Current status of project SWEETS: Estimating thermospheric neutral mass densities from satellite data at various altitudes

2021 ◽  
Author(s):  
Sandro Krauss ◽  
Barbara Suesser-Rechberger ◽  
Saniya Behzadpour ◽  
Torsten Mayer-Guerr ◽  
Manuela Temmer ◽  
...  
Keyword(s):  
Solar Wind Plasma ◽  
Scientific Data ◽  
Current Status ◽  
Joint Analysis ◽  
Density Estimates ◽  
Magnetic Field Data ◽  
Analysis And Evaluation ◽  
Kinematic Orbit ◽  
Solar Events ◽  
The Impact

<p>Within the project SWEETS (funded by the FFG Austria) it is intended to develop a forecasting model, to predict the expected impact of solar events, like coronal mass ejections (CMEs), on satellites at different altitudes between 300-800 km. For the realization, scientific data, such as kinematic orbit information and accelerometer measurements, from a wide variety of satellites are incorporated. Based on the evaluation of the impact of several hundred solar events on the thermosphere the forecasting will be realized through a joint analysis and evaluation of solar wind plasma and magnetic field data observed at the Lagrange point L1.<br>In this contribution we show first preliminary results of thermospheric densities estimates based on kinematic orbit information for different satellite missions (e.g., TerraSAR-X, TanDEM-X, Swarm A-C, GRACE, GRACE-FO, CHAMP). To validate the outcome, we compare the results with state-of-the-art thermospheric models as well as with densities estimated from accelerometer measurements if available. Finally, for some specific CME events we will perform a comparison between the post-processed density estimates and results from our preliminary forecasting tool.</p>

Clinical Pharmacokinetic Studies in Pregnant Women and the Relevance of Pharmacometric Tools

2019 ◽  
Vol 25 (5) ◽  
pp. 483-495 ◽  
Author(s):  
André Dallmann ◽  
Paola Mian ◽  
Johannes Van den Anker ◽  
Karel Allegaert
Keyword(s):  
Pregnant Women ◽  
Clinical Pharmacokinetic ◽  
Individual Variability ◽  
Current Status ◽  
Pharmacokinetic Studies ◽  
Full Potential ◽  
Pbpk Models ◽  
Pregnancy And Postpartum ◽  
Population Pk ◽  
The Impact

Background: In clinical pharmacokinetic (PK) studies, pregnant women are significantly underrepresented because of ethical and legal reasons which lead to a paucity of information on potential PK changes in this population. As a consequence, pharmacometric tools became instrumental to explore and quantify the impact of PK changes during pregnancy. Methods: We explore and discuss the typical characteristics of population PK and physiologically based pharmacokinetic (PBPK) models with a specific focus on pregnancy and postpartum. Results: Population PK models enable the analysis of dense, sparse or unbalanced data to explore covariates in order to (partly) explain inter-individual variability (including pregnancy) and to individualize dosing. For population PK models, we subsequently used an illustrative approach with ketorolac data to highlight the relevance of enantiomer specific modeling for racemic drugs during pregnancy, while data on antibiotic prophylaxis (cefazolin) during surgery illustrate the specific characteristics of the fetal compartments in the presence of timeconcentration profiles. For PBPK models, an overview on the current status of reports and papers during pregnancy is followed by a PBPK cefuroxime model to illustrate the added benefit of PBPK in evaluating dosing regimens in pregnant women. Conclusions: Pharmacometric tools became very instrumental to improve perinatal pharmacology. However, to reach their full potential, multidisciplinary collaboration and structured efforts are needed to generate more information from already available datasets, to share data and models, and to stimulate cross talk between clinicians and pharmacometricians to generate specific observations (pathophysiology during pregnancy, breastfeeding) needed to further develop the field.

Perspectives on the Situation

2018 ◽  
pp. 66-96
Author(s):  
Harry T. Reis ◽  
John G. Holmes
Keyword(s):  
Personality Traits ◽  
Current Status ◽  
Psychological Processes ◽  
Social Psychological ◽  
The Impact

This chapter reviews major theoretical positions on the influence of situations for the understanding of both personality and social–psychological processes. We review the history and current status of this topic, and we describe in some detail two recent theories that seem particularly amenable toward resolving the disparate approaches that this distinction often engenders. Broadly considered, our position is that personality and situations must be considered interacting factors, but in a theoretically specific way. The concept of affordance—that situations provide opportunities for the expression of certain personality traits—is central to our analysis. We also discuss several issues that personality and social psychologists might profitably consider to provide better grounding for theories and research about the impact of situations on behavior.

Tourism research for the GCC region: Current status and future research directions

2021 ◽  
pp. 135481662199996
Author(s):  
Ali Salman Saleh ◽  
Charbel Bassil ◽  
Arsalan Safari
Keyword(s):  
United Arab Emirates ◽  
Current Status ◽  
Future Research ◽  
Research Directions ◽  
Regional Tourism ◽  
Research Theme ◽  
Tourism Sector ◽  
Future Research Directions ◽  
Meta Analyses ◽  
The Impact

Tourism in the Gulf Cooperation Council (GCC) countries has recently been considered by policymakers as a new avenue for economic diversification. Despite the considerable literature concerning the impact of tourism worldwide, only a limited number of studies have looked at the tourism sector in the GCC region or analyzed its economic, sociocultural, and environmental impacts. This article therefore conducts a systematic review of the state of the literature related to tourism in the GCC region. It provides effective insights about the current status, gaps, and challenges and proposes future research directions in this area for academics, practitioners, and policymakers with an interest in regional tourism development. The preferred reporting items for systematic reviews and meta-analyses approach was used to identify and select the papers. Some 23 papers were identified and analyzed. The majority of these studies focused on the United Arab Emirates, specifically the Dubai emirate. We found the most dominant research theme to be tourism planning.

scholarly journals Viability Assessment in Liver Transplantation—What Is the Impact of Dynamic Organ Preservation?

Biomedicines ◽  
2021 ◽  
Vol 9 (2) ◽  
pp. 161
Author(s):  
Rebecca Panconesi ◽  
Mauricio Flores Carvalho ◽  
Matteo Mueller ◽  
David Meierhofer ◽  
Philipp Dutkowski ◽  
...  
Keyword(s):  
Liver Function ◽  
Organ Preservation ◽  
Ex Situ ◽  
Current Status ◽  
Intensive Care Treatment ◽  
Viability Assessment ◽  
Great Opportunity ◽  
Continuous Increase ◽  
Diagnostic Time ◽  
The Impact

Based on the continuous increase of donor risk, with a majority of organs classified as marginal, quality assessment and prediction of liver function is of utmost importance. This is also caused by the notoriously lack of effective replacement of a failing liver by a device or intensive care treatment. While various parameters of liver function and injury are well-known from clinical practice, the majority of specific tests require prolonged diagnostic time and are more difficult to assess ex situ. In addition, viability assessment of procured organs needs time, because the development of the full picture of cellular injury and the initiation of repair processes depends on metabolic active tissue and reoxygenation with full blood over several hours or days. Measuring injury during cold storage preservation is therefore unlikely to predict the viability after transplantation. In contrast, dynamic organ preservation strategies offer a great opportunity to assess organs before implantation through analysis of recirculating perfusates, bile and perfused liver tissue. Accordingly, several parameters targeting hepatocyte or cholangiocyte function or metabolism have been recently suggested as potential viability tests before organ transplantation. We summarize here a current status of respective machine perfusion tests, and report their clinical relevance.

67 Current Status and Future Prospective of the Use of Plant Bioactive Compounds in Dairy and Beef Cattle

2021 ◽  
Vol 99 (Supplement_1) ◽  
pp. 132-132
Author(s):  
Sergio Calsamiglia ◽  
Maria Rodriguez-Prado ◽  
Gonzalo Fernandez-Turren ◽  
Lorena Castillejos
Keyword(s):  
Beef Cattle ◽  
Essential Oils ◽  
Average Daily Gain ◽  
Rumen Fermentation ◽  
Production Performance ◽  
In Vivo Studies ◽  
Current Status ◽  
The Impact

Abstract In the last 20 years there has been extensive in vitro research on the effects of plant extracts and essential oils on rumen microbial fermentation. The main objectives have been to improve energy metabolism through a reduction in methane emissions and an increase in propionate production; and to improve protein metabolism by reducing proteolysis and deamination. While the positive results from in vitro studies has stimulated the release of commercial products based on blends of essential oils, there is limited in vivo evidence on the rumen fermentation and production performance effects. A literature search was conducted to select in vivo studies where information on rumen fermentation and animal performance was reported. For dairy cattle, we identified 37 studies of which 21 were adequate to test production performance. Ten studies reported increases and 3 decreases in milk yield. For beef cattle, we identified 20 studies with rumen fermentation profile and 22 with performance data. Average daily gain improved in 7 and decreased in 1 study. Only 1 out of 16 studies reported an improvement in feed efficiency. Data indicate that out of more than 500 products tested in vitro, only around 20 have been tested in vivo in different mixtures and doses. The use of statistical approaches will allow to describe the conditions, doses and responses in dairy and beef cattle performance. The search for postruminal effects offers another alternative use. Evidence for effects on the intestinal and systemic effects on the immune system and antioxidant status (i.e., capsicum, garlic, eugenol, cinnamaldehyde curcuma, catechins, anethol or pinene), and in the modulation of metabolic regulation (capsicum, cinnamaldehyde, curcuma or garlic) may open the opportunity for future applications. However, stability of the product in the GI tract, description of the mechanisms of action and the impact of these changes on performance needs to be further demonstrated.

scholarly journals Dryland Food Security in Ethiopia: Current Status, Opportunities, and a Roadmap for the Future

2021 ◽  
Vol 13 (11) ◽  
pp. 6503
Author(s):  
Yu Peng ◽  
Hubert Hirwa ◽  
Qiuying Zhang ◽  
Guoqin Wang ◽  
Fadong Li
Keyword(s):  
Food Security ◽  
Current Status ◽  
Future Research ◽  
Systematic Research ◽  
Security Assessment ◽  
Security Issue ◽  
Sustainable Development Goal ◽  
Zero Hunger ◽  
The Impact

Given the impact of COVID-19 and the desert locust plague, the Ethiopian food security issue has once again received widespread attention. Its food crisis requires comprehensive and systematic research to achieve the United Nations Sustainable Development Goal of zero hunger. This review discusses the current situation and the causes of food security in Ethiopia. We focus on the challenges in the food security assessment field. The article lists seven typical causes of food insecurity and three roots of food security in Ethiopia. Long-term food security assessment and a comprehensive understanding and manageability for food security causes are considered as the main existing research challenges. Climate-resilient management, water management, and long-term ecosystem network monitoring and data mining are suggested as potential roadmap for future research.

The impact of stigma and discrimination on the quality of life and social disability in persons with a diagnosis of mental disorder. A pilot study

2017 ◽  
Vol 41 (S1) ◽  
pp. S571-S571
Author(s):  
T.M. Gondek ◽  
K. Kotowicz ◽  
A. Kiejna
Keyword(s):  
Quality Of Life ◽  
Pilot Study ◽  
Mental Disorders ◽  
Mental Disorder ◽  
Public Information ◽  
Scientific Data ◽  
Social Disability ◽  
Stigma And Discrimination ◽  
The Impact

Stigma and discrimination of persons diagnosed with mental disorder is a common issue. In many European countries, research studies on the prevalence and implications of this problem are conducted in order to better understand how to overcome it. In Poland, there is a scarcity of such studies, what results in neglecting this issue by the policy makers. The objective of the study is to assess the prevalence of stigma and discrimination affecting the patients hospitalized in psychiatric day units and in-patient wards between 2016–2017 as well as to analyze the relationship between the stigma and the quality of life and social disability in persons with a mental disorder diagnosis of F20–F48 according to ICD-10, aged 18–65, in a day ward and an in-patient ward settings. The pilot study presents the data gathered from a preliminary sample of 20 patients of both genders diagnosed with the aforementioned mental disorders, equaling 10 per cent of the targeted total study sample. The quality of life is assessed with WHOQOL-Bref, WHO-5 questionnaire and Rosenberg self-esteem scale, while social disability is measured with the second version of the Groningen Social Disabilities Schedule. The assessment of the impact of stigma on the social disability of persons with mental disorders and their quality of life can be useful in the context of developing evidence-based interventions for these persons, while it could also provide the scientific data to support public information campaigns aiming at tackling the stigma against persons with mental disorders in Poland.Disclosure of InterestThe authors have not supplied their declaration of competing interest.

Infection control: current status. risks, research, rules and recycling

2021 ◽  
Vol 14 (2) ◽  
pp. 59-66
Author(s):  
Jennifer Haworth ◽  
Jonathan Sandy ◽  
Anthony J Ireland
Keyword(s):  
Infection Control ◽  
Best Practice ◽  
Mainland China ◽  
Current Status ◽  
Infectious Agents ◽  
Emerging Infections ◽  
Healthcare Waste ◽  
Control Procedures ◽  
The Uk ◽  
The Impact

We are living through a period of immense change following the outbreak of the COVID-19 pandemic in mainland China in December 2019. Even before the pandemic, the cost of managing healthcare-associated infections in the UK was considerable. The risk of acquiring any infection from the dental environment must be reduced to a minimum. As we have observed in recent years, new infectious agents emerge frequently, and the dental profession must be ready to respond appropriately and quickly. Orthodontic practice presents unique challenges in relation to infection control procedures. The impact of healthcare waste on the environment must also be considered. CPD/Clinical Relevance: This paper describes the range of infectious agents posing a risk to dental team members and patients. The aim is to place the recent coronavirus pandemic in the context of other recent emerging infections. Some of the latest research regarding infection control procedures is reviewed. Current best practice is described.

Influential Factors for Older Users’ Acceptance of eHealth Services: an Integrated Acceptance Framework (IAF) (Preprint)

2021 ◽  
Author(s):  
Jiyeon Yu ◽  
Angelica de Antonio ◽  
Elena Villalba-Mora
Keyword(s):  
Systematic Review ◽  
Older Adults ◽  
New Technologies ◽  
Meta Analysis ◽  
Health Condition ◽  
Influential Factors ◽  
Current Status ◽  
Five Dimensions ◽  
The Impact ◽  
Acceptance Factors

BACKGROUND eHealth and Telehealth play a crucial role in assisting older adults who visit hospitals frequently or who live in nursing homes and can benefit from staying at home while being cared for. Adapting to new technologies can be difficult for older people. Thus, to better apply these technologies to older adults’ lives, many studies have analyzed acceptance factors for this particular population. However, there is not yet a consensual framework to be used in further development and the search for solutions. OBJECTIVE This paper presents an Integrated Acceptance Framework (IAF) for the older user’s acceptance of eHealth, based on 43 studies selected through a systematic review. METHODS We conducted a four-step study. First, through a systematic review from 2010 to 2020 in the field of eHealth, the acceptance factors and basic data for analysis were extracted. Second, we carried out a thematic analysis to group the factors into themes to propose and integrated framework for acceptance. Third, we defined a metric to evaluate the impact of the factors addressed in the studies. Last, the differences amongst the important IAF factors were analyzed, according to the participants’ health conditions, verification time, and year. RESULTS Through the systematic review, 731 studies were founded in 5 major databases, resulting in 43 selected studies using the PRISMA methodology. First, the research methods and the acceptance factors for eHealth were compared and analyzed, extracting a total of 105 acceptance factors, which were grouped later, resulting in the Integrated Acceptance Framework. Five dimensions (i.e., personal, user-technology relational, technological, service-related, environmental) emerged with a total of 23 factors. Also, we assessed the quality of the evidence. And then, we conducted a stratification analysis to reveal the more appropriate factors depending on the health condition and the assessment time. Finally, we assess which are the factors and dimensions that are recently becoming more important. CONCLUSIONS The result of this investigation is a framework for conducting research on eHealth acceptance. To elaborately analyze the impact of the factors of the proposed framework, the criteria for evaluating the evidence from the studies that have extracted factors are presented. Through this process, the impact of each factor in the IAF has been presented, in addition to the framework proposal. Moreover, a meta-analysis of the current status of research is presented, highlighting the areas where specific measures are needed to facilitate e-Health acceptance.

The Impact of Race/Ethnicity on the Outcomes of Burn Patients: A Systematic Review of the Literature

2021 ◽  
Author(s):  
Jasmine Peters ◽  
Mariel S Bello ◽  
Leigh Spera ◽  
T Justin Gillenwater ◽  
Haig A Yenikomshian
Keyword(s):  
Systematic Review ◽  
Native American ◽  
The United States ◽  
Current Status ◽  
Surgical Trauma ◽  
Insurance Status ◽  
Inclusion Criteria ◽  
Burn Care ◽  
Race Ethnicity ◽  
The Impact

Abstract Racial and ethnic disparities are endemic to the United States and are only beginning to attract the attention of researchers. With an increasingly diverse population, focused and tailored medicine to provide more equitable care is needed. For surgical trauma populations, this topic is a small but expanding field and still rarely mentioned in burn medicine. Disparities in prevention, treatment, and recovery outcomes between different racial and ethnic minorities who are burned are rarely discussed. The purpose of this study is to determine the current status of identified disparities of care in the burn population literature and areas of future research. A systematic review was conducted of literature utilizing PubMed for articles published between 2000-2020. Searches were used to identify articles that crossed the burn term (burn patient OR burn recovery OR burn survivor OR burn care) and a race/ethnicity and insurance status-related term (race/ethnicity OR African-American OR Black OR Asian OR Hispanic OR Latino OR Native American OR Indigenous OR Mixed race OR 2 or more races OR socioeconomic status OR insurance status). Inclusion criteria were English studies in the US that discussed disparities in burn injury outcomes or risk factors associated with race/ethnicity. 1,169 papers were populated, 55 were reviewed, and 36 articles met inclusion criteria. Most studies showed minorities had poorer inpatient and outpatient outcomes. While this is a concerning trend, there is a paucity of literature in this field and more research is needed to create culturally-tailored medical care and address the needs of disadvantaged burn survivors.

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