The Association of Pulmonary Functions with Glycemic Control and Microvascular Complications in Patients with Type II Diabetes Mellitus

2015 ◽  
Vol 16 (2) ◽  
pp. 48-52
Author(s):  
Gülay Ulusal Okyay ◽  
Ezgi Coskun Yenigün ◽  
Ahmet Hondur ◽  
Yildiz Coruh ◽  
Cagla Pinar Tastan Uzunmehmetoglu ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Glycemic Control ◽  
Type Ii Diabetes ◽  
Microvascular Complications ◽  
Type Ii Diabetes Mellitus ◽  
Type Ii ◽  
Pulmonary Functions

scholarly journals Status and Effect of Vitamin D on Microvascular Complication in Type II Diabetes Mellitus Patients

2017 ◽  
Vol 21 (1) ◽  
pp. 34-37
Author(s):  
P Krushna Kishore ◽  
Ipsita Choudhary
Keyword(s):  
Diabetes Mellitus ◽  
Vitamin D ◽  
Glycemic Control ◽  
Type Ii Diabetes ◽  
Microvascular Complications ◽  
Hypovitaminosis D ◽  
Type Ii Diabetes Mellitus ◽  
Microvascular Complication ◽  
Type Ii ◽  
Vitamin D Levels

ABSTRACT Introduction Vitamin D has a great impact on human health and disease. Recent studies proved that hypovitaminosis D is a possible risk factor for the pathogenesis of diabetes and its complications. In the present study, we evaluated vitamin D levels and its correlation with the duration of diabetes, sex, glycosylated hemoglobin (HbA1C), and microvascular complications in type II diabetes mellitus (T2DM) patients with and without microvascular complications. Objectives To study and correlate vitamin D levels and its relation with duration of diabetes, sex, glycemic control, and microvascular complication in T2DM patients with and without microvascular complications. Materials and methods Cross-sectional case–control study of 200 patients (35–70 years) suffering from T2DM was included. The T2DM patients without microvascular complications served as control group. Enrolled subjects underwent complete physical examination to detect the presence of microvascular complications, which includes microfilament tests, detailed fundus examination, urinary microalbumin/creatinine ratio. Fasting blood sugar, HbA1C, and serum vitamin D were also measured by using serum sample. Results Prevalence of vitamin D deficiency and insufficiency was found to be significantly higher in T2DM patients with microvascular complications (19.54 ± 2.56 vs 28.57 ± 2.93) as compared with T2DM patients without microvascular complications (p < 0.001). Hypovitaminosis D was found to be significantly more in females (60.75%) compared with males (39.96%) in both the study groups (p < 0.0001). Hypovitaminosis D was correlated with glycemic control and prevalence of microvascular complications. Conclusion Vitamin D is correlated with glycemic status and sex difference and has a role in pathogenesis of T2DM and its complications. How to cite this article Kishore PK, Choudhary I. Status and Effect of Vitamin D on Microvascular Complication in Type II Diabetes Mellitus Patients. Indian J Med Biochem 2017;21(1):34-37.

scholarly journals Association of Hyperuricemia and Urinary Albumin Excretion with Glycosylated Hemoglobin in Patients with Type II Diabetes Mellitus

2017 ◽  
Vol 2 (1) ◽  
pp. 1-6
Author(s):  
Jai P Yogi ◽  
Anita Semar
Keyword(s):  
Diabetes Mellitus ◽  
Uric Acid ◽  
Glycemic Control ◽  
Serum Uric Acid ◽  
Type Ii Diabetes ◽  
Microvascular Complications ◽  
Glycosylated Hemoglobin ◽  
Positive Association ◽  
Type Ii Diabetes Mellitus ◽  
Type Ii

ABSTRACT Type II diabetes mellitus (DM) is the most common endocrine disorder and a leading cause of morbidity and mortality across the world. Long-standing diabetes and a poor glycemic control are the major factors which contribute to the development of various microvascular complications of diabetes. Microvascular changes in kidneys lead to microalbuminuria, which may further lead to end-stage renal disease (ESRD) if left untreated. Elevated serum uric acid level has been recognized as a marker of endothelial dysfunction which contributes to the development of microvascular changes in various organs. The main objective of the present study was to assess the association of serum uric acid and urine microalbumin levels with glycosylated hemoglobin (HbA1c) in type II DM patients. One hundred diagnosed cases of type II DM were enrolled for the study. Blood samples were collected and estimated for fasting blood sugar, serum uric acid, and HbA1c. Also, 24-hour urine samples were collected and analyzed for microalbumin. A positive association (r = 0.203) was observed between HbA1c and serum uric acid. The study also suggested a positive association between glycemic control and microalbuminuria (r = 0.237) in diabetic patients. A strong positive association was also observed between uric acid and urine microalbumin levels (r = 0.338). Findings of the study, therefore, recommend that development of microvascular complications in type II DM patients can be averted by adopting dietary control and healthy lifestyle changes. Strict glycemic control and lowering of serum uric acid levels can be helpful in minimizing the risk of developing nephropathy and its progression toward ESRD. How to cite this article Fiza B, Yogi JP, Choudhary J, Semar A, Sinha M. Association of Hyperuricemia and Urinary Albumin Excretion with Glycosylated Hemoglobin in Patients with Type II Diabetes Mellitus. J Mahatma Gandhi Univ Med Sci Tech 2017;2(1):1-6.

scholarly journals Correlation of microalbuminuria with neuropathy in type-II diabetes mellitus patients

2018 ◽  
Vol 5 (5) ◽  
pp. 1143
Author(s):  
P. K. Bariha ◽  
K. M. Tudu ◽  
Shiny Thomas Kujur
Keyword(s):  
Diabetes Mellitus ◽  
Type Ii Diabetes ◽  
Microvascular Complications ◽  
Type Ii Diabetes Mellitus ◽  
Motor Neuropathy ◽  
Type Ii ◽  
Study Population ◽  
Factor Evaluation ◽  
The Mean ◽  
Microvascular And Macrovascular Complications

Background: The microvascular and macrovascular complications in diabetes mellitus resulting in microalbuminuria and diabetic neuropathy in common in developing country like India. The aim of the study has been undertaken to emphasis upon the association of microalbuminuria with neuropathy.Methods: The study was undertaken among 124 Type-II diabetes patients in the Department of Medicine, VIMSAR, Burla, Odisha between October 2015 to September 2017. Detail history, clinical examination, BMI, laboratory investigation like FBS, PPBS, HbA1C, nerve conduction study was done, and data were analysed and compiled.Results: Out of 124 patients the mean age of male patients in the study was 49.75 years and that of female patients was 50.36 years. The mean age of the study population was 50.18 years. The mean BMI in patients with and without microalbuminuria was 23.95±2.04kg/m2 and 21.57±2.89kg/m2 respectively. The mean HbA1C value in patients with and without microalbuminuria was 9.96±3.380 and 8.75±3.25 respectively.Conclusions: Microalbuminuria is significantly associated with presence of neuropathy. The most common type of neuropathy observed in this study was distal symmetrical sensory motor neuropathy. Hence, microalbuminuria has an important role as a biochemical marker for risk factor evaluation of microvascular complications in type 2 diabetes mellitus.

scholarly journals Evaluation of the Relationship between Type II Diabetes Mellitus and the Prevalence of Apical Periodontitis in Root-Filled Teeth Using Cone Beam Computed Tomography: An Observational Cross-Sectional Study

2019 ◽  
Vol 28 (6) ◽  
pp. 533-538
Author(s):  
Selen Nihal Sisli
Keyword(s):  
Diabetes Mellitus ◽  
Computed Tomography ◽  
Glycemic Control ◽  
Cone Beam Computed Tomography ◽  
Type Ii Diabetes ◽  
Type Ii Diabetes Mellitus ◽  
Apical Periodontitis ◽  
Cone Beam ◽  
Control Group ◽  
Type Ii

Objective: This study aimed to investigate the prevalence of apical periodontitis (AP) in patients with type II diabetes mellitus (DM) with either optimal glycemic control (OGC) or poor glycemic control (PGC) compared with nondiabetics using cone beam computed tomography (CBCT). Subjects and Methods: The periapical status of 75 teeth with adequate root canal treatment performed at least 1 year ago that could be visualized in the field of view of CBCT images of 43 DM patients (29 females, 14 males) was compared with a control group consisting of 162 teeth of 86 nondiabetics (56 females, 30 males). In addition, the DM group was divided into subgroups according to the patients’ mean glycated hemoglobin level as either having OGC or PGC. The periapical status of the teeth was evaluated using the CBCT periapical index (CBCTPAI), and AP was diagnosed as a CBCTPAI ≥1. χ2, Fisher’s exact test, and independent-samples t tests were used for the statistical analysis, and p < 0.05 was considered significant. Results: Significant differences between the DM group and the control group were observed (p< 0.05) in terms of AP (the frequencies of both CBCTPAI ≥1 and CBCTPAI ≥3) and the frequency of cardiovascular disease, while there were no significant differences between the DM subgroups (p > 0.05). Conclusion: The prevalence of AP and severe bone destruction in periapical tissues was significantly higher in the DM patients compared with the nondiabetic patients.

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