scholarly journals CONSEQUENCES OF INTERMITTENT FASTING FOR NEUROPLASTICITY: AN INTEGRATIVE REVIEW

2021 ◽  
Keyword(s):  
Weight Loss ◽  
Immune System ◽  
Energy Metabolism ◽  
Signaling Pathways ◽  
Human Development ◽  
Intermittent Fasting ◽  
Modern Technique ◽  
Historical Factor ◽  
Dietary Strategy ◽  
Cellular Components

Neuroplasticity occurs from human development until the end of senility and, despite the dependence on food, the regulation of the diet on neurons and nerve synapses is not restricted to the availability of nutrients. In turn, intermittent fasting, as a dietary strategy, represents not only a modern technique for weight loss, but also an important historical factor for the occurrence of persistent organic adaptations. Based on this interrelation, evidence was collected from databases that associated, positively or negatively, neuroplasticity with intermittent fasting in humans. From the review of the selected articles, the various ways in which intermittent fasting affects neuroplasticity, influencing energy metabolism, triggering signaling pathways, modulating components of the immune system and altering cellular components were identified. All of these changes create a favorable environment for the emergence and maintenance of neurons, as well as for the formation of new nerve synapses.

scholarly journals Molecular Pathogenesis of Hodgkin Lymphoma: Past, Present, Future

2020 ◽  
Vol 21 (18) ◽  
pp. 6623 ◽  
Author(s):  
Marc Bienz ◽  
Salima Ramdani ◽  
Hans Knecht
Keyword(s):  
Immune System ◽  
Targeted Therapy ◽  
Signaling Pathways ◽  
Hodgkin Lymphoma ◽  
Genetic Instability ◽  
Host Immune System ◽  
Cellular Interactions ◽  
Classical Hodgkin Lymphoma ◽  
The Past

Our understanding of the tumorigenesis of classical Hodgkin lymphoma (cHL) and the formation of Reed–Sternberg cells (RS-cells) has evolved drastically in the last decades. More recently, a better characterization of the signaling pathways and the cellular interactions at play have paved the way for new targeted therapy in the hopes of improving outcomes. However, important gaps in knowledge remain that may hold the key for significant changes of paradigm in this lymphoma. Here, we discuss the past, present, and future of cHL, and review in detail the more recent discoveries pertaining to genetic instability, anti-apoptotic signaling pathways, the tumoral microenvironment, and host-immune system evasion in cHL.

Time-Restricted Eating, Intermittent Fasting, and Fasting-Mimicking Diets in Weight Loss

2021 ◽  
Author(s):  
Maura Fanti ◽  
Amrendra Mishra ◽  
Valter D. Longo ◽  
Sebastian Brandhorst
Keyword(s):  
Weight Loss ◽  
Intermittent Fasting

scholarly journals Imaging the cellular components of the immune system for advancing diagnosis and immunotherapy of cancers

2021 ◽  
Vol 10 ◽  
pp. 100138
Author(s):  
K. Bhise ◽  
S. Sau ◽  
R. Alzhrani ◽  
M.A. Rauf ◽  
K. Tatiparti ◽  
...  
Keyword(s):  
Immune System ◽  
Cellular Components

scholarly journals Immunoregulatory Property of C-Type Lectin-Like Receptors in Fibrosing Interstitial Lung Diseases

2020 ◽  
Vol 21 (10) ◽  
pp. 3665
Author(s):  
Wiwin Is Effendi ◽  
Tatsuya Nagano ◽  
Helmia Hasan ◽  
Resti Yudhawati
Keyword(s):  
Immune System ◽  
Signaling Pathways ◽  
Intracellular Signaling ◽  
Lung Diseases ◽  
Wound Repair ◽  
Tissue Injury ◽  
Interstitial Lung Diseases ◽  
Downstream Signaling ◽  
Cytokine Activation ◽  
Immune Impairment

The innate immune system identifies exogenous threats or endogenous stress through germline-encoded receptors called pattern recognition receptors (PRRs) that initiate consecutive downstream signaling pathways to control immune responses. However, the contribution of the immune system and inflammation to fibrosing interstitial lung diseases (ILD) remains poorly understood. Immunoreceptor tyrosine-based motif-bearing C-type lectin-like receptors (CTLRs) may interact with various immune cells during tissue injury and wound repair processes. Dectin-1 is a CTLR with dominant mechanisms manifested through its intracellular signaling cascades, which regulate fibrosis-promoting properties through gene transcription and cytokine activation. Additionally, immune impairment in ILD facilitates microbiome colonization; hence, Dectin-1 is the master protector in host pulmonary defense against fungal invasion. Recent progress in determining the signaling pathways that control the balance of fibrosis has implicated immunoreceptor tyrosine-based motif-bearing CTLRs as being involved, either directly or indirectly, in the pathogenesis of fibrosing ILD.

THE EFFECT OF INTERMITENT FASTING DIET ON KIDNEY FUNCTION

2020 ◽  
Vol 1 (2) ◽  
pp. 65-70
Author(s):  
Esa Indah Ayudia ◽  
Huntari Harahap ◽  
Irfannuddin Irfannuddin
Keyword(s):  
Weight Loss ◽  
Renal Function ◽  
Kidney Function ◽  
Laboratory Tests ◽  
Intermittent Fasting ◽  
Early Prevention ◽  
Total Body Fat ◽  
Restriction Method ◽  
Total Body ◽  
Renal Function Tests

  Obesity is a condition in which the ratio of body weight and height exceeds the specified standards. Obesity is an increase in total body fat, that is, if you are found to be overweight> 20% in men and 25% in women because of fat. The intermittent fasting diet is a calorie restriction method that is widely used for health or weight loss reasons. Overall kidney function is based on nephron function and impaired function is caused by decreased nephron action. Several laboratory tests have been developed to evaluate kidney function and identify the disorder early on. This can help clinicians to take early prevention and management in order to prevent the progression of kidney disorders to kidney failure. Renal function tests are carried out by examining the levels of urea and cretinin.    

Cardiometabolic Benefits of Intermittent Fasting

2021 ◽  
Vol 41 (1) ◽  
pp. 333-361
Author(s):  
Krista A. Varady ◽  
Sofia Cienfuegos ◽  
Mark Ezpeleta ◽  
Kelsey Gabel
Keyword(s):  
Weight Loss ◽  
Eating Behaviors ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Diet Therapy ◽  
Cardiometabolic Health ◽  
Intermittent Fasting ◽  
Disordered Eating Behaviors ◽  
Alternate Day Fasting ◽  
Clinically Significant

This review aims to summarize the effects of intermittent fasting on markers of cardiometabolic health in humans. All forms of fasting reviewed here—alternate-day fasting (ADF), the 5:2 diet, and time-restricted eating (TRE)—produced mild to moderate weight loss (1–8% from baseline) and consistent reductions in energy intake (10–30% from baseline). These regimens may benefit cardiometabolic health by decreasing blood pressure, insulin resistance, and oxidative stress. Low-density lipoprotein cholesterol and triglyceride levels are also lowered, but findings are variable. Other health benefits, such as improved appetite regulation and favorable changes in the diversity of the gut microbiome, have also been demonstrated, but evidence for these effects is limited. Intermittent fasting is generally safe and does not result in energy level disturbances or increased disordered eating behaviors. In summary, intermittent fasting is a safe diet therapy that can produce clinically significant weight loss (>5%) and improve several markers of metabolic health in individuals with obesity.

Sign in / Sign up

Export Citation Format

Share Document