scholarly journals A combined genotype of three SNPs in the bovine gene is related to growth performance in Chinese cattle

2017 ◽  
Vol 60 (4) ◽  
pp. 357-362 ◽  
Author(s):  
Jieping Huang ◽  
Qiuzhi Zheng ◽  
Shuzhe Wang ◽  
Qiongqiong Zhang ◽  
Lijun Jiang ◽  
...  
Keyword(s):  
Energy Metabolism ◽  
Growth Traits ◽  
Association Studies ◽  
Equilibrium Analysis ◽  
Production Traits ◽  
Bovine Gene ◽  
Chinese Cattle ◽  
Expression Of Genes ◽  
Potential Association ◽  
High Selection

Abstract. PPARD is involved in multiple biological processes, especially for those associated with energy metabolism. PPARD regulates lipid metabolism through up-regulate expression of genes associating with adipogenesis. This makes PPARD a significant candidate gene for production traits of livestock animals. Association studies between PPARD polymorphisms and production traits have been reported in pigs but are limited for other animals, including cattle. Here, we investigated the expression profile and polymorphism of bovine PPARD as well as their association with growth traits in Chinese cattle. Our results showed that the highest expression of PPARD was detected in kidney, following by adipose, which is consistent with its involvement in energy metabolism. Three SNPs of PPARD were detected and used to undergo selection pressure according the result of Hardy–Weinberg equilibrium analysis (P < 0.05). Moreover, all of these SNPs showed moderate diversity (0.25 < PIC < 0.5), indicating their relatively high selection potential. Association analysis suggested that individuals with the GAAGTT combined genotype of three SNPs detected showed optimal values in all of the growth traits analyzed. These results revealed that the GAAGTT combined genotype of three SNPs detected in the bovine PPARD gene was a significant potential genetic marker for marker-assisted selection in Chinese cattle. However, this should be further verified in larger populations before being applied to breeding.

scholarly journals Copy Number Variations and Expression Levels of Guanylate-Binding Protein 6 Gene Associated with Growth Traits of Chinese Cattle

Animals ◽  
2020 ◽  
Vol 10 (4) ◽  
pp. 566
Author(s):  
Dan Hao ◽  
Xiao Wang ◽  
Bo Thomsen ◽  
Haja N. Kadarmideen ◽  
Xiaogang Wang ◽  
...  
Keyword(s):  
Body Weight ◽  
Copy Number ◽  
Growth Traits ◽  
Binding Protein ◽  
Association Studies ◽  
Copy Number Variations ◽  
The Body ◽  
Expression Levels ◽  
Chinese Cattle ◽  
Guanylate Binding Protein

Association studies have indicated profound effects of copy number variations (CNVs) on various phenotypes in different species. In this study, we identified the CNV distributions and expression levels of guanylate-binding protein 6 (GBP6) associated with the growth traits of Chinese cattle. The results showed that the phenotypic values of body size and weight of Xianan (XN) cattle were higher than those of Nanyang (NY) cattle. The medium CNV types were mostly identified in the XN and NY breeds, but their CNV distributions were significantly different (adjusted p < 0.05). The association analysis revealed that the body weight, cannon circumference and chest circumference of XN cattle had significantly different values in different CNV types (p < 0.05), with CNV gain types (Log22−ΔΔCt > 0.5) displaying superior phenotypic values. We also found that transcription levels varied in different tissues (p < 0.001) and the CNV gain types showed the highest relative gene expression levels in the muscle tissue, consistent with the highest phenotypic values of body weight and cannon circumference among the three CNV types. Consequently, our results suggested that CNV gain types of GBP6 could be used as the candidate markers in the cattle-breeding program for growth traits.

A novel SNP of PLAG1 gene and its association with growth traits in Chinese cattle

Gene ◽  
2019 ◽  
Vol 689 ◽  
pp. 166-171 ◽  
Author(s):  
Jia-Lin Zhong ◽  
Jia-Wei Xu ◽  
Jian Wang ◽  
Yi-fan Wen ◽  
Hui Niu ◽  
...  
Keyword(s):  
Growth Traits ◽  
Chinese Cattle ◽  
Novel Snp

scholarly journals Prioritization of autoimmune disease-associated genetic variants that perturb regulatory element activity in T cells

2021 ◽  
Author(s):  
Kousuke Mouri ◽  
Michael H. Guo ◽  
Carl G. de Boer ◽  
Greg A. Newby ◽  
Matteo Gentili ◽  
...  
Keyword(s):  
T Cells ◽  
Autoimmune Disease ◽  
Association Studies ◽  
Regulatory Element ◽  
Genome Wide Association Studies ◽  
Expression Of Genes ◽  
Human T Cell ◽  
Allele Specific ◽  
Reporter Assays ◽  
Element Activity

Genome-wide association studies have uncovered hundreds of autoimmune disease-associated loci; however, the causal genetic variant(s) within each locus are mostly unknown. Here, we perform high-throughput allele-specific reporter assays to prioritize disease-associated variants for five autoimmune diseases. By examining variants that both promote allele-specific reporter expression and are located in accessible chromatin, we identify 60 putatively causal variants that enrich for statistically fine-mapped variants by up to 57.8-fold. We introduced the risk allele of a prioritized variant (rs72928038) into a human T cell line and deleted the orthologous sequence in mice, both resulting in reduced BACH2 expression. Naive CD8 T cells from mice containing the deletion had reduced expression of genes that suppress activation and maintain stemness. Our results represent an example of an effective approach for prioritizing variants and studying their physiologically relevant effects.

scholarly journals Mapping of quantitative trait loci influencing daily body weight gain (DBWG) on chromosome 6 in German Holstein population

2006 ◽  
Vol 22 (1-2) ◽  
pp. 35-46 ◽  
Author(s):  
M. Reißmann ◽  
P. Reinecke ◽  
U. Müller ◽  
S. Abdel-Rahman
Keyword(s):  
Body Weight ◽  
Weight Gain ◽  
Fine Mapping ◽  
Marker Assisted Selection ◽  
Growth Traits ◽  
Body Weight Gain ◽  
Chromosome 6 ◽  
Production Traits ◽  
Daily Body Weight ◽  
Holstein Population

Twelve microsatellite markers on chromosome 6 were analyzed in German Holstein population to detect and locate QTL affecting daily body weight gain (DBWG). The results indicate promising location for QTL controlling daily body weight gain trait on chromosome 6. Where, three markers BMS2508 BM3026 and TGLA37 at three different positions in a distance 15.2 cM on BTA6 were associated with significant effects for daily body weight gain trait (DBWG). Comparison between this finding and previously identified QTL support the location of a QTL for growth traits on chromosome 6, where a significant QTL for birth and yearling weight was previously identified on chromosome 6 tightly close to marker BM3026. Finding from this study could be used in subsequent fine-mapping work and applied to marker-assisted selection (MAS) of production traits.

scholarly journals The Effect of Different Programs of Exercise on The Expression of Genes Associated with Endurance and Energy Metabolism

2021 ◽  
pp. 482-490
Author(s):  
Neşe AKPINAR KOCAKULAK ◽  
Serpil TAHERİ ◽  
Elif Funda ŞENER ◽  
Kenan AYCAN ◽  
Yusuf ÖZKUL
Keyword(s):  
Energy Metabolism ◽  
Expression Of Genes

Genetic parameters for daily live-weight gain, live fleshiness and bone thinness in station-tested Piemontese young bulls

2001 ◽  
Vol 72 (3) ◽  
pp. 449-456 ◽  
Author(s):  
A. Albera ◽  
R. Mantovani ◽  
G. Bittante ◽  
A. F. Groen ◽  
P. Carnier
Keyword(s):  
Weight Gain ◽  
Genetic Parameters ◽  
Growth Traits ◽  
Genetic Correlations ◽  
Live Weight ◽  
Adaptation Period ◽  
Production Traits ◽  
Multiple Trait ◽  
Live Weight Gain ◽  
Total Gain

AbstractEstimates of genetic parameters for beef production traits were obtained for Piemontese cattle. Data were from 988 young bulls station-tested from 1989 till 1998. Bulls entered the station at 6 to 8 weeks of age and, after an adaptation period of 3 months, were tested for growth, live fleshiness and bone thinness. Length of test was 196 days. Growth traits considered were gain at farm, gain during the adaptation period, gain on test and total gain at the station. Six different fleshiness traits and bone thinness were scored on live animals at the end of the test using a linear system. Live evaluations of fleshiness were adjusted for the weight at scoring in order to provide an assessment of conformation independent of body size. Genetic parameters were estimated using animal models. Heritability of live-weight gain ranged from 0·20 in the adaptation period to 0·60 for total gain at the station. Genetic correlations between gains at station in different periods were high (from 0·63 to 0·97). Residual correlation between gain during the adaptation period and gain during test was negative, probably due to the occurrence of compensatory growth of the animals.Live fleshiness traits and bone thinness were of moderate to high heritability (from 0·34 to 0·55) and highly correlated indicating that heavy muscled bulls also have thin bones. Accuracy of breeding values and therefore response to selection were improved by multiple trait analysis of the live fleshiness traits and bone thinness. Overall weight gain at the station had a moderate negative genetic correlation with all live fleshiness traits and bone thinness (from –0·11 to –0·39).

scholarly journals Single nucleotide polymorphism of the β-lactoglobulin gene in sheep breeds reared in Bulgaria

2020 ◽  
Vol 23 (3) ◽  
pp. 295-303
Author(s):  
D. Gencheva
Keyword(s):  
Single Nucleotide Polymorphism ◽  
Polymorphic Locus ◽  
Association Studies ◽  
Allele Frequencies ◽  
Production Traits ◽  
Nucleotide Polymorphism ◽  
Single Nucleotide ◽  
Sheep Population ◽  
Sheep Breeds ◽  
Β Lactoglobulin

In the present study, single nucleotide polymorphism in exon II of the β-lactoglobulin gene was investigated in four Bulgarian sheep breeds: Bulgarian Dairy Synthetic Population sheep (BDSP), Copper-red Shumen sheep (CRSH), Stara Zagora sheep (STZG) and Pleven Blackhead sheep (PLBH). Two genetic variants of β-LG gene (A and B) have been identified through PCR-RFLP assay. A 103 bp fragment of the polymorphic β-LG locus were amplified and digested with endonuclease enzyme RsaI. The obtained restriction fragments revealed three genotypes: AA, AB and BB, observed in 31%, 65.5% and 3.5% of the BDSP population and in 48%, 28% and 24% of CRSH sheep population, respectively, with departure from the Hardy-Weinberg equilibrium (P<0.05) in these groups. The allele frequencies demonstrated a prevalence of the A allele (0.638 and 0.620) over the B allele (0.362 and 0.380) in both populations. On the contrary, the distribution of allele frequencies in STZG and PLBH was 0.240 and 0.100 for allele A, respectively and 0.760 and 0.900 for allele B. Therefore, the homozygous BB genotype in these sheep populations was more frequently encountered (0.520 and 0.800) than the heterozygous AB genotype (0.480 and 0.200), with HWE correspondence (P>0.1). The homozygous genotype AA was absent in STZG and PLBH sheep populations. The greatest Nei’s genetic distance calculated by UPGMA method was found between the populations BDSPand PLBH (0.5334), while the closest relationship (0.0006) was established between CRSH and BDSP. The results obtained from the present investigation confirmed the presence of the SNP polymorphism in exon II of the β-lactoglobulin gene. Therefore, the genetic variability established in this polymorphic locus could be applied in further association studies with milk production traits in sheep.

Effect of copy number variation of PLA2G2A gene to growth traits in Chinese cattle

Gene ◽  
2021 ◽  
pp. 146014
Author(s):  
Peng Yang ◽  
Cuicui Cai ◽  
Mengxiao Niu ◽  
Xian Liu ◽  
Hongli Wang ◽  
...  
Keyword(s):  
Copy Number Variation ◽  
Copy Number ◽  
Growth Traits ◽  
Chinese Cattle ◽  
Number Variation
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