scholarly journals Fracture in a girl with graves’ disease induced by osteoporosis: A case report

2021 ◽  
Vol 2 (3) ◽  
Author(s):  
Kotb Abbass Metwalley ◽  
◽  
Hekma Saad Farghaly ◽  
Keyword(s):  
Lumbar Vertebrae ◽  
Humeral Fracture ◽  
Graves Disease ◽  
Z Score ◽  
Mineral Density ◽  
X Ray ◽  
Femur Neck ◽  
One Year ◽  
Left Humerus ◽  
Overt Hyperthyroidism

A 6-year-old girl with long-standing Graves’ Disease (GD) presented with a left oblique non-displaced humeral fracture. Examination reveals signs of thyrotoxicosis and mild swelling of her left humerus. Investigations confirmed severe overt hyperthyroidism due to GD. A dual-energy X-ray Absorptiometry (DXA) of the lumbar vertebrae (L1-4) and femoral neck revealed that Z-score were -2.9 and -2.1, respectively, representing below the expected range for age which is consistent with osteoporosis. The girl was commenced on carbimazole in a dose of 5 mg two times daily and propranolol 10 mg two times daily. After one year of treatment, she returned to a euthyroid state, and Bone Mineral Density (BMD) increase by 19% and 23% of the lumbar spine and femur neck, respectively Keywords: Osteoporosis; Graves’ disease; Fracture.

scholarly journals VLIYaNIE ISSLEDOVANIYa MINERAL'NOY PLOTNOSTI KOSTI (MPK) V STANDARTNYKh LOKALIZATsIYaKh I DOPOLNITEL'NYKh IZMERENIY MPK NA USTANOVLENIE DIAGNOZA OSTEOPOROZA

2005 ◽  
Vol 8 (2) ◽  
pp. 21-24
Author(s):  
M P RUBIN ◽  
R E ChEChURIN
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Mineral Density ◽  
X Ray ◽  
Diagnostic Categories ◽  
Fracture Threshold ◽  
Femur Neck ◽  
Two Sides ◽  
Adjacent Vertebra

The aim of the study was to improve the quality of densitometric evaluations of bone mineral density disorders. Dual-energy x-ray absorbtiometry data collected in 874 females were analyzed. All patients had got bone mineral density examination of the lumbar spine, proximal femur at the both sides; some of the patients also had been measured at the distal radius. We hypothesize that the judgment of diagnostic categories (osteoporosis stages) should include consideration of bone mineral density data both for L2-L4 and for any of two adjacent vertebra, as well as variations of the femur neck data between the two sides. Ultradistal forearm bone densitometry was carried out for osteopenic patients who had had a Colles'fracture -to estimate fracture risk for the opposite radius. The osteoporotic fracture threshold for such cases may be at T-Score of -.1.

scholarly journals Is bone health of young atopic dermatitis patients a significant healthcare problem?

2021 ◽  
Author(s):  
Sooyoung Kim ◽  
Jimi Choi ◽  
Moon Kyun Cho ◽  
Nam Hoon Kim ◽  
Sin Gon Kim ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Lumbar Spine ◽  
Bone Health ◽  
Smoking Status ◽  
Control Group ◽  
Z Score ◽  
Mineral Density ◽  
Control Groups ◽  
Femur Neck ◽  
And Control

Abstract Background Atopic dermatitis (AD) incidence has increased over the past decades, especially among young adults. However, their bone health has not been clearly elucidated with discordant results. Objective We aimed to investigate the bone mineral density (BMD) measured by double energy X-ray absorptiometry and Z-score at the lumbar spine, femur neck, and total femur to evaluate the risk of osteoporosis in men aged <50 years and premenopausal women with AD.Methods The Korea National Health and Nutrition Examination Survey 2007-2009 data were used in this case-control cohort study. We included young AD patients (aged 19≤ and <50 years) diagnosed by a doctor and compared these patients with 1:5 propensity score weighting controls by age, sex, body mass index (BMI), vitamin D level, and alcohol/smoking status. Results We analyzed 311 (weighted n=817,014) AD patients and 1,555 (weighted n=4,155,855) controls. BMD at the lumbar spine was significantly lower in the male AD group than in the male control group (mean ± SE, 0.989 ± 0.002 vs. 0.954 ± 0.016, P = 0.03) while BMDs at the femur neck and total femur were comparable. For women, BMDs at the three sites were not significantly different between the AD and control groups. Low bone mass (defined by a Z-score of ≤2.0) was not significantly different between the AD and control groups in both sexes. Conclusions Bone health, especially BMD and Z-score, in young AD patients were comparable with those without AD. AD was not a risk factor for low BMD.

The Prevalence of Disordered Eating, Menstrual Dysfunction, and Low Bone Mineral Density among US Collegiate Athletes

2006 ◽  
Vol 16 (1) ◽  
pp. 1-23 ◽  
Author(s):  
Katherine A. Beals ◽  
Amanda K. Hill
Keyword(s):  
Bone Mineral Density ◽  
Disordered Eating ◽  
Bone Mineral ◽  
Collegiate Athletes ◽  
Z Score ◽  
Mineral Density ◽  
Menstrual Dysfunction ◽  
X Ray ◽  
Low Bone Mineral Density ◽  
Menstrual History

The purpose of this study was to examine the prevalence of disordered eating (DE), menstrual dysfunction (MD), and low bone mineral density (BMD) among US collegiate athletes (n = 112) representing 7 different sports (diving, swimming, x-country, track, tennis, field hockey, and softball) and determine differences in prevalence existed between athletes participating in lean-build (LB) and non-lean build (NLB) sports. DE and MD were assessed by a health, weight, dieting, and menstrual history questionnaire. Spinal BMD was determined via dual energy x-ray absorptiometry. Twenty-eight athletes met the criteria for DE, twenty-nine for MD, and two athletes had low BMDs (using a Z score below −2.0). Ten athletes met the criteria for two disorders (one with disordered eating and low BMD and nine with disordered eating and menstrual dysfunction), while only one athlete met the criteria for all three disorders. Using a Z score below −1.0, two additional athletes met the criteria for all three disorders and three more athletes met the criteria for a combination of two disorders. With the exception of MD, which was significantly more prevalent among LB vs. NLB sports (P = 0.053), there were no differences between the groups in the prevalence of individual disorders or combinations of disorders. These data indicate that the combined prevalence of DE, MD, and low BMD among collegiate athletes is small; however, a significant number suffer from individual disorders of the Triad.

scholarly journals Evaluation and Management of Skeletal Health in Celiac Disease: Position Statement

2012 ◽  
Vol 26 (11) ◽  
pp. 819-829 ◽  
Author(s):  
Mona A Fouda ◽  
Aliya A Khan ◽  
Muhammad Sultan ◽  
Lorena P Rios ◽  
Karen McAssey ◽  
...  
Keyword(s):  
Celiac Disease ◽  
Position Statement ◽  
Current Evidence ◽  
Mineral Density ◽  
High Fracture ◽  
Skeletal Health ◽  
X Ray ◽  
Increased Risk ◽  
One Year

OBJECTIVE: To review the evaluation and management of skeletal health in patients with celiac disease (CD), and to make recommendations on screening, diagnosis, treatment and follow-up of low bone mineral density (BMD) in CD patients.METHODS: A multidisciplinary team developed clinically relevant questions for review. An electronic search of the literature was conducted using the MEDLINE and EMBASE databases from 1996 to 2010. All original studies, reviews and guidelines, both pediatric and adult, were included. A document summarizing the results of the review and proposed recommendations was prepared and underwent multiple revisions until consensus was reached.RESULTS: At diagnosis, approximately one-third of adult CD patients have osteoporosis, one-third have osteopenia and one-third have normal BMD. Children with CD have low bone mass at diagnosis. Adult and pediatric CD patients are at increased risk of fractures.DISCUSSION: For adults, serum calcium, albumin, 25(OH) vitamin D3, parathyroid hormone and 24 h urine calcium testing should be performed at diagnosis; patients with ‘classic’ CD and those at risk for osteoporosis should undergo a dual x-ray absorptiometry scan. An abnormal baseline dual x-ray absorptiometry scan should be repeated one to two years after initiation of a gluten-free diet (GFD). For children, BMD should be assessed one year after diagnosis if GFD adherence is not strict. A GFD is the most important treatment for bone loss. Supplemental antiresorptives may be justified in those who remain at high fracture risk (eg, postmenopausal women, older men) after implementation of a GFD.CONCLUSION: Current evidence does not support the screening of all CD patients for low BMD at diagnosis. Follow-up BMD assessment should be performed one to two years after initiation of a GFD.

scholarly journals AB0609 RADIOFREQUENCY ECHOGRAPHIC MULTI-SPECTROMETRY FOR THE ASSESSMENT OF BOTH FEMORA IN PREGNANT WOMEN

2021 ◽  
Vol 80 (Suppl 1) ◽  
pp. 1340.1-1340
Author(s):  
E. Kirilova ◽  
N. Kirilov ◽  
S. Vladeva
Keyword(s):  
Bone Mineral Density ◽  
Femoral Neck ◽  
Pregnant Women ◽  
Bone Mineral ◽  
Dual Energy ◽  
Z Score ◽  
Mineral Density ◽  
X Ray ◽  
The Mean ◽  
The Right

Background:Radiofrequency Echographic Multi-Spectrometry (REMS) is a non-ionizing innovative approach for the assessment of REMS-based bone mineral density (BMD) of the axial skeleton. The principle of the REMS technology is based on the analysis of native raw unfiltered ultrasound signals during an echographic scan of the lumbar spine or the femoral neck [1]. Several studies demonstrated the high concordance with dual energy X-ray absorptiometry (DXA) in terms of measured BMD with this novel technology [2,3]. In previous published literature it was envisaged to apply this technology for the examination of the axial bone density in pregnant women. Pregnancy-associated bone loss has been demonstrated as decreased bone mineral density (BMD) in previous studies [4].Objectives:The aim of the current study is to compare the BMD values of both femora between pregnant and non-pregnant women matched for age and BMI using the novel REMS technology.Methods:Of total fifty women twenty pregnant women (40%) and thirty non-pregnant women (60%) were included in the study. The mean age of the pregnant women was 32 years ± 5 standard deviations (SD), (range 25-41 years) and the mean age of the non-pregnant women was 30 years ± 6 standard deviations (SD), (range 24-39 years). REMS approach was used to assess REMS-based BMD and REMS-based Z-score values of the femoral neck. Furthermore, body mass index (BMI) and gestational age in weeks were evaluated.Results:The mean BMI of the pregnant women was 26 kg/m2 ± 7 kg/m2 (range 14 kg/m2-42 kg/m2) and those of the non-pregnant women was 25 kg/m2 ± 5 kg/m2 (range 16 kg/m2-35 kg/m2). The mean gestational age was 20 weeks’ gestation ± 5 weeks’ gestation (range 13-27 weeks’ gestation). REMS-based mean BMD of the left femoral neck of the pregnant women was 0.793 g/cm2 ± 0.167 g/cm2 (range 0.563 g/cm2-1.154 g/cm2). REMS-based mean BMD of the right femoral neck of the pregnant women was 0.828 g/cm2 ± 0.153 g/cm2 (range 0.570 g/cm2-1.161 g/cm2). After comparing left femoral neck BMD with the right femoral neck BMD of the pregnant women, we found a linear correlation (R=0.764). Left femoral neck BMD value (0.793 g/cm2) of the pregnant women was significantly lower than those of the non-pregnant women (0.854 g/cm2), p=0.002. The mean left femoral Z-score of the pregnant women (-0.1 SD with range -2.5 SD-2.9 SD) was also significantly lower compared to those of the non-pregnant women (1.2 SD with range -1.5 SD-3.1 SD), p=0.003.Conclusion:This is the first study which provides data about BMD and Z-score values of both femora in pregnant women assessed with the radiation-free REMS technology. Pregnant women demonstrated significantly lower femoral neck BMD values and Z-scores compared to those of the non-pregnant women. Innovative REMS method could be very helpful for making decision about the treatment of pregnant women who are at risk of lower BMD due to concomitant diseases and/or treatment associated with osteoporosis.References:[1]Casciaro S, Conversano F, Pisani P, Muratore M. New perspectives in echographic diagnosis of osteoporosis on hip and spine. Clin Cases Miner Bone Metab. 2015; 12(2):142-150.[2]Nikolov M, Nikolov N. AB0908 Assessment of the impact of the lean mass with body composition by dual-energy x-ray absorptiometry on the bone mineral density. Annals of the Rheumatic Diseases 2020; 79:1756.[3]Chakova M., Chernev D., Kashukeeva P., Krustev P., Abedinov F. Lumbar Sympathectomy - Literature Review. International Journal of Science and Research (IJSR) Volume 7 Issue 8, August 2018 ISSN (Online): 2319-7064.[4]Degennaro, V. A.; Cagninelli, G.; Lombardi, F. A. “VP34.12: First assessment of maternal status during pregnancy by means of radiofrequency echographic multi-spectrometry technology”. Ultrasound in Obstetrics & Gynecology. 2020, 56 (S1): 199.Disclosure of Interests:None declared.

ASYMMETRY OF BONE MINERAL DENSITY OF THE HIPS IN PATIENTS WITH UNILATERAL KNEE OSTEOARTHRITIS: A CROSS-SECTIONAL STUDY

2011 ◽  
Vol 14 (01) ◽  
pp. 1150005 ◽  
Author(s):  
Alireza Ashraf ◽  
Seyed Mostafa Jazayeri Shooshtari ◽  
Kaynoosh Homayouni ◽  
Sharareh Roshanzamir ◽  
Mohsen Zafarghasempoor ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Knee Osteoarthritis ◽  
Bone Mineral ◽  
Lumbar Vertebrae ◽  
Cross Sectional Study ◽  
Z Score ◽  
Sectional Study ◽  
Mineral Density ◽  
Cross Sectional ◽  
T Score

Background: Osteoarthritis of any joint may exert different effects on bone mineral density that may be the result of several mechanisms including change in the pattern of weight load distribution. In this cross-sectional study we tried to find correlations between unilateral knee osteoarthritis and bone mineral density of hips and lumbar vertebrae. Methods: Forty three patients with knee osteoarthritis (unilateral or more severe in one side) were recruited in this study. The American college of Rheumatology Criteria was followed for the diagnosis of osteoarthritis. Dual X-Ray absorptiometry was used to obtain the T score and the Z score of the hips and lumbar vertebrae. Results: The T score and Z score of the hip and T score of the femoral neck, at the side with ipsilateral knee osteoarthritis was lower than the other side (p < 0.05). The mean Z score and T score of the vertebrae was negative irrespective of the side of osteoarthritis. Conclusions: Bone mineral density of the hip with ipsilateral knee osteoarthritis was lower than the other side, which suggests that BMD may be sensitive to some extent in detecting osteoporosis in these patients; it has also been observed that osteoarthritis might not affect bone mineral density of the hips and lumbar vertebrae in the same manner or to the same extent.

scholarly journals Osteopenic syndrome in liquidators of the Chernobyl power plant accident consequences

1994 ◽  
Vol 40 (4) ◽  
pp. 24-27 ◽  
Author(s):  
L. Ya. Rozhinskaya ◽  
Ye. I. Marova ◽  
B. M. Rassokhin ◽  
G. S. Purtova ◽  
A. I. Bukhman ◽  
...  
Keyword(s):  
Power Plant ◽  
Lumbar Vertebrae ◽  
Radiation Doses ◽  
Mineral Density ◽  
X Ray ◽  
Group I ◽  
Painful Syndrome ◽  
Vertebral Bodies ◽  
Group 2 ◽  
Group 1

Bone system was examined in 112 liquidators; in 71 of these osseous tissue density was studied by osseous densitometer using bienergetic x-ray absorptiometry and in 45 x-ray examinations, analyses of biochemical and hormonal parameters were carried out. Spinal painful syndrome was detected in 61 to 82 % of the examinees. For analysis of densitometric and x-ray parameters the liquidators were divided into 2 groups: group I included those who worked at the power plant in 1986 (55 %) and group 2 were those who worked there in 1987-1989. Radiation doses in group 1 reliably surpassed those in group 2 (p0.001). Bone mineral density in the lumbar vertebrae was significantly lower in group 1 as against group 2 and lower in both groups us. controls. More than 5 % osseous mineral loss was revealed in 73 % of group 1 liquidators and in 43 % of group 2 ones. Analysis of spinal roentgenograms in 45 liquidators showed a high incidence of negligible and moderately expressed osteoporosis without compression fractures of vertebral bodies: osteopenia signs were found in 87 % of group 1 examinees complaining of pain in the spine and in 73 % of group 2 examinees; signs of osteochondrosis and spondylosis were detected in 40 % of group 1 and in 47 % of group 2 subjects. Hence, a higher incidence of osteopenia in liquidators, more manifest condition and its higher detection rate in subjects exposed to higher radiation doses indicate a certain contribution of radiation factor to the development of the osteopenia syndrome in liquidators.

scholarly journals Bone mineral density in children with juvenile idiopathic arthritis after one year of treatment with etanercept

2018 ◽  
Vol 146 (5-6) ◽  
pp. 297-302
Author(s):  
Gordana Susic ◽  
Marija Atanaskovic ◽  
Roksanda Stojanovic ◽  
Goran Radunovic
Keyword(s):  
Bone Mineral Density ◽  
Juvenile Idiopathic Arthritis ◽  
Rheumatoid Factor ◽  
Bone Mineral ◽  
Mineral Metabolism ◽  
Z Score ◽  
Mineral Density ◽  
Bone Mineral Metabolism ◽  
Systemic Jia ◽  
One Year

Introduction/Objective. Juvenile idiopathic arthritis (JIA) is the most frequent chronic inflammatory, rheumatic disease of childhood, associated with disturbance of bone mineral metabolism, which develops gradually and progressively, and if untreated eventually leads to osteoporosis in adulthood. The aim of our study was to evaluate bone mineral density (BMD) in patients with JIA treated with etanercept over a period of one year. Methods. The prospective cohort study included 94 JIA patients (66 female, 28 male), their median age being 14.77 years. BMD was measured by dual-energy X-ray absorptiometry on the lumbar spine. Disease activity was assessed using the American College of Rheumatology Pedi 50 criteria. Results. After one year of treatment with etanercept, we found a statistically significant increment in all osteodensitometry variables (p < 0.001). Annual enhancement for the whole group was as follows: bone mineral content 15.8%, BMD 7.2%, BMDvol 4.2%. Z-score improved from -0.86 to -0.58 SD at the last visit, but decreased in rheumatoid factor-positive polyarthritis patients. Patients with systemic JIA had the lowest Z-score. Z-score correlated with functional disability level. BMD was lower in the group treated with glucocorticoids. Conclusion. Our results showed significant improvement of bone mineral density in children with JIA after one year of treatment with etanercept. Rheumatoid factor-positive and systemic JIA subtypes and treatment with glucocorticoids are the risk factors for impairing bone mineral metabolism.

The Use of Computer Technology in Standardization of the Parameters of X-Ray Densitometry

10.12737/9082 ◽  
2015 ◽  
Vol 22 (1) ◽  
pp. 75-79
Author(s):  
Захаров ◽  
I. Zakharov
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Regional Differences ◽  
Lumbar Vertebrae ◽  
Dual Energy ◽  
Mineral Density ◽  
Population Database ◽  
X Ray ◽  
Computerized System

Currently, the radiation techniques are dominant in the diagnosis of osteoporosis, among them the dual-energy X-ray absorptiometry (DXA) is the leading. This method is based on the determination of bone mineral density. The article describes a computerized system Standart LS (Russia), which standardizes the parameters of bone mineral density, depending on the type of densitometry equipment and evaluates the results of X-ray densitometry taking into account a regional perspective. The developed program and population database of parameters of bone mineral density were the results of retrospective analysis of the dual-energy X-ray absorptiometry in 1504 women living in Kemerovo region. The dual-energy X-ray absorptiometry was performed with a bone densitometer Lunar-DPX-NT (GE Healthcare, UK). Initially, the bone mineral density of the first-fourth lumbar vertebrae was studied; then, the standardization of other parameters of densitometric systems was carried out (Hologic, Norland). The algorithm of the computer program consists of three phases: the introduction of parameters of bone mineral density, the standardization and the processing according to a type of densitometer and an age of a subject. After data processing, the values of Z-criteria are given out according to the recommendations of the International Society for Clinical Densitometry. The developed computerized system will contribute to a more accurate assessment of bone mineral density in the women, taking into account regional differences.

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