scholarly journals Catheter Related Bloodstream Infection by Brevibacterium casei in a Patient with B Cell Acute Lymphoid leukemia - A Case Report

2021 ◽  
Vol 8 (7) ◽  
pp. 9-13
Author(s):  
Smita Deshkar ◽  
Niranjan Patil ◽  
Pranali Balmiki
Keyword(s):  
B Cell ◽  
Blood Stream Infection ◽  
Blood Stream ◽  
Comorbid Conditions ◽  
Lymphoid Leukemia ◽  
Blood Stream Infections ◽  
Indwelling Catheters ◽  
Acute Lymphoid Leukemia ◽  
Gram Positive Bacteria

Patients with long term indwelling catheters with underlying immunosuppression or comorbid conditions are predisposed to develop catheter related blood stream infections with unusual organisms. Brevibacterium spp. are catalase-positive, non spore-forming, non-motile, aerobic, Gram-positive bacteria. Brevibacterium spp werenot considered a human pathogen, until recently few infections were noted. We report a case of catheter related blood stream infection by Brevibacterium casei in 17 year old young adult with B cell acute lymphoid leukemia. Patient was treated successfully with intravenous Vancomycin and Piperacillin-tazobactam along with peripherally inserted central catheter removal. Keywords: Brevibacterium casei, Catheter related blood stream infections, Sepsis, Immunocompromised

scholarly journals Bacterial and Fungal Profile, Drug Resistance Pattern and Associated Factors of Isolates Recovered From Blood Samples of Patients Referred to Ethiopian Public Health Institute: Cross-Sectional Study

2021 ◽  
Author(s):  
Etsehiwot Adamu Tsegaye ◽  
Dejenie Shiferaw Teklu ◽  
Zelalem Tazu Bonger ◽  
Abebe Assefa Negeri ◽  
Tesfaye Legesse Bedada ◽  
...  
Keyword(s):  
Risk Factors ◽  
Burkholderia Cepacia ◽  
Blood Stream Infection ◽  
Blood Stream ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Blood Stream Infections ◽  
Gram Positive Bacteria ◽  
Blood Specimens

Abstract Background Blood stream infections are serious infections that usually induce prolongation of hospital stay, morbidity and mortality in several countries including Ethiopia. The aim of this study was to determine bacterial and fungal profile, their drug resistance patterns, and risk factors associated with blood stream infections. Methods A cross sectional study design was conducted from February 23 to June 23, 2020 at Ethiopian public health. A structured questionnaire was used to collect data on socio-demographic factors and clinical conditions. Blood specimens were analyzed using standard microbiological techniques. Antimicrobial susceptibility tests were performed using Kirby-Bauer disc diffusion technique and Vitek compact 2. Simple and multiple logistic regressions were used to assess the potential risk factors. Results A total of 175 pathogens isolated from 346 blood specimens. Of these, 60% Gram-negative bacteria, 30.86% Gram-positive bacteria and 9.14% fungal isolates were identified. Burkholderia cepacia and Coagulase negative staphylococcus were the predominant pathogen among Gram-negative and Gram-positive bacteria respectively. Among fungus, Candidia krusei (56.25%) was the most predominant isolate. The highest proportions of antibacterial resistance were observed among 3rd generation cephalosporin and penicillin. Most fungal isolates expressed resistance to fluconazole. Sex (p = 0.007), age (p < 0.001) and use of invasive medical devices (p = 0.003) were identified as risk factors for bacterial blood stream infections. Conclusion The study showed high prevalence of blood stream infection was due to Burkholderia cepacia and non-Candidia albicans spp. This finding alarming ongoing investigation of blood stream infection is important for recognizing future potential preventive strategies including environmental hygiene and management of comorbid medical diseases to reduce the problem.

scholarly journals Bacterial and fungal profile, drug resistance pattern and associated factors of isolates recovered from blood samples of patients referred to Ethiopian Public Health Institute: cross-sectional study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Etsehiwot Adamu Tsegaye ◽  
Dejenie Shiferaw Teklu ◽  
Zelalem Tazu Bonger ◽  
Abebe Aseffa Negeri ◽  
Tesfaye Legesse Bedada ◽  
...  
Keyword(s):  
Risk Factors ◽  
Blood Stream Infection ◽  
Blood Stream ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Blood Stream Infections ◽  
Gram Negative ◽  
Gram Positive Bacteria ◽  
Blood Specimens

Abstract Background Blood stream infections are serious infections that usually induce prolongation of hospital stay, morbidity and mortality in several countries including Ethiopia. The aim of this study was to determine bacterial and fungal profile, their drug resistance patterns, and risk factors associated with blood stream infections. Methods A cross sectional study design was conducted from February 23 to June 23, 2020 at Ethiopian public health. A structured questionnaire was used to collect data on socio-demographic factors and clinical conditions. Blood specimens were analyzed using standard microbiological techniques. Antimicrobial susceptibility tests were performed using Kirby–Bauer disc diffusion technique and Vitek compact 2. Simple and multiple logistic regressions were used to assess the potential risk factors. Results A total of 175 pathogens isolated from 346 blood specimens. Of these, 60% Gram-negative bacteria, 30.86% Gram-positive bacteria and 9.14% fungal isolates were identified. Burkholderia cepacia and Coagulase negative staphylococcus were the predominant pathogen among Gram-negative and Gram-positive bacteria respectively. Among fungus, Candida krusei (56.25%) was the most predominant isolate. The highest proportions of antibacterial resistance were observed among 3rd generation cephalosporin and penicillin. Most fungal isolates expressed resistance to fluconazole. Sex (P = 0.007), age (P < 0.001) and use of invasive medical devices (P = 0.003) were identified as risk factors for bacterial blood stream infections. Conclusion The study showed high prevalence of blood stream infection was due to B. cepacia and non-C. albicans spp. This finding alarming ongoing investigation of blood stream infection is important for recognizing future potential preventive strategies including environmental hygiene and management of comorbid medical diseases to reduce the problem.

scholarly journals E2A-PBX1 Remodels Oncogenic Signaling Networks in B-cell Precursor Acute Lymphoid Leukemia

2016 ◽  
Vol 76 (23) ◽  
pp. 6937-6949 ◽  
Author(s):  
Jesús Duque-Afonso ◽  
Chiou-Hong Lin ◽  
Kyuho Han ◽  
Michael C. Wei ◽  
Jue Feng ◽  
...  
Keyword(s):  
B Cell ◽  
Signaling Networks ◽  
Cell Precursor ◽  
Oncogenic Signaling ◽  
Lymphoid Leukemia ◽  
Acute Lymphoid Leukemia

scholarly journals The Impact of the Introduction of Innovative REDS Scale for the Evaluation of Central Tunnelled Catheter (CTC) Exit Site on Infection Prevention in Long-Term Haemodialyzed Patients

2021 ◽  
Vol 8 ◽  
Author(s):  
Tomasz Porazko ◽  
Edyta Stasiak ◽  
Marian Klinger
Keyword(s):  
Blood Stream Infection ◽  
Bloodstream Infections ◽  
Cost Effective ◽  
Blood Stream ◽  
Site Infection ◽  
Exit Site ◽  
Exit Site Infection ◽  
The Impact

Central tunneled catheter (CTC)-related infections are a leading cause of a catheter loss, thus being the source of significant morbidity and mortality. The study aims at evaluating the impact of the implementation of the innovative redness, edema, discharge and tenderness, symptoms (REDS) scale (devised by the authors) for the description of the tunnel condition on the frequency of infection in long-term catheter users. The same cohort of the 40 patients was observed for 4 years altogether: 2 years before and 2 years after REDS application. The results, as well as follow-up evaluation of participants, were compared. The 2-year cumulative incidence of the CTC exit site infection (ESI) dropped significantly (log-rank p &lt; 0.001) from 0.89 episode/1,000 catheter days (53.5%, 95% CI [35.9%; 66.2%]) in the period before REDS was used—to 0.26 episode/1,000 catheter days (18.6%, 95% CI [6.1%; 29.4%]) in the time of REDS application. There were also significantly fewer episodes of ESI complicated with catheter-related blood stream infection (CRBSI) requiring the CTC removal (0.6 episode/1,000 catheter days; 18.6%, 95% CI [6.1%; 29.4%] vs. 0.3 episode/1,000 catheter days; 4.7%, 95% CI [0.0; 10.7%]; log-rank p = 0.04, in pre-REDS and REDS time, respectively). The REDS scale appears to be a simple, cost-effective tool reducing the frequency of the tunneled CTC exit site infection and associated bloodstream infections.

Sign in / Sign up

Export Citation Format

Share Document