scholarly journals Analysis of dux4 expression in bone marrow and re-discussion of dux4 function in the health and disease

2021 ◽  
Author(s):  
Ceren Hangul ◽  
Oznur Tokta ◽  
Sibel Berker Karauzum ◽  
Bahar Akkaya ◽  
Hulya Yildirim ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Health And Disease

scholarly journals Quantification of plasma cell dynamics using mathematical modelling

2018 ◽  
Vol 5 (1) ◽  
pp. 170759 ◽  
Author(s):  
Marcel Mohr ◽  
Dirk Hose ◽  
Anja Seckinger ◽  
Anna Marciniak-Czochra
Keyword(s):  
Mathematical Model ◽  
Bone Marrow ◽  
Mathematical Modelling ◽  
Plasma Cells ◽  
Cell Dynamics ◽  
Growth And Survival ◽  
Specific Antibodies ◽  
Health And Disease ◽  
Potential Basis ◽  
The Impact

Plasma cells (PCs) are the main antibody-producing cells in humans. They are long-lived so that specific antibodies against either pathogens or vaccines are produced for decades. PC longevity is attributed to specific areas within the bone marrow micro-environment, the so-called ‘niche’, providing the cells with required growth and survival factors. With antigen encounters, e.g. infection or vaccination, new PCs are generated and home to the bone marrow where they compete with resident PCs for the niche. We propose a parametrized mathematical model describing healthy PC dynamics in the bone marrow. The model accounts for competition for the niche between newly produced PCs owing to vaccination and resident PCs. Mathematical analysis and numerical simulations of the model allow explanation of the recovery of PC homoeostasis after a vaccine-induced perturbation, and the fraction of vaccine-specific PCs inside the niche. The model enables quantification of the niche-related dynamics of PCs, i.e. the duration of PC transition into the niche and the impact of different rates for PC transitions into and out of the niche on the observed cell dynamics. Ultimately, it provides a potential basis for further investigations in health and disease.

scholarly journals 3D models of the bone marrow in health and disease: yesterday, today, and tomorrow

2018 ◽  
Vol 9 (01) ◽  
pp. 37-52 ◽  
Author(s):  
Annamarija Raic ◽  
Toufik Naolou ◽  
Anna Mohra ◽  
Chandralekha Chatterjee ◽  
Cornelia Lee-Thedieck
Keyword(s):  
Bone Marrow ◽  
3D Models ◽  
Health And Disease ◽  
Image Position

Abstract

scholarly journals Quantification and three-dimensional microanatomical organization of the bone marrow

2017 ◽  
Vol 1 (6) ◽  
pp. 407-416 ◽  
Author(s):  
Cesar Nombela-Arrieta ◽  
Markus G. Manz
Keyword(s):  
Bone Marrow ◽  
Blood Cells ◽  
Structural Organization ◽  
Imaging Techniques ◽  
White Blood Cells ◽  
Three Dimensional ◽  
The Body ◽  
Cellular Composition ◽  
Spatial Logic ◽  
Health And Disease

Abstract Bone marrow (BM) constitutes one of the largest organs in mice and humans, continuously generating, in a highly regulated manner, red blood cells, platelets, and white blood cells that together form the majority of cells of the body. In this review, we provide a quantitative overview of BM cellular composition, we summarize emerging knowledge on its structural organization and cellular niches, and we argue for the need of multidimensional approaches such as recently developed imaging techniques to uncover the complex spatial logic that underlies BM function in health and disease.

scholarly journals Osteoimmunology: Interactions of the Bone and Immune System

2008 ◽  
Vol 29 (4) ◽  
pp. 403-440 ◽  
Author(s):  
Joseph Lorenzo ◽  
Mark Horowitz ◽  
Yongwon Choi
Keyword(s):  
Bone Marrow ◽  
Immune System ◽  
Immune Cells ◽  
Bone Cells ◽  
The Other ◽  
Organ Systems ◽  
Health And Disease ◽  
The Many ◽  
And Function ◽  
Broad Overview

Abstract Bone and the immune system are both complex tissues that respectively regulate the skeleton and the body’s response to invading pathogens. It has now become clear that these organ systems often interact in their function. This is particularly true for the development of immune cells in the bone marrow and for the function of bone cells in health and disease. Because these two disciplines developed independently, investigators in each don’t always fully appreciate the significance that the other system has on the function of the tissue they are studying. This review is meant to provide a broad overview of the many ways that bone and immune cells interact so that a better understanding of the role that each plays in the development and function of the other can develop. It is hoped that an appreciation of the interactions of these two organ systems will lead to better therapeutics for diseases that affect either or both.

The bone marrow microenvironment in health and disease at a glance

2018 ◽  
Vol 131 (4) ◽  
pp. jcs201707 ◽  
Author(s):  
Rahul Kumar ◽  
P. Sonika Godavarthy ◽  
Daniela S. Krause
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Microenvironment ◽  
Health And Disease

scholarly journals What a Clinical Hematologist Should Know about T Cells?

2020 ◽  
pp. 20-32
Author(s):  
Sanjeev Kumar Sharma
Keyword(s):  
Bone Marrow ◽  
T Cells ◽  
T Cell ◽  
Short Review ◽  
Cell Precursor ◽  
Peripheral Tissues ◽  
Memory T Cell ◽  
Basic Understanding ◽  
Health And Disease ◽  
Secondary Lymphoid Organs

T cell’s journey begins from the bone marrow and ends in the peripheral tissues by either fighting the infections or residing in the secondary lymphoid organs as memory T cell. Thymus plays most important role in transforming a docile T cell precursor into a warrior. T cell is one of the most important cells in health and disease. Various diseases originate from qualitative or quantitative defects in T cells leading to various inherited and acquired diseases. This simple and short review is focused on the basic understanding and clinical hematologist’s perspective of T cells.

scholarly journals Bone Vasculature and Bone Marrow Vascular Niches in Health and Disease

2020 ◽  
Vol 35 (11) ◽  
pp. 2103-2120 ◽  
Author(s):  
Junyu Chen ◽  
Michelle Hendriks ◽  
Alexandros Chatzis ◽  
Saravana K Ramasamy ◽  
Anjali P Kusumbe
Keyword(s):  
Bone Marrow ◽  
Health And Disease ◽  
Bone Vasculature

scholarly journals Bone marrow and bone: a functional unit

2002 ◽  
Vol 173 (3) ◽  
pp. 387-394 ◽  
Author(s):  
JE Compston
Keyword(s):  
Bone Marrow ◽  
Immune Cells ◽  
Bone Cells ◽  
Bone Remodelling ◽  
Functional Unit ◽  
Bone Cell ◽  
Unit Cells ◽  
Health And Disease ◽  
The Relationship ◽  
Bone Physiology

Bone and bone marrow, although often regarded as separate systems, function as a single unit. Cells in the bone marrow are the precursors of bone remodelling cells and exert an important regulatory role both on their own development and the remodelling process, acting as mediators for the effects of systemic and local factors. Other cells, such as immune cells and megakaryocytes, also contribute to the regulation of bone cell development and activity. Many diseases that affect the bone marrow have profound effects on bone, involving interactions between abnormal and normal marrow cells and those of bone. Although recent advances in bone physiology have produced new insights into the relationship between bone marrow and bone cells, much remains to be learnt about the mechanisms by which marrow and bone act in synergy to regulate bone remodelling, both in health and disease.

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