Clinical course of new coronavirus infection in patients of the dispensary group

2021 ◽  
Vol 342 (10) ◽  
pp. 31-36
Author(s):  
P.E. Krainyukov ◽  
A.V. Demyanenko ◽  
T.N. Mashkov ◽  
V.G. Abashin
Keyword(s):  
Clinical Course ◽  
Coronavirus Infection

scholarly journals COMPARISON OF BIOCHEMICAL PARAMETERS OF PATIENTS WITH LIVER CIRRHOSIS WITH AND WITHOUT COVID-19

InterConf ◽  
2021 ◽  
pp. 288-294
Author(s):  
Nurgul Toktogulova ◽  
Elvira Zhakisheva ◽  
Turarbek Kaliev ◽  
Umid Satarov ◽  
Alena Smirnova
Keyword(s):  
Liver Cirrhosis ◽  
Liver Damage ◽  
Biochemical Parameters ◽  
Clinical Course ◽  
Age Groups ◽  
Coronavirus Infection ◽  
Liver Tests

There have been many published studies on how COVID-19 can affect the liver and how the severity of liver damage can influence the clinical course of COVID-19. The article describes the features of the biochemical parameters of the liver in different age groups developing with a new coronavirus infection using the example of observations in the department of gastroenterology. In patients under 60 years of age with liver cirrhosis in combination with Covid-19, along with deeper changes in liver tests, a decrease in hemoglobin, leukopenia and thrombocytopenia was observed.

scholarly journals EPIDEMIOLOGIC ASPECTS IN PREVENTION OF THE NEW CORONAVIRUS INFECTION (COVID-19): LITERATURE REVIEW

2021 ◽  
pp. 167-176
Author(s):  
T.M. Butaev ◽  
◽  
A.S. Tsirikhova ◽  
D.V. Kabaloeva ◽  
D.O. Kudukhova ◽  
...  
Keyword(s):  
Literature Review ◽  
Clinical Course ◽  
Public Healthcare ◽  
Resident Physicians ◽  
Rapid Spread ◽  
The World ◽  
History Of ◽  
Coronavirus Infection ◽  
The Moment

At the end of 2019 the mankind had to face a new coronavirus infection with higher virulence which resulted in its rapid spread all over the world and in an ultimate pandemic. Initially a new virus which causes COVID-19 was called 2019-nCoV but it soon acquired its well-known name, SARS-CoV-2. We can positively state that this new coronavirus infec- tion will remain in the history of world public healthcare as a disease that caused a collapse in rendering medical aid. Un- doubtedly, this new coronavirus infection has changed customary lifestyle of the overall world population.This review can be considered problematic in its essence and focuses on examining contemporary trends in the official epidemiologic situation in the world regarding the new coronavirus infection (SARS-CoV-2). Having analyzed several for- eign and domestic documents, the authors revealed a necessity to enhance levels and quality of COVID-19 epidemiologic diagnostics. There is a suggestion being considered at the moment on including additional clinical and diagnostic activities aimed at preventing further spread of the new coronavirus infection. We should note that data on COVID-19-related mortal- ity and morbidity are renewed every day and every hour. Given that, it seems rather difficult to keep in line with the latest trends in COVID-19 prevention and epidemiologic diagnostics. However, the authors made an attempt to possibly collect all the latest data on epidemiological peculiarities related to clinical course of the new coronavirus infection. The authors have a hope that this review will be useful for epidemiologists when they detect new cases of the diseases as well as for lecturers at medical higher educational establishments when they train students and resident physicians.

scholarly journals Epidemiological Features of New Coronavirus Infection (COVID-19). Communication 1: Modes of Implementation of Preventive and Anti-Epidemic Measures

2020 ◽  
pp. 6-13 ◽  
Author(s):  
V. V. Kutyrev ◽  
A. Yu. Popova ◽  
V. Yu. Smolensky ◽  
E. B. Ezhlova ◽  
Yu. V. Demina ◽  
...  
Keyword(s):  
Clinical Course ◽  
General Structure ◽  
Age Groups ◽  
Reproductive Rate ◽  
Response Models ◽  
Serial Interval ◽  
The World ◽  
Coronavirus Infection ◽  
The Russian Federation

The review analyses the information on the epidemiological situation on COVID-19 around the world. Presented is the assessment of the major epidemiological parameters (basic reproductive rate, lethality, incubation period, and serial interval). Demonstrated is the share of severe cases among different age groups and the general structure of incidence by the severity of clinical course. The paper provides the classification of response models internationally depending upon the complex of measures undertaken at different stages of epidemic process. Reviewed are the key response actions to control the COVID-19 transmission in different countries of the world and the Russian Federation and given is the assessment of their effectiveness.

scholarly journals Incretin-Based Therapies Role in COVID-19 Era: Evolving Insights

2020 ◽  
Vol 25 (6) ◽  
pp. 494-496
Author(s):  
Anca Pantea Stoian ◽  
Nikolaos Papanas ◽  
Martin Prazny ◽  
Ali A. Rizvi ◽  
Manfredi Rizzo
Keyword(s):  
Scientific Community ◽  
Clinical Course ◽  
Mechanisms Of Action ◽  
Disease Pathogenesis ◽  
Prognostic Variables ◽  
Dipeptidyl Peptidase 4 ◽  
Treatment Regimens ◽  
Antidiabetic Treatment ◽  
Coronavirus Infection

The current coronavirus disease 2019 (COVID-19) pandemic has led the scientific community to breach new frontiers in the understanding of human physiology and disease pathogenesis. It has been hypothesized that the human dipeptidyl peptidase 4 (DPP4) enzyme receptor may be a functional target for the spike proteins of severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2). Since DPP4-inhibitors are currently used for the treatment of patients with type-2 diabetes (T2DM), there is currently high interest in the possibility that these agents, or incretin-based therapies (IBTs) in general, may be of benefit against the new coronavirus infection. Diabetes is associated with increased COVID-19 severity and mortality, and accumulating evidence suggests that IBTs may favorably alter the clinical course of SARS-CoV-2 infection due to their inherent mechanisms of action. Further research into prognostic variables associated with various antidiabetic treatment regimens, and in particular the IBT, in patients with T2DM affected by the COVID-19 pandemic is therefore warranted.

Features of virus infection COVID-19 during the pregnancy

2020 ◽  
Vol 18 (6) ◽  
pp. 20-23
Author(s):  
D. I. SHEVELEVA ◽  
◽  
A. V. ROMANOVSKAYA ◽  
N. F. KHVOROSTUKHINA ◽  
◽  
...  
Keyword(s):  
Polymerase Chain Reaction ◽  
Pregnant Women ◽  
Lower Respiratory Tract ◽  
Clinical Course ◽  
Polymerase Chain Reaction Method ◽  
Chain Reaction ◽  
Reaction Method ◽  
Gestational Stage ◽  
Coronavirus Infection ◽  
Polymerase Chain

The purpose of the research was to study the features of the clinical course of COVID-19 viral infection in pregnant women, depending on the gestational stage. Material and methods. Included the study of 67 pregnant women with COVID-19 at different periods of gestation. The age of women ranged from 16 to 41 years. All pregnant women were hospitalized to the infectious diseases departments of Saratov hospitals. During the period of hospitalization, the examination of women was carried out according to the methodological recommendations of the Ministry of Health of Russia for coronavirus infection in pregnant women. During virological examination of mucus from the pharynx and nose, using the reverse transcription polymerase chain reaction method, the RNA of the COVID-19 virus was found in all pregnant women. Results. COVID-19 most frequently infects primipara in the I (61,6%) and III (70,6%) trimester of gestation and multipara in the II (62,5%) trimester of gestation with burdened obstetrics-gynecological anamnesis (58,3%) and accompanying pathologies (41,5%). In pregnant women with COVID-19, mild and intermediate forms of the disease prevailed (31,3% and 47,8% respectiely). The frequency of coronavirus infection in the I (38,8%) and II (35,8%) trimesters of gestation increases the frequency of that in the III (25,3%) trimester. Among women with COVID-19, the following symptoms were observed: decrease in smell and taste in 66 (98,5%) cases, sore throat in 59 (85%) cases, increased body temperature in 61 (90,9%) cases. Lesions of lower respiratory tract was observed in all stages of gestation, pneumonias were less frequent in the I trimester. In all cases the COVID-19 course had a favorable outcome, with no lethality.

Impact of a new coronavirus infection on the clinical course of immunoinflammatory rheumatic diseases

2021 ◽  
Vol 13 (2) ◽  
pp. 39-47
Author(s):  
Vadim I. Mazurov ◽  
Irina B. Belyaeva ◽  
Lubov E. Sarantseva ◽  
Anton L. Chudinov ◽  
Roman A. Bashkinov ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Viral Infection ◽  
Rheumatic Diseases ◽  
Biological Therapy ◽  
Clinical Course ◽  
Underlying Disease ◽  
Clinical Rheumatology ◽  
Undifferentiated Arthritis ◽  
Saint Petersburg ◽  
Coronavirus Infection

BACKGROUND: The COVID-19 pandemic poses a particular threat to patients suffering from immunoinflammatory rheumatic diseases. New coronavirus infection has been found to be accompanied by the development of a wide range of extrapulmonary clinical and laboratory manifestations, which are characteristic of a number of immunoinflammatory rheumatic diseases. AIM: To evaluate the features of the clinical course of immunoinflammatory rheumatic diseases in patients who underwent new coronavirus infection. MATERIALS AND METHODS: The clinical course of immunoinflammatory rheumatic diseases was analyzed in 324 patients who underwent new coronavirus infection from March 2020 to February 2021 and were treated at the Clinical Rheumatology Hospital No. 25, Saint Petersburg, for exacerbation of the underlying disease. RESULTS: Analysis showed that the risk factors for severe new coronavirus infection in patients with immunoinflammatory rheumatic diseases were: age over 60, comorbidities, use of prednisolone in a dose greater than 12,5 mg, and ESR values 40 mm/hour before the development of new coronavirus infection. There was no effect of immunosuppressive and biological therapy on the severity of the course of viral infection. There was no effect of immunosuppressive therapy and biological therapy on the severity of the course of viral infection in patients with immunoinflammatory rheumatic diseases. The development of the postinfectious syndrome was observed in 1/4 of patients, which was characterized by the formation of postinfectious arthritis in 3,6% of patients, transformation of undifferentiated arthritis into various rheumatic diseases in 49% of patients (more often into early rheumatoid arthritis), as well as exacerbation of the underlying disease in 83,4% of patients with an advanced stage of rheumatoid arthritis. In patients with mixed connective tissue disease, there was a significant increase in immunologic activity due to antinuclear factor (up to a maximum of 1:163 840). Clinical cases of the development of arthritis associated with viral infection and the debut of rheumatoid arthritis after an new coronavirus infection are presented. CONCLUSIONS: New coronavirus infection in the cohort of patients with immunoinflammatory rheumatic diseases observed in the Clinical Rheumatology Hospital No. 25, Saint Petersburg, proceeded in the variant of medium severity in half of patients, initiated the development of lung lesions in 68,6% of patients, arthritis associated with viral infection in 3,6% of patients, immunoinflammatory rheumatic diseases which transformed from undifferentiated arthritis in 49% of cases and exacerbation of the main disease in an overwhelming number of patients. Patients with immunoinflammatory rheumatic diseases have a high risk of adverse outcome of new coronavirus infection, especially in cases of unstable course of the disease or exacerbation of this group of diseases.

scholarly journals Clinical course of COVID-19 infection in elderly patient with melanoma on nivolumab

2020 ◽  
Vol 26 (5) ◽  
pp. 1289-1294 ◽  
Author(s):  
Emre Yekedüz ◽  
Bengü Dursun ◽  
Güle Ç Aydın ◽  
Satı C Yazgan ◽  
Halis H Öztürk ◽  
...  
Keyword(s):  
Viral Infections ◽  
Clinical Course ◽  
Good Condition ◽  
Metastatic Malignant Melanoma ◽  
Chronic Viral Infections ◽  
Important Target ◽  
Programmed Death ◽  
Programmed Death 1 ◽  
New Type ◽  
Coronavirus Infection

Outbreak of the new type coronavirus infection, known as coronavirus infection 2019 (COVID-19), has begun in December 2019, in Wuhan, China. As of today, 3 April 2020, 972,640 people affected and 50,325 people died from Severe Acute Respiratory Syndrome-Coronavirus 2. There is not any standard treatment for coronavirus infection 2019; however, there are promising data for hydroxychloroquine and some anti-retroviral drugs. Programmed death-1 (PD-1)/programmed death ligand-1 (PDL-1) pathway is an important target for the cancer immunotherapy. However, there is a robust pre-clinical and clinical data regarding inhibitor effect of this pathway on the acute or chronic viral infections. Thus, blockade of this pathway may lead to an anti-viral effect and decrease viral load. Here, we report the clinical course of coronavirus infection 2019 infection of a patient in whom older aged, having multiple co-morbidities, and taking nivolumab for metastatic malignant melanoma. In contrast to her older age, comorbidities, and cancer diagnosis, she was in a good condition, and there was also no pneumonia finding. We think that this good clinical course of coronavirus infection 2019 infection may be related to blockade of PD-1/PDL-1 pathway with nivolumab. It is impossible to say that blockade of PD-1/PDL-1pathway is a treatment option for COVID-19; however, we want to share our experience.

scholarly journals The treatment of children infected with COVID-19 in a non-core hospital

2020 ◽  
Vol 11 (2) ◽  
pp. 5-14 ◽  
Author(s):  
Dmitry O. Ivanov ◽  
Dmitry V. Zabolotskii ◽  
Victor A. Koriachkin ◽  
Yury S. Alexandrovich ◽  
Vladimir V. Kopylov ◽  
...  
Keyword(s):  
Clinical Course ◽  
Public Health Problem ◽  
International Committee ◽  
World Health ◽  
Level Control ◽  
X Ray ◽  
Coronavirus Infection ◽  
Health Organization ◽  
Treatment Of Infection ◽  
Ultrasound Features

According to the World Health Organization (WHO), viral diseases form serious public health problem. WHO announced that the disease caused by the new virus named coronavirus disease 2019 or Coronavirus disease 2019 (COVID-19), and the virus causing the infection was named SARS-Cov-2 by the International Committee on Taxonomy of Viruses. Children usually have asymptomatic or mild forms. However, children with comorbidity are in risk of developing severe forms of COVID-19. The review presents modern ideas about the amount of laboratory tests in cases of suspected presence of the SARS-CoV-2 virus, methods of radio diagnostic (computer tomography, x-ray, thorax ultrasound), features of the clinical course of infection in children depending on the severity of the of infection and indicated detailed criteria for severe forms of coronavirus infection. Special attention is focused on the clinical monitoring of children in a non-core hospital: the detection of leukopenia and lymphopenia, CRP level control, monitoring of coagulation disorders, providing tests on other respiratory viruses. Specific recommendations, comprehensive to date, on the use of drugs for the treatment of children with COVID-19 upon admission to a non-core hospital are given. The organisational issues of treatment children infected with COVID-19 in a non-core hospital are described in details. Special attention is focused on the compliance of strict safety rules by staff working with infected patients entering and leaving the Red zone. Thus, the proper organisation of the units for the treatment of children infected with COVID-19 in a non-core hospital, taking into account the features of their disease, will make it possible to provide complete and high-quality treatment of infection during the pandemic.

scholarly journals Evaluation of Intensive Care Measures in Children with Severe New Coronavirus Infection in Pediatric Intensive Care Units

2021 ◽  
Vol 18 (6) ◽  
pp. 7-14
Author(s):  
Yu. S. Аleksandrovich ◽  
D. V. Prometnoy ◽  
P. I. Mironov ◽  
K. V. Pshenisnov ◽  
P. E. Аnchutin ◽  
...  
Keyword(s):  
Intensive Care ◽  
Clinical Course ◽  
Volume Overload ◽  
Pediatric Intensive Care ◽  
Therapeutic Strategies ◽  
Disease Outcome ◽  
Moderate Correlation ◽  
Intravenous Fluid Administration ◽  
Coronavirus Infection ◽  
Number Of Publications

Currently, the number of publications on specific features of the clinical course and outcomes of new coronavirus infection COVID-19 in children is steadily increasing, but there are practically no works demonstrating the effectiveness of intensive care interventions, which served as the basis for the present analysis.The objective is to assess the effectiveness of primary intensive care interventions in children with a severe course of new coronavirus infection.Subjects and Methods. 94 patients were examined. Evaluation of intensive care measures was carried out upon admission to ICU.Results. It was found that corticosteroids were used only in 55 (58.5%) patients (χ2 = 5.254, p = 0.022, Pearson conjugation criterion = 0.130). A moderate correlation was established between the unjustified prescription of prednisolone and the unfavorable disease outcome (χ2 = 27.98, p < 0.001, Pearson conjugation criterion = 0.296). The moderate strength of the association between the prescription of antibacterial drugs and the disease outcome was noted (χ2 = 34.01, p < 0.001, Pearson conjugation criterion = 0.331). In all lethal cases, there was volume overload due to excessive intravenous fluid administration (χ2 = 5.14, p = 0.024).Conclusion: individual therapeutic strategies do not have a direct significant impact on outcomes of new coronavirus infection in children, however, the delivery of comprehensive intensive care presented in clinical guidelines is associated with the patient's recovery.

scholarly journals Genetic determinants of the response to coronavirus infection COVID-19

2020 ◽  
Author(s):  
SV Poyarkov ◽  
VV Makarov ◽  
SA Kraevoy ◽  
SM Yudin
Keyword(s):  
Life Cycle ◽  
Clinical Manifestation ◽  
Clinical Course ◽  
Viral Life Cycle ◽  
Genetic Determinants ◽  
Allelic Variants ◽  
Prevention And Treatment ◽  
Coronavirus Infection ◽  
Personalized Approach

The heterogeneity of the clinical manifestation of COVID-19 may be associated with the characteristics of the genome of both humans and the virus. A combination of allelic variants of genes associated with viral life cycle can determine susceptibility to SARS-CoV-2 infection. Allelic variants in genes ACE1, ACE2, TMPRSS2, IL6, SLC6A20, LZTFL1, CCR9, FYCO1, CXCR6, and XCR1 can determine the severity of COVID-19. Analysis of the genomes of COVID-19 patients with different clinical course and development on their basis of model for stratification of people according to the degree of susceptibility and severity of manifestation will allow to develop a personalized approach for the prevention and treatment of COVID-19.

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