A Decisive Review to Understand the Basic Fundamentals of Novel Corona Viruse Disease

Author(s):  
Sweta Sweta ◽  
Navdeep Singh

With the development and spread of 2019 novel coronavirus (2019-nCoV), also known as the severe acute respiratory syndrome coronavirus 2, a new public health disaster is threatening the world (SARS-CoV-2). In December 2019, the virus was discovered in bats and transmitted to humans via unidentified intermediary species in Wuhan, Hubei Province, China. To date (05/03/2020), there have been roughly 96,000 recorded cases of coronavirus disease 2019 (COVID-2019) and 3300 documented deaths. The disease is spread through inhalation or contact with contaminated droplets, with a 2 to 14-day incubation period. Fever, cough, sore throat, dyspnea, weariness, and malaise are common symptoms. The disease is mild in most people; in some (usually the elderly and those with comorbidities), it can lead to pneumonia, ARDS (acute respiratory distress syndrome), and multi-organ failure. A large number of persons are asymptomatic. The case fatality rate is expected to be between 2 and 3%. Specimen collection, assay collection, serology, nucleic acid testing or molecular testing, and target selection for RT-PCR are all examples of laboratory diagnosis. Home isolation of suspected cases and those with mild illnesses, as well as tight infection control measures in hospitals, including contact and droplet precautions, are all part of the prevention strategy. The virus has a lower fatality rate than its two ancestors, SARS-CoV and Middle East respiratory sickness coronavirus (MERS-CoV). The global consequences of this new epidemic are still unknown.

2020 ◽  
Vol 4 (1) ◽  
pp. 44-51
Author(s):  
Bhagawaty Kalikotay

   There is a new public health crises threatening the world with the emergence and spread of 2019 novel coronavirus (2019-nCoV) or the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). There have been around 25,300,975 reported cases of coronavirus disease 2019 (COVID-2019) and 848,673 reported deaths to date (30/08/2020). Extensive literature review of publicly available information to summarize sign and symptoms as well as prevention of COVID-19 was carried out. The disease is transmitted by inhalation or contact with infected droplets and the incubation period ranges from 2 to 14 days. The symptoms are usually fever, cough, sore throat, breathlessness, fatigue, malaise among others. The disease is mild in most people; in some (usually the elderly and those with comorbidities), it may progress to pneumonia, acute respiratory distress syndrome (ARDS) and multi organ dysfunction. Many people are asymptomatic. The case fatality rate is estimated to range from 2 to 3%. Diagnosis is by demonstration of the virus in respiratory secretions by special molecular tests. Common laboratory findings include elevated C-reactive protein (CRP). Prevention entails home isolation of suspected cases and those with mild illnesses and strict infection control measures at hospitals that include contact and droplet precautions.


2020 ◽  
Author(s):  
Parth M. Kapatel ◽  
Nagma ara Malik

The new public health crisis threatening the world with the emergence due to the spreading of 2019 novel coronavirus (2019-nCoV) or it can also say as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The virus instigated in bats and was transmitted to humans through yet unknown transitional animals in Wuhan, Hubei province, China in December 2019. There have been around 3.04 million reported cases by WHO of coronavirus disease 2019 (COVID-2019) and 895 thousand are recovered, 211 thousand reported deaths to date (28/04/2020) from all over the world. The disease is spread by inhalation/breathing or interaction with infected droplets. The quarantine period ranges from 2 to 14 days. The symptoms are typically breathlessness, cough, sore throat, fever, fatigue, malaise, among others. The disease is mild in most people; while in about some (generally the aged and those with comorbidities), it may progress to pneumonia, acute respiratory distress syndrome (ARDS) and multi-organ dysfunction. Many people are asymptomatic. Treatment is very essentially supportive; the role of antiviral agents is up till now to be recognized. Prevention requires home quarantine of alleged cases and those with mild illnesses and severe infection control measures at hospitals that contain interaction, touch and droplet precautions.


Author(s):  
Wagida A. Anwar ◽  
Amany Mokhtar

AbstractThe first case of coronavirus disease 2019 (COVID-19) in Egypt was reported on 14 February 2020 and the number of reported cases has increased daily. The purpose of this study is to describe the current situation of Covid-19 in Egypt and to predict the expected timing of the peak of this epidemic using current confirmed cases and deaths. We used one of the online tools; the Epidemic Calculator that utilizes, the well-known SEIR compartmental model. We utilized the daily reports published by the Egyptian Ministry of Health & Population from 14 February to 11 May 2020. Given the highest calculated case fatality rate (7.7%), the number of hospitalized individuals is expected to peak in the middle of June with a peak of hospitalized cases of 20,126 individuals and total expected deaths 12,303. We recommend strengthening of the Egyptian preventive and control measures so as to decrease the CFR and the number of cases to the least possible as we approach the epidemic peak. It is most important that appropriate quarantine measures are retained., the quarantine measures should not be relaxed before the end of June, 2020.


2020 ◽  
Author(s):  
Parth M. Kapatel ◽  
Nagma ara Malik

The new public health crisis threatening the world with the emergence due to the spreading of 2019 novel coronavirus (2019-nCoV) or it can also say as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The virus instigated in bats and was transmitted to humans through yet unknown transitional animals in Wuhan, Hubei province, China in December 2019. There have been around 3.04 million reported cases by WHO of coronavirus disease 2019 (COVID-2019) and 895 thousand are recovered, 211 thousand reported deaths to date (28/04/2020) from all over the world. The disease is spread by inhalation/breathing or interaction with infected droplets. The quarantine period ranges from 2 to 14 days. The symptoms are typically breathlessness, cough, sore throat, fever, fatigue, malaise, among others. The disease is mild in most people; while in about some (generally the aged and those with comorbidities), it may progress to pneumonia, acute respiratory distress syndrome (ARDS) and multi-organ dysfunction. Many people are asymptomatic. Treatment is very essentially supportive; the role of antiviral agents is up till now to be recognized. Prevention requires home quarantine of alleged cases and those with mild illnesses and severe infection control measures at hospitals that contain interaction, touch and droplet precautions.


2020 ◽  
Vol 11 (SPL1) ◽  
pp. 462-468
Author(s):  
Latika kothari ◽  
Sanskruti Wadatkar ◽  
Roshni Taori ◽  
Pavan Bajaj ◽  
Diksha Agrawal

Coronavirus disease 2019 (COVID-19) is a communicable infection caused by the novel coronavirus resulting in severe acute respiratory syndrome coronavirus 2 (SARS-CoV). It was recognized to be a health crisis for the general population of international concern on 30th January 2020 and conceded as a pandemic on 11th March 2020. India is taking various measures to fight this invisible enemy by adopting different strategies and policies. To stop the COVID-19 from spreading, the Home Affairs Ministry and the health ministry, of India, has issued the nCoV 19 guidelines on travel. Screening for COVID-19 by asking questions about any symptoms, recent travel history, and exposure. India has been trying to get testing kits available. The government of India has enforced various laws like the social distancing, Janata curfew, strict lockdowns, screening door to door to control the spread of novel coronavirus. In this pandemic, innovative medical treatments are being explored, and a proper vaccine is being hunted to deal with the situation. Infection control measures are necessary to prevent the virus from further spreading and to help control the current situation. Thus, this review illustrates and explains the criteria provided by the government of India to the awareness of the public to prevent the spread of COVID-19.


Author(s):  
A. Wilder-Smith

Abstract Purpose of review The COVID-19 pandemic poses a major global health threat. The rapid spread was facilitated by air travel although rigorous travel bans and lockdowns were able to slow down the spread. How does COVID-19 compare with other emerging viral diseases of the past two decades? Recent findings Viral outbreaks differ in many ways, such as the individuals most at risk e.g. pregnant women for Zika and the elderly for COVID-19, their vectors of transmission, their fatality rate, and their transmissibility often measured as basic reproduction number. The risk of geographic spread via air travel differs significantly between emerging infectious diseases. Summary COVID-19 is not associated with the highest case fatality rate compared with other emerging viral diseases such as SARS and Ebola, but the combination of a high reproduction number, superspreading events and a globally immunologically naïve population has led to the highest global number of deaths in the past 20 decade compared to any other pandemic.


2020 ◽  
Vol 99 (5) ◽  
pp. 481-487 ◽  
Author(s):  
L. Meng ◽  
F. Hua ◽  
Z. Bian

The epidemic of coronavirus disease 2019 (COVID-19), originating in Wuhan, China, has become a major public health challenge for not only China but also countries around the world. The World Health Organization announced that the outbreaks of the novel coronavirus have constituted a public health emergency of international concern. As of February 26, 2020, COVID-19 has been recognized in 34 countries, with a total of 80,239 laboratory-confirmed cases and 2,700 deaths. Infection control measures are necessary to prevent the virus from further spreading and to help control the epidemic situation. Due to the characteristics of dental settings, the risk of cross infection can be high between patients and dental practitioners. For dental practices and hospitals in areas that are (potentially) affected with COVID-19, strict and effective infection control protocols are urgently needed. This article, based on our experience and relevant guidelines and research, introduces essential knowledge about COVID-19 and nosocomial infection in dental settings and provides recommended management protocols for dental practitioners and students in (potentially) affected areas.


Author(s):  
Richard A. Neher ◽  
Robert Dyrdak ◽  
Valentin Druelle ◽  
Emma B. Hodcroft ◽  
Jan Albert

A novel coronavirus (SARS-CoV-2) first detected in Wuhan, China, has spread rapidly since December 2019, causing more than 80,000 confirmed infections and 2,700 fatalities (as of Feb 27, 2020). Imported cases and transmission clusters of various sizes have been reported globally suggesting a pandemic is likely.Here, we explore how seasonal variation in transmissibility could modulate a SARS-CoV-2 pandemic. Data from routine diagnostics show a strong and consistent seasonal variation of the four endemic coronaviruses (229E, HKU1, NL63, OC43) and we parameterize our model for SARS-CoV-2 using these data. The model allows for many subpopulations of different size with variable parameters. Simulations of different scenarios show that plausible parameters result in a small peak in early 2020 in temperate regions of the Northern Hemisphere and a larger peak in winter 2020/2021. Variation in transmission and migration rates can result in substantial variation in prevalence between regions.While the uncertainty in parameters is large, the scenarios we explore show that transient reductions in the incidence rate might be due to a combination of seasonal variation and infection control efforts but do not necessarily mean the epidemic is contained. Seasonal forcing on SARS-CoV-2 should thus be taken into account in the further monitoring of the global transmission. The likely aggregated effect of seasonal variation, infection control measures, and transmission rate variation is a prolonged pandemic wave with lower prevalence at any given time, thereby providing a window of opportunity for better preparation of health care systems.


2021 ◽  
Vol 15 (02) ◽  
pp. 204-208
Author(s):  
Ayman Ahmed ◽  
Nouh Saad Mohamed ◽  
Sarah Misbah EL-Sadig ◽  
Lamis Ahmed Fahal ◽  
Ziad Bakri Abelrahim ◽  
...  

The steadily growing COVID-19 pandemic is challenging health systems worldwide including Sudan. In Sudan, the first COVID-19 case was reported on 13th March 2020, and up to 11 November 2020 there were 14,401 confirmed cases of which 9,535 cases recovered and the rest 3,750 cases were under treatment. Additionally, 1,116 deaths were reported, indicating a relatively high case fatality rate of 7.7%. Several preventive and control measures were implemented by the government of Sudan and health partners, including the partial lockdown of the country, promoting social distancing, and suspending mass gathering such as festivals and performing religious practices in groups. However, new cases still emerging every day and this could be attributed to the noncompliance of the individuals to the advocated preventive measurements.


2020 ◽  
Author(s):  
Letizia Consoli ◽  
Vittorio Bendotti ◽  
Sara Cicchinelli ◽  
Federico Gaioni ◽  
Paola Prandolini ◽  
...  

Abstract In December 2019, a novel coronavirus (SARS-Cov-2) was first reported in Wuhan, China, and rapidly spread around the world, leading to an international emerging public health emergency. As reported from Chinese experiences, approximately 20% of patients had a severe course, requiring intensive care, with an overall case fatality rate of 2.3%. In diagnosis, chest computed tomography most commonly showed ground-glass opacity with or without consolidative patterns.Herein we report a case of a patient affected by COVID-19 pneumonia referred in the emergency department of our institution on 4 April 2020 with peculiar lung ultrasound findings.


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