OCL for Rich Domain Models Implementation - An Incremental Aspect based Solution

2015 ◽  
Author(s):  
Alberto-Manuel Fernández-Álvarez ◽  
Daniel Fernández-Lanvin ◽  
Manuel Quintela-Pumares
Keyword(s):  
Rich Domain ◽  
Domain Models

METHOD FOR SYNTHESIS OF CONCEPTUAL DATA MODELS BASED ON PROCESS DOMAIN MODELS

2020 ◽  
pp. 80-87
Author(s):  
С.И. Рябухин
Keyword(s):  
Data Modeling ◽  
Database Design ◽  
Data Models ◽  
Process Models ◽  
Domain Models ◽  
Conceptual Data

Процессные модели предметной области широко применяются при проектировании баз данных, а именно в ходе концептуального моделирования данных. Предлагается решение проблемы неоднозначности преобразования процессных доменных моделей типа SADT в концептуальные модели данных. Domain process models are widely used in database design, namely in conceptual data modeling. The solution of the problem of ambiguity of transformation of process domain models of the SADT type into conceptual data models is proposed.

Nogo-A Activates NF-κB Through Its N-Terminal Proline Rich Domain*

2009 ◽  
Vol 36 (3) ◽  
pp. 371-377 ◽  
Author(s):  
Jin-Xiang DAI ◽  
Keng CHEN ◽  
Wei-Lin JIN ◽  
Gong JU
Keyword(s):  
Rich Domain

Extending the Rule Space Model to a Semantically-Rich Domain: Diagnostic Assessment in Architecture.

1993 ◽  
Author(s):  
Irvin R. Katz ◽  
Michael E. Martinez ◽  
Kathleen Sheehan ◽  
Kikumi K. Tatsuoka
Keyword(s):  
Diagnostic Assessment ◽  
Space Model ◽  
Rich Domain ◽  
Rule Space ◽  
Rule Space Model

On the Power of the Object

2017 ◽  
Author(s):  
Liubov Vetoshkina ◽  
Yrjö Engeström ◽  
Annalisa Sannino
Keyword(s):  
Point Of View ◽  
The Political ◽  
Material Objects ◽  
Human Beings ◽  
Work Activities ◽  
Skilled Performance ◽  
Rich Domain ◽  
Boat Building ◽  
Building Activity ◽  
History Of

By skillfully shaping and producing objects human beings externalize and make real their future-oriented imaginaries and visions. Material objects created by skilled performance make human lifeworlds durable. From the point of view of history making, wooden boat building is a particularly rich domain of skilled performance. This chapter is based on two research sites, one in Finland and the other in Russia. The analysis is divided into four layers or threads of history making, namely personal history, the history of the wooden boat community, the political history of the nations and their relations, and the history of the boats themselves as objects of boat-building activity. The chapter ends by discussing our findings and their implications for the understanding of skilled performance and history making in work activities and organizations.

scholarly journals Implementing Zn2+ ion and pH-value control into artificial mussel glue proteins by abstracting a His-rich domain from preCollagen

Soft Matter ◽  
2021 ◽  
Author(s):  
Sandra Arias ◽  
Shahrouz Amini ◽  
Jana M. Krüger ◽  
Lukas D. Bangert ◽  
Hans G. Börner
Keyword(s):  
Ph Value ◽  
Control Mechanisms ◽  
Rich Domain ◽  
Glue Proteins ◽  
Β Sheets ◽  
Mussel Adhesive

A chemically activated mussel-inspired polymerization of a His-rich peptide, yielded artificial mussel glue proteins, where β-sheets can be triggered to mimic both adhesive motifs and cohesion control mechanisms of the mussel adhesive apparatus.

scholarly journals Structural comparison of CD163 SRCR5 from different species sheds some light on its involvement in porcine reproductive and respiratory syndrome virus-2 infection in vitro

2021 ◽  
Vol 52 (1) ◽  
Author(s):  
Hongfang Ma ◽  
Rui Li ◽  
Longguang Jiang ◽  
Songlin Qiao ◽  
Xin-xin Chen ◽  
...  
Keyword(s):  
Scavenger Receptor ◽  
Host Cells ◽  
Respiratory Syndrome Virus ◽  
Swine Industry ◽  
Prrs Virus ◽  
Rich Domain ◽  
Serious Disease ◽  
The One ◽  
And Control

AbstractPorcine reproductive and respiratory syndrome (PRRS) is a serious disease burdening global swine industry. Infection by its etiological agent, PRRS virus (PRRSV), shows a highly restricted tropism of host cells and has been demonstrated to be mediated by an essential scavenger receptor (SR) CD163. CD163 fifth SR cysteine-rich domain (SRCR5) is further proven to play a crucial role during viral infection. Despite intense research, the involvement of CD163 SRCR5 in PRRSV infection remains to be elucidated. In the current study, we prepared recombinant monkey CD163 (moCD163) SRCR5 and human CD163-like homolog (hCD163L1) SRCR8, and determined their crystal structures. After comparison with the previously reported crystal structure of porcine CD163 (pCD163) SRCR5, these structures showed almost identical structural folds but significantly different surface electrostatic potentials. Based on these differences, we carried out mutational research to identify that the charged residue at position 534 in association with the one at position 561 were important for PRRSV-2 infection in vitro. Altogether the current work sheds some light on CD163-mediated PRRSV-2 infection and deepens our understanding of the viral pathogenesis, which will provide clues for prevention and control of PRRS.

scholarly journals The Evolution of the Scavenger Receptor Cysteine-Rich Domain of the Class A Scavenger Receptors

2015 ◽  
Vol 6 ◽  
Author(s):  
Nicholas V. L. Yap ◽  
Fiona J. Whelan ◽  
Dawn M. E. Bowdish ◽  
G. Brian Golding
Keyword(s):  
Scavenger Receptor ◽  
Scavenger Receptors ◽  
Class A ◽  
Rich Domain ◽  
Cysteine Rich Domain

scholarly journals Malaria parasites both repress host CXCL10 and use it as a cue for growth acceleration

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Yifat Ofir-Birin ◽  
Hila Ben Ami Pilo ◽  
Abel Cruz Camacho ◽  
Ariel Rudik ◽  
Anna Rivkin ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Life Cycle ◽  
Cerebral Malaria ◽  
Survival Strategy ◽  
Parasitic Disease ◽  
Malaria Parasites ◽  
Sensing System ◽  
Rich Domain ◽  
Cargo Delivery ◽  
Low Levels

AbstractPathogens are thought to use host molecular cues to control when to initiate life-cycle transitions, but these signals are mostly unknown, particularly for the parasitic disease malaria caused by Plasmodium falciparum. The chemokine CXCL10 is present at high levels in fatal cases of cerebral malaria patients, but is reduced in patients who survive and do not have complications. Here we show a Pf ‘decision-sensing-system’ controlled by CXCL10 concentration. High CXCL10 expression prompts P. falciparum to initiate a survival strategy via growth acceleration. Remarkably, P. falciparum inhibits CXCL10 synthesis in monocytes by disrupting the association of host ribosomes with CXCL10 transcripts. The underlying inhibition cascade involves RNA cargo delivery into monocytes that triggers RIG-I, which leads to HUR1 binding to an AU-rich domain of the CXCL10 3’UTR. These data indicate that when the parasite can no longer keep CXCL10 at low levels, it can exploit the chemokine as a cue to shift tactics and escape.

scholarly journals The Combined Human Genotype of Truncating TTN and RBM20 Mutations Is Associated with Severe and Early Onset of Dilated Cardiomyopathy

Genes ◽  
2021 ◽  
Vol 12 (6) ◽  
pp. 883
Author(s):  
Anna Gaertner ◽  
Julia Bloebaum ◽  
Andreas Brodehl ◽  
Baerbel Klauke ◽  
Katharina Sielemann ◽  
...  
Keyword(s):  
Heart Failure ◽  
Dilated Cardiomyopathy ◽  
Early Onset ◽  
Target Genes ◽  
Frameshift Mutation ◽  
Rna Binding ◽  
Splicing Factor ◽  
Binding Motif ◽  
Rich Domain ◽  
Generation Sequencing

A major cause of heart failure is cardiomyopathies, with dilated cardiomyopathy (DCM) as the most common form. Over 40 genes are linked to DCM, among them TTN and RBM20. Next Generation Sequencing in clinical DCM cohorts revealed truncating variants in TTN (TTNtv), accounting for up to 25% of familial DCM cases. Mutations in the cardiac splicing factor RNA binding motif protein 20 (RBM20) are also known to be associated with severe cardiomyopathies. TTN is one of the major RBM20 splicing targets. Most of the pathogenic RBM20 mutations are localized in the highly conserved arginine serine rich domain (RS), leading to a cytoplasmic mislocalization of mutant RBM20. Here, we present a patient with an early onset DCM carrying a combination of (likely) pathogenic TTN and RBM20 mutations. We show that the splicing of RBM20 target genes is affected in the mutation carrier. Furthermore, we reveal RBM20 haploinsufficiency presumably caused by the frameshift mutation in RBM20.

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