scholarly journals History, evolution and newer perspectives of rabies vaccines

2021 ◽  
Vol 52 (3) ◽  
Keyword(s):  
Prevention And Control ◽  
Animal Health ◽  
Case Fatality ◽  
Human Rabies ◽  
Effective Prevention ◽  
The Public ◽  
History Evolution ◽  
Health Communities ◽  
And Control ◽  
The Impact

Rabies continues to be one of the most deadly infectious diseases known to human race since antiquity, with a case fatality rate almost 100 per cent after the onset of clinical disease. The disease still has a significant impact on human and animal living all over the globe. It is found on all continents where terrestrial animals exist, with the bulk of animal and human cases documented in resource-constrained African and Asian countries, where thousands of human deaths are being recorded annually. The disease produces one of the most agonising deaths in humans and it is likely that the global statistic of roughly 59,000 human rabies fatalities per year is an underestimate. Scientific innovations that led to the successful development of several vaccines and immunisation policies in identified ‘at risk’human and animal populationshave gained a great reputation in minimising the impact of disease across wide portions of the globe.Vaccines continue to be the most significant triumphs of the combined global efforts of the public and animal health communities and has achieved significant strides in the treatment, prevention, and control of disease. This paper describes the history, evolution, and accomplishments of human ingenuity, scientific endeavour, and the joint global efforts of the public and animal health communities that resulted in evolving an effective prevention and control strategies.

scholarly journals Reflecting on the first two COVID-19 deaths in Uganda: a public health case study

2020 ◽  
Author(s):  
Joseph Kawuki ◽  
Quraish Sserwanja ◽  
Nathan Obore ◽  
Johnson Wang ◽  
Joseph Lau
Keyword(s):  
Public Health ◽  
Health Center ◽  
Prevention And Control ◽  
Support Staff ◽  
Effective Prevention ◽  
The Public ◽  
First Case ◽  
Health Relevance ◽  
And Control

Abstract Objective: COVID-19 being a rapidly evolving pandemic, early lessons from the first deaths must be learnt to help feed into the public health guidelines. This study, therefore, aims to present the first two deaths due to COVID-19 in Uganda and their public health relevance.Cases: The first case was a 34-year female and support staff at a health center II. She first presented with COVID-19 like symptoms before dying on 21st July 2020. The second case was an 80 years old female, who also presented with COVID-19 like symptoms before dying on 24th July 2020. The postmortem samples of both cases were confirmed positive for COVID-19. Conclusion: This study identifies a need for timely identification and testing of COVID-19 suspects, strengthening of health center capacity, as well as more awareness for effective prevention and control of COVID-19.

scholarly journals Changes in Prevalence of Nosocomial Infection Pre- and Post-COVID-19 pandemic from a Tertiary Hospital in China

2021 ◽  
Author(s):  
Chunmei Su ◽  
Zhiqin Zhang ◽  
Xu Zhao ◽  
Hanlin Peng ◽  
Yi Hong ◽  
...  
Keyword(s):  
Nosocomial Infection ◽  
Nosocomial Infections ◽  
Prevention And Control ◽  
Control Measures ◽  
Gastrointestinal Infections ◽  
Effective Prevention ◽  
Oral Infections ◽  
Prevention And Control Measures ◽  
And Control ◽  
The Impact

Abstract Background: Nosocomial infections (NIs) are an important cause of mortality, and increasing evidence reveals that the prevalence of NIs can be reduced through effective prevention and control measures. The aim of this study was to investigate the impact of the prevention and control measures for the COVID-19 pandemic on NIs.Methods: A retrospective study was conducted to analyze the prevalence of NIs before and after COVID-19 pandemic for six months in the Children’s Hospital of Soochow University.Results: A total of 39,914 patients in 2019 and 34,645 patients in 2020 were admitted to the hospital during the study. There were 1.39% (481/34645) of patients with NIs in 2020, which was significantly lower than the 2.56% (1021/39914) of patients in 2019. The rate of critical and fatal cases was also decreased. Except for the ICU, the prevalence of nosocomial infection in most departments decreased from 2019 to 2020. Regarding the source of infections, a significant reduction was mainly observed in respiratory (0.99% vs 0.42%, p=0.000) and digestive tract (0.63% vs 0.14%, p=0.000). The microorganism analysis of respiratory infections indicated an obvious decline in acinetobacters and fungi. The most significant decline of pathogens in gastrointestinal infections was observed for rotavirus. The comparison of catheter-related nosocomial infections between 2019 and 2020 did not show significant differences. Conclusions: The prevention and control measures for the COVID-19 pandemic have reduced the nosocomial infection in almost all departments, except the ICU, mainly regarding respiratory, gastrointestinal, and oral infections, while catheter-related infections did not show any differences.

scholarly journals Rabies mortality and morbidity associated with animal bites in Africa: A case for Integrated Rabies Diseases Surveillance, Prevention and Control - A Scoping review

2020 ◽  
Author(s):  
Peter Nyasulu ◽  
Jacqueline Weyer ◽  
Rea Tschopp ◽  
Adane Mihret ◽  
Abraham Aseffa ◽  
...  
Keyword(s):  
Rural Areas ◽  
Prevention And Control ◽  
Animal Health ◽  
Global Strategy ◽  
World Health ◽  
Human Rabies ◽  
Post Exposure Prophylaxis ◽  
African Countries ◽  
Rabies Control ◽  
And Control

Background: Rabies a neglected tropical disease, mostly affecting poor and vulnerable populations living in remote rural areas in developing countries. The disease continues to pose a significant public health a threat with an estimated 59,000 dog-transmitted human deaths, of which an estimated 21,476 human deaths occur in Africa each year. The global strategy has been set by the quartite World Health Organization (WHO), the World Organization for Animal Health (OIE), the Food and Agriculture Organization of the United Nations (FAO) and the Global Alliance for Rabies Control (GARC), aiming for "zero human deaths associated with dog transmitted rabies by 2030". African countries, however, face several challenges and there are still gaps in controlling rabies. The aim of this study review is to determine rabies prevalence, mortality and associated risk factors in both human population and animal population and to evaluate the presence or absence of integrated one health surveillance response in African nations. Methods and analysis: We will conduct an electronic literature searches on PubMed, CINAHL, (Cumulative Index of Nursing and Allied Health Literature), Scopus, and Web of Science and other relevant databases. Reference lists from identified published articles or reviews and conference abstracts will also be searched for relevant articles. Published and unpublished literatures (grey) will be included in the search. The findings will be presented graphically in terms of mortality, morbidity, interventions for rabies control in Africa, research gaps identified, available research evidence, rabies surveillance, prevention and control and adverse events. Conclusion: This review will contribute to the coordination of interventions for surveillance, prevention, and control with African countries as country-based gaps and challenges and opportunities will be highlighted. In addition, the scaling up of post-exposure prophylaxis (PEP rabies will be evaluated in African countries and the projection to achieve the target of "zero deaths of human rabies by 2030" in Africa.

scholarly journals Supportive or Confining? The Impact of War Metaphors From the COVID-19 Pandemic on Persons With Disabilities in Mainland China

2021 ◽  
Vol 9 ◽  
Author(s):  
Ren-Xing Chen ◽  
Zhong-Ming Ge ◽  
Shu-Ling Hu ◽  
Wei-Zhong Tang
Keyword(s):  
Prevention And Control ◽  
Research Method ◽  
Mainland China ◽  
Well Being ◽  
Informal Support ◽  
Persons With Disabilities ◽  
The Public ◽  
Public Crisis ◽  
And Control ◽  
The Impact

Ensuring the well-being of persons with disabilities (PWDs) is a priority in the public sector during the coronavirus disease 2019 (COVID-19) pandemic. To contain this unprecedented public crisis in China, a set of nationwide anti-epidemic discourse systems centered on war metaphors has guided the epidemic's prevention and control. While the public is immersed in the joy brought by the stage victory, most ignore the situation of the disadvantaged PWDs. Accordingly, this study adopts and presents a qualitative research method to explore the impact of war metaphors on PWDs. The results showed that while there was some formal and informal support for PWDs during this period, they were increasingly marginalized. Owing to the lack of a disability lens and institutional exclusion, PWDs were placed on the margins of the epidemic prevention and control system like outsiders. Affected by pragmatism under war metaphors, PWDs are regarded as non-contributory or inefficient persons; therefore, they are not prioritized and are thus placed into a state of being voiceless and invisible. This research can provide inspiration for improving public services for PWDs in the context of COVID-19.

scholarly journals Renewed Global Partnerships and Redesigned Roadmaps for Rabies Prevention and Control

2011 ◽  
Vol 2011 ◽  
pp. 1-18 ◽  
Author(s):  
Tiziana Lembo ◽  
Michaël Attlan ◽  
Hervé Bourhy ◽  
Sarah Cleaveland ◽  
Peter Costa ◽  
...  
Keyword(s):  
Prevention And Control ◽  
Animal Health ◽  
Health Sector ◽  
Integrated Approach ◽  
Health Concern ◽  
Human Rabies ◽  
Global Public Health ◽  
Canine Rabies ◽  
And Control ◽  
Rabies Prevention

Canine rabies, responsible for most human rabies deaths, is a serious global public health concern. This zoonosis is entirely preventable, but by focusing solely upon rabies prevention in humans, this “incurable wound” persists at high costs. Although preventing human deaths through canine rabies elimination is feasible, dog rabies control is often neglected, because dogs are not considered typical economic commodities by the animal health sector. Here, we demonstrate that the responsibility of managing rabies falls upon multiple sectors, that a truly integrated approach is the key to rabies elimination, and that considerable progress has been made to this effect. Achievements include the construction of global rabies networks and organizational partnerships; development of road maps, operational toolkits, and a blueprint for rabies prevention and control; and opportunities for scaling up and replication of successful programs. Progress must continue towards overcoming the remaining challenges preventing the ultimate goal of rabies elimination.

scholarly journals A knowledge, attitudes, and practices study on ticks and tick-borne diseases in cattle among farmers in a selected area of eastern Bhutan

PLoS ONE ◽  
2021 ◽  
Vol 16 (2) ◽  
pp. e0247302
Author(s):  
Jamyang Namgyal ◽  
Tenzin Tenzin ◽  
Sylvia Checkley ◽  
Tim J. Lysyk ◽  
Sangay Rinchen ◽  
...  
Keyword(s):  
Prevention And Control ◽  
Animal Health ◽  
Control Measures ◽  
Favorable Attitude ◽  
Feeding System ◽  
Livestock Farming ◽  
Effective Prevention ◽  
Adequate Knowledge ◽  
Prevention And Control Measures ◽  
And Control

Livestock farming plays an important role in supporting the livelihood of resource-poor subsistence farmers in Bhutan. However, ticks and tick-borne diseases (TBDs) are one of the major constraints to livestock farming due to their negative effect on health and production. To date, no study has been conducted in Bhutan to assess farmers’ knowledge, attitude, and practices (KAP) about ticks and TBDs in cattle, although such information is essential in ensuring the development and adoption of effective prevention and control measures. Therefore, a KAP survey was conducted among 246 cattle owners in the Samkhar sub-district of eastern Bhutan in June 2019, using a structured questionnaire. Based on our scoring criteria, 52% [95%CI: 45.5–58.4] had adequate knowledge about ticks as potential vectors of diseases. Logistic regression analysis showed that the individuals who practiced a stall-feeding system of cattle rearing were 2.8 times [OR = 2.8 (95%CI: 1.66–4.78)] more likely to have adequate knowledge than others. Sixty-eight percent [95%CI: 62.5–74.4] had a favorable attitude toward tick prevention and control programs. Men were 1.95 times [OR = 1.95 (95%CI: 1.09–3.55)] more likely to have a favorable attitude than women, and the individuals who practiced a stall-feeding system were 2.59 times [OR = 2.59 95%CI: 1.45–4.78)] more likely to have a favorable attitude than others, after adjusting for the effect of other variables in the model. Overall, only 38% [95%CI 32.5–45] of the respondents reported tick infestation as one of the most important animal health problems, but 100% reported using acaricides to control ticks in cattle. Despite a high level of acaricide usage, the level of knowledge was low among the farmers interviewed. Findings from this study underline the importance of considering identified knowledge gaps and initiating education efforts to improve the adoption of effective tick prevention and control measures among farmers.

scholarly journals Maintenance of Fish Health in Aquaculture: Review of Epidemiological Approaches for Prevention and Control of Infectious Disease of Fish

2018 ◽  
Vol 2018 ◽  
pp. 1-10 ◽  
Author(s):  
Ayalew Assefa ◽  
Fufa Abunna
Keyword(s):  
Infectious Disease ◽  
Traffic Control ◽  
Prevention And Control ◽  
Control Strategies ◽  
Disease Outbreaks ◽  
Effective Prevention ◽  
Disease Case ◽  
And Control ◽  
Water Treatments ◽  
The Impact

Aquaculture is rapidly growing part of agriculture worldwide. It makes up around 44 percent of total fish production globally. This increased growth of production is achieved despite facing many challenges in the aquaculture environment. Among production limiting challenges, the infectious disease takes the lion share by causing multibillion-dollar loss annually. To reduce the impact of the fish disease, it is necessary to address health constraints based on scientifically proven and recommended ways. This review aims at pointing out some of the best approaches to prevention and control of infectious disease in aquaculture. Among the effective prevention and control strategies, vaccination is one of the key practices. Types of vaccines for use in fish include killed vaccines, attenuated vaccines, DNA vaccines, recombinant technology vaccines, and synthetic peptide vaccines. Administration techniques of vaccines in fish include oral, injection, or immersion methods. Antibiotics are also in use in aquaculture despite their side effects in the development of drug resistance by microorganisms. Biological and chemical disease control strategies such as using probiotics, prebiotics, and medicinal plants are widely in use. Biosecurity measures in aquaculture can keep the safety of a facility from certain disease-causing agents that are absent in particular system. Farm-level biosecurity measures include strict quarantine measures, egg disinfection, traffic control, water treatments, clean feed, and disposal of mortalities. In conclusion, rather than trying to treat every disease case, it advisable to follow a preventive approach before the event of any disease outbreaks.

scholarly journals Changes in prevalence of nosocomial infection pre- and post-COVID-19 pandemic from a tertiary Hospital in China

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Chunmei Su ◽  
Zhiqin Zhang ◽  
Xu Zhao ◽  
Hanlin Peng ◽  
Yi Hong ◽  
...  
Keyword(s):  
Nosocomial Infection ◽  
Nosocomial Infections ◽  
Prevention And Control ◽  
Control Measures ◽  
Gastrointestinal Infections ◽  
Effective Prevention ◽  
Oral Infections ◽  
Prevention And Control Measures ◽  
And Control ◽  
The Impact

Abstract Background Nosocomial infections (NIs) are an important cause of mortality, and increasing evidence reveals that the prevalence of NIs can be reduced through effective prevention and control measures. The aim of this study was to investigate the impact of the prevention and control measures for the COVID-19 pandemic on NIs. Methods A retrospective study was conducted to analyze the prevalence of NIs before and after COVID-19 pandemic for 6 months in the Children’s Hospital of Soochow University. Results A total of 39,914 patients in 2019 and 34,645 patients in 2020 were admitted to the hospital during the study. There were 1.39% (481/34645) of patients with NIs in 2020, which was significantly lower than the 2.56% (1021/39914) of patients in 2019. The rate of critical and fatal cases was also decreased. In addition, the rate of appropriate handwashing, the number of protective gloves and aprons used per person and the number of healthcare staff per patients were significantly increased. Except for the ICU, the prevalence of nosocomial infection in most departments decreased from 2019 to 2020. Regarding the source of infections, a significant reduction was mainly observed in respiratory (0.99% vs 0.42%, p = 0.000) and digestive tract (0.63% vs 0.14%, p = 0.000). The microorganism analysis of respiratory infections indicated an obvious decline in acinetobacters and fungi. The most significant decline of pathogens in gastrointestinal infections was observed for rotavirus. The comparison of catheter-related nosocomial infections between 2019 and 2020 did not show significant differences. Conclusions The prevention and control measures for the COVID-19 pandemic have reduced the nosocomial infection in almost all departments, except the ICU, mainly regarding respiratory, gastrointestinal, and oral infections, while catheter-related infections did not show any differences.

scholarly journals Does the Policy of Ecological Forest Rangers (EFRs) for the Impoverished Populations Reduce Forest Disasters?—Empirical Evidence from China

Forests ◽  
2022 ◽  
Vol 13 (1) ◽  
pp. 80
Author(s):  
Zhongcheng Yan ◽  
Feng Wei ◽  
Xin Deng ◽  
Chuan Li ◽  
Qiang He ◽  
...  
Keyword(s):  
Local Governments ◽  
Prevention And Control ◽  
Well Being ◽  
Forest Resource ◽  
Forest Protection ◽  
Effective Prevention ◽  
Significant Difference ◽  
Resource Endowments ◽  
And Control ◽  
The Impact

The effective prevention and control of forest disasters is important for forest resources and the well-being of those living in forested areas. This study evaluates the impact of a policy that employs a rural impoverished population as ecological forest rangers (EFRs) for the incidence of forest disasters. We estimate a generalized difference in differences (DID) model using nationwide provincial-level forest disaster data combined with regional data in all policy pilot areas. There are three primary findings. (1) The implementation of the EFR policy failed to effectively reduce the incidence of forest fires, forest pests, forest diseases, forest rodents and other forest disasters, which shows that the EFR policy has not achieved the goal of “forest protection”. (2) The effect of the EFR policy on forest disaster control is not significantly different among provinces with different forest resource endowments and different levels of social and economic development. This shows that there is no significant difference in the implementation of EFR policies between different forest resource endowments and different socioeconomic development areas. (3) The EFR policy failed to achieve the effective coordination of the dual goals of “poverty reduction” and “ecological protection”; this is the main reason for the failure to reduce the incidence of forest disasters while reducing poverty. The pressure of this policy neglected the “forest management and protection” function of the policy and the corresponding assessment requirements. At the same time, the central government also neglected the assessment of the prevention and control of “forest disasters” by local governments when implementing this policy. Ultimately, the opportunism of local governments and ecological rangers was strengthened. Therefore, the goals of environmental service payment items and the corresponding evaluation index settings need to be matched to truly achieve the established goals.

scholarly journals Accounting for underreporting in mathematical modelling of transmission and control of COVID-19 in Iran

2020 ◽  
Author(s):  
Meead Saberi ◽  
Homayoun Hamedmoghadam ◽  
Kaveh Madani ◽  
Helen M. Dolk ◽  
Andrei S. Morgan ◽  
...  
Keyword(s):  
Reproduction Number ◽  
Estimation Method ◽  
Case Fatality ◽  
Transmission Model ◽  
School Closures ◽  
The Public ◽  
Case Fatality Ratio ◽  
And Control ◽  
The Impact ◽  
Pharmaceutical Interventions

SUMMARYBackgroundIran has been the hardest hit country by the outbreak of SARS-CoV-2 in the Middle East with 74,877 confirmed cases and 4,683 deaths as of 15 April 2020. With a relatively high case fatality ratio and limited testing capacity, the number of confirmed cases reported is suspected to suffer from significant under-reporting. Therefore, understanding the transmission dynamics of COVID-19 and assessing the effectiveness of the interventions that have taken place in Iran while accounting for the uncertain level of underreporting is of critical importance. We use a mathematical epidemic model utilizing official confirmed data and estimates of underreporting to understand how transmission in Iran has been changing between February and April 2020.MethodsWe developed a compartmental transmission model to estimate the effective reproduction number and its fluctuations since the beginning of the outbreak in Iran. We associate the variations in the effective reproduction number with a timeline of interventions and national events. The estimation method also accounts for the underreporting due to low case ascertainment by estimating the percentage of symptomatic cases using delay-adjusted case fatality ratio based on the distribution of the delay from hospitalization-to-death.FindingsOur estimates of the effective reproduction number ranged from 0.66 to 1.73 between February and April 2020, with a median of 1.16. We estimate a reduction in the effective reproduction number during this period, from 1.73 (95% CI 1.60 – 1.87) on 1 March 2020 to 0.69 (95% CI 0.68-0.70) on 15 April 2020, due to various non-pharmaceutical interventions including school closures, a ban on public gatherings including sports and religious events, and full or partial closure of non-essential businesses. Based on these estimates and given that a near complete containment is no longer feasible, it is likely that the outbreak may continue until the end of the 2020 if the current level of physical distancing and interventions continue and no effective vaccination or therapeutic are developed and made widely available.InterpretationThe series of non-pharmaceutical interventions and the public compliance that took place in Iran are found to be effective in slowing down the speed of the spread of COVID-19 within the studied time period. However, we argue that if the impact of underreporting is overlooked, the estimated transmission and control dynamics could mislead the public health decisions, policy makers, and general public especially in the earlier stages of the outbreak.FundingNil.

Sign in / Sign up

Export Citation Format

Share Document