scholarly journals Comparative assessment of predictions in ungauged basins – Part 2: Flood and low flow studies

2013 ◽  
Vol 10 (1) ◽  
pp. 411-447 ◽  
Author(s):  
J. L. Salinas ◽  
G. Laaha ◽  
M. Rogger ◽  
J. Parajka ◽  
A. Viglione ◽  
...  

Abstract. The objective of this paper is to assess the performance of methods that predict low flows and flood runoff in ungauged catchments. The aim is to learn from the similarities and differences between catchments in different places, and to interpret the differences in performance in terms of the underlying climate-landscape controls. The assessment is performed at two levels. The Level 1 assessment is a meta-analysis of 14 low flow prediction studies reported in the literature involving 3112 catchments, and 20 flood prediction studies involving 3023 catchments. The Level 2 assessment consists of a more focused and detailed analysis of individual basins from selected studies from Level 1 in terms of how the leave-one-out cross-validation performance depends on climate and catchment characteristics as well as on the regionalisation method. The results indicate that both flood and low flow predictions in ungauged catchments tend to be less accurate in arid than in humid climates and more accurate in large than in small catchments. There is also a tendency towards a somewhat lower performance of regressions than other methods in those studies that apply different methods in the same region, while geostatistical methods tend to perform better than other methods. Of the various flood regionalisation approaches, index methods show significantly lower performances in arid catchments than regression methods or geostatistical methods. For low flow regionalisation, regional regressions are generally better than global regressions.

2013 ◽  
Vol 17 (7) ◽  
pp. 2637-2652 ◽  
Author(s):  
J. L. Salinas ◽  
G. Laaha ◽  
M. Rogger ◽  
J. Parajka ◽  
A. Viglione ◽  
...  

Abstract. The objective of this paper is to assess the performance of methods that predict low flows and flood runoff in ungauged catchments. The aim is to learn from the similarities and differences between catchments in different places, and to interpret the differences in performance in terms of the underlying climate-landscape controls. The assessment is performed at two levels. The Level 1 assessment is a meta-analysis of 14 low flow prediction studies reported in the literature involving 3112 catchments, and 20 flood prediction studies involving 3023 catchments. The Level 2 assessment consists of a more focused and detailed analysis of individual basins from selected studies from Level 1 in terms of how the leave-one-out cross-validation performance depends on climate and catchment characteristics as well as on the regionalisation method. The results indicate that both flood and low flow predictions in ungauged catchments tend to be less accurate in arid than in humid climates and more accurate in large than in small catchments. There is also a tendency towards a somewhat lower performance of regressions than other methods in those studies that apply different methods in the same region, while geostatistical methods tend to perform better than other methods. Of the various flood regionalisation approaches, index methods show significantly lower performance in arid catchments than regression methods or geostatistical methods. For low flow regionalisation, regional regressions are generally better than global regressions.


2013 ◽  
Vol 10 (1) ◽  
pp. 375-409 ◽  
Author(s):  
J. Parajka ◽  
A. Viglione ◽  
M. Rogger ◽  
J. L. Salinas ◽  
M. Sivapalan ◽  
...  

Abstract. The objective of this assessment is to compare studies predicting runoff hydrographs in ungauged catchments. The aim is to learn from the differences and similarities between catchments in different locations, and to interpret the differences in performance in terms of the underlying climate and landscape controls. The assessment is performed at two levels. The Level 1 assessment is a meta-analysis of 34 studies reported in the literature involving 3874 catchments. The Level 2 assessment consists of a more focused and detailed analysis of individual basins from selected studies from Level 1 in terms of how the leave-one-out cross-validation performance depends on climate and catchment characteristics as well as on the chosen regionalisation method. The results indicate that runoff hydrograph predictions in ungauged catchments tend to be more accurate in humid than in arid catchments and more accurate in large than in small catchments. The dependence of performance on elevation differs by regions and depends on how aridity varies with elevation and air temperature. The effect of parameter regionalisation method on model performance differs between studies. However, there is a tendency towards a somewhat lower performance of regressions than other methods in those studies that apply different methods in the same region. In humid catchments spatial proximity and similarity methods perform best while in arid catchments similarity and parameter regression methods perform slightly better. For studies with a large number of catchments (dense stream gauge network) there is a tendency for spatial proximity and geostatistics to perform better than regression or regionalisation based on simple averaging of model parameters from gauged catchments. There was no clear relationship between predictive performance and the number of regionalised model parameters. The implications of the findings are discussed in the context of model building.


2013 ◽  
Vol 17 (5) ◽  
pp. 1783-1795 ◽  
Author(s):  
J. Parajka ◽  
A. Viglione ◽  
M. Rogger ◽  
J. L. Salinas ◽  
M. Sivapalan ◽  
...  

Abstract. The objective of this assessment is to compare studies predicting runoff hydrographs in ungauged catchments. The aim is to learn from the differences and similarities between catchments in different locations, and to interpret the differences in performance in terms of the underlying climate and landscape controls. The assessment is performed at two levels. The Level 1 assessment is a meta-analysis of 34 studies reported in the literature involving 3874 catchments. The Level 2 assessment consists of a more focused and detailed analysis of individual basins from selected studies from Level 1 in terms of how the leave-one-out cross-validation performance depends on climate and catchment characteristics as well as on the chosen regionalisation method. The results indicate that runoff-hydrograph predictions in ungauged catchments tend to be more accurate in humid than in arid catchments and more accurate in large than in small catchments. The dependence of performance on elevation differs by regions and depends on how aridity varies with elevation and air temperature. The effect of the parameter regionalisation method on model performance differs between studies. However, there is a tendency towards a somewhat lower performance of regressions than other methods in those studies that apply different methods in the same region. In humid catchments spatial proximity and similarity methods perform best while in arid catchments similarity and parameter regression methods perform slightly better. For studies with a large number of catchments (dense stream gauge network) there is a tendency for spatial proximity and geostatistics to perform better than regression or regionalisation based on simple averaging of model parameters from gauged catchments. There was no clear relationship between predictive performance and the number of regionalised model parameters. The implications of the findings are discussed in the context of model building.


2017 ◽  
Vol 73 (11) ◽  
pp. 2522-2533 ◽  
Author(s):  
Zunjia Wen ◽  
Wenting Wang ◽  
Haiying Zhang ◽  
Chao Wu ◽  
Jianping Ding ◽  
...  

2014 ◽  
Vol 13 (3) ◽  
pp. 123-133 ◽  
Author(s):  
Wiebke Goertz ◽  
Ute R. Hülsheger ◽  
Günter W. Maier

General mental ability (GMA) has long been considered one of the best predictors of training success and considerably better than specific cognitive abilities (SCAs). Recently, however, researchers have provided evidence that SCAs may be of similar importance for training success, a finding supporting personnel selection based on job-related requirements. The present meta-analysis therefore seeks to assess validities of SCAs for training success in various occupations in a sample of German primary studies. Our meta-analysis (k = 72) revealed operational validities between ρ = .18 and ρ = .26 for different SCAs. Furthermore, results varied by occupational category, supporting a job-specific benefit of SCAs.


2021 ◽  
Vol 13 ◽  
pp. 175883592110069
Author(s):  
Jie Zhang ◽  
Yushuai Yu ◽  
Yuxiang Lin ◽  
Shaohong Kang ◽  
Xinyin Lv ◽  
...  

Aims: Currently, there are many approaches available for neoadjuvant therapy for human epidermal growth factor receptor 2 (HER2)-positive breast cancer that improve therapeutic efficacy but are also controversial. We conducted a two-step Bayesian network meta-analysis (NMA) to compare odds ratios (ORs) for pathologic complete response (PCR) and safety endpoints. Methods: The Cochrane Central Register of Controlled Trials, PubMed, Embase, and online abstracts from the American Society of Clinical Oncology and San Antonio Breast Cancer Symposium were searched comprehensively and systematically. Phase II/III randomised clinical trials for targeted therapy in at least one arm were included. Results: A total of 9779 published manuscripts were identified, and 36 studies including 10,379 patients were finally included in our analysis. The NMA of PCR showed that dual-target therapy is better than single-target therapy and combination chemotherapy is better than monochemotherapy. However, anthracycline did not bring extra benefits, whether combined with dual-target therapy or single-target therapy. On the other hand, the addition of endocrine therapy in the HER2-positive, hormone receptor (HR)-positive subgroup might have additional beneficial effects but without significant statistical difference. By performing a conjoint analysis of the PCR rate and safety endpoints, we found that ‘trastuzumab plus pertuzumab’ and ‘T-DM1 containing regimens’ were well balanced in terms of efficacy and toxicity in all target regimens. Conclusion: In summary, trastuzumab plus pertuzumab-based dual-target therapy with combination chemotherapy regimens showed the highest efficacy of all optional regimens. They also achieved the best balance between efficacy and toxicity. As our study showed that anthracycline could be replaced by carboplatin, we strongly recommended TCbHP as the preferred choice for neoadjuvant treatment of HER2-positive breast cancer. We also look forward to the potential value of T-DM1 in improving outcomes, which needs further study in future trials.


2021 ◽  
pp. 1-10
Author(s):  
Xian Li ◽  
Yan Tian ◽  
Yu-Xiang Yang ◽  
Ya-Hui Ma ◽  
Xue-Ning Shen ◽  
...  

Background: Several studies showed that life course adiposity was associated with Alzheimer’s disease (AD). However, the underlying causality remains unclear. Objective: We aimed to examine the causal relationship between life course adiposity and AD using Mendelian randomization (MR) analysis. Methods: Instrumental variants were obtained from large genome-wide association studies (GWAS) for life course adiposity, including birth weight (BW), childhood body mass index (BMI), adult BMI, waist circumference (WC), waist-to-hip ratio (WHR), and body fat percentage (BFP). A meta-analysis of GWAS for AD including 71,880 cases and 383,378 controls was used in this study. MR analyses were performed using inverse variance weighted (IVW), weighted median, and MR-Egger regression methods. We calculated odds ratios (ORs) per genetically predicted standard deviation (1-SD) unit increase in each trait for AD. Results: Genetically predicted 1-SD increase in adult BMI was significantly associated with higher risk of AD (IVW: OR = 1.03, 95% confidence interval [CI] = 1.01–1.05, p = 2.7×10–3) after Bonferroni correction. The weighted median method indicated a significant association between BW and AD (OR = 0.94, 95% CI = 0.90–0.98, p = 1.8×10–3). We also found suggestive associations of AD with WC (IVW: OR = 1.03, 95% CI = 1.00–1.07, p = 0.048) and WHR (weighted median: OR = 1.04, 95% CI = 1.00–1.07, p = 0.029). No association was detected of AD with childhood BMI and BFP. Conclusion: Our study demonstrated that lower BW and higher adult BMI had causal effects on increased AD risk.


2021 ◽  
Vol 09 (01) ◽  
pp. E9-E13
Author(s):  
Sachin Srinivasan ◽  
Peter D. Siersema ◽  
Madhav Desai

Abstract Background and study aims Diminutive colorectal polyps are increasingly being detected and it is not clear whether jumbo biopsy forceps (JBF) has comparable efficacy to that of cold snare polypectomy (CSP) for management of these lesions. Methods An electronic literature search was performed for studies comparing resection rates of JBF and CSP for diminutive polyps (≤ 5 mm). The primary outcome was incomplete resection rate (IRR). Secondary outcomes included failure of tissue retrieval and complication rates (post-polypectomy bleeding, perforation etc.). Leave-one-out analysis was performed to examine the disproportionate role of any of the studies. Meta-analysis outcomes and heterogeneity (I2) were computed using Comprehensive meta-analysis software. Results A total of 4 studies (3 randomized controlled trials and 1 retrospective study) with 407 patients and 569 total polyps (mean size of 3.62 mm) was included for analysis. IRR of JBF was slightly higher than that of CSP (10.2 % vs 7.2 %) but this was not statistically significantly different (Pooled OR 1.76; 95 % CI 0.94–3.28; I2 = 0). Leave-one-out analysis showed no significant difference in the pooled OR comparison either. Two of the 4 studies reported 0 % failure of tissue retrieval for JBF and 1 % and 4.3 % for CSP. There were no complications for either group from the 2 studies that reported this outcome. The quality of the included studies was moderate to high. Conclusions This systematic review with only limited data shows that JBF and CSP are not statistically different in completely removing diminutive polyps, although careful endoscopic assessment is needed to ensure complete removal of all polyp tissue.


Animals ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 758
Author(s):  
Fiona Esam ◽  
Rachel Forrest ◽  
Natalie Waran

The influence of the COVID-19 pandemic on human-pet interactions within New Zealand, particularly during lockdown, was investigated via two national surveys. In Survey 1, pet owners (n = 686) responded during the final week of the five-week Alert Level 4 lockdown (highest level of restrictions—April 2020), and survey 2 involved 498 respondents during July 2020 whilst at Alert Level 1 (lowest level of restrictions). During the lockdown, 54.7% of owners felt that their pets’ wellbeing was better than usual, while only 7.4% felt that it was worse. Most respondents (84.0%) could list at least one benefit of lockdown for their pets, and they noted pets were engaged with more play (61.7%) and exercise (49.7%) than pre-lockdown. Many respondents (40.3%) expressed that they were concerned about their pet’s wellbeing after lockdown, with pets missing company/attention and separation anxiety being major themes. In Survey 2, 27.9% of respondents reported that they continued to engage in increased rates of play with their pets after lockdown, however, the higher levels of pet exercise were not maintained. Just over one-third (35.9%) of owners took steps to prepare their pets to transition out of lockdown. The results indicate that pets may have enjoyed improved welfare during lockdown due to the possibility of increased human-pet interaction. The steps taken by owners to prepare animals for a return to normal life may enhance pet wellbeing long-term if maintained.


Author(s):  
Niki Christou ◽  
Jeremy Meyer ◽  
Christophe Combescure ◽  
Alexandre Balaphas ◽  
Joan Robert-Yap ◽  
...  

Abstract Importance Rectal cancers occupy the eighth position worldwide for new cases and deaths for both men and women. These cancers have a high tendency to form metastases in the mesorectum but also in the lateral lymph nodes. The therapeutic approach for the involved lateral lymph nodes remains controversial. Objective We performed a systematic review and meta-analysis to assess the prevalence of metastatic lateral lymph nodes in patients with lateral lymph node dissection (LLND) for rectal cancer, which seems to be a fundamental and necessary criterion to discuss any possible indications for LLND. Methods Data sources–study selection–data extraction and synthesis–main outcome and measures. We searched MEDLINE, EMBASE and COCHRANE from November 1, 2018, to November 19, 2018, for studies reporting the presence of metastatic lateral lymph nodes (iliac, obturator and middle sacral nodes) among patients undergoing rectal surgery with LLND. Pooled prevalence values were obtained by random effects models, and the robustness was tested by leave-one-out sensitivity analyses. Heterogeneity was assessed using the Q-test, quantified based on the I2 value and explored by subgroup analyses. Results Our final analysis included 31 studies from Asian countries, comprising 7599 patients. The pooled prevalence of metastatic lateral lymph nodes was 17.3% (95% CI: 14.6–20.5). The inter-study variability (heterogeneity) was high (I2 = 89%). The pooled prevalence was, however, robust and varied between 16.6% and 17.9% according to leave-one-out sensitivity analysis. The pooled prevalence of metastatic lymph nodes was not significantly different when pooling only studies including patients who received neoadjuvant treatment or those without neoadjuvant treatment (p = 0.44). Meta-regression showed that the pooled prevalence was associated with the sample size of studies (p < 0.05), as the prevalence decreased when the sample size increased. Conclusion The pooled prevalence of metastatic lateral lymph nodes was 17.3% among patients who underwent rectal surgery with LLND in Asian countries. Further studies are necessary to determine whether this finding could impact the therapeutic strategy (total mesorectal excision with LLND versus total mesorectal excision with neoadjuvant radiochemotherapy).


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