The relationship between microscopic hematuria and bladder cancer: are currently available diagnostic methods reliable?

The article shows the need to develop diagnostic methods for monitoring the quality of lubrication systems, which makes it possible to study the dynamic processes of contacting elements of the friction systems of instrument mechanisms, taking into account roughness parameters, the presence of local surface defects of elements and the bearing capacity of a lubricant. In the present article, a modern diagnostic model has been developed to control the quality of the processes of production and operation of friction systems of instrument assemblies. With the help of the developed model, it becomes possible to establish the relationship of diagnostic and design parameters of the mechanical system, as well as the appearance of possible local defects and lubricant state, which characterize the quality of friction systems used in many mechanical assemblies of the mechanisms of devices. The research results are shown in the form of nomograms to assess the defects of the elements of friction mechanisms of the mechanisms of the devices.

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The Analysis of PTPN6 for Bladder Cancer: An Exploratory Study Based on TCGA

Disease Markers ◽

10.1155/2020/4312629 ◽

2020 ◽

Vol 2020 ◽

pp. 1-8

Author(s):

Chengquan Shen ◽

Jing Liu ◽

Jirong Wang ◽

Xiaokun Yang ◽

Haitao Niu ◽

...

Keyword(s):

Bladder Cancer ◽

T Cells ◽

Survival Analysis ◽

Prognostic Value ◽

Molecular Mechanisms ◽

Tyrosine Phosphatase ◽

Gene Set Enrichment Analysis ◽

Expression Level ◽

Pathologic Features ◽

The Relationship

PTPN6 (protein tyrosine phosphatase nonreceptor type 6), a tyrosine phosphatase, is known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Previous studies have demonstrated that PTPN6 expression is relatively elevated in several malignancies. However, the role of PTPN6 in bladder cancer (BC) remains unclear. The purpose of this study was to explore the prognostic value of PTPN6 in BC. RNA-seq data from The Cancer Genome Atlas (TCGA) was used to identify the expression level of PTPN6 in BC. The relationship between clinical pathologic features and PTPN6 were analyzed with the Wilcoxon signed-rank test. The prognostic and predictive value of PTPN6 was evaluated by survival analysis and nomogram. Gene Set Enrichment Analysis (GSEA) was conducted to explore the potential molecular mechanisms of PTPN6 in BC. Finally, Tumor Immune Estimation Resource (TIMER) was applied to investigate the relationship between PTPN6 and immune cell infiltration in the tumor microenvironment. Results indicated that PTPN6 was overexpressed in BC tissues compared with normal bladder tissues and was significantly correlated with grade, stage, T, and N. Survival analysis showed that low expression of PTPN6 was significantly related to the poor overall survival (OS) in BC patients. Coexpression analysis showed that PTPN6 and TNFRSF14 (Tumor necrosis factor receptor superfamily member 14) have a close correlation in BC. GSEA showed that multiple cancer-associated signaling pathways are differentially enriched in the PTPN6 high expression phenotype. Moreover, the expression level of PTPN6 was positively associated with the infiltration of B cells, CD4+T cells, dendritic cells, and neutrophils and negatively associated with CD8+ T cells and macrophages in BC. In conclusion, we identified that PTPN6 may be a novel prognostic biomarker in BC based on the TCGA database. Further clinical trials are needed to confirm our observations and mechanisms underlying the prognostic value of PTPN6 in BC also deserve further experimental exploration.

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Involvement of the Androgen and Glucocorticoid Receptors in Bladder Cancer

International Journal of Endocrinology ◽

10.1155/2015/384860 ◽

2015 ◽

Vol 2015 ◽

pp. 1-10 ◽

Cited By ~ 9

Author(s):

Lucien McBeth ◽

Maria Grabnar ◽

Steven Selman ◽

Terry D. Hinds

Keyword(s):

Bladder Cancer ◽

Glucocorticoid Receptors ◽

Lifestyle Risk Factors ◽

Glucocorticoid Signaling ◽

Major Player ◽

Inflammatory Processes ◽

Lifestyle Risk ◽

Relationship Of ◽

The Relationship ◽

Male To Female

Bladder cancer is encountered worldwide having been associated with a host of environmental and lifestyle risk factors. The disease has a male to female prevalence of 3 : 1. This disparity has raised the possibility of the androgen receptor (AR) pathway being involved in the genesis of the disease; indeed, research has shown that AR is involved in and is likely a driver of bladder cancer. Similarly, an inflammatory response has been implicated as a major player in bladder carcinogenesis. Consistent with this concept, recent work on anti-inflammatory glucocorticoid signaling points to a pathway that may impact bladder cancer. The glucocorticoid receptor- (GR-)αisoform has an important role in suppressing inflammatory processes, which may be attenuated by AR in the development of bladder cancer. In addition, a GR isoform that is inhibitory to GRα, GRβ, is proinflammatory and has been shown to induce cancer growth. In this paper, we review the evidence of inflammatory mediators and the relationship of AR and GR isoforms as they relate to the propensity for bladder cancer.

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Study on Diagnostic Methods to Evaluate the Relationship Between Fuel Injection Pattern and Spray Characteristics at the Swirl Nozzle Injector.

TRANSACTIONS OF THE JAPAN SOCIETY OF MECHANICAL ENGINEERS Series B ◽

10.1299/kikaib.69.504 ◽

2003 ◽

Vol 69 (678) ◽

pp. 504-511

Author(s):

Tsuneaki ISHIMA ◽

Ryoichi SUKENA ◽

Tomio OBOKATA ◽

Katsuyoshi KAWACHI ◽

Kazumitsu KOBAYASHI

Keyword(s):

Fuel Injection ◽

Diagnostic Methods ◽

Spray Characteristics ◽

The Relationship

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1788 THE RELATIONSHIP BETWEEN RENIN-ANGIOTENSIN SYSTEM BLOCKADE AND TUMOR RECURRENCE IN NON-MUSCLE INVASIVE BLADDER CANCER

The Journal of Urology ◽

10.1016/j.juro.2013.02.2878 ◽

2013 ◽

Vol 189 (4S) ◽

Author(s):

Kazuyuki Yuge ◽

Akira Miyajima ◽

Nobuyuki Tanaka ◽

Suguru Shirotake ◽

Takeo Kosaka ◽

...

Keyword(s):

Bladder Cancer ◽

Tumor Recurrence ◽

Renin Angiotensin System ◽

Invasive Bladder Cancer ◽

Muscle Invasive Bladder Cancer ◽

Angiotensin System ◽

Renin Angiotensin ◽

Muscle Invasive ◽

The Relationship

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THE RELATIONSHIP BETWEEN THE ESTIMATED TUMOR GROWTH SPEED AND INDICES OF BROMODEOXYURIDINE (BrdU) INCORPORATION AND THE PROLIFERATING CELL NUCLEAR ANTIGEN (PCNA) EXPRESSION IN SUPERFICIAL BLADDER CANCER

The Japanese Journal of Urology ◽

10.5980/jpnjurol1989.88.868 ◽

1997 ◽

Vol 88 (10) ◽

pp. 868-873 ◽

Cited By ~ 1

Author(s):

Tomonori Ota ◽

Hideyuki Akaza ◽

Kazunori Hattori ◽

Katsunori Uchida

Keyword(s):

Bladder Cancer ◽

Tumor Growth ◽

Proliferating Cell Nuclear Antigen ◽

Superficial Bladder Cancer ◽

Nuclear Antigen ◽

Brdu Incorporation ◽

Growth Speed ◽

The Relationship ◽

Proliferating Cell

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Fewer tumour draining sentinel nodes in patients with progressing muscle invasive bladder cancer, after neoadjuvant chemotherapy and radical cystectomy

World Journal of Urology ◽

10.1007/s00345-019-03025-w ◽

2019 ◽

Vol 38 (9) ◽

pp. 2207-2213

Author(s):

Julia Alvaeus ◽

Robert Rosenblatt ◽

Markus Johansson ◽

Farhood Alamdari ◽

Tomasz Jakubczyk ◽

...

Keyword(s):

Bladder Cancer ◽

Neoadjuvant Chemotherapy ◽

Radical Cystectomy ◽

Progressive Disease ◽

Clinical Staging ◽

Invasive Bladder Cancer ◽

Muscle Invasive Bladder Cancer ◽

Sentinel Nodes ◽

Muscle Invasive ◽

The Relationship

Abstract Purpose To examine the relationship between the number of tumour draining sentinel nodes (SNs) and pathoanatomical outcomes, in muscle-invasive bladder cancer (MIBC), in patients undergoing neoadjuvant chemotherapy (NAC) and radical cystectomy (RC). Materials and Methods In an ongoing prospective multicenter study, we included 230 patients with suspected urothelial MIBC from ten Swedish urological centers. All underwent TURb and clinical staging. From the cohort, 116 patients with urothelial MIBC; cT2-cT4aN0M0, underwent radical cystectomy (RC) and lymphadenectomy with SN-detection (SNd). 83 patients received cisplatin-based NAC and 33 were NAC-naïve. The number and locations of detected SNs and non-SNs were recorded for each patient. The NAC treated patients were categorized by pathoanatomical outcomes post-RC into three groups: complete responders (CR), stable disease (SD) and progressive disease (PD). Selected covariates with possible impact on SN-yield were tested in uni -and multivariate analyses for NAC-treated patients only. Results In NAC treated patients, the mean number of SNs was significantly higher in CR patients (3.3) and SD patients (3.6) compared with PD patients (1.4) (p = 0.034). In a linear multivariate regression model, the number of harvested nodes was the only independent variable that affected the number of SNs (p = 0.0004). Conclusions The number of tumor-draining SNs in NAC-treated patients was significantly lower in patients with progressive disease.

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