KASNI (CICHORIUM INTYBUS L.): A REVIEW ON MEDICINAL UTILITY IN PERSPECTIVE OF UNANI MEDICINE

Kasni (Cichorium intybus L.) or Chicory is a perennial herb of the dandelion family, (Asteraceae), usually with bright blue flowers, rarely white or pink which is used widely in Unani System of Medicine. It is an erect and procumbent herb that attains about 40-80cm hight. There are two main varieties of Kasni one issweet and second is wild. The most popular variety of Kasni used for medicinal purposes is Cichorium intybus L. Different parts of the herb are used for medicinal purposes like leaves, seeds and root. It is well known for the resolvent action of internal organs and especially for its hepatoprotective and nephroprotective properties, regarding the hepatoprotective activity, chicory extract reduces the levels of hepatic enzymes such as alanine aminotransferase, aspartate aminotransferase and alkaline phosphatase. It contains dietary fiber Inulin which is useful in treating diabetes and constipation. Besides inulin it contains other chemical constituents like sesquiterpene lactones, coumarins, citric and tartaric acids, lactic, acetic, palmitic, pyruvic acid etc. Its leaves contain vitamin B2 and C, root contains series of glucofructosans. The main actions which are attributed to chicory are deobstruent, diuretic, blood purifier, antipyretic and antiinflammatory as mentioned in Unani medicine. It is recommended in the treatment of jaundice, gastritis, ascites, arthritis, asthma and many other disorders, either alone or in compound form. This review gives knowledge on distribution, morphology, phytochemistry and pharmacological aspects along with its therapeutic uses in perspective of Unani System of Medicine.

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Kasni (Cichorium intybus): A Unani Hepatoprotective Drug

Journal of Drug Delivery and Therapeutics ◽

10.22270/jddt.v10i4.4162 ◽

2020 ◽

Vol 10 (4) ◽

pp. 238-241

Author(s):

, Anju ◽

Ghazala Javed ◽

Rasikh Javaid ◽

Farah Ahmed

Keyword(s):

English Language ◽

Kidney Diseases ◽

Cichorium Intybus ◽

Perennial Herb ◽

Classical Literature ◽

Liver Disorders ◽

Therapeutic Uses ◽

Phytochemical Studies ◽

Hepatoprotective Drug ◽

Bright Blue

Kasni (Cichorium intybus Linn.) is a powerful hepatoprotective and nephroprotective drug which has been extensively used in Unani System of Medicine. It is commonly known as chicory in English language. It is an erect perennial herb of the dandelion family Asteraceae. There are two types of Kasni depending on colour of the flowers which are usually bright blue and white or pink rarely. Chicory consists of a dietary fibre called as Inulin which is very useful in treating diabetes and constipation. As per Unani classical literature, it has been extensively used as Mufatteh Sudud (Deobstruent), Musaffi Dam (Blood Purifier), Muqawwi Kabid (Hepatic Tonic), Muqaiwwi Meda (Tonic for Stomach), Waram e Meda (Gastritis), Amraz e Kabid (Liver Disorders), Ghisyan (Nausea and Vomiting), Amraze Kulliya (Kidney Diseases), etc. The root of Kasni possesses various properties such as Aperient, Cholagogue, Deobstruent, Diuretic, Emmenagogue, Febrifuge, Resolvent. Its leaves’ decoction is used as lithotriptic and also useful in elimination of internal mucus. This paper gives an overview of types, phytochemical studies, pharmacological actions and therapeutic uses of Kasni as per Unani classical literature and current scientific studies. Keywords: Kasni, Cichorium intybus Linn., Unani System of Medicine, Hepatoprotective, Unani drug.

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Kasani beej (Cichorium intybus): Ayurvedic View, Folk View, Phytochemistry and Modern Therapeutic Uses

International Journal for Research in Applied Sciences and Biotechnology ◽

10.31033/ijrasb.8.2.14 ◽

2021 ◽

Vol 8 (2) ◽

pp. 114-125

Author(s):

Shailja Choudhary ◽

Hemlata Kaurav ◽

Gitika Chaudhary

Keyword(s):

Medicinal Plant ◽

Arid Regions ◽

Sesquiterpene Lactones ◽

Cichorium Intybus ◽

Vegetable Crop ◽

Therapeutic Uses ◽

Traditional Remedy ◽

Coffee Substitute ◽

Phytochemical Constituents ◽

Asteraceae Family

Cichorium intybus is commonly known as Chicory, kasani. It is a recognized medicinal plant that belongs to the Asteraceae family. This plant is a well-known traditional herb used in various medicinal systems like Ayurveda, Unani and Siddha medicinal system to treat variety of diseases ranging from wounds to diabetes. The species is native to the European region (Mediterranean region) but can also grow in the temperate and semi-arid regions. The juice extracted from this plant is used as a traditional remedy to cure uterus cancer and tumors. The plant is well-known for its roots that are used as an additive in coffee as it provides bitterness in taste without the caffeine. It is also reported that the roots of the plant contain 40% inulin and acts as an anti-diabetic agent. Historically, the plant was cultivated by ancient Egyptians as a medicinal plant, vegetable crop, coffee substitute and also used as animal forage. Cichorium intybus contains various phytochemical constituents mainly sesquiterpene lactones, caffeic acid derivatives, inulin flavonoids, alkaloids, phenols, steroids terpenoids and many more. The reported pharmacological properties of the C. intybus plant include hepatoprotective, anti-diabetic, anti-cancerous, anti-inflammatory, analgesic, cardiovascular, antioxidant, antimicrobial, anthelmintic, antimalarial, anti-allergic and gastroprotective activities. In this review article, the medicinal and ayurvedic importance of C. intybus plant along with its phytochemicals are briefly explained.

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Saussurea lappa: A Comprehensive Review on its Pharmacological Activity and Phytochemistry

Current Traditional Medicine ◽

10.2174/2215083805666190626144909 ◽

2020 ◽

Vol 6 (1) ◽

pp. 13-23

Author(s):

Reyaz Hassan ◽

Mubashir Hussain Masoodi

Keyword(s):

Biological Activity ◽

Adverse Effects ◽

Chemical Constituents ◽

Literature Survey ◽

Perennial Herb ◽

Comprehensive Review ◽

Saussurea Lappa ◽

Therapeutic Uses ◽

Wide Range ◽

Anti Inflammatory

Around 3000 species of Saussurea are known, however Saussurea lappa Clarke which is perennial herb and has been traditionally used as anticancer, anti-inflammatory, antiviral, medicine without many adverse effects. Phytochemistry of Saussurea lappa after thorough literature survey revealed various varied and copious metabolites such as sesquiterpenes, flavonoids, phytosterols, lignans, terpenes. Many of these compounds have been found to possess a wide range of biological activity such as anticancer, anti-inflammatory, anti-hepatotoxic, anti-viral, etc. Among sesquiterpenes particularly Dehydrocostuslactone, dihydrocostunolide, costunolide Lappadilactone, have been isolated as the main chemical constituents. This review aims to cover published work from public databases (e.g. PubMed, Google Scholar, ResearchGate) and Non-English, Ph.D./MS thesis databases (e.g. CKNIChina, Jairo-Japan, Myto-Malaysia, Shodhganga-India) with a particular focus on phytochemistry and therapeutic uses of different fractions as well as isolated compounds from Saussurea lappa.

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A study on the effects of sample pre-treatment on the amount of sesquiterpene lactones found in chicory ( Cichorium Intybus L. ) by ELISA and by HPLC

Zeitschrift f�r Lebensmitteluntersuchung und -Forschung A ◽

10.1007/s002170050060 ◽

1997 ◽

Vol 204 (3) ◽

pp. 189-193 ◽

Cited By ~ 6

Author(s):

Angeline M. Peters ◽

A. van Amerongen

Keyword(s):

Sesquiterpene Lactones ◽

Cichorium Intybus ◽

Pre Treatment

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TERMINALIA CHEBULA: SUCCESS FROM BOTANY TO ALLOPATHIC AND AYURVEDIC PHARMACY

Asian Journal of Pharmaceutical and Clinical Research ◽

10.22159/ajpcr.2016.v9i5.13074 ◽

2016 ◽

Vol 9 (5) ◽

pp. 21

Author(s):

Varun Garg ◽

Barinder Kaur ◽

Sachin Kumar Singh ◽

Bimlesh Kumar

Keyword(s):

Chemical Constituents ◽

Present Review ◽

Terminalia Chebula ◽

Pharmacological Activities ◽

Therapeutic Uses ◽

Anti Cancer ◽

Anti Oxidant ◽

Anti Inflammatory

ABSTRACTTerminalia chebula (TC) is a unique herb having various therapeutic potentials as anti-inflammatory, antioxidant, anticancer, and digestant. It belongsto family Combretaceae. In the present review, an attempt has been made to decipher classification, chemical constituents, therapeutic uses, andpatents that have been reported for TC. Various pharmacological activities of TC that make it as potential medicine and its Ayurvedic formulationsare highlighted.Keywords: Terminalia chebula, Anti-oxidant, Anti-cancer, Ayurvedic formulations, Anti-oxidant.

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Chemical Constituents of Eupatorium japonicum and Anti-Inflammatory, Cytotoxic, and Apoptotic Activities of Eupatoriopicrin on Cancer Stem Cells

Evidence-based Complementary and Alternative Medicine ◽

10.1155/2021/6610347 ◽

2021 ◽

Vol 2021 ◽

pp. 1-12

Author(s):

Minh Giang Phan ◽

Thi Thao Do ◽

Thi Nga Nguyen ◽

Thi Viet Huong Do ◽

Ngoc Phuc Dong ◽

...

Keyword(s):

Anticancer Agents ◽

Human Cancer ◽

Biological Activities ◽

Chemical Constituents ◽

Sesquiterpene Lactones ◽

No Production ◽

Bioactive Constituents ◽

Anti Inflammatory ◽

First Time ◽

Eupatorium Japonicum

Eupatorium japonicum Thunb. of the plant family Asteraceae is a popular traditional herb in Vietnam. However, its chemical constituents as well as bioactive principles have not been investigated yet. We investigated the phytochemistry of E. japonicum in Vietnam and isolated seventeen compounds (1–17) including phytosterols, terpenoids, phenolic acids, flavonoids, fatty alcohols, and fatty acids. They were structurally determined by MS and NMR analysis. Except for compounds 6 and 12, all the other compounds were identified for the first time from E. japonicum. Since many sesquiterpene lactones with α-methylene γ-lactone ring are reported as anti-inflammatory and anticancer agents, eupatoriopicrin (10), 1-hydroxy-8-(4,5-dihydroxytigloyloxy)eudesma-4(15),11(13)-dien-6,12-olide (11) were selected among the isolates for biological assays. Compound 10 was identified as the main bioactive sesquiterpene lactone of E. japonicum showing its potent anti-inflammatory and cytotoxic activity through inhibiting NO production and the growth of HepG2 and MCF-7 human cancer cell lines. For the first time, eupatoriopicrin (10) was demonstrated to strongly inhibit NTERA-2 human cancer stem cell (CSC) line in vitro. It is noticeable that the cytotoxicity of eupatoriopicrin against NTERA-2 cells is mediated by its apoptosis-inducing capability of 10 as demonstrated by the results of Hoechst 33342 staining, flow cytometry apoptosis analysis, and caspase-3 activity assays. The biological activities of the main bioactive constituents 1–7, 10, 12, and 15 supported the reported anti-inflammatory and anticancer properties of extracts from E. japonicum.

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