  
Dragana Rakašević ◽  
Dijana Trišić
Keyword(s):  
Photodynamic Therapy ◽  
High Power ◽  
Root Canal ◽  
Endodontic Treatment ◽  
Canal System ◽  
Root Canals ◽  
Treatment Review ◽  
Root Canal System ◽  
Power Diode ◽  
High Power Diode Laser

SUMMARYLasers have found important role in clinical application, science and scientific research. The aim of this review is to focus on using soft tissue laser in endodontic treatments.The main goal of endodontic treatment is elimination of pathogenic microorganisms from root canal system. Laser light has the ability to reach parts of the tissue and areas where classical techniques and instruments cannot. New approaches to disinfecting root canals have been proposed recently, which include the use of high-power diode lasers, as well as disinfection of the root canal by using photodynamic therapy. A research is necessary to define a precise protocol for high-power laser and photodynamic therapy in treatment of the root canal system.

scholarly journals Micro-tomographic characterization of the root and canal system morphology of mandibular first premolars in a Chilean population

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Alfredo Sierra-Cristancho ◽  
Luis González-Osuna ◽  
Daniela Poblete ◽  
Emilio A. Cafferata ◽  
Paola Carvajal ◽  
...  
Keyword(s):  
Root Canal ◽  
Multiple Root ◽  
Root Anatomy ◽  
Type I ◽  
Micro Computed Tomography ◽  
Canal System ◽  
Root Canals ◽  
Wide Range ◽  
Root Canal System ◽  
Chilean Population

AbstractThis study aimed to analyze the root anatomy and root canal system morphology of mandibular first premolars in a Chilean population. 186 teeth were scanned using micro-computed tomography and reconstructed three-dimensionally. The root canal system morphology was classified using both Vertucci’s and Ahmed’s criteria. The radicular grooves were categorized using the ASUDAS system, and the presence of Tomes’ anomalous root was associated with Ahmed’s score. A single root canal was identified in 65.05% of teeth, being configuration type I according to Vertucci’s criteria and code 1MP1 according to Ahmed’s criteria. Radicular grooves were observed in 39.25% of teeth. The ASUDAS scores for radicular grooves were 60.75%, 13.98%, 12.36%, 10.22%, 2.15%, and 0.54%, from grade 0 to grade 5, respectively. The presence of Tomes’ anomalous root was identified only in teeth with multiple root canals, and it was more frequently associated with code 1MP1–2 of Ahmed’s criteria. The root canal system morphology of mandibular first premolars showed a wide range of anatomical variations in the Chilean population. Teeth with multiple root canals had a higher incidence of radicular grooves, which were closely related to more complex internal anatomy. Only teeth with multiple root canals presented Tomes’ anomalous root.

scholarly journals Efficacy of Toluidine Blue—Mediated Antimicrobial Photodynamic Therapy on Candida spp. A Systematic Review

Antibiotics ◽  
2021 ◽  
Vol 10 (4) ◽  
pp. 349
Author(s):  
Rafał Wiench ◽  
Dariusz Skaba ◽  
Jacek Matys ◽  
Kinga Grzech-Leśniak
Keyword(s):  
Photodynamic Therapy ◽  
Toluidine Blue ◽  
Randomized Clinical Trials ◽  
Oral Candidiasis ◽  
In Vitro Studies ◽  
Cochrane Central Register ◽  
Antimicrobial Photodynamic Therapy ◽  
Candida Spp ◽  
Denture Stomatitis

The effectiveness of antimicrobial photodynamic therapy (aPDT) in the treatment of oral yeast infections was examined many times in recent years. The authors of this review tried to address the question: “Should TBO (toluidine blue ortho)-mediated aPDT be considered a possible alternative treatment for oral candidiasis?”. PubMed/Medline and the Cochrane Central Register of Controlled Trials (CEN-TRAL) databases were searched from 1997 up to the 27th of October 2020 using a combination of the following keywords: (Candida OR Candidiasis oral OR Candidosis oral OR denture stomatitis) AND (toluidine blue OR photodynamic therapy OR aPDT OR photodynamic antimicrobial chemotherapy OR PACT OR photodynamic inactivation OR PDI). Animal studies or in vitro studies involving Candida albicans (C. albicans) and/or nonalbicans stain, randomized clinical trials (RCT) involving patients with oral candidiasis or denture stomatitis published solely in English language were included. Candida elimination method in animal, in vitro studies and RCT used was TBO-mediated aPDT. Exactly 393 studies were taken into consideration. Then, after analyzing titles and abstracts of said studies, 361 were excluded. Only 32 studies ended up being selected for in-depth screening, after which 21 of them were included in this study. All studies reported the antifungal effectiveness of aPDT with TBO against C. albicans and non-albicans Candida. In studies conducted with planktonic cells, only one study showed eradication of C. albicans. All others showed partial elimination and only one of them was not statistically significant. Experiments on yeast biofilms, in all cases, showed partial, statistically significant cell growth inhibition and weight reduction (a reduction in the number of cells—mainly hyphae) and the mass of extracellular polymeric substance (EPS). In vivo aPDT mediated by TBO exhibits antifungal effects against oral Candida spp.; however, its clinical effectiveness as a potent therapeutic strategy for oral yeast infections requires further investigation.

scholarly journals Evaluation of Interference of Calcium Hydroxide-based Intracanal Medication in Filling Root Canal Systems

2011 ◽  
Vol 12 (5) ◽  
pp. 368-371 ◽  
Author(s):  
Matheus Melo Pithon ◽  
Deyla Duarte Vilela ◽  
Manoel Matos Neto ◽  
Alexandre Mascarenhas Villela
Keyword(s):  
Calcium Hydroxide ◽  
Clinical Significance ◽  
Root Canal ◽  
Canal System ◽  
Root Canals ◽  
Anterior Teeth ◽  
Knowing That ◽  
Group I ◽  
Canal Systems ◽  
Root Canal System

ABSTRACT Aim To evaluate the interference of the intracanal medication Calen® (SSWhite, São Paulo, Brazil) on the filling of simulated lateral canals. Materials and methods Twenty human anterior teeth were used. Before the endodontic filling procedures the access of cavity was made, and after this root canals were made in all the teeth to simulate the presence of lateral canals. After preparation, the teeth were randomly divided into two groups (n=10). In group I, the root canal system was filled directly after chemicalmechanical preparation; in group II, endodontic treatment was performed in multiple sessions, and after preparation the calcium hydroxide-based intracanal medication Calen® was inserted. After the period of 7 days, the root canals were vigorously irrigated and then they were filled. Next, the teeth were radiographed to verify the quality of the filling. Results The results demonstrated that the teeth treated in a single session, without calcium hydroxide medication, presented 47 canals out of 60 with radiographic evidence of filling, whereas the teeth in which intracanal medication was used, only 07 presented a radiographic image compatible with filling (p < 0.05). Conclusion The use of the calcium hydroxide-based medication Calen made it difficult to obtain a hermetic filling of the root canal system. Clinical significance The clinical significance of this work basing on the fact that once the dentist knowing that property obliteration of calcium hydroxide can be taken care when they are used in the presence of lateral canals. How to cite this article Vilela DD, Neto MM, Villela AM, Pithon MM. Evaluation of Interference of Calcium Hydroxide-based Intracanal Medication in Filling Root Canal Systems . J Contemp Dent Pract 2011;12(5):368-371.

scholarly journals COMPARATIVE QUALITY ASSESSMENT OF ROOT CANAL PREPARATION WITH DIFFERENT SYSTEMS OF ENDODONTIC INSTRUMENTS

2020 ◽  
Vol 73 (6) ◽  
pp. 1145-1148
Author(s):  
Maryna A. Goray ◽  
Nataliia G. Gadzhula ◽  
Olena V. Muntian ◽  
Olena L. Cherepakha ◽  
Larysa F. Kurdysh
Keyword(s):  
Root Canal ◽  
Canal System ◽  
Universal Group ◽  
Root Canals ◽  
Root Canal System ◽  
High Degree ◽  
Dentine Surface ◽  
Apical Area

The aim: To compare the quality of root canal system preparation with the use of manual K-files, machine Protaper Universal and Silk files by in vitro studies. Materials and methods: Root canals preparation in 45 extracted premolars was performed in three groups with 15 teeth in each with K-files, Protaper Universal and Silk files. Transverse sections of the dental root were prepared. Histologically were assessed: amount of sawdust and predentin remaining, the purity degree of root canal walls. Results: When calculating the sawdust amount at the distance of 3 mm from an apex, a high degree of contamination was observed in the manual K-file group: 53.3% versus 33.3% in the Protaper Universal group and against 20.0% in the Silk file group. The amount of predentin after root canal treatment with manual files reached 25-30%. At the distance of 5 mm from the apex the root canals with high and medium purity degree were detected in 86.7% with Silk files and 80.0% with Protaper Universal files used. All predentin was removed when working with Protaper Universal and Silk files. Conclusions: In the histological sections of the root canals treated with K-files, the larger amount of dentine particles and predentin has been revealed than when using machine tools. The largest amount of predentin and dentine were removed with Protaper Universal files. Silk endodontic system is better for treatment of the root canals dentine surface in the apical area compared to Protaper Universal and K-files.

scholarly journals Endodontic Irrigation Solutions: A Review

2017 ◽  
Vol 7 (3) ◽  
pp. 54 ◽  
Author(s):  
Celalettin Topbas ◽  
Ozkan Adiguzel
Keyword(s):  
Root Canal ◽  
Native Speakers ◽  
Antimicrobial Properties ◽  
Canal System ◽  
Root Canals ◽  
Native Speakers Of English ◽  
Root Canal System ◽  
Dentin Tubules ◽  
Endodontic Irrigation ◽  
Organic Tissue

The goal of endodontic treatment is to remove all the vital and necrotic tissues, microorganisms and microbial byproducts from root canal system. This goal can be achieved through chemical and mechanical debridement of root canals. This article narrates the specifics and requirements of the irrigation solutions. Sodium hypochlorite is proposed as the primary irrigant by virtue of its organic tissue dissolution capacity and broad antimicrobial properties. On the other hand, chelation solutions are recommended as auxiliary solutions to remove the smear layer or to hinder its formation on dentin surface. Thus, it's hoped that sealers and root canal fillers can penetrate to dentin tubules and obturate the canals hermetically. There are new studies on traditional irrigants especially on some irrigants that can replace sodium hypoclorite. This article reviews the new irrigants which can be used in future endodontic practice, and their advantages and limitations. Moreover, actions and interactions of recently used irrigants are adverted.   How to cite this article: Topbas C, Adiguzel O. Endodontic Irrigation Solutions: A Review. Int Dent Res 2017;7:54-61.  Linguistic Revision: The English in this manuscript has been checked by at least two professional editors, both native speakers of English.

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