Vitamin-D Level in Patients with Type-2 Diabetes Mellitus of different Age and Sex: its Effects on BMI, Calcium Level

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Zarghuna Khan ◽  
Munazza Khan ◽  
Sher Bahadur ◽  
Zafaruddin Khan ◽  
Yasir Khan ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Vitamin D ◽  
Blood Sugar ◽  
Type Ii Diabetes ◽  
Calcium Level ◽  
Calcium Concentration ◽  
Type Ii Diabetes Mellitus ◽  
Type Ii ◽  
Type 2 Diabetic

Background: Type II diabetes is one of vital health problems in Pakistan. Type 2 diabetic patients are more prone to developVitamin-D deficiency and hypocalcaemia however, the effect of age, sex, ethnicity, BMI and socioeconomic status also has a role inaffecting the outcomes. The aim of this study was to compare Vitamin-D level in patients with type-2 Diabetic Mellitus of differentage and sex and to determine the association of vitamin-D level with BMI, calcium and blood sugar level.Objectives: The main objective of this study was to determine and compare the changes in Vitamin- D and serum calcium level inpatients with type- 2 diabetes mellitus with respect to their Body Mass Index (BMI), age, sex and ethnic groups.Material and Methods: This was a cross-sectional analytical study, carried out in the outpatient department of endocrine unit ofHayatabad Medical Complex, Pakistan from 1st July 2018 to 31st august 2018. Using convenient sampling technique, patients withknown cases of Type II diabetes mellitus of all age groups, regardless of gender, ethnic group were consented to be part of thestudy. Patients taking vitamin D and calcium supplements and patients with renal and liver diseases were excluded. For vitamin Dand Calcium concentration 5 ml blood was taken. Data was recorded on a structured Proforma and entered into SPSS version22.0. For comparison student's t-test was used while Pearson correlation was used for determining the association betweenvitamin-D, BMI, blood sugar level and calcium concentration, where P-value <0.05 was considered as significant.Results: A total of 238 individuals with mean age of 51.24 ± 7.7 out of whom 103(49.2%) were males and 121(50.8%) werefemales. The mean vitamin-D concentration was 17.86 ± 15.3 ng/ml and mean calcium level was 8.50 ± 0.6 mg/dL respectively.Regarding vitamin D deficiency males were more affected as compared to females (p=0.04). However in case of calciumconcentration there was no significant difference (p=0.17). The relationship observed between blood sugar level and vitamin D wasweakly inverse (r =-0.035, P = 0.5). However the inverse relationship of sugar level and calcium was significant (r=-0.135, p=0.01).Conclusion: Type-II diabetes mellitus leads may lead to low calcium levels where males are more prone to be affected. Thiscondition aggravates with increase in age. This study basically concludes that vitamin-D deficiency in inversely associated withtype-2 diabetes.

scholarly journals Clinical evaluation of an Ayurvedic Formulation in the management of Avaranajanya Madhumeha (Type 2 Diabetes Mellitus)

2019 ◽  
Vol 1 ◽  
pp. 50-64
Author(s):  
DEVASHISH BHARDWAJ ◽  
VEENIT K. AGNIHOTRI ◽  
PRANAV PANDYA
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Blood Sugar ◽  
Type Ii Diabetes ◽  
Type Ii Diabetes Mellitus ◽  
Type Ii ◽  
Research Plan ◽  
Urine Sugar ◽  
Diabetes Patients

A research plan has been developed in the present study to address the problems associated with Avaranajanya Madhumeha (type 2 diabetes). This research plan is based on the treatment methods of Ayurveda (ancient Indian medicine) and utilization of modern scientific methods as research tools. A specific ayurvedic herbo-mineral formulation has been prepared in Ghansatt (solid extract) form; the selected eight herbs and one herbo-mineral have anti-hyperglycemic (PRAMEHA HARA) and antihypercholestermic (MEDOHARA) properties with rejuvenative (RASAYANA) effects as described in classical ayurvedic methods. 15 diagnosed type II diabetes mellitus patients were selected through accidental sampling. Ayurvedic formulation was prescribed to type II diabetes patients for one year along with dietary restrictions. Diabetic diagnostic parameters of these patients like Fasting Blood Sugar (FBS), Post Patrum Blood Sugar (PPBS), Glycocylated Hemoglobin (HbA1C) and Urine Sugar Fasting were monitored every three months; these were measured before and after intervention. The obtained data were statistically analyzed through paired t-test. There was significant reduction in FBS level, PPBS level, HbA1C level and urine fasting sugar level in type 2 diabetes patients who completed the clinical trial successfully. Thus, ayurvedic formulation treatment lead to an overall significant reduction in blood sugar and urine sugar levels in type II diabetes patients. No side effects were noted during the study period. This study suggests that the ayurvedic formulation had very good hypoglycemic effects proved by clinical improvement and bio-chemical analysis of diabetes parameters in the treatment of type II diabetes mellitus.

scholarly journals Management Of Diabetes Mellitus Type 2 For Elderly: Taichi Exercise To Reduce Blood Sugar Levels

2021 ◽  
Vol 1 (2) ◽  
pp. 112-117
Author(s):  
Fahruddin Kurdi ◽  
Zainal Abidin ◽  
Ratna Puji Priyanti ◽  
Anja Hesnia Kholis
Keyword(s):  
Diabetes Mellitus ◽  
Blood Sugar ◽  
Type Ii Diabetes ◽  
Sampling Technique ◽  
Type Ii Diabetes Mellitus ◽  
Rank Test ◽  
Type Ii ◽  
Patients With Diabetes ◽  
Sugar Levels

Elderly are high risk for the development of type 2 diabetes due to the combined effects of increasing insulin resistance and impaired pancreatic function with aging. Diabetes mellitus is a chronic disease that causes insulin in the pancreas is not effective one of the treatments that can be done by diabetics to reduce blood sugar levels One of them with physical activity, the activity is taichi exercises.The purpose of this study was to investigate the effect of taichi exercises on reducing blood sugar levels in patients with type II diabetes mellitus.The design of this study was pre-experiment one group pre-test and post-test design with a population of 88 patients and a sample of 44 respondents. Research sampling technique used purposive sampling. Data collection with observation sheets. The intervention was carried out four times during 4 weeks. Before the intervention, sugar levels of type II diabetics were classified as moderate as 24 people (54.5%) and high as many as 20 people (45.5%). After the management of taichi exercises sugar levels experienced changes in the categories of good as many as 16 people (36.4%), moderate as many as 20 people (45.5%) and high as many as 8 people (18.2%). Data analized with Wilcoxon Signed Rank test with a significant level α = 0.05, the result ρ-value = 0.001 means ρ-value <α so that there is a significant effect of taichi exercises on decreasing blood sugar levels in patients with type II diabetes mellitus. Blood sugar levels in patients with diabetes mellitus before doing taichi exercises with the number of respondents 44 people mostly experienced changes, evidenced by the level of blood sugar levels from moderate levels to good. Keywords: Elderly, Taichi, Diabetes Mellitus, Blood sugar level

scholarly journals Frequency of peripheral neuropathy in newly diagnosed cases of type II diabetes mellitus.

2021 ◽  
Vol 28 (10) ◽  
pp. 1443-1446
Author(s):  
Altaf Ahmad Yar ◽  
Munaza Javed ◽  
Muzamul Shahzad ◽  
Javed Iqbal ◽  
Muhammad Imran Aslam ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Peripheral Neuropathy ◽  
Blood Sugar ◽  
Type Ii Diabetes ◽  
Type Ii Diabetes Mellitus ◽  
Cross Sectional Study ◽  
Type Ii ◽  
Newly Diagnosed ◽  
Cross Sectional

Objective: The aim of this study is to determine the frequency of peripheral neuropathy in newly diagnosed cases of type II diabetes mellitus. Study Design: Cross Sectional Study. Setting: Department of Medicine at Avicenna Medical & Dental College, Lahore. Period: 1st February 2020 to 31st July 2020. Material & Methods: One hundred and twenty newly diagnosed patients of type 2 diabetes mellitus were enrolled in this study. Patients detailed demographically recorded after getting written consent. Patients were diagnosed for the duration of 4-weeks and calculated fasting blood sugar (FBS) of ≥126mg/dl, and Random Blood Sugar (RBS) of ≥200 mg/dl or HbA1c ≤6.5. Results: Seventy (58.3%) were males and rest 50 (41.7%) were females with mean age 37.15±10.91 years. Mean body mass index of the patients was 22.48±3.66 kg/m2. Forty two (35%) patients had symptoms of peripheral neuropathy while that patient’s who did not have any symptom was 78 (65%). Same symptoms were observed within 4-weeks and we noticed that 23 (19.2%) patients showed peripheral neuropathy and rest 97 (80.8%) patients did not have any symptoms. Conclusion: The frequency of peripheral neuropathy is higher in early stages of type II diabetes mellitus and its frequency can be reduced to diagnose within a month.

scholarly journals Comparative assessment of serum levels of vitamin d3 in chronic generalised periodontitis patients with type 2 diabetes mellitus and in simple gingivitis patients - A clinico-bio chemical study

2021 ◽  
Vol 6 (3) ◽  
pp. 161-164
Author(s):  
Gonabhavi Siri Chandana ◽  
Ramesh Amirisetty ◽  
Neelam Manojvaibhav ◽  
Ramesh Nichenametla ◽  
Shanti Prathyusham ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Vitamin D ◽  
Type 2 Diabetes Mellitus ◽  
Periodontal Disease ◽  
Bone Metabolism ◽  
Type Ii Diabetes ◽  
Type Ii Diabetes Mellitus ◽  
Type Ii

The role of vitamin D was well established in bone metabolism as well as in the inflammatory process of a disease. The periodontal disease which is a chronic inflammatory condition with destructive bone metabolism and type II diabetes mellitus which is a metabolic condition with more prone to inflammatory reactions are prevalent in middle-aged patients. Hence the present study is done to assess the vitamin D levels in serum of chronic generalized periodontitis patients with type2 Diabetes mellitus and simple gingivitis patients  Two groups with 50 patients of both periodontal disease with type 2 diabetes and 50 simple gingivitis patients of age 35 to 55 years old were recruited in this study. For all the patient's serum 25(OH)D levels, oral hygiene index (OHI), Russel’s periodontal index, and presence of bony defects in radiographs were assessed.After assessment of all the parameters patients with periodontal disease and type 2 diabetes mellitus showed significantly higher proportion levels than the simple gingivitis patients and significantly lower levels in 25(OH)D (&#60;From the results, it was concluded that generalized periodontitis patients with type II diabetes mellitus showed higher levels of 25-hydroxyvitamin D levels than simple gingivitis patients.

STUDY OF SERUM VITAMIN-D IN TYPE-2 DIABETES MELLITUS PATIENTS.

2021 ◽  
pp. 187-188
Author(s):  
Ajay Jain ◽  
Debina sarkar ◽  
G.G. Kaushik ◽  
Ankita Sharma
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Vitamin D ◽  
Type 2 Diabetes Mellitus ◽  
Blood Sugar ◽  
Healthy Subjects ◽  
Serum Vitamin ◽  
Serum Vitamin D ◽  
Type 2 Diabetic

Background: Type-2 diabetes mellitus (T2DM) is a progressive and chronic disease characterized by both β-cell dysfunction and increased insulin resistance. Diabetes mellitus is now considered a giant killer disease of the 21st century with its vicious prongs in the South-East Asian countries, specially India, which is rightly said to be the ''Diabetes Capital'' of the world. Vitamin D has important effects on insulin action, and may impact on a number of pathways which may be of importance in the development of type 2 diabetes mellitus. Materials & Methods: In this study 62 Type-2 diabetic patients, 62 healthy controls were enrolled. Biochemical analytes measured were Serum glucose (Fasting Blood Sugar & Post Prandial Blood Sugar), Glycosylated Haemoglobin, Serum Vitamin-D. Results: The mean Serum Vitamin-D in Type-2 diabetic subjects were (16.3 ±3.0) while in healthy subjects(controls) the values were (39.3±5.2) respectively. These values were found to be statistically highly signicant(p<0.001). Conclusion: Serum Vitamin-D levels were decreased in Type 2 diabetic subjects as compared to the values in healthy subjects(controls).

DIABETIC STRIATOPATHY: A RARE PRESENTATION OF NONKETOTIC HYPERGLYCEMIA

2021 ◽  
pp. 108-109
Author(s):  
Ranjan Mallick ◽  
Shyam Sunder Hembram ◽  
Ram Chandra Bhadra Chandra Bhadra
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type Ii Diabetes ◽  
Western Europe ◽  
Rare Complication ◽  
Type Ii Diabetes Mellitus ◽  
Type Ii ◽  
Rare Presentation ◽  
Acute Hyperglycaemia

Type II Diabetes Mellitus is one of the most common non-communicable diseases with innumerable & potentially life threatening complications. In 2017, approximately 462 million individuals were affected by type 2 diabetes corresponding to 6.28% of the world's population (4.4% of those aged 15-49 years, 15% of those aged 50-69, and 22% of those aged 70+), or a prevalence rate of 6059 cases per 100,000. Over 1 million deaths per year can be attributed to diabetes alone, making it the ninth leading cause of mortality. The burden of diabetes mellitus is rising globally, and at a much faster rate in developed regions, such as Western Europe. The gender distribution is equal, and the incidence peaks at around 55 years of age. Global prevalence of type 2 diabetes is projected to increase to 7079 individuals per 100,000 by 2030, reecting a continued rise across all regions of the world.[¹] . Two of the common complications due to acute hyperglycaemia are Diabetic Ketocidosis & Non ketotic hyperosmolar coma which are considered a spectrum of the same complication due to low circulating levels of insulin leading to impaired glucose metabolism by insulin dependant tissues with rising levels of anti-insulin hormones like glucagon, cortisol & catecholamines due to intracellular starvation resulting in hypergylcemia & fatty acid breakdown & ketonemia. Amongst the numerous complications of Type II Diabetes Mellitus, here we present a rare complication of acute hyperglycaemia and its radiological picture in the central nervous system. A 56 year old female patient with a history of Type II Diabetes Mellitus with Hypertension under long term medication came for a private consultation with a complaint of Right sided involuntary, random, irregular, inging and ailing, rapid, non-patterned movements for past 7 days. The patient was advised for an urgent MRI of Brain which demonstrated high T1 signal & low T2/FLAIR intensity with no diffusion restriction of DWI & ADC map in left sided putamen & head of caudate nucleus. We illustrated a rare classical nding of acute hyperglycemic effect on brain in a case of long standing Type II Diabetes Mellitus despite being on medications

scholarly journals Elevated serum uric acid and triglycerides level in the patients with Type II Diabetes Mellitus- a Nepalese case control study

2017 ◽  
Vol 2 (2) ◽  
pp. 26-34
Author(s):  
Hridaya Parajuli ◽  
Jyotsna Shakya ◽  
Bashu Dev Pardhe ◽  
Puspa Raj Khanal ◽  
Narayan Prasad Parajuli ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Uric Acid ◽  
Serum Uric Acid ◽  
Type Ii Diabetes ◽  
Type Ii Diabetes Mellitus ◽  
Diabetic Patients ◽  
Type Ii ◽  
Significant Difference

Background: Hyperuricemia is associated with type 2 diabetes, which is a metabolic disorder of multiple etiologies resulting from defects in insulin action. The present study wascarried out to look for any association between uric acid and Type II Diabetes Mellitus and also status of triacylglycerol level among those patients.Methods: The blood samples were collected 100 diabetic and 100 non-diabetic individuals in the department of biochemistry and then analyzed for estimation of blood glucose, Uric Acid and Triacylglycerol level.Results: The average level of serum uric acid in diabetic patients was higher (5.706±1.617) in comparison to non diabetic subjects (4.322±0.784) with statistically significant difference (p≤0.05). For female the result indicate there was a positive correlation between (FBS and triglycerides) and (triglycerides and uric acids) which was statistically significant (r =-0.465, n = 41, p = 0.002) and(r =-0.370, n = 41, p = 0.017) respectively.Conclusions: This study documents that hyperuricemia is associated with type 2 diabetes mellitus. Furthermore, the serum triacylglycerol and serum uric acid is also found to be associated risk factors for diabetic complications. Hence, timely diagnosis and management of diabetes is vital to control the complications related to diabetes.Ann. Clin. Chem. Lab. Med. 2016:2(1); 26-34

scholarly journals Influence of Glycated Haemoglobin Levels on Intraocular Pressure in patients with Type –II Diabetes Mellitus

2019 ◽  
Vol 11 (1) ◽  
pp. 19-23
Author(s):  
Ajai Agrawal ◽  
Shubham Ahuja ◽  
Anupam Singh ◽  
Ramanuj Samanta ◽  
Sanjeev Kumar Mittal
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Intraocular Pressure ◽  
Type Ii Diabetes ◽  
Type Ii Diabetes Mellitus ◽  
Type Ii ◽  
Group I ◽  
Hba1c Levels

Introduction: Patients with diabetes mellitus are at a higher risk of developing primary open angle glaucoma (POAG) as compared to non-diabetic patients. Objectives: To determine whether there is a correlation between hyperglycemic levels and intraocular pressure (IOP) and to identify patients of Type II diabetes mellitus who are at a higher risk of developing glaucoma. Materials and Methods: This was a hospital based, cross sectional study performed on patients with type II diabetes mellitus, at a tertiary health care center in Uttarakhand, India between July, 2018 and September, 2018. 318 eyes of 159 patients with Type2 diabetes mellitus were included in the study. IOP was measured by Goldmannappla nation to no meter and central corneal thickness was measured with specula microscope in all patients, in addition to glycated hemoglobin levels (HbA1c) and fasting and post-prandial blood glucose levels. The data was analysed using SPSS 22 software. Results: Mean IOP was found to be 15.75 ± 3.18 mm Hg in patients with HbA1c levels between 6.5%-12% (Group I) and 17.42 ± 2.67 mm Hg in patients with HbA1c levels more than 12 % (Group II). The difference between the two groups was statistically significant (P =0.013). Out of 159 patients with Type 2 Diabetes mellitus, a total of 11 patients had IOP more than 21mm Hg in one or both the eyes. Conclusion: Hyperglycaemic levels as determined by raised HbA1c levels are associated with higher intraocular pressures in patients with type 2 diabetes mellitus.

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