Association of cognitive function with increased risk of cancer death and all-cause mortality: Longitudinal analysis, systematic review, and meta-analysis of prospective observational studies

Background Disturbed cognitive function is associated with several causes of mortality; however, the association between cognitive function and the risk of cancer death has not been extensively investigated yet. We aimed to evaluate the association of cognitive function with the risk of cancer death and all-cause mortality in the PROspective Study of Pravastatin in the Elderly at Risk (PROSPER) and Leiden 85-plus Study. Additionally, a systematic review and meta-analysis of longitudinal studies were conducted to evaluate the association of cognitive function and risk of cancer death. Methods Risk of cancer death and all-cause mortality were reported using hazard ratios (HRs) with 95% confidence interval (CI) in tertiles of cognitive function of PROSPER and Leiden85-Plus Study. Additionally, PubMed, Embase, Web of Science, Cochrane, PsycINFO, Academic Search Premier, CINHAL, and Emcare were searched up to November 1st, 2020 to perform a systematic review and meta-analysis. The relative risks (RRs) with 95%CI of cancer death per each standard deviation lower performance in cognitive measurements were calculated. Results Participants of PROSPER had 1.65-fold (95%CI 1.11–2.47) greater risk of cancer death (P for trend = 0.016) and 1.85-fold (95%CI 1.46–2.34) higher risk of all-cause mortality (P for trend<0.001), in multivariable models. Results of the Leiden-85 Plus Study showed that subjects with MMSE score below 24 had a lower chance of cancer death (HR 0.79, 95%CI 0.36–1.70, P for trend = 0.820) but had 2.18-fold (95%CI 1.57–3.02) higher risk of all-cause mortality compared to the reference group (P for trend<0.001). Besides, the results of systematic review and meta-analysis showed that per each standard deviation lower performance in cognitive function, individuals were at a 10% higher chance of cancer death (RR 1.10, 95%CI 1.00–1.20, P-value = 0.044). Conclusions Lower cognitive function performance is associated with a marginally increased risk of cancer death, in line with a significantly greater risk of all-cause mortality.

Pengaruh Insentif Finansial dan Non Finansial terhadap Kinerja Karyawan Hotel Timeshare dengan Variabel Mediasi Kepuasan Kerja

Employee performance is seen as what an employee does and what he doesn't do. Employee performance involves the quality and quantity of output, attendance at work, and timeliness of output. The level of absenteeism is quite high where an average of 14.59% per month. This can have a negative effect on employee performance, meaning that the higher the level of absenteeism will affect the lower performance of the employee. There are indications that employee job satisfaction is not optimal due to inaccurate provision of financial and non-financial incentives. Given this phenomenon, it is interesting to study given the tendency of low employee performance, the possibility of giving inappropriate or unsatisfactory incentives which causes low job satisfaction. Data were collected using a questionnaire method to 104 respondents at Karma Royal Bali. Data were analyzed using SmartPLS software. The results are that financial incentives and non-financial incentives have a positive and significant effect on job satisfaction and job satisfaction as a mediator between financial incentives and non-financial incentives on employee performance at Karma Royal Bali.

Performance of early literacy students in cognitive-linguistic skills during the pandemic

Introduction: The Covid-19 pandemic made discrepancies between the different educational realities more evident for schoolchildren in the beginning of literacy. Objective: to characterize the performance of cognitive-linguistic skills of students in early literacy phases during the pandemic. Methods: Twenty-two elementary school students participated in this study, distributed in GI 1st year students and 2nd year GII students, submitted to the application of the Cognitive-Linguistic Skills Assessment Protocol for students in the initial stage of literacy. Results: Students from GI and GII showed average performance for writing the name and writing the alphabet in sequence. The GI presented a refusal response for the subtests of word dictation, pseudoword dictation and picture dictation, word repetition and visual sequential memory of shapes and poor performance for alphabet recognition in random order and average performance for alphabet recognition in sequence. GII showed lower performance for the subtests of word dictation, pseudoword dictation, picture dictation and superior performance for alphabet recognition in random order, alphabet in sequence and visual sequential memory of shapes. Discussion: The appropriation of the letter-sound relationship mechanism raises questions, since it evidenced the difficulty of all students in cognitive-linguistic skills necessary for the full development of reading and writing in an alphabetic writing system such as Brazilian Portuguese . Conclusion: Students in the 1st and 2nd years showed lower performance in cognitive-linguistic skills important for learning reading and writing.

Will Someone Be Checking My Work? The Effect of Psychological Entitlement and the Expectation of Being Monitored on Task Performance and Misreporting

Psychological entitlement is a sense that one deserves more than others, and is correlated with a host of negative workplace behaviors. Because entitled individuals have a strong desire for the approval of others, we examine whether increasing the expectation of being monitored can limit some of these negative behaviors. We find that when the expectation of being monitored is low, psychological entitlement is associated with lower performance and higher misreporting. In contrast, when the expectation of being monitored is high, not only are these behaviors reduced, but performance increases and misreporting decreases for entitled individuals. Our results suggest that expectations of performance monitoring can be used to improve workplace outcomes for entitled employees.

RT-Sniper: A Low-Overhead Defense Mechanism Pinpointing Cache Side-Channel Attacks

Since cache side-channel attacks have been serious security threats to multi-tenant systems, there have been several studies to protect systems against the attacks. However, the prior studies have limitations in determining only the existence of the attack and/or occupying too many computing resources in runtime. We propose a low-overhead pinpointing solution, called RT-Sniper, to overcome such limitations. RT-Sniper employs a two-level filtering mechanism to minimize performance overhead. It first monitors hardware events per core and isolates a suspected core to run a malicious process. Then among the processes running on the selected core, RT-Sniper pinpoints a malicious process through a per-process monitoring approach. With the core-level filtering, RT-Sniper has an advantage in overhead compared to the previous works. We evaluate RT-Sniper against Flush+Reload and Prime+Probe attacks running SPEC2017, LMBench, and PARSEC benchmarks on multi-core systems. Our evaluation demonstrates that the performance overhead by RT-Sniper is negligible (0.3% for single-threaded applications and 2.05% for multi-threaded applications). Compared to the previous defense solutions against cache side-channel attacks, RT-Sniper exhibits better detection performance with lower performance overhead.

Subordinates' performance-prove goal orientation and their perception of abusive supervision

I investigated the relationship between subordinates' performanceprove goal orientation and their perception of abusive supervision, and examined whether feedback-seeking behavior toward supervisors mediated this link. I collected data using a three-wave survey of 173 employees who were working in a variety of occupations in Taiwan. Empirical results indicate that when subordinates had a performanceprove goal orientation, their perception of abusive supervision was partially decreased through their feedback-seeking behavior toward supervisors. Specifically, those employees with a higher (vs. lower) performance-prove goal orientation sought more feedback from supervisors and, thus, perceived abusive supervision to a lesser degree. These findings contribute to the literature on the antecedents of abusive supervision in terms of subordinate-related factors. Managerial implications are proposed to enable employees to be aware of how their job performance is understood and viewed by their supervisors.

Improving Aphasic Speech Recognition by Using Novel Semi-Supervised Learning Methods on AphasiaBank for English and Spanish

Automatic speech recognition in patients with aphasia is a challenging task for which studies have been published in a few languages. Reasonably, the systems reported in the literature within this field show significantly lower performance than those focused on transcribing non-pathological clean speech. It is mainly due to the difficulty of recognizing a more unintelligible voice, as well as due to the scarcity of annotated aphasic data. This work is mainly focused on applying novel semi-supervised learning methods to the AphasiaBank dataset in order to deal with these two major issues, reporting improvements for the English language and providing the first benchmark for the Spanish language for which less than one hour of transcribed aphasic speech was used for training. In addition, the influence of reinforcing the training and decoding processes with out-of-domain acoustic and text data is described by using different strategies and configurations to fine-tune the hyperparameters and the final recognition systems. The interesting results obtained encourage extending this technological approach to other languages and scenarios where the scarcity of annotated data to train recognition models is a challenging reality.

Assessing Customer Satisfaction: A Case in Logistics Service Company

This study aims to assess customer satisfaction of a logistics service company in Indonesia. Several researches employed the classical importance-performance analysis (IPA) to accomplish the objective; instead, this research used importance performance competitor analysis (IPCA). IPCA is considered as a remedy for IPA since the later has been criticized for several reasons, e.g., the relative structure of IPA and its lack of competitors’ consideration. A case study has been conducted to show the applicability of IPCA. Result shows that several service attributes have to be improved since they have lower performance than the competitor. Recommendations that can be done as a part to continuous improvement were provided. Finally, we also show that using IPA—without considering the competitor—would bring the management to a misleading interpretation. Keywords—Customer satisfaction; importance performance competitor analysis; logistics service

Assessing the impact of a journal club elective on literature evaluation performance

Introduction: The study assessed the impact of a journal club (JC) elective on literature evaluation performance during the first three advanced pharmacy practice experiences (APPE). Methods: Students who took a JC elective were compared to students who did not take the JC elective in regards to scores on APPE JC and overall APPE literature evaluation. Results: Of 186 eligible participants, 22 participants completed the JC elective. APPE JC and APPE literature evaluation scores were similar between groups. First semester APPE JC scores were positively correlated with scores earned in the JC elective (r=0.452, p=0.045). Conclusions: Students in the elective did not have significantly different APPE JC scores compared to students who did not take the elective; however, there was a correlation and potential predictive association to APPE JC scores. The JC elective may identify students at risk of lower performance during APPEs so that they may receive additional support.

Klotho KL-VS haplotype does not improve cognition in a population-based sample of adults age 55–87 years

The heterozygous human Klotho KL-VS haplotype has been associated with improved cognitive performance but results are inconsistent. Here we assessed Klotho KL-VS haplotype and cognition using data from the third examination of the population-based Heinz Nixdorf Recall Study. We analyzed cognition tests (immediate and delayed word list, Trail-Making Test [TMT] part A and B, Maze test, interference condition of the Stroop color-word test, verbal fluency) and their associations with Klotho KL-VS haplotype. The Klotho KL-VS haplotype is classified by the V-allele at SNP rs9536314 (F352V) and the S-allele at SNP rs9527025 (C370S). Heterozygotes for the KL-VS haplotype were compared with non-carriers. Analyses were performed in 1812 subjects (55–87 years). We found consistent but only slightly lower performance in heterozygous carriers of the KL-VS haplotype in all tasks with Z-scores ranging between Z = − 0.042 (verbal fluency) and − 0.17 (TMT part A). Differences between carriers and non-carriers were similar for men and women for all tests but TMT part B (interaction contrast = 8.4 s (95% CI − 2.3; 19.1)). While cognition declined with age, we found an effect modification by age (55–65 years, 66–75 years, > 75 years). In the 66–75 years KL-VS heterozygous age group, lower performance was seen in memory, visual attention and motor speed. Contrary to our hypothesis, heterozygous carriers of the KL-VS haplotype did not show enhanced performance in cognitive tests in our study.