THROMBOCYTOPENIA AND ELEVATED ALANINE AMINOTRANSFERASE LEVELS IN MALARIA PATIENTS

Objective: To study thrombocytopenia and elevated ALT levels in malaria patients reporting to Pak Med Level II+ Hospital XII and XIII, UN Mission Liberia, West Africa. Study Design: Cross sectional study. Place and Duration of Study: Departments of Pathology and Medicine, Pak Med Level II+ Hospital XII and XIII, UN Mission Liberia, West Africa, from Feb 2015 to Dec 2016. Methodology: In total of 100 febrile patients of both gender and all ages reported to Pak Med Level II+ Hospital XII and XIII, Liberia with clinical features of malaria and having positive malarial parasite (MP) on any of the methods of immune chromatography (ICT) or microscopic film were included. The febrile patients with typical clinical features of malaria but having negative MP both on ICT and microscopic methods were excluded.Pretreatment whole blood in EDTA was collected for testing MP on ICT and by microscopic method including MP index and platelets, while serum for ALT. Results: Out of total 100 patients, 75 were males, 25 females with mean age of 38 ± 5 years. MP was found positive on MP film in 95% and on ICT in 88% cases. Thrombocytopenia was found in 69% and ALT was elevated in 60% cases. Mean and SD for platelets count was 129 ± 72 x 109/L and of ALT 76 ± 66 U/L. Mean of MP index was 0.49 ranging from 0 to 3.5%. Correlation of MP index with platelets and ALT was found insignificant, although in malaria patients, platelets and ALT was inversely correlated significantly with each other showing low platelets along with elevated ALT levels. Conclusion: In malaria patients, thrombocytopenia and elevated ALT are frequent findings, which may not definitely correlate with MP index. So it is advisable to test for platelet count and ALT in all patients of malaria for early diagnosis and better management.

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Knowledge of breast cancer among medical students in Syrian Private University, Syria: a cross-sectional study

BMC Medical Education ◽

10.1186/s12909-021-02673-0 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Hlma Ismail ◽

Mosa Shibani ◽

Hanaa Wael Zahrawi ◽

Ali Fouad Slitin ◽

Mhd Amin Alzabibi ◽

...

Keyword(s):

Breast Cancer ◽

Risk Factors ◽

Medical Students ◽

Clinical Features ◽

Smoking Status ◽

Private University ◽

Cross Sectional Study ◽

General Information ◽

Sectional Study ◽

Cross Sectional

Abstract Background Breast cancer is the most common cancer among women and the second leading cause of cancer death globally. Since early diagnosis is crucial to reducing mortality, high levels of knowledge regarding general information, risk factors, and symptoms are required among healthcare professionals to deliver breast cancer care. This study aimed to determine Syrian medical students’ knowledge about breast cancer in the fields of general knowledge, common clinical features, and risk factors. Methods This cross-sectional study was conducted at the Syrian Private University in October 2019 (Breast Cancer Awareness Month), Damascus, during the Syrian war crisis. Data were collected through self-administered surveys and analyzed using the Statistical Package for Social Sciences version 25.0 (SPSS Inc., United States). The chi-square test was applied to assess the relationship between the level of knowledge and gender. One way analysis of variance was performed to assess the overall differences in mean knowledge score by study year, GPA, mother’s education, and source of information. Unpaired Student’s T-test was used to analyze the differences in mean knowledge scores (continuous variable) based on smoking status and alcohol consumption. Results Of 320 students, 301 completed the questionnaire (response rate = 94.0%), of which 179(59.5%) were males. The study revealed above-average knowledge scores (total mean = 68.4%) regarding breast cancer, general information (71.9%), common clinical features (71.6%), and risk factors (71.6%). Clinical students (4th, 5th, and 6th years) scored higher compared with pre-clinical students (1st, 2nd, and 3rd years). Conclusion This study showed above-average knowledge scores regarding breast cancer. More efforts to correct misinformation, through reassessing the university curriculum and promoting awareness about breast cancer are required.

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Comparative analysis of the long-term effect of two families of high-flux polysulfone dialysers on platelet count: a retrospective cross-sectional study

Therapeutics and Clinical Risk Management ◽

10.2147/tcrm.s143708 ◽

2017 ◽

Vol Volume 13 ◽

pp. 1415-1422 ◽

Cited By ~ 1

Author(s):

Rosaria Del Giorno ◽

Lorenzo Berwert ◽

Silvio Pianca ◽

Giorgia Bianchi ◽

Olivier Giannini ◽

...

Keyword(s):

Platelet Count ◽

Comparative Analysis ◽

Cross Sectional Study ◽

Term Effect ◽

High Flux ◽

Sectional Study ◽

Cross Sectional ◽

Long Term Effect

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247 Cross sectional study of vitamin D and associated clinical features from a large adult CF unit

Journal of Cystic Fibrosis ◽

10.1016/s1569-1993(12)60416-0 ◽

2012 ◽

Vol 11 ◽

pp. S119

Author(s):

D.J. Dhasmana ◽

K. Rowland-Jones ◽

W. Banya ◽

N. Simmonds

Keyword(s):

Vitamin D ◽

Clinical Features ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional ◽

Large Adult

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Impact of metabolic syndrome and clinical features on functioning in patients with bipolar disorder: a cross-sectional study

Brazilian Journal of Psychiatry ◽

10.1590/1516-4446-2019-0622 ◽

2020 ◽

Vol 42 (4) ◽

pp. 373-381

Author(s):

Hanife Kocakaya ◽

Emrah Songur ◽

Sedat Batmaz ◽

Zekiye Çelikbaş ◽

Önder Küçük

Keyword(s):

Metabolic Syndrome ◽

Bipolar Disorder ◽

Clinical Features ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional

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The prevalence and clinical features of depressive syndrome in children with epilepsy in Cipto Mangunkusumo Hospital, Jakarta

Paediatrica Indonesiana ◽

10.14238/pi44.5.2004.193-6 ◽

2016 ◽

Vol 44 (5) ◽

pp. 193

Author(s):

Rini Sunarwati ◽

Dwi Putro Widodo ◽

Bambang Madiyono ◽

Willy Edith HP

Keyword(s):

Clinical Features ◽

Cross Sectional Study ◽

Depressive Syndrome ◽

Pediatric Epilepsy ◽

Depression Symptoms ◽

Child Depression ◽

Sectional Study ◽

Cross Sectional ◽

Symptoms Of Depression ◽

Child Depression Inventory

Background Symptoms of depression often emerge in childrenwith epilepsy, but parents or caregivers are not always able torecognize them.Objective To assess the prevalence and clinical features of de-pressive syndrome among pediatric epilepsy patients in CiptoMangunkusumo Hospital, Jakarta.Methods This was a cross-sectional study on children aged 8-18 years. Child Depression Inventory (CDI) was used as theinstrument for assessing depressive symptoms.Results Depressive syndrome was found in 34 out of 89 subjects.The three most frequent depression symptoms were self-deprecation (via peer comparison), indecisiveness, and pessimism.Frequency of seizures, mode of therapy, and EEG result wereimportant factors in the development of depressive syndrome inchildren with epilepsy.Conclusions The prevalence of depressive syndrome in childrenwith epilepsy was 38%. Symptoms of depression mostly found inthis study were self-deprecation (via peer comparison), indecisive-ness, and pessimism

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Platelet count can predict the grade of esophageal varices in cirrhotic patients: a cross-sectional study

F1000Research ◽

10.12688/f1000research.28005.2 ◽

2021 ◽

Vol 10 ◽

pp. 101

Author(s):

Anum Afsar ◽

Muhammad Nadeem ◽

Syed Asim Ali Shah ◽

Huma Hussain ◽

Aysha Rani ◽

...

Keyword(s):

Platelet Count ◽

Negative Correlation ◽

Esophageal Varices ◽

Significant Negative Correlation ◽

Cross Sectional Study ◽

Variceal Hemorrhage ◽

Sectional Study ◽

Cross Sectional ◽

Grade Ii ◽

Cirrhotic Patients

Background: Bleeding from esophageal varices is a life-threatening complication in cirrhosis. Screening endoscopy is recommended in cirrhotic patients to identify patients at risk of variceal hemorrhage, but this is an invasive procedure and has limitations. Therefore, thrombocytopenia has been proposed to predict the existence and grade of esophageal varices. The aim of the current study was to determine a correlation between platelet count and grades of esophageal varices in patients with liver cirrhosis. Methods: This cross-sectional study was conducted at the POF Hospital, Wah Cantt from 1st October, 2017 to 30th May, 2018. Newly diagnosed cases of cirrhosis having varices of any grade on endoscopy were included. Endoscopic findings of patients were standardized using Paquet grading system. On the basis of platelet count, patients were divided into four subgroups. Platelet count groups were correlated with grading of esophageal varices using Spearman rank correlations. Chi Square test was used to see association between the platelet count and grade of esophageal varices. Results: 110 patients were included in the study, 55.5% (n=61) were male. Mean age of the patients was 59.89±9.01 years. Platelet count was <50,000/uL in 35.5% patients, 50,000-99,000/uL in 26.4%, 100,000-150000 in 12.7%, and >150,000/uL in 25.5% patients. Grade I esophageal varices were found in 23.6% of patients, whereas grade II, III and IV were found in 24.5%, 33.6% and 18.2% of patients, respectively. Mean platelet count was 213884.62/mm3 in patients with grade I varices, whereas it was 119518.52/mm3, 58386.49/mm3 and 21600.00/mm3 in patients with grade II, III and IV varices, respectively (p=<0.0001). A significant negative correlation between platelet count and grades of esophageal varices was found (p<0.001). Conclusion: Platelet count can predict the grade of esophageal varices in cirrhotic patients. There is significant negative correlation between platelet count and grades of esophageal varices.

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