scholarly journals Copy Number Variations and Expression Levels of Guanylate-Binding Protein 6 Gene Associated with Growth Traits of Chinese Cattle

Animals ◽  
2020 ◽  
Vol 10 (4) ◽  
pp. 566
Author(s):  
Dan Hao ◽  
Xiao Wang ◽  
Bo Thomsen ◽  
Haja N. Kadarmideen ◽  
Xiaogang Wang ◽  
...  
Keyword(s):  
Body Weight ◽  
Copy Number ◽  
Growth Traits ◽  
Binding Protein ◽  
Association Studies ◽  
Copy Number Variations ◽  
The Body ◽  
Expression Levels ◽  
Chinese Cattle ◽  
Guanylate Binding Protein

Association studies have indicated profound effects of copy number variations (CNVs) on various phenotypes in different species. In this study, we identified the CNV distributions and expression levels of guanylate-binding protein 6 (GBP6) associated with the growth traits of Chinese cattle. The results showed that the phenotypic values of body size and weight of Xianan (XN) cattle were higher than those of Nanyang (NY) cattle. The medium CNV types were mostly identified in the XN and NY breeds, but their CNV distributions were significantly different (adjusted p < 0.05). The association analysis revealed that the body weight, cannon circumference and chest circumference of XN cattle had significantly different values in different CNV types (p < 0.05), with CNV gain types (Log22−ΔΔCt > 0.5) displaying superior phenotypic values. We also found that transcription levels varied in different tissues (p < 0.001) and the CNV gain types showed the highest relative gene expression levels in the muscle tissue, consistent with the highest phenotypic values of body weight and cannon circumference among the three CNV types. Consequently, our results suggested that CNV gain types of GBP6 could be used as the candidate markers in the cattle-breeding program for growth traits.

scholarly journals Copy Number Variation of the CADM2 Gene and Its Association with Growth Traits in Yak

Animals ◽  
2019 ◽  
Vol 9 (12) ◽  
pp. 1008 ◽  
Author(s):  
Fei Ge ◽  
Congjun Jia ◽  
Min Chu ◽  
Chunnian Liang ◽  
Ping Yan
Keyword(s):  
Body Weight ◽  
Copy Number Variation ◽  
Copy Number ◽  
Growth Traits ◽  
Quantitative Polymerase Chain Reaction ◽  
The Body ◽  
Gene Copy ◽  
Common Source ◽  
Economic Traits ◽  
Number Variation

Copy number variation (CNV) is currently accepted as a common source of genetic variation. It is reported that CNVs may influence the resistance to disease and complex economic traits, such as residual feed intake, muscle formation, and fat deposition in livestock. Cell adhesion molecule 2 (CADM2) is expressed widely in the brain and adipose tissue and can regulate body weight through the central nervous system. Growth traits are important economic traits for animal selection. In this study, we aimed to explore the effect of CADM2 gene copy number variants on yak growth traits. Here, two CNVs in the CADM2 gene were investigated using the quantitative polymerase chain reaction (qPCR), and the association of the CNVs with growth traits in yak was analyzed using statistical methods by SPSS software. Differences were considered significant if the p value was < 0.05. Statistical analysis indicated significant association of CADM2-CNV2 with the body weight of the Chinese Ashidan yak. A significant effect of CNV2 (p < 0.05) was found on body weight at 6 months. In CNV2, the gain-type copy number variation exhibited greater performance than the other variants, with greater body weight observed at 6 months (p < 0.05). To the best of our knowledge, this is the first attempt to investigate the function of CADM2-CNVs and their association with growth traits in animals. This may be a useful candidate marker in marker-assisted selection of yaks.

Associations of MYH3 gene copy number variations with transcriptional expression and growth traits in Chinese cattle

Gene ◽  
2014 ◽  
Vol 535 (2) ◽  
pp. 106-111 ◽  
Author(s):  
Yao Xu ◽  
Tao Shi ◽  
Hanfang Cai ◽  
Yang Zhou ◽  
Xianyong Lan ◽  
...  
Keyword(s):  
Copy Number ◽  
Growth Traits ◽  
Gene Copy Number ◽  
Copy Number Variations ◽  
Gene Copy ◽  
Transcriptional Expression ◽  
Chinese Cattle ◽  
Myh3 Gene

Associations of GBP2 gene copy number variations with growth traits and transcriptional expression in Chinese cattle

Gene ◽  
2018 ◽  
Vol 647 ◽  
pp. 101-106 ◽  
Author(s):  
Gui-Min Zhang ◽  
Li Zheng ◽  
Hua He ◽  
Cheng-Chuang Song ◽  
Zi-Jing Zhang ◽  
...  
Keyword(s):  
Copy Number ◽  
Growth Traits ◽  
Gene Copy Number ◽  
Copy Number Variations ◽  
Gene Copy ◽  
Transcriptional Expression ◽  
Chinese Cattle

scholarly journals Detection of 15-bp Deletion Mutation within PLAG1 Gene and Its Effects on Growth Traits in Goats

Animals ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. 2064
Author(s):  
Zhenyu Wei ◽  
Ke Wang ◽  
Hui Wu ◽  
Zhen Wang ◽  
Chuanying Pan ◽  
...  
Keyword(s):  
Body Weight ◽  
Growth Traits ◽  
Body Height ◽  
The Body ◽  
Chest Circumference ◽  
Dairy Goat ◽  
Cashmere Goat ◽  
Indel Mutation ◽  
Body Stature ◽  
Body Index

Stature and weight are important growth and development traits for animals, which also significantly affect the productivity of livestock. Polymorphic adenoma gene 1 (PLAG1) is located in the growth-related quantitative trait nucleotides (QTN), and its variation has been determined to significantly affect the body stature of bovines. This study found that novel 15-bp InDel could significantly influence important growth traits in goats. The frequencies of genotypes of the 15-bp mutation and relationship with core growth traits such as body weight, body height, height at hip cross, chest circumference, hip width and body index were explored in 1581 individuals among 4 Chinese native goat breeds. The most frequent genotypes of Shaanbei white Cashmere goat (SWCG), Inner Mongolia White Cashmere goat (IMCG) and Guanzhong Dairy goat (GZDG) were II genotypes (insertion/insertion), and the frequency of ID genotype (insertion/deletion) was found to be slightly higher than that of II genotype in Hainan Black goat (HNBG), showing that the frequency of the I allele was higher than that of the D allele. In adult goats, there were significant differences between 15-bp variation and body weight, chest circumference and body height traits in SWCG (p < 0.05). Furthermore, the locus was also found to be significantly correlated with the body index of HNBG (p = 0.044) and hip width in GZDG (p = 0.002). In regard to lambs, there were significant differences in height at the hip cross of SWCG (p = 0.036) and hip width in IMWC (p = 0.005). The corresponding results suggest that the 15-bp InDel mutation of PLAG1 is associated with the regulation of important growth characteristics of both adult and lamb of goats, which may serve as efficient molecular markers for goat breeding.

Effect of copy number variation of PLA2G2A gene to growth traits in Chinese cattle

Gene ◽  
2021 ◽  
pp. 146014
Author(s):  
Peng Yang ◽  
Cuicui Cai ◽  
Mengxiao Niu ◽  
Xian Liu ◽  
Hongli Wang ◽  
...  
Keyword(s):  
Copy Number Variation ◽  
Copy Number ◽  
Growth Traits ◽  
Chinese Cattle ◽  
Number Variation

scholarly journals Novel copy number variations of the CHRM3 gene associated with gene expression and growth traits in Chinese Datong yak (Bos grunniens)

2020 ◽  
Vol 48 (1) ◽  
pp. 156-165
Author(s):  
Habtamu Abera Goshu ◽  
Wu Xiaoyun ◽  
Min Chu ◽  
Bao Pengjia ◽  
Ding Xue Zhi ◽  
...  
Keyword(s):  
Gene Expression ◽  
Copy Number ◽  
Growth Traits ◽  
Copy Number Variations ◽  
Bos Grunniens

scholarly journals The effect of lycopene and vitamin E on the growth performance, quality and oxidative stability of chicken leg meat

2011 ◽  
Vol 56 (No. 12) ◽  
pp. 536-544 ◽  
Author(s):  
M. Englmaierová ◽  
I. Bubancová ◽  
T. Vít ◽  
M. Skřivan
Keyword(s):  
Body Weight ◽  
Vitamin E ◽  
Oxidative Stability ◽  
Dry Matter ◽  
Growth Traits ◽  
Cholesterol Content ◽  
The Body ◽  
Control Treatment ◽  
Dietary Vitamin ◽  
Control Group

&nbsp;A 2 &times; 3 factorial design experiment was conducted to evaluate the effect of adding lycopene <br />(0 and 75 mg/kg) and vitamin E (0.50 and 100 mg/kg) to the diet of chickens. Moreover, the study investigated growth traits, oxidative stability and chemical composition of leg meat and the vitamin content of meat and liver. The study was conducted using five hundred and forty Ross 308 male broilers that were assigned to one of the six dietary treatments. Significant interactions between lycopene and vitamin E additions affected the body weight of 21-days-old chickens (P = 0.005), the malondialdehyde content in fresh leg meat (P &lt; 0.001) and leg meat stored for 3 days at temperatures of 2.5 to 4&deg;C (P = 0.032), the cholesterol content in leg meat (P &lt; 0.001) and the lycopene content in liver (P = 0.006). The chickens with the highest body weight were fed 75 mg/kg of lycopene and 50 mg/kg of vitamin E. The vitamin E supplement increased the oxidative stability of fresh and stored leg muscle (P &lt; 0.001). The lowest mean cholesterol value (3.49 g/kg of dry matter) was found out in the meat from broilers that were fed 75 mg/kg of lycopene in contrast to broilers fed the control treatment without lycopene (3.93 g/kg of dry matter). Dietary vitamin E significantly reduced the fat content (P = 0.033) and increased the ash content of&nbsp;leg meat. The highest lycopene concentration in liver (2.82 mg/kg of dry matter) was in chickens that were fed the highest levels of vitamin E and lycopene in contrast with the control group (0.28 mg/kg of dry matter). &nbsp;

scholarly journals Combined Analysis with Copy Number Variation Identifies Risk Loci in Lung Cancer

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Xinlei Li ◽  
Xianfeng Chen ◽  
Guohong Hu ◽  
Yang Liu ◽  
Zhenguo Zhang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Copy Number ◽  
Association Studies ◽  
Copy Number Variations ◽  
Genome Wide Association Studies ◽  
Potential Candidate ◽  
Cancer Etiology ◽  
Combined Analysis ◽  
Recombination Hotspots ◽  
Underlying Mechanisms

Background. Lung cancer is the most important cause of cancer mortality worldwide, but the underlying mechanisms of this disease are not fully understood. Copy number variations (CNVs) are promising genetic variations to study because of their potential effects on cancer.Methodology/Principal Findings. Here we conducted a pilot study in which we systematically analyzed the association of CNVs in two lung cancer datasets: the Environment And Genetics in Lung cancer Etiology (EAGLE) and the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial datasets. We used a preestablished association method to test the datasets separately and conducted a combined analysis to test the association accordance between the two datasets. Finally, we identified 167 risk SNP loci and 22 CNVs associated with lung cancer and linked them with recombination hotspots. Functional annotation and biological relevance analyses implied that some of our predicted risk loci were supported by other studies and might be potential candidate loci for lung cancer studies.Conclusions/Significance. Our results further emphasized the importance of copy number variations in cancer and might be a valuable complement to current genome-wide association studies on cancer.

scholarly journals Integrative Analysis of Phenomic, Genomic, and Transcriptomic to Identify Potential Functional Genes of Yaks in Plain and Plateau

2020 ◽  
Author(s):  
Jiabo Wang ◽  
Jiuqiang Guan ◽  
Kangzhu Yixi ◽  
Tao Shu ◽  
Zhixin Chai ◽  
...  
Keyword(s):  
Body Weight ◽  
Association Studies ◽  
The Body ◽  
Tibet Plateau ◽  
Multidimensional Data ◽  
Genome Wide Association Studies ◽  
Beef Quality ◽  
Meat Weight ◽  
Significant Difference ◽  
Head Weight

AbstractBackgroundThe yak is an important source of livelihood for the people living in the Qinghai-Tibet Plateau. Most genetics detection studies have focused on the comparison between different tissues of different breeds, both living in the Plateau and in the plains. The genetic background and complex regulatory relationship have frequently puzzled researchers. In this study, we divided a population of 10 yaks into two subgroups, namely Plateau (living in the Plateau) and Plain (living in the plains). Phenomic, genomic, and transcriptomic analyses were used to reveal the molecular genetic type in the body weight, slaughter, and beef quality of yaks.ResultsWe found a significant difference (P <0.01) between the third (60 days), fourth (90 days), fifth (120 days), and sixth (150 days) weights of Plateau and plain subpopulations. The difference in body weight was due to differences in kidney weight, meat weight, fur weight, and head weight. However, the beef quality was not significantly different. We identified 540 Differentially Expressed Genes (DEGs). Using weighted gene co-expression network analysis (WGCNA), we have constructed a co-express network, and the modules were strongly related to traits. In the genome-wide association studies (GWAS), we detected significant 156, 52, 33, 15, and 3 signals in the meat weight, head weight, fur weight, liver weight, and the last body weight traits. Based on the epigenome-wide association studies (eWAS) results, we created a link relationship between the DEGs expression level and genotype.ConclusionIn summary, our study demonstrated the effectiveness and representative of multidimensional data from a finite number of yak populations. The study highlights the underlying way, as well as a related network, to yield new information on genome genetics and pathogen-host interactions of both the living Plateau and plain yak populations.

scholarly journals Effect of body weight of goats and lactation order on the growth rate of kids in the suckling period

2011 ◽  
Vol 27 (3) ◽  
pp. 1193-1200 ◽  
Author(s):  
M. Zujovic ◽  
N. Memisi ◽  
V. Bogdanovic ◽  
Z. Tomic ◽  
N. Maksimovic ◽  
...  
Keyword(s):  
Growth Rate ◽  
Body Weight ◽  
Milk Yield ◽  
Growth Traits ◽  
Statistical Significance ◽  
The Body ◽  
Individual Growth ◽  
Positive Sign ◽  
Suckling Period ◽  
Final Body Weight

The paper presents results of investigation of milk yield by lactation, by order, and mother's body weight on growth rate of kids of the domestic Balkan goat. Daily weight gains of 376 single kids (168 male and 208 female), in three monthly intervals, and their final body weight at 90 days of age were established. Variability of analyzed traits was presented using descriptive statistics parameters, and differences of growth traits for weight gain of kids resulting from the effect of milk yield of female goats by order of lactation were investigated by single analysis of variance. The effect of independent variables, mothers' milk yield and body weight, on body weight of kids was tested using multiple regression analysis. During the entire suckling period, established average values for kids body weight differed significantly (P<0.001), increasing from the 1st toward later lactations. At 90 days of age the lowest values were established in kids from the youngest mothers (11.86 kg), while for kids of mothers in the fourth or later lactations these values were higher (13.93 kg). Coefficients of determination indicate that the variability percentage for individual growth traits of kids was in the 0.08 - 0.17 interval, indicating its significance. Both "b" coefficients (b1 and b2) are positive and statistically highly significant, except for coefficient b2 in the analysis of body weight of kids at birth. The positive sign and high statistical significance indicate a pronounced effect of mother's milk yield and body weight on the body weight of kids up to 90 days of age.

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