scholarly journals A comprehensive review on the application of artificial intelligence in drug discovery.

Author(s):  
Ashrulochan Sahoo ◽  
Ghulam Mehdi Dar

The 21st century is witnessing immense achievements in human history, starting from home science to space science. Artificial Intelligence (AI) is a salient one among these feats, the critical factor of the 4th industrial revolution. Health is the primary and essential asset for the continuity of human civilization on this planet. Not only must we address the deadly existing diseases like Cancer, AIDS, Alzheimer's, heart diseases, gastrointestinal diseases, etc., but on top of that, we must effectively predict, prevent and respond to potential pathogens capable of causing havoc like the recent outbreak caused by SARS-CoV-2. AI-enabled technology with the computational capacity of a computer and reasoning ability of humans saves surplus labor and time that is majorly consumed in target validation, lead optimization, molecular representation, and designing reaction pathways, which traditionally is a decade-long way of searching, visualizing, studying, imagining, experimenting and maintaining a ton of data. This article would focus on how AI will help find the drug-like properties in the compound screening phase predicting the Structure-Activity Relationship (SAR) and ADMET properties in lead identification and optimization phases, sustainable development of chemicals in the synthesis phases up to AI's assistance in the successful conduct of clinical trials and repurposing.

2019 ◽  
Vol 8 (1) ◽  
Author(s):  
Nguyen Duy Dung

Characteristics of the industrial revolution 4.0 is the wide application of high-tech achievements, especially information technology, digitalization, artificial intelligence, network connections for management to create sudden changes in socio-economic development of many countries. Therefore, to reach the high-tech time, many magazines in Vietnam have changed dramatically, striving to reach the international scientific journal system of ISI, Scopus. The publication of international standard scientific journal will meet the demand of publishing research results of local scientists, on the other hand contribute to strengthening exchange, cooperation, international integration in science and technology.


2020 ◽  
Vol 31 (3) ◽  
pp. 347-363
Author(s):  
Peter Waring ◽  
Azad Bali ◽  
Chris Vas

The race to develop and implement autonomous systems and artificial intelligence has challenged the responsiveness of governments in many areas and none more so than in the domain of labour market policy. This article draws upon a large survey of Singaporean employees and managers (N = 332) conducted in 2019 to examine the extent and ways in which artificial intelligence and autonomous technologies have begun impacting workplaces in Singapore. Our conclusions reiterate the need for government intervention to facilitate broad-based participation in the productivity benefits of fourth industrial revolution technologies while also offering re-designed social safety nets and employment protections. JEL Codes: J88, K31, O38, M53


2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Kathleen Murphy ◽  
Erica Di Ruggiero ◽  
Ross Upshur ◽  
Donald J. Willison ◽  
Neha Malhotra ◽  
...  

Abstract Background Artificial intelligence (AI) has been described as the “fourth industrial revolution” with transformative and global implications, including in healthcare, public health, and global health. AI approaches hold promise for improving health systems worldwide, as well as individual and population health outcomes. While AI may have potential for advancing health equity within and between countries, we must consider the ethical implications of its deployment in order to mitigate its potential harms, particularly for the most vulnerable. This scoping review addresses the following question: What ethical issues have been identified in relation to AI in the field of health, including from a global health perspective? Methods Eight electronic databases were searched for peer reviewed and grey literature published before April 2018 using the concepts of health, ethics, and AI, and their related terms. Records were independently screened by two reviewers and were included if they reported on AI in relation to health and ethics and were written in the English language. Data was charted on a piloted data charting form, and a descriptive and thematic analysis was performed. Results Upon reviewing 12,722 articles, 103 met the predetermined inclusion criteria. The literature was primarily focused on the ethics of AI in health care, particularly on carer robots, diagnostics, and precision medicine, but was largely silent on ethics of AI in public and population health. The literature highlighted a number of common ethical concerns related to privacy, trust, accountability and responsibility, and bias. Largely missing from the literature was the ethics of AI in global health, particularly in the context of low- and middle-income countries (LMICs). Conclusions The ethical issues surrounding AI in the field of health are both vast and complex. While AI holds the potential to improve health and health systems, our analysis suggests that its introduction should be approached with cautious optimism. The dearth of literature on the ethics of AI within LMICs, as well as in public health, also points to a critical need for further research into the ethical implications of AI within both global and public health, to ensure that its development and implementation is ethical for everyone, everywhere.


2021 ◽  
pp. 036354652110086
Author(s):  
Prem N. Ramkumar ◽  
Bryan C. Luu ◽  
Heather S. Haeberle ◽  
Jaret M. Karnuta ◽  
Benedict U. Nwachukwu ◽  
...  

Artificial intelligence (AI) represents the fourth industrial revolution and the next frontier in medicine poised to transform the field of orthopaedics and sports medicine, though widespread understanding of the fundamental principles and adoption of applications remain nascent. Recent research efforts into implementation of AI in the field of orthopaedic surgery and sports medicine have demonstrated great promise in predicting athlete injury risk, interpreting advanced imaging, evaluating patient-reported outcomes, reporting value-based metrics, and augmenting the patient experience. Not unlike the recent emphasis thrust upon physicians to understand the business of medicine, the future practice of sports medicine specialists will require a fundamental working knowledge of the strengths, limitations, and applications of AI-based tools. With appreciation, caution, and experience applying AI to sports medicine, the potential to automate tasks and improve data-driven insights may be realized to fundamentally improve patient care. In this Current Concepts review, we discuss the definitions, strengths, limitations, and applications of AI from the current literature as it relates to orthopaedic sports medicine.


Author(s):  
Zarina Khisamova ◽  
Ildar Begishev

The humanity is now at the threshold of a new era when a widening use of artificial intelligence (AI) will start a new industrial revolution. Its use inevitably leads to the problem of ethical choice, it gives rise to new legal issues that require urgent actions. The authors analyze the criminal law assessment of the actions of AI. Primarily, the still open issue of liability for the actions of AI that is capable of self-learning and makes a decision to act / not to act, which is qualified as a crime. As a result, there is a necessity to form a system of criminal law measures of counteracting crimes committed with the use of AI. It is shown that the application of AI could lead to four scenarios requiring criminal law regulation. It is stressed that there is a need for a clear, strict and effective definition of the ethical boundaries in the design, development, production, use and modification of AI. The authors argue that it should be recognized as a source of high risk. They specifically state that although the Criminal Code of the Russian Fe­deration contains norms that determine liability for cybercrimes, it does not eliminate the possibility of prosecution for infringements committed with the use of AI under the general norms of punishment for various crimes. The authors also consider it possible to establish a system to standardize and certify the activities of designing AI and putting it into operation. Meanwhile, an autonomous AI that is capable of self-learning is considerably different from other phenomena and objects, and the situation with the liability of AI which independently decides to undertake an action qualified as a crime is much more complicated. The authors analyze the resolution of the European Parliament on the possibility of granting AI legal status and discuss its key principles and meaning. They pay special attention to the issue of recognizing AI as a legal personality. It is suggested that a legal fiction should be used as a technique, when a special legal personality of AI can be perceived as an unusual legal situation that is different from reality. It is believed that such a solution can eliminate a number of existing legal limitations which prevent active involvement of AI into the legal space.


Author(s):  
Manju Jose

This paper emphasizes the possibility of merging artificial intelligence and Blockchain technologies to solve academic qualifications forgery issues in the educational sectors. Empirical data is collected through interviews with specialists and technical people who are interested in the emerging technologies of the Fourth Industrial Revolution and focus group discussions in the field, as well as from reports in the reviewed literary articles. Scientific journals have also been accessed to analyse the paper goals and objectives. The findings suggest that emerging technologies can be integrated to become more efficient and effective in detecting fraud and forgery before it occurs. Considerable attention should be given to reducing and combating these issues because they have significant negative impacts on the economy and education. Accordingly, the study makes recommendations based on the results and areas of future research, considering the establishment of a unified and integrated system. Initially it will be applied as a pilot in Sultanate of Oman, then gradually it will be extended to the Gulf Cooperation Council States (GCC) and internationally particularly the affiliated and the recognized educational institutions to avoid the phenomena that affects the reputation and quality of education institutions and academic qualifications. The conclusion considers the impacts of the proposed system in the education and economy as well in general.


2019 ◽  
Vol 20 (1) ◽  
pp. 82
Author(s):  
Unung Vera Wardina ◽  
Nizwardi Jalinus ◽  
Lise Asnur

Vocational education purpose is to produce ready-to-work graduates who have the relevant skills for current job employment. Entering the industrial revolution era 4.0 there were massive changes in various industries and workers' ability needs. This article intends to examine the implications of the industrial revolution 4.0 era for vocational education curriculum. Based on the study of various sources and business practices, it is necessary to develop vocational education curriculum that are in accordance with the era of industrial revolution 4.0 and relevant to answering the needs of new skills, such as the ability to create and manage coding, big data, and artificial intelligence. The vocational curriculum needs to apply blended learning, which integrates face-to-face and online learning, so as to more effectively build graduates' abilities and skills. The curriculum also needs to contain mastery of 4.0 competencies such as data literacy, technology literacy and human literacy. In order for the vocational education curriculum to have a broad impact, the government, educational institutions, industries must work together to revitalize the approach and content of the vocational education curriculum. Teachers must also be able to implement good learning to produce optimal graduate performance. Pendidikan vokasi merupakan pendidikan yang menghasilkan lulusan siap kerja yang memiliki keterampilan sesuai kebutuhan dunia kerja. Memasuki era revolusi indusri 4.0 terjadi perubahan yang masif pada perbagai industri dan kebutuhan kemampuan pekerja. Artikel ini bermaksud mengkaji implikasi era revolusi industri 4.0 bagi kurikulum pendidikan vokasi. Berdasarkan kajian berbagai sumber dan praktek bisnis, diperlukan pengembangan kurikulum pendidikan vokasi yang sesuai dengan era revolusi industri 4.0 dan relevan menjawab kebutuhan keterampilan baru, seperti kemampuan membuat dan mengelola coding, big data, dan artificial intelligence. Kurikulum vokasi perlu menerapkan pembelajaran blended learning, yang mengintegrasikan pembelajaran tatap muka dan online, supaya lebih efektif membangun kemampuan dan ketrampilan lulusan. Kurikulum juga perlu memuat penguasaan kompetensi 4.0 seperti literasi data, literasi teknologi dan literasi manusia. Agar kurikulum pendidikan vokasi menghasilkan dampak yang luas, pemerintah, lembaga pendidikan, industri harus bersinergi untuk merevitalisasi pendekatan dan isi kurikulum pendidikan vokasi. Pengajar juga harus dapat menyelenggarakan pembelajaran yang baik untuk menghasilkan kinerja optimal lulusan.


Author(s):  
B. M. Moiseenko ◽  
A. A. Meldo ◽  
L. V. Utkin ◽  
I. Yu. Prokhorov ◽  
M. A. Ryabinin ◽  
...  

In the century of the fourth industrial revolution, there is a rapid progress of technological developments in medicine. Possibilities of collecting large amounts of digital information and the modern computer capacity growth are reasons for the increased attention to artificial intelligence (AI) and its role in the diagnostics and the prediction of diseases. In the diagnostics, AI aims to model the human intellectual activity, providing assistance to a practicing doctor in the processing of big data. Development of AI can be considered as a way for implementation and ensuring of national political and economic interests in the health care improvement. Lung cancer is on the first position of cancer incidences. This implies that the development and implementation of computed-aided systems for lung cancer diagnostic is very urgent and important. The article presents the results concerning the development of a computed-aided system for the lung nodule detection, which is based on the processing of computed tomography data. Perspectives of the AI application to the lung cancer diagnostics are discussed. There is a few information about a role of Russian developments in this area in foreign and domestic literature.


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