Effect of Trishothadi Lepam on Tropical foot ulcer – Case Report

2020 ◽  
Vol 8 (05) ◽  
Author(s):  
Jayshree Satpute ◽  
Rajesh Gundre ◽  
Chandrakant Chate
Keyword(s):  
Wound Healing ◽  
Healing Process ◽  
Foot Ulcer ◽  
Cost Effective ◽  
Underlying Mechanism ◽  
Complete Healing ◽  
Wound Healing Process ◽  
Ulcer Case ◽  
Group A ◽  
Group B

Siravyadhana and Trishothadi Lepam application was intended for healthy wound healing. Probably it will have an understanding of underlying mechanism of relieving vascular stasis, reducing venous congestion and beginning of re-vascularization and other wound healing process. The Group-B showing maximum percentage of benefit followed by Group-A. Hence it can be concluded that overall benefit is found maximum in Group-A where Siravyadhana with Trishothadi Lepam was administered. The  drug  Trishothadi Lepam might be shown the efficacy due to Lekhana, Kledahara, Shoshana, Shotha & Dahahara, RaktaShodhaka and Twaka Prasadana properties. this procedure is found to be very much safe, simple, cost-effective, easily administered in the patients of foot ulcers leading them for complete healing avoiding the most unwanted outcome of amputation.

Prospective Study to Evaluate Effect of Autologus Plasma Injection in the Wound Site immediately after Primary Wound Closure on Wound Healing

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Mahmoud A Elshafai ◽  
Khaled A Reyad ◽  
Ahmed Y Elrifai ◽  
Samar E Sallam
Keyword(s):  
Wound Healing ◽  
Wound Care ◽  
Healing Process ◽  
Control Group ◽  
Wound Healing Process ◽  
Primary Wound Closure ◽  
Plasma Injection ◽  
Group A ◽  
Group B ◽  
Interventional Group

Abstract Corresponding Background Wound healing Process and Scars are still a nightmare for the surgeon and the author: patient as well, because of the large number and wide variability of factors affecting the process itself. Plasma injection is a very promising futuristic therapy and can be superior to PRP injection having more abundant growth factors, fibrin and healing promoters. Aim of the Work to evaluate the effect of injection of the whole plasma components in the wound site intradermally immediately after primary wound closure on the process of wound healing. Patients and Methods This prospective co-operative study included 20 patients having wounds in different sites of the abdomen after approval of research ethical committee of the Faculty of Medicine, Ain Shams University at July 2018, The patients are divided into two groups: an interventional group (group A) 10 cases which are received plasma treatment together with the usual wound care, and a control group (group B) 10 cases which are received the usual wound care only without plasma treatment, in the period between August 2018 to March 2019. Results We have found a faster wound healing process, higher cosmetic results, better color match, more patients' satisfaction and lower susceptibility to complications in the interventional group (A) that received plasma injection than in the control group (B) which received only the usual wound care without plasma injection reflecting the positive impact of plasma injection on the wound healing process. Conclusion We concluded that there are reasonable amount of data that warrant continued research and usage of plasma in the process of wound healing.

A Clinical Study on Vrana Shodhana Action of Gomutra Arka in Dushtavrana w.s.r. to Diabetic Foot Ulcer

2017 ◽  
Vol 2 (06) ◽  
Author(s):  
Mrudul Mohan ◽  
Sanjay Sharma ◽  
Shyam Prasad M. ◽  
Rajneesh V. Giri ◽  
Gururaja D.
Keyword(s):  
Clinical Study ◽  
Diabetic Foot ◽  
Healing Process ◽  
Foot Ulcer ◽  
Diabetic Foot Ulcer ◽  
Wound Healing Process ◽  
Surrounding Area ◽  
Post Test ◽  
Group A ◽  
Group B

Context: The diabetic foot ulcer, being chronic in nature involves various tissues, it can be considered as Dushtavrana in Ayurveda. Proper Care for diabetic foot with medication and procedures that has hastened the healing process with less complication is the need of the hour. Aim: To evaluate the Vrana Shodhana action of Gomutra Arka in Dushtavrana w.s.r. to diabetic foot ulcers. Settings and Design: It is a clinical study with pre-test and post-test design. Total number of patient’s taken for the study was 40 excluding dropouts. The patients selected for the study were divided in to 2 groups, Group-A and Group-B, consisting of 20 patients each. Materials and Methods: The wound is examined, exudates, debris, slough were removed, the surrounding area was cleaned and pad soaked in Gomutra Arka was placed and wound dressing was done once in a day. Duration of study was 45 days or till the formation of granulation tissue whichever is earlier, assessment was done every 7 days. For healing Jatyadi Taila was applied after the Shodhana Kriya with Gomutra Arka. Conclusion: Gomutra Arka was having good results in reducing burning sensation, itching, smell, size, depth, discharge, edge, floor and presence of granulation tissues compared to Betadine. Both drugs have equal effect in reducing pain. Both drugs have Shodhana, Lekhana properties, hastens the wound healing process which helps in reduction of wound size. It can be concluded that Gomutra Arka application is effective in all types of Diabetic foot ulcer by their faster, effective Shodhana, Lekhana, Vedana Shamaka, Kandu Shamaka, Daha Shamaka properties compared to Betadine.

scholarly journals Angiosome based revascularization for diabetic foot ulcer

2019 ◽  
Vol 6 (10) ◽  
pp. 3474
Author(s):  
Ahmed M. Hossny ◽  
Mahmoud S. Eldesouky ◽  
Mohamed A. Abdellatif
Keyword(s):  
Diabetic Foot ◽  
Healing Process ◽  
Foot Ulcer ◽  
Diabetic Foot Ulcer ◽  
Complete Healing ◽  
Controlled Study ◽  
University Hospitals ◽  
Acceptable Result ◽  
Group A ◽  
Group B

Background: The purpose of this study was to analyze the clinical benefit in wound healing and limb preservation after infrapopliteal endovascular revascularization guided by an angiosome model of perfusion in the healing process of diabetic foot ulcers.Methods: This is a prospective controlled study was conducted on 60 patients with critical lower limb ischemia in the form of diabetic foot ulcer and/or gangrene. The study period started from August 2017 until February 2019. Patients included in the study were essentially attending the Vascular Outpatient Clinic at Menoufia University Hospitals and Nasser Institute for Search and Treatment at Cairo treated by infra-popliteal angioplasty.Results: The 60 patients of our study who underwent successful infra-popliteal angioplasty we found that after six months 18 patients in the direct group A (85.71%), 9 patients in indirect group B (42.85%) and 17 patients in combined group C (94.44%) showed complete healing of their wounds and that 18 patients in group A (85.71%), 15 patients in group B (71.42%) and 17 patients in group C (94.44%) have their limbs salvaged total 50 patients (83.33%).Conclusions: We concluded that dilation of angiosome target artery plus any other significant tibial artery lesions should be considered and indirect revascularization should not be denied with acceptable result over time.

scholarly journals Efek Terapi Oksigen Hiperbarik (TOHB) pada Penyembuhan Ulkus Kaki DM Tipe 2 Berdasarkan Skor PEDIS

2019 ◽  
Vol 11 (2) ◽  
pp. 110
Author(s):  
Ekanova R. N. Sumarauw ◽  
Mendy J. Hatibie ◽  
Djony E. Tjandra ◽  
Fredrik G. Langi
Keyword(s):  
Wound Healing ◽  
Diabetic Foot ◽  
Controlled Trial ◽  
Healing Process ◽  
Foot Ulcer ◽  
Diabetic Foot Ulcer ◽  
Control Group ◽  
Wound Healing Process ◽  
Holistic Treatment ◽  
The Third

Abstract: Diabetic foot ulcer (DFU) is still a health problem related to the extent amount of time in wound healing process hence increasing the treatment cost. Given any methods that are not sat-isfying, encourage the search of other methods that would increase the wound healing rate, in which hyperbaric oxygen therapy (HBOT) is amongst them. The DFU patient that receives HBOT shows a significant increase in angiogenesis process markedly by faster epithelialization and granulation process. This study was aimed to prove that HBOT could accelerate the wound healing process among DFU patients measured by wound size and depth of PEDIS score. This was a ran-domized controlled trial study, conducted at Surgery Department of Prof. Dr. R. D. Kandou Gen-eral Hospital from September 2018 to March 2019. There were 20 DFU patients divided into two groups, each of 10 patients. The control group received a holistic treatment, meanwhile the HBOT group received a holistic treatment added with the inclusion of HBOT. PEDIS score assessment of DFU in HBOT group was measured before and after the third HBOT session, meanwhile the con-trol group was measured on the first and the third day. The results showed that the difference in PEDIS score value was markedly found in HBOT group compared to the control group (2 vs. 0, P=0.001). Conclusion: HBOT could enhance the wound healing process in DFU patients based on the declined PEDIS score.Keywords: HBOT, PEDIS score, diabetic foot ulcerAbstrak: Ulkus kaki diabetik (UKD) masih merupakan masalah kesehatan terkait proses penyembuhan lama sehingga biaya pengobatan meningkat. Belum adanya metode penanganan yang memuaskan, mendorong pencarian metode percepatan penyembuhan luka, salah satunya ialah terapi oksigen hiperbarik (TOHB). Penderita UKD yang menjalani tambahan TOHB diketahui mengalami peningkatan proses angiogenesis yang menghasilkan proses epitelialisasi dan granulasi yang lebih cepat. Tujuan penelitian ialah untuk membuktikan bahwa TOHB dapat mempercepat proses penyembuhan UKD, dinilai berdasarkan ukuran dan kedalaman luka melalui skor PEDIS. Penelitian ini menggunakan randomized controlled trial dan dilaksanakan di Bagian Bedah RSUP Prof. Dr. R.D. Kandou Manado sejak September 2018 sampai dengan Maret 2019. Subyek penelitian sebanyak 20 penderita UKD, dibagi dalam dua kelompok, masing-masing 10 penderita. Kelompok kontrol menjalani penanganan holistik UKD, sedangkan kelompok TOHB menjalani penanganan holistik UKD dengan TOHB. Penilaian skor PEDIS terhadap UKD pada kelompok TOHB dilakukan sebelum dan sesudah TOHB sesi ke-3, sedangkan pada kelompok kontrol dilakukan penilaian pada hari ke-1 dan hari ke-3 sesudahnya. Hasil penelitian mendapatkan bahwa perubahan skor PEDIS yang terjadi antara kedua pengukuran terlihat lebih besar pada kelompok TOHB dibandingkan kelompok kontrol (2 vs 0, P=0,001). Simpulan. TOHB mempercepat proses penyembuhan UKD dinilai dari penurunan skor PEDIS.Kata kunci: TOHB, skor PEDIS, ulkus kaki diabetik

Micronutrients and Natural Compounds Status and Their Effects on Wound Healing in the Diabetic Foot Ulcer

2017 ◽  
Vol 16 (4) ◽  
pp. 244-250 ◽  
Author(s):  
Kanokwan Kulprachakarn ◽  
Sakaewan Ounjaijean ◽  
Jukkrit Wungrath ◽  
Raj Mani ◽  
Kittipan Rerkasem
Keyword(s):  
Wound Healing ◽  
Diabetic Foot ◽  
Healing Process ◽  
Foot Ulcer ◽  
Diabetic Foot Ulcer ◽  
Herbal Remedies ◽  
Current Evidence ◽  
Wound Healing Process ◽  
Impaired Wound Healing ◽  
Wide Range

The diabetic foot ulcer (DFU) is an invariably common complication of diabetes mellitus, it is also a significant cause of amputation as well as extended hospitalization. As most patients with DFU suffer from malnutrition, which has been related to improper metabolic micronutrients status, alterations can affect impaired wound healing process. Micronutrients and herbal remedies applications present a wide range of health advantages to patients with DFU. The purpose of this review is to provide current evidence on the potential effect of dietary supplementations such as vitamins A, C, D, E, magnesium, zinc, copper, iron, boron, and such naturally occurring compounds as Aloe vera, Naringin, and Radix Astragali (RA) and Radix Rehmanniae (RR) in the administration of lower extremity wounds, especially in DFU, and to present some insights for applications in the treatment of DFU patients in the future.

Significance of integral hematological indexes for predicting postoperative wound healing in the experiment

2018 ◽  
pp. 49-54
Author(s):  
А.А. Супильников ◽  
В.Н. Шабалин
Keyword(s):  
Wound Healing ◽  
Healing Process ◽  
The Body ◽  
Male Rats ◽  
Control Group ◽  
Wound Healing Process ◽  
The Third ◽  
Group A ◽  
Clinically Significant ◽  
White Mongrel

Цель исследования - оценка возможности использования интегральных гематологических индексов для выбора оптимальной модели ушивания послеоперационных ран в эксперименте. Методика. Исследование проводили на 297 белых беспородных крысах-самцах массой 190-210 г, которые были разделены на 3 группы, по 99 крыс в каждой. Одна группа являлась контрольной, у второй группы крыс был смоделирован раневой процесс с натяжением брюшной стенки; у третьей группы животных - модель раневого процесса с применением трансплантата нанокомпозитного материала. Определяли следующие интегральные гематологические индексы: индекс Кребса; коэффициент Бредекка; лейкоцитарный индекс; индекс соотношения нейтрофилов и моноцитов; индекс соотношения лимфоцитов и моноцитов; индекс соотношения лимфоцитов и эозинофилов; коэффициент отношения альбуминов к глобулинам; оксипролиновый коэффициент. Результаты. Установлены статистически значимые колебания показателей интегральных гематологических индексов в динамике заживления послеоперационной раны у крыс. Заключение. На основе полученных результатов был сделан вывод, что особенности динамики интегральных гематологических индексов, выявленные на различных моделях раневого процесса, отражают неспецифические и специфические защитные реакции организма в целом, позволяют делать прогноз дальнейшего течения и исхода раневого процесса, а также обеспечивают возможность выбора оптимальной модели ушивания послеоперационной раны. The article presents results of predicting the wound healing process using integral hematological indexes. The aim of the study was to describe the dynamics of integral hematological indexes of wound healing process in rats to predict its outcome. The study included 297 white mongrel male rats weighing 190-210 g, which were divided into three groups, 99 rats in each. One group was a control group; in the second group, a wound healing process with abdominal wall tension was modeled; in the third group, a wound healing process with a graft was modeled. The following integrated hematological indexes were determined: Krebs index; Bredeck index; leukocyte index; neutrophil/monocyte ratio; lymphocyte/monocyte ratio; lymphocyte/eosinophil ratio; albumin/globulin ratio; and oxyproline coefficient. The study showed that changes in values of integral hematological indexes were mostly statistically and clinically significant. We concluded that changes in integral hematological indexes in different models of wound healing reflect nonspecific and specific protective responses of the body as a whole and allow to predict further course and outcome of the wound healing process.

First Report on the Use of Larvae of Cochliomyia macellaria (Diptera: Calliphoridae) for Wound Treatment in Veterinary Practice

2019 ◽  
Vol 57 (3) ◽  
pp. 965-968 ◽  
Author(s):  
F S Masiero ◽  
E S V Aguiar ◽  
D I B Pereira ◽  
P J Thyssen
Keyword(s):  
Wound Healing ◽  
Healing Process ◽  
Complete Healing ◽  
Wound Healing Process ◽  
Wound Treatment ◽  
Treatment Alternative ◽  
Qualitative And Quantitative ◽  
Cochliomyia Macellaria ◽  
Complex Wound ◽  
Points Of View

Abstract Factors contributing to the delay or prevention of the natural wound healing process include infection and ineffective conventional treatment. Alternative therapies, such as the maggot debridement therapy (MDT), may be helpful for successful treatment in these cases. Aiming to disseminate information about the possibility of using other species of flies for wound treatment, besides the best known Lucilia sericata Meigen, 1826 (Diptera, Calliphoridae), we report here a successful MDT case with the application of Cochliomyia macellaria (Fabricius, 1775) larvae to treat an infected wound with extensive area of necrotic tissue in a dog. Five sterile larvae were applied to each square-cm of lesion and kept on the animal for only 48 h. The healing was successful, from both qualitative and quantitative points of view. The ratio of wound healing (RWH) reached almost 50% on the 5th day and 100% on the 14th day after MDT. Although the overall animal prognosis had been unfavorable, mainly due to the sepsis, the patient began to recover and had improved clinical condition from the fifth day after MDT. This study shows the importance and effectiveness of MDT in promoting faster and more complete healing of a complex wound.

Characteristics of microbial drug resistance and its correlates in chronic diabetic foot ulcer infections

2014 ◽  
Vol 63 (10) ◽  
pp. 1377-1385 ◽  
Author(s):  
Thokur S. Murali ◽  
Shettigar Kavitha ◽  
Jain Spoorthi ◽  
Deepika V. Bhat ◽  
Alevoor S. Bharath Prasad ◽  
...  
Keyword(s):  
Immune Response ◽  
Wound Healing ◽  
Diabetic Foot ◽  
Healing Process ◽  
Foot Ulcer ◽  
Diabetic Foot Ulcer ◽  
Wound Healing Process ◽  
Diabetic Patients ◽  
Bacterial Strains ◽  
Microbial Drug Resistance

While virulence factors and the biofilm-forming capabilities of microbes are the key regulators of the wound healing process, the host immune response may also contribute in the events following wound closure or exacerbation of non-closure. We examined samples from diabetic and non-diabetic foot ulcers/wounds for microbial association and tested the microbes for their antibiotic susceptibility and ability to produce biofilms. A total of 1074 bacterial strains were obtained with staphylococci, Pseudomonas, Citrobacter and enterococci as major colonizers in diabetic samples. Though non-diabetic samples had a similar assemblage, the frequency of occurrence of different groups of bacteria was different. Gram-negative bacteria were found to be more prevalent in the diabetic wound environment while Gram-positive bacteria were predominant in non-diabetic ulcers. A higher frequency of monomicrobial infection was observed in samples from non-diabetic individuals when compared to samples from diabetic patients. The prevalence of different groups of bacteria varied when the samples were stratified according to age and sex of the individuals. Several multidrug-resistant strains were observed among the samples tested and most of these strains produced moderate to high levels of biofilms. The weakened immune response in diabetic individuals and synergism among pathogenic micro-organisms may be the critical factors that determine the delicate balance of the wound healing process.

scholarly journals Use of platelet concentrate gel in second-intention wound healing: a case report

2021 ◽  
Vol 15 (1) ◽  
Author(s):  
Vincenzo Davide Palumbo ◽  
Stefano Rizzuto ◽  
Giuseppe Damiano ◽  
Salvatore Fazzotta ◽  
Andrea Gottardo ◽  
...  
Keyword(s):  
Wound Healing ◽  
Chronic Wounds ◽  
Platelet Rich Plasma ◽  
Healing Process ◽  
Recovery Period ◽  
Cost Effective ◽  
Platelet Concentrate ◽  
Wound Healing Process ◽  
Cost Effective Treatment ◽  
Healing Wound

Abstract Background Wound healing is a complex and dynamic process. Healing of acute and chronic wounds can be impaired by patient factors (that is, comorbidities) and/or wound factors (that is, infection). Regenerative medicine products, such as autologous/homologous platelet-rich plasma gel, may speed up the healing process. Autologous/homologous platelet-rich plasma is an advanced wound therapy used for hard-to-heal acute and chronic wounds. The cytokines and growth factors contained in platelet-rich plasma play a crucial role in the healing process. Case presentation A 61-year-old Caucasian male patient, suffering from mental retardation following meningitis, with a transplanted kidney due to prior renal impairment, and under immunosuppressant therapy, was submitted to aneurysmectomy of his proximal left forearm arteriovenous fistula. A few days later, the patient came to our attention with substantial blood loss from the surgical site. The wound presented no signs of healing, and after fistula reparation and considering persistent infection of the surgical site (by methicillin-resistant Staphylococcus aureus), surgeons decided for second-intention healing. To favor healing, 10 mL homologous platelet concentrate gel was sequentially applied. After each application, wound was covered with nonadherent antiseptic dressing. After only seven applications of homologous platelet concentrate gel, wound completely recovered and no amputation was necessary. Conclusions Topical application of homologous platelet-rich plasma gel in healing wound shows beneficial results in wound size reduction and induces granulation tissue formation. Platelet-rich plasma could be a safe and cost-effective treatment for managing the cutaneous wound healing process to shorten the recovery period and thereby improve patient quality of life.

scholarly journals COMPARISON OF EFFICACY OF BEVACIZUMAB VS MITOMYCIN-C IN AUGMENTEDTRA BECULECTOMY

2020 ◽  
pp. 44-46
Author(s):  
Dr.(Major) Jitendra Kumar ◽  
Dr.(LT COL) Rajnish Kumar ◽  
Dr. (LT COL) Sumit Kumar Singh ◽  
Debarshi Jana
Keyword(s):  
Mitomycin C ◽  
Open Angle Glaucoma ◽  
Healing Process ◽  
Wound Healing Process ◽  
Percentage Decrease ◽  
Department Of Ophthalmology ◽  
Group A ◽  
Vasculogenesis And Angiogenesis ◽  
Group B ◽  
Endothelial Growth Factor

Background: Bevacizumab is inhibitor of vascular endothelial growth factor (VEGF), which plays a major role in physiological vasculogenesis and angiogenesis. Currently pegaptanib, ranibizumab and bevacizumab are the monoclonal antibodies used against VEGF. Aims: To compare the efficacy of subconjunctival bevacizumab to that of subtenonmitomycin-C (MMC) on the wound healing process in trabeculectomy. Materials and methods: Department of Ophthalmology, Command Hospital (Eastern Command), Kolkata. Patients of Primary Open Angle Glaucoma ( POAG). January 2016 –June 2017. Two groups: 30 in each group. (Calculated after assuming α error 0.05, power 80%). Randamization was done using website; www.graphpad.com/quickcalcs/index. patients were devided in two groups- Group A, who underwent trabeculectomy with mitomycin-C and group B, who underwent trabeculectomy with bevacizumab. Result & Analysis: In both groups intraocular pressure (IOP) was taken in preoperative, 01month, 06 month, 12 month and 18 month post operative period. Percentage decrease in IOP from pre-op is studied at 01, 06, 12 and 18 months. Conclusion: Glaucoma is a leading cause of irreversible blindness throughout the world. It has become the second most common cause of bilateral blindness. Lowering of the IOP is the first priority in POAG with anti glaucoma medications, however if patient’s IOP is uncontrolled with maximally tolerated antiglaucoma medications or there is noncompliance to anti glaucoma medications then patients can be planned for surgery to achieve target IOP. Trabeculectomy is the mainstay of surgical management of glaucoma.

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