scholarly journals An Evaluation of the Antioxidant and Blood Lead Lowering Effect of Vernonia Amygdalina Aqueous Extract on Lead Acetate Induced Oxidative Stress in Wistar Rats

2017 ◽  
pp. 193-199 ◽  
Author(s):  
Odewusi Odeyinka Olufunsho ◽  
Tope-Ajayi Ayodele
Keyword(s):  
Oxidative Stress ◽  
Aqueous Extract ◽  
Lead Acetate ◽  
Wistar Rats ◽  
Blood Lead ◽  
Vernonia Amygdalina ◽  
Lowering Effect

Honey prevents neurobehavioural deficit and oxidative stress induced by lead acetate exposure in male wistar rats- a preliminary study

2015 ◽  
Vol 31 (1) ◽  
pp. 37-44 ◽  
Author(s):  
Wahab Imam Abdulmajeed ◽  
Habeeb Bolakale Sulieman ◽  
Maymunah Oloruntosin Zubayr ◽  
Aminu Imam ◽  
Abdulbasit Amin ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Lead Acetate ◽  
Wistar Rats ◽  
Male Wistar Rats ◽  
Preliminary Study ◽  
And Oxidative Stress

Berberis vulgaris L. effects on oxidative stress and liver injury in lead-intoxicated mice

2017 ◽  
Vol 14 (1) ◽  
Author(s):  
Jawhar Laamech ◽  
Jaouad El-Hilaly ◽  
Hamadi Fetoui ◽  
Yassine Chtourou ◽  
Hanane Gouitaa ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Body Weight ◽  
Aqueous Extract ◽  
Lead Acetate ◽  
Protein Carbonyls ◽  
Control Group ◽  
Distilled Water ◽  
Once Daily ◽  
Group 2 ◽  
Mice Liver

AbstractBackgroundL. (BV), commonly known as “MethodsSixty IOPS mice were divided into six groups and were treated as follows: group 1 (normal control) received double distilled water; group 2 (toxic control) received lead acetate (5 mg/kg body weight/day) in double distilled water for 40 days; groups 3–6 received BV aqueous extract at doses of 25, 50, 100 and 150 mg/kg body weight , respectively, once daily for 30 days from 11 day after beginning of lead acetate exposure to the end of the experiment.ResultsToxic control group showed a significant alteration of serum alanine-aminotransferase (ALT), aspartate-aminotransferase (AST), total cholesterol (TC), total bilirubin (TB), catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx) and reduced glutathione (GSH). Histological assessment of lead-intoxicated mice liver revealed alterations in hepatocytes and focal necrosis. BV treatment significantly prevented lead accumulation, increased ALT, AST, TC, and TB, inhibited lipid peroxidation and protein carbonyls(PCO) formation. Additionally, BV extract normalized the antioxidant enzymes (CAT, SOD and GPx), GSH and architecture of liver tissues.ConclusionsBV aqueous extract exerts significant hepatoprotective effects against lead-induced oxidative stress and liver dysfunction. The BV effect may be mediated through the enhancement of antioxidant status, lead-chelating abilities and free radicals quenching.

scholarly journals Effects of Aqueous Extract of Ocimum gratissimum Leaves and Vitamin C on Lead Acetate-induced Changes in the Thymus of Adult Wistar Rats

2019 ◽  
pp. 1-9
Author(s):  
G. N. Okechukwu ◽  
E. Ezor ◽  
E. Finbarrs-Bello ◽  
L. N. Ebube ◽  
G. C. Uzomba ◽  
...  
Keyword(s):  
Vitamin C ◽  
Aqueous Extract ◽  
Lead Acetate ◽  
Wistar Rats ◽  
Lead Toxicity ◽  
Wistar Rat ◽  
Ocimum Gratissimum ◽  
Ameliorative Effect ◽  
Male Wistar Rats ◽  
Induced Changes

Lead is a heavy metal found in earth’s crust. It is a widespread and insidious environmental toxin known as a severe and aggressive contaminant to human and animal organisms’ health status. This work is aimed at evaluating the effect of aqueous extract of Ocimum gratissimum (OG) on lead induced changes in the thymus of adult albino wistar rats. Thirty five male Wistar rats were used in the study and were randomly divided into seven groups with five rats in each group. The rats in Group one (G1) served as the Control and received distilled water. Group 2 received 120 mg/kg body weight (bwt) of lead acetate, G3 received 375 mg/kg bwt of OG only. G4 received 120 mg/kg bwt of lead acetate and OG extract at 375 mg/kg bwt., G5 received 120 mg/kg bwt of lead and OG at 750 mg/kg bwt. G6 received 375 mg/kg bwt of OG in two weeks followed by 120 mg/kg bwt of lead acetate for one week, while G7 received 120 mg/kg bwt of lead acetate and Vitamin C at 11900 mg/kg. All the administrations were carried out orally for twenty one (21) days. At the end of the administration, the rats were fasted for 24 hours. They weighted and humanely sacrificed via cervical dislocation. The thymus were harvested in all the groups and prepared for histological studies using routine haematoxylin and eosin (H&E) staining techniques. The result of the present study shows that lead possessed a distortive effect in the histoarchitecture of thymus of the wistar rat in G2 when compared with G1. Treatment of these experimental animals with vitamin C prove to posses more ameliorative effect in restoring the histoarchitecture on lead toxicity in the thymus closed to normal than OG. Therefore, it is suggested that aqueous extract OG can act via the same pathway as vitamin C, in maintaining the normal histological structures of the thymus of adult albino wistar rat exposed to lead toxicity.

scholarly journals Ameliorative Effect of Trevo Dietary Supplement Against Lead Acetate Nephrotoxicity

2022 ◽  
Vol 16 (1) ◽  
pp. 34-42
Author(s):  
Omotayo B. Ilesanmi ◽  
◽  
Eni-yimini Solomon Agoro ◽  
Keyword(s):  
Oxidative Stress ◽  
Uric Acid ◽  
Lead Acetate ◽  
Wistar Rats ◽  
Antioxidant Properties ◽  
Kidney Tissue ◽  
Lead Toxicity ◽  
Serum Levels ◽  
Tissue Samples ◽  
Male Wistar Rats

Background: Trevo is a nutritional supplement with numerous bioactive natural products, with detoxifying and antioxidant properties. The purpose of this study was to investigate the ability of Trévo to protect against oxidative stress induced by lead in the kidneys of male Wistar rats. Methods: Thirty-five healthy male Wistar rats were divided into five groups of seven rats each, using a randomized design. I=control; II=15 mg/kg of lead acetate (PbA); III=2 ml/kg of trevo+PbA; IV=5 ml/kg of trevo+PbA; V=5 ml/kg of trevo. Animals were treated with trevo for five days before co-administration with lead intraperitoneally for 10 consecutive days. Animals were sacrificed 24hr after the last administration, blood samples were collected via cardiac puncture, and processed for assessment of urea, creatinine, and uric acid (UA), while the kidney samples were excised and processed for the following biochemical assays: Malondialdehyde (MDA), Glutathione-S-Transferase (GST), Catalase (CAT), Superoxide Dismutase (SOD), and Reduced Glutathione (GSH). Results: Injection of PbA caused a significant increase in the serum levels of urea, creatinine, and uric acid, and a significant increase (P<0.001) in the MDA concentration, and decreases in GSH concentration, CAT, SOD, and GST activities (P<0.05) as compared to the controls. Pretreatment with trevo prevented the oxidative stress induced by lead acetate in the kidney tissue samples and improve the renal function. The protective effect was evident at 5 ml/kg of trevo. Conclusion: The results showed that trevo was nephroprotective against lead toxicity and the activity might be linked to the presence of numerous antioxidant phytochemicals present in trevo.

Flavonoid fractions of diosmin and hesperidin mitigate lead acetate-induced biochemical, oxidative stress, and histopathological alterations in Wistar rats

2021 ◽  
Author(s):  
Ibrahim Yusuf Lamidi ◽  
Hudu Garba Mikail ◽  
Sani Adamu ◽  
Isaac Oluwatobi Akefe ◽  
Mohammed Bashir Tijjani ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Lead Acetate ◽  
Wistar Rats ◽  
Histopathological Alterations
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