scholarly journals The response of TNF-α, IL-6 serum levels and lipid profiles to two aerobic training frequencies with the same volume in obese middle-aged women with type 2 diabetic

2021 ◽  
Vol 14 (1) ◽  
pp. 59-72
Author(s):  
ali rajabi ◽  
ali akbarnejad ◽  
Marefat siahkohian ◽  
morteza yari
Keyword(s):  
Aerobic Training ◽  
Serum Levels ◽  
Lipid Profiles ◽  
Middle Aged ◽  
Tnf Α ◽  
Type 2 Diabetic

Effect of pomegranate seed oil on the expression of PPAR-γ and pro-inflammatory biomarkers in obese type 2 diabetic patients

2019 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Yaser Khajebishak ◽  
Laleh Payahoo ◽  
Hamed Hamishehkar ◽  
Mohammadreza Alivand ◽  
Mahdieh Alipour ◽  
...  
Keyword(s):  
Serum Levels ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Content Type ◽  
Ppar Γ ◽  
Tnf Α ◽  
Pomegranate Seed ◽  
Hs Crp ◽  
Type 2 Diabetic

Purpose Diabetes is one of the most prevailed chronic diseases in the world. Pro-inflammatory cytokines play a key role in the type 2 diabetes mellitus. Pomegranate seed oil (PSO) has potential anti-inflammatory properties. The purpose of this study is to evaluate the antidiabetic effects of the use of PSO on the expression of peroxisome proliferator-activated receptor-gamma (PPAR-γ), pro-inflammatory biomarkers and lipid profile levels in obese type 2 diabetic patients. Design/methodology/approach In total, 52 patients were randomly assigned to the PSO (n = 26) and placebo (n = 26) groups. Subjects received daily PSO 3 g placebo (paraffin) in 1 g soft-gel capsules (along with breakfast, lunch and dinner meals) for eight weeks. Findings Serum levels of fasting blood sugar (FBS) decreased from 161.46 ± 34.44 to 143.50 ± 24.2 mg/dL (p = 0.008), IL-6 decreased from 5.17 ± 2.25 to 4.52 ± 1.90 (p = 0.049) and tumor necrosis factor alpha (TNF-α) significantly decreased from 9.17 ± 4.13 to 7.74 ± 2.44 pmol/mL in PSO group (p = 0.030). However, changes in the expression of PPAR-γ gene, serum levels of hs-CRP and lipid profile levels were not significant. Research limitations/implications Lack of PSO concentration measurements and the short duration of the study were the key limitations. Future randomized clinical trials with a longer period of follow-up are needed to assess the potential anti-diabetic effects of PSO. Originality/value Administration of PSO in obese type 2 diabetic patients reduced the levels of FBS, interleukin 6 and TNF-α; nevertheless, changes in the insulin, lipid profiles and hs-CRP were not significant.

Influance of regular swimming on serum levels of CRP, IL-6, TNF-α in high-fat diet-induced type 2 diabetic rats

2016 ◽  
Vol 35 (04) ◽  
pp. 469-476 ◽  
Author(s):  
Rafighe Ghiasi ◽  
Farhad Ghadiri Soufi ◽  
Gisou Mohaddes ◽  
Alireza Alihemmati ◽  
Mohammad H. Somi ◽  
...  
Keyword(s):  
High Fat Diet ◽  
Serum Levels ◽  
Diabetic Rats ◽  
High Fat ◽  
Tnf Α ◽  
Type 2 Diabetic

Evaluation of urinary TNF-α and KIM-1 biomarkers in T2DM in Upper Egypt

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Magdy EL Sharkawy ◽  
Samir K Abdul-Hamid ◽  
Tarek T Elmelegy ◽  
Mohammed F Adawy
Keyword(s):  
Diabetic Nephropathy ◽  
Early Stage ◽  
Clinical Syndrome ◽  
Diabetic Patients ◽  
University Hospitals ◽  
Type 2 Diabetic Patients ◽  
Cross Sectional ◽  
Tnf Α ◽  
Type 2 Diabetic

Abstract Background Diabetes mellitus (DM) is the most frequent cause of chronic kidney failure in both developed and developing countries. Diabetic nephropathy, is a clinical syndrome characterized by albuminuria (>300 mg/day) with permanent and irreversible decrease in glomerular filtration rate (GFR). Aim of the Work To study the role of urinary TNF-α and urine KIM-1 in type 2 diabetic patients as predictors of DN comparative with albuminuria. Patients and Methods This is a cross-sectional study which include 90 type-2 diabetic patients and 30 controls selected from the outpatient clinic of Assiut University hospitals. All patients gave an informed consent and approval for the study was obtained from the IRB committee of the Assiut Medical Faculty. The recruited patients were divided into three groups: Normo-albuminuria Group (A) (n = 30): UACR less than 30 mg/gm, Microalbuminuria Group (B) (n = 30): UACR between 30-299 mg/gm and Macro-albuminuria Group (C) (n = 30): UACR equal or more than 300 mg/gm. Assess Urinary TNF-α and urine KIM-1 in comparision with albuminuria. Results Urinary KIM-1 and urinary TNF-α are statically significant with albuminuria in patients in the early stage of diabetic nephropathy (eGFR _60 mL/min/1.73 m2).Also there are statically significance between patients with macroalbuminuria than microalbuminuria. Conclusion The results of this study recommend the use of KIM-1 and TNF-α as good predictors of early detection of development of diabetic nephropathy.

scholarly journals Effect of Aspirin on the Expression of Hepatocyte NF-κB and Serum TNF-α in Streptozotocin-Induced Type 2 Diabetic Rats

2011 ◽  
Vol 26 (6) ◽  
pp. 765 ◽  
Author(s):  
Xiaodong Sun ◽  
Fang Han ◽  
Junling Yi ◽  
Lina Han ◽  
Ben Wang
Keyword(s):  
Diabetic Rats ◽  
Tnf Α ◽  
Type 2 Diabetic

Visfatin, TNF-α and IL-6 mRNA Expression is Increased in Mononuclear Cells from Type 2 Diabetic Women

2007 ◽  
Vol 39 (10) ◽  
pp. 758-763 ◽  
Author(s):  
P. Tsiotra ◽  
C. Tsigos ◽  
E. Yfanti ◽  
E. Anastasiou ◽  
M. Vikentiou ◽  
...  
Keyword(s):  
Mrna Expression ◽  
Mononuclear Cells ◽  
Tnf Α ◽  
Type 2 Diabetic
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