Concept of Granthi with reference to uterine fibroid: An Ayurveda review

Uterine fibroids are the commonest benign tumor of the uterus and also the commonest benign solid tumor in the female. It can cause significant morbidity in women of a reproductive life span. The exact cause of uterine fibroid is unknown. Prevalence of uterine fibroid 5 -20 % of women in the reproductive age group. It can cause significant morbidity in women of a reproductive life span. Not all fibroids cause symptoms. 50% of women are asymptomatic. Fibroids mainly cause symptoms like menorrhagia, dysmenorrhea and cause pressure symptoms on adjacent viscera i. e. bladder, uterus, rectum which affects the everyday activities of women. In Ayurveda all gynecological disease explained under the term yonivyapad. It can be explained as the anatomical and functional abnormalities of the female reproductive system. In Ayurveda granthi can be correlated with the uterine fibroid. In modern science uterine fibroid treats medically, surgically. But it is challenging to establish a satisfactory conservatory medical treatment to date. so in Ayurveda the main purpose is the management of granthi by samprapti vighatan by use of medicine.

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Predictors and symptomatic burden of uterine fibroids among women in South-Eastern India: a cross-sectional survey analysis

International Journal of Reproduction Contraception Obstetrics and Gynecology ◽

10.18203/2320-1770.ijrcog20190278 ◽

2019 ◽

Vol 8 (2) ◽

pp. 524

Author(s):

Dharitri Swain ◽

Chanchal Yadav ◽

Jyoti Kumari ◽

Monika Rani ◽

Priyanka Daunrai Rongmei ◽

...

Keyword(s):

Risk Factors ◽

Uterine Fibroid ◽

Uterine Fibroids ◽

Overweight And Obesity ◽

Reproductive Age ◽

Age Group ◽

Women Of Reproductive Age ◽

Cross Sectional ◽

Associated Risk Factors ◽

Reproductive Age Group

Background: Uterine fibroid is the most common pelvic tumor in women of reproductive age and are asymptomatic in at least 50% of affected women. Various risk factors are associated with development of uterine fibroids during this reproductive age. The present study established various associated risk factors increases the prevalence of uterine fibroid among reproductive age group and clinical symptoms burden of diagnosed case.Methods: A cross sectional study design was used to collect samples for a period of six months in an OPD basis. Purposive sampling technique was used to select the 362 sample of reproductive age group (15-45 years) women in a tertiary care hospital, Southeastern India. Women diagnosed with uterine fibroid by ultrasonography were included as cases. Symptomatic features and associated risk factors of UF were collected through structure interview schedule.Results: Point prevalence of uterine fibroid among women in reproductive age group during the period of six months was 20%. Majority of them were in the age group of 30-39 years. Demographic factor such as overweight and obesity and consume dairy products daily has increased the prevalence of UF, whereas use of oral contraceptive pills and normal BMI had inverse relationship with UF risk. Most of the cases reported of having menstrual disturbances like heavy bleeding, passes blood clots during menstruation, prolonged period, urinary symptoms and pressure symptoms were considered independent predicting factors for the occurrence of uterine fibroid.Conclusions: Uterine fibroid is more prevalent among women of reproductive age causing various bleeding and renal symptoms that can have negative impact on quality of women’s life.

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Clinicopathological features of uterine fibroid in a tertiary care teaching hospital

International Journal of Research in Medical Sciences ◽

10.18203/2320-6012.ijrms20213943 ◽

2021 ◽

Vol 9 (10) ◽

pp. 3115

Author(s):

Priyanka Singh ◽

Sadaf Mirza ◽

Pawan Trivedi ◽

Tanya Singh

Keyword(s):

Uterine Fibroid ◽

Histopathological Examination ◽

Tertiary Care ◽

Clinical Manifestations ◽

Uterine Fibroids ◽

Reproductive Age ◽

Cystic Degeneration ◽

Proliferative Endometrium ◽

Benign Tumours ◽

Reproductive Age Group

Background: Uterine fibroids are one of the common benign tumours of uterus seen in women of reproductive age group. These constitute 5-10% of all these tumours.Methods: Total of 56 patients above 21 years of age reporting to OPD or emergency of gynaecology department of the Mayo Institute and found to be suffering from leiomyoma of the uterus were included in the study.Results: Clinical manifestations seen in cases with uterine fibroid. Menstrual irregularities were seen in 69.64% of cases. 39.28% suffered from abdominal pain and infertility was seen in 10.71% cases. Endometrial changes during the histopathological examination. In 71.42% of cases, proliferative endometrium was found. Secretory endometrium was seen in 14.28% and atrophic in 8.92%. Conclusions: Leiomyoma is the most well-known uterine tumor seen in gynecological practice. Feminine aggravations are the commonest manifestation of which menorrhagia is the most well-known show. The vast majority of these tumors are intramural in area. The most widely recognized example of endometrium noticed is proliferative. Hyaline degeneration, myxoid degeneration and cystic degeneration are the normal auxiliary changes found in fibroid uterus.

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Large cervical fibroid: a rare case report

International Journal of Reproduction Contraception Obstetrics and Gynecology ◽

10.18203/2320-1770.ijrcog20193577 ◽

2019 ◽

Vol 8 (8) ◽

pp. 3414

Author(s):

Sunanda N.

Keyword(s):

Uterine Fibroids ◽

Total Abdominal Hysterectomy ◽

Large Mass ◽

Abdominal Hysterectomy ◽

Reproductive Age ◽

Pelvic Tumors ◽

Rare Case Report ◽

Tender Mass ◽

Restricted Mobility ◽

Reproductive Age Group

Although leiomyomas are the most common pelvic tumors presenting in the reproductive age group, cervical fibroids are rare accounting for 2% of all uterine fibroids. We report a case of 40 year old lady presenting with a firm, non-tender mass of 22-24 weeks size pregnant uterus with restricted mobility. Laparotomy showed a large mass arising from the anterior lip of cervix, with a small uterus pushed posteriorly. Enucleation followed by total abdominal hysterectomy was done. Large cervical fibroids are rare, presenting with surgical difficulties. Careful dissection by expert hands is needed in the management of such cases.

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Reproductive Uncertainty and the Evolution of Iteroparity: Why Don't Flatfish Put All Their Eggs in One Basket?

Canadian Journal of Fisheries and Aquatic Sciences ◽

10.1139/f81-130 ◽

1981 ◽

Vol 38 (8) ◽

pp. 968-977 ◽

Cited By ~ 42

Author(s):

Derek A. Roff

Keyword(s):

Reproductive Success ◽

Life Span ◽

Intrinsic Rate ◽

Intrinsic Rate Of Increase ◽

Rate Of Increase ◽

Age Of Maturity ◽

Reproductive Life ◽

Reproductive Life Span ◽

Engraulis Ringens ◽

Using Data

Murphy's hypothesis that variation in reproductive life span is an adaptive response to variation in the predictability of reproductive success is examined. Murphy's contention that this hypothesis explains the variation in reproductive life span within the clupeids is reexamined incorporating further data on the Peruvian anchovy (Engraulis ringens). A nonsignificant correlation is now obtained between reproductive life span and brood strength variation; thus, the hypothesis is called into question. An alternative explanation is presented that considers the interaction between life history parameters: because it is necessary for the intrinsic rate of increase to exceed zero, variation in one parameter must be associated with variation in at least one other parameter. In the clupeids it is noted that the age of maturity and reproductive life span vary in concert and it is suggested that this provides an explanation of variation in reproductive life span. These two hypotheses are examined using data on the family Pleuronectidae, the flatfish. No correlation exists between reproductive life span and the degree of fluctuation in brood strength but there is a significant correlation between reproductive life span and age of maturity. It is concluded that variation in reproductive life span within the flatfish group is not a response to variation in reproductive success but rather a correlate of variation in age of maturity.Key words: flatfish, Pleuronectidae, iteroparity, natural selection, reproduction, clupeids

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PohnB6F1: A Cross of Wild and Domestic Mice That Is a New Model of Extended Female Reproductive Life Span

The Journals of Gerontology Series A ◽

10.1093/gerona/62.11.1187 ◽

2007 ◽

Vol 62 (11) ◽

pp. 1187-1198 ◽

Cited By ~ 16

Author(s):

K. Flurkey ◽

Y. Brandvain ◽

S. Klebanov ◽

S. N. Austad ◽

R. A. Miller ◽

...

Keyword(s):

Life Span ◽

New Model ◽

Reproductive Life ◽

Reproductive Life Span

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Chromosome errors in human eggs shape natural fertility over reproductive life span

Science ◽

10.1126/science.aav7321 ◽

2019 ◽

Vol 365 (6460) ◽

pp. 1466-1469 ◽

Cited By ~ 30

Author(s):

Jennifer R. Gruhn ◽

Agata P. Zielinska ◽

Vallari Shukla ◽

Robert Blanshard ◽

Antonio Capalbo ◽

...

Keyword(s):

Life Span ◽

Chromosome Segregation ◽

Pregnancy Loss ◽

Natural Fertility ◽

Congenital Disorders ◽

Human Oocytes ◽

Reproductive Life ◽

Reproductive Life Span ◽

Quantitative Explanation ◽

Chromosome Nondisjunction

Chromosome errors, or aneuploidy, affect an exceptionally high number of human conceptions, causing pregnancy loss and congenital disorders. Here, we have followed chromosome segregation in human oocytes from females aged 9 to 43 years and report that aneuploidy follows a U-curve. Specific segregation error types show different age dependencies, providing a quantitative explanation for the U-curve. Whole-chromosome nondisjunction events are preferentially associated with increased aneuploidy in young girls, whereas centromeric and more extensive cohesion loss limit fertility as women age. Our findings suggest that chromosomal errors originating in oocytes determine the curve of natural fertility in humans.

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