scholarly journals Kasni (Cichorium intybus): A Unani Hepatoprotective Drug

2020 ◽  
Vol 10 (4) ◽  
pp. 238-241
Author(s):  
, Anju ◽  
Ghazala Javed ◽  
Rasikh Javaid ◽  
Farah Ahmed
Keyword(s):  
English Language ◽  
Kidney Diseases ◽  
Cichorium Intybus ◽  
Perennial Herb ◽  
Classical Literature ◽  
Liver Disorders ◽  
Therapeutic Uses ◽  
Phytochemical Studies ◽  
Hepatoprotective Drug ◽  
Bright Blue

Kasni (Cichorium intybus Linn.) is a powerful hepatoprotective and nephroprotective drug which has been extensively used in Unani System of Medicine. It is commonly known as chicory in English language. It is an erect perennial herb of the dandelion family Asteraceae. There are two types of Kasni depending on colour of the flowers which are usually bright blue and white or pink rarely. Chicory consists of a dietary fibre called as Inulin which is very useful in treating diabetes and constipation. As per Unani classical literature, it has been extensively used as Mufatteh Sudud (Deobstruent), Musaffi Dam (Blood Purifier), Muqawwi Kabid (Hepatic Tonic), Muqaiwwi Meda (Tonic for Stomach), Waram e Meda (Gastritis), Amraz e Kabid (Liver Disorders), Ghisyan (Nausea and Vomiting), Amraze Kulliya (Kidney Diseases), etc. The root of Kasni possesses various properties such as Aperient, Cholagogue, Deobstruent, Diuretic, Emmenagogue, Febrifuge, Resolvent. Its leaves’ decoction is used as lithotriptic and also useful in elimination of internal mucus. This paper gives an overview of types, phytochemical studies, pharmacological actions and therapeutic uses of Kasni as per Unani classical literature and current scientific studies. Keywords: Kasni, Cichorium intybus Linn., Unani System of Medicine, Hepatoprotective, Unani drug.

KASNI (CICHORIUM INTYBUS L.): A REVIEW ON MEDICINAL UTILITY IN PERSPECTIVE OF UNANI MEDICINE

2020 ◽  
Vol 13 (2) ◽  
Author(s):  
Mohd Afsahul Kalam ◽  
Bazila Majeed ◽  
Aieman Yaqoob ◽  
Riehana Ghani ◽  
Shafiqur Rahman
Keyword(s):  
Chemical Constituents ◽  
Sesquiterpene Lactones ◽  
Hepatoprotective Activity ◽  
Cichorium Intybus ◽  
Perennial Herb ◽  
Internal Organs ◽  
Unani Medicine ◽  
Tartaric Acids ◽  
Therapeutic Uses ◽  
Bright Blue

Kasni (Cichorium intybus L.) or Chicory is a perennial herb of the dandelion family, (Asteraceae), usually with bright blue flowers, rarely white or pink which is used widely in Unani System of Medicine. It is an erect and procumbent herb that attains about 40-80cm hight. There are two main varieties of Kasni one issweet and second is wild. The most popular variety of Kasni used for medicinal purposes is Cichorium intybus L. Different parts of the herb are used for medicinal purposes like leaves, seeds and root. It is well known for the resolvent action of internal organs and especially for its hepatoprotective and nephroprotective properties, regarding the hepatoprotective activity, chicory extract reduces the levels of hepatic enzymes such as alanine aminotransferase, aspartate aminotransferase and alkaline phosphatase. It contains dietary fiber Inulin which is useful in treating diabetes and constipation. Besides inulin it contains other chemical constituents like sesquiterpene lactones, coumarins, citric and tartaric acids, lactic, acetic, palmitic, pyruvic acid etc. Its leaves contain vitamin B2 and C, root contains series of glucofructosans. The main actions which are attributed to chicory are deobstruent, diuretic, blood purifier, antipyretic and antiinflammatory as mentioned in Unani medicine. It is recommended in the treatment of jaundice, gastritis, ascites, arthritis, asthma and many other disorders, either alone or in compound form. This review gives knowledge on distribution, morphology, phytochemistry and pharmacological aspects along with its therapeutic uses in perspective of Unani System of Medicine.

PHENOLIC COMPOUNDS AND ANTIOXIDANT ACTIVITY GLYCYRRHIZA PALLIDIFLORA HERB (GLYCYRRHIZA PALLIDIFLORA MAXIM.)

2021 ◽  
pp. 42-46
Author(s):  
Maltseva E.M. ◽  
Egorova I.N. ◽  
Pinchuk L.G.
Keyword(s):  
Antioxidant Activity ◽  
Phenolic Compounds ◽  
Russian Far East ◽  
Far East ◽  
Biologically Active ◽  
Perennial Herb ◽  
Total Phenolic ◽  
Plant Antioxidants ◽  
Phytochemical Studies ◽  
First Time

Pale-flowered licorice (Glycyrrhiza pallidiflora Maxim.) is the pea family (Fabaceae) perennial herb. It is a Russian Far East endemic. Pale-flowered licorice refers to the false (not sweet) licorice section (Pseudoglycyrrhiza Krug.), which do not accumulate glycyrrhizin derivatives. The G. pallidiflora successful introduction has been carried out over the past 5 years in the “Apothecary garden” territory, FRC UUH SB RAS, Kemerovo. Phytochemical studies screening biologically active compounds main classes of the plant aerial part confirmed the presence of a complex of phenolic compounds. The content of catechin derivatives and condensed-type tannins - proanthocyanidins (PAC) data in G. pallidiflora herb were obtained for the first time. In different years of cultivation, licorice herb accumulates phenolic compounds - up to 2.83 ± 0.22% in terms of gallic acid, flavonoids - up to 2.44 ± 0.03% in terms of rutin and PAC in terms of cyanidine chloride - up to 2.61 ± 0.11%. It was found that the maximum content of the phenolic compounds and PAC sum was observed in the herb for 4 years development. The greatest number of flavonoids accumulates in the herb harvested in the 3rd year of cultivation. A positive significant linear relation was found between antioxidant activity (AOA) and the total phenolic compounds and PAC content (r≥0.98). Considering that BAC with IC values ≤ 50 μg / ml in the DPPH assay refer to active antioxidant’s licorice herb can be classified as a plant with high antioxidant potential. It was found that the iron chelating activity of the G. pallidiflora herb is in direct dependence (r≥0.94) on the content of flavonoids. The obtained results demonstrate the importance of further study of this plant as a source of BAC, including plant antioxidants.

scholarly journals Kasani beej (Cichorium intybus): Ayurvedic View, Folk View, Phytochemistry and Modern Therapeutic Uses

2021 ◽  
Vol 8 (2) ◽  
pp. 114-125
Author(s):  
Shailja Choudhary ◽  
Hemlata Kaurav ◽  
Gitika Chaudhary
Keyword(s):  
Medicinal Plant ◽  
Arid Regions ◽  
Sesquiterpene Lactones ◽  
Cichorium Intybus ◽  
Vegetable Crop ◽  
Therapeutic Uses ◽  
Traditional Remedy ◽  
Coffee Substitute ◽  
Phytochemical Constituents ◽  
Asteraceae Family

Cichorium intybus is commonly known as Chicory, kasani. It is a recognized medicinal plant that belongs to the Asteraceae family. This plant is a well-known traditional herb used in various medicinal systems like Ayurveda, Unani and Siddha medicinal system to treat variety of diseases ranging from wounds to diabetes. The species is native to the European region (Mediterranean region) but can also grow in the temperate and semi-arid regions. The juice extracted from this plant is used as a traditional remedy to cure uterus cancer and tumors. The plant is well-known for its roots that are used as an additive in coffee as it provides bitterness in taste without the caffeine. It is also reported that the roots of the plant contain 40% inulin and acts as an anti-diabetic agent. Historically, the plant was cultivated by ancient Egyptians as a medicinal plant, vegetable crop, coffee substitute and also used as animal forage. Cichorium intybus contains various phytochemical constituents mainly sesquiterpene lactones, caffeic acid derivatives, inulin flavonoids, alkaloids, phenols, steroids terpenoids and many more. The reported pharmacological properties of the C. intybus plant include hepatoprotective, anti-diabetic, anti-cancerous, anti-inflammatory, analgesic, cardiovascular, antioxidant, antimicrobial, anthelmintic, antimalarial, anti-allergic and gastroprotective activities. In this review article, the medicinal and ayurvedic importance of C. intybus plant along with its phytochemicals are briefly explained.

scholarly journals Ethnobotanical study of medicinal plants used in Ahar-Arasbaran (protected area in East Azerbaijan Province of Iran)

2019 ◽  
Vol 40 (2) ◽  
pp. 209-214
Author(s):  
Mostafa Ebadi ◽  
Rosa Eftekharian
Keyword(s):  
Medicinal Plants ◽  
Cold Treatment ◽  
Ethnobotanical Study ◽  
Medicinal Species ◽  
Basic Step ◽  
Growing Seasons ◽  
Therapeutic Uses ◽  
Digestive Disorders ◽  
East Azerbaijan ◽  
Phytochemical Studies

Iran is an ancient country in the usage of medicinal plants and Ahar is known as one of the richest regions of medicinal plants. The traditional knowledge about medicinal plants is the basic step in many drug productions and these kinds of information should be documented through botanical investigations. The present study is the first survey conducted in this region and its primary point is to distinguish such plants and to present their application in traditional medicine. In this study, the data was gathered by talking with indigenous individuals to identify medicinal plants with local importance developed during the 2015 and 2016 growing seasons. Scientific names and therapeutic uses are also mentioned. The results obtained from the present study indicated that there were 46 medicinal species of 23 families in Ahar and local people mainly used Lamiaceae and Asteraceae then Rosaceae, Brassicaceae, Fabaceae, and Zygophyllaceae medicinal taxa. Medicinal plants were mostly used to treat intestinal-digestive disorders, for cold treatment and for soothing pain. According to results, significant ethnobotanical data on medicinal plants gives premise information to future pharmacological and phytochemical studies. Also, this document can be utilized as a part of protecting indigenous knowledge.

Saussurea lappa: A Comprehensive Review on its Pharmacological Activity and Phytochemistry

2020 ◽  
Vol 6 (1) ◽  
pp. 13-23
Author(s):  
Reyaz Hassan ◽  
Mubashir Hussain Masoodi
Keyword(s):  
Biological Activity ◽  
Adverse Effects ◽  
Chemical Constituents ◽  
Literature Survey ◽  
Perennial Herb ◽  
Comprehensive Review ◽  
Saussurea Lappa ◽  
Therapeutic Uses ◽  
Wide Range ◽  
Anti Inflammatory

Around 3000 species of Saussurea are known, however Saussurea lappa Clarke which is perennial herb and has been traditionally used as anticancer, anti-inflammatory, antiviral, medicine without many adverse effects. Phytochemistry of Saussurea lappa after thorough literature survey revealed various varied and copious metabolites such as sesquiterpenes, flavonoids, phytosterols, lignans, terpenes. Many of these compounds have been found to possess a wide range of biological activity such as anticancer, anti-inflammatory, anti-hepatotoxic, anti-viral, etc. Among sesquiterpenes particularly Dehydrocostuslactone, dihydrocostunolide, costunolide Lappadilactone, have been isolated as the main chemical constituents. This review aims to cover published work from public databases (e.g. PubMed, Google Scholar, ResearchGate) and Non-English, Ph.D./MS thesis databases (e.g. CKNIChina, Jairo-Japan, Myto-Malaysia, Shodhganga-India) with a particular focus on phytochemistry and therapeutic uses of different fractions as well as isolated compounds from Saussurea lappa.

scholarly journals PRELIMINARY PHARMACOGNOSTICAL, PHYTOCHEMICAL STUDY AND HPTLC ANALYSIS OF COSTUS PICTUS D.DON.

2021 ◽  
pp. 11-24
Author(s):  
Hasna.T ◽  
Vivek.P ◽  
Manojkumar.N
Keyword(s):  
Water Extract ◽  
Ethanolic Extract ◽  
Cost Effective ◽  
Water Soluble ◽  
Vascular Bundles ◽  
Classical Literature ◽  
Phytochemical Study ◽  
Parenchyma Cells ◽  
Rf Values ◽  
Phytochemical Studies

The ancient wisdom in Ayurveda medicine is still not exhaustively explored. Multiple exotic plants existent in India which are not described in classical literature of Ayurveda are commonly referred to as Anukta Dravya (undocumented). Costus pictus D.Don is such a plant, recently introduced in India from Mexico, which is used for renal disorders there. In India, it is used in Diabetes mellitus. This is proven for antidiabetic, antioxidant, anticancerous, antimicrobial and diuretic actions. It is an easily propagated, palatable and cost effective plant. Identification through pharmacognostical and phytochemical studies is essential for the standardization of any plant. The green leaf is narrowly elliptic with 10 to 25cm length and 2.5 to 6cm width. Microscopy revealed presence of vascular bundles, unicellular trichomes in upper epidermis, thin walled parenchyma cells in ground tissue and layers of parenchymatous hypodermis. Powder microscopy showed presence of epidermal parenchyma cells with underlying chlorenchyma group of fibers and fibro vascular bundles.TLC photo documentation revealed presence of many phytoconstituents with different Rf values. Densitometric scan showed many peaks, 10 at 254nm, 11 at 366nm, 6 at 520nm and 9 at 620 nm after derivatisation. Moisture content was 20%. The percentage of total ash, acid insoluble ash, and water insoluble ash was determined. The water soluble extractive value was 22.57 which is highest among all the extracts. The results indicated the presence of alkaloid, steroids, tannins, flavanoids, phenol, carbohydrate and resin in ethanolic extract and steroid, flavanoids, phenols, saponins, tannins and glycosides in water extract.

scholarly journals Therapeutic Potential of Evolvulus alsinoides

2019 ◽  
Vol 9 (4-s) ◽  
pp. 696-701 ◽  
Author(s):  
Mantasha Binth Siraj ◽  
Asim Ali Khan ◽  
Umar Jahangir
Keyword(s):  
English Language ◽  
Therapeutic Potential ◽  
Contemporary Literature ◽  
Research Work ◽  
Pharmacological Action ◽  
Search Term ◽  
Classical Literature ◽  
Evolvulus Alsinoides ◽  
Comprehensive Search ◽  
Medicinal Properties

Background: Evolvulusalsinoidesis a well-known herbal drug possessing various promising medicinal properties described by prominent ancient scholars and also numerous preclinical and clinical researches has been performed, thus attestingit’s ample of pharmacological actions. So, thorough review of classical as well as contemporary literature has been executed on Evolvulusalsinoides to validate the pharmacological actions mentioned.           . Methods:For classical review,a comprehensive search of Unani literature is done and for latest research work on evolvulus, articles published in English language using PubMed, MEDLINE, and the Google scholar with search term including Sahnkpushpi, sankhaoli, Evolvulusalsinoides since 1991 to 2019 is done. Results: The search includescontemporary literature, ethnomedicinal sources and 35 research articles from 1992 to 2019 which further ascertains various pharmacological actions being mentioned in Unani literature including anti-inflammatory, anti-diarrheal, anti-helminthic, anti-convulsantand nootropicproperty of herb. Conclusion: The pharmacological action and therapeutic application of Shankhaholi/ Shankpushpiwhich ismentioned inclassical Unani literature are in accordance with latest research. Despite of having several researches on Evolvulusalsinoides there are still numerous indications mentioned in classical literature which are yet to be explored.   Keywords: Evolvulusalsinoides, herb, Unani, contemporary.  

scholarly journals Glimpses of Chandranighantu of Nepal: An Appraisal

The Healer ◽  
2020 ◽  
Vol 1 (1) ◽  
pp. 26-31
Author(s):  
Bijendra Shah ◽  
Shubhangi Kamble ◽  
Bishun D. Patel ◽  
Shiv Mangal Prasad
Keyword(s):  
Medicinal Plants ◽  
Critical Review ◽  
English Language ◽  
Animal Products ◽  
Therapeutic Uses ◽  
Hidden Knowledge ◽  
History Of ◽  
Resource Material ◽  
Unique Style ◽  
Modern Era

Introduction: Chandranighantu is a handwritten manuscript of Ayurveda about 250 years ago in Nepal by a well-known Vaidhya at that time of King Chandra Shamsher. It was believed that the dynasty brought to publish the manuscript with his name as Chandranighantu. It was completed in total of ten volume containing more than 900 medicinal plants and 200 minerals and metals which were available in Nepal only. Till date 5 volumes have been translated into Nepali and English language keeping the original along with; and published by Government of Nepal, but many stakeholders of Ayurveda especially Dravyaguna scholars are still unware of it worldwide. Hence, it was attempted to highlight its importance among Ayurveda scholars, researchers and practitioners. The aim of this documentation is to explore glimpses of Chandranighantu of Nepal and propagate its uniqueness regarding explanation of medicinal plants in the editions as well as handmade manuscripts with colour sketches. Methods: Singhadurbar Vaidykhana Vikas Samiti (SDVKVS), Ministry of Health and Population, Government of Nepal published the Chandranighantu (Volume I) in 2012 A.D., as a primary resource material. It was reviewed and glimpses or peculiarities have been compiled, critically analysed and presented in this work. Results: Chandranighantu has been written after Bhava Prakash Nighantu because most of the references have been taken from Raj nighantu, Kaidev nighantu, Madanpal nighantu and Bhava Prakash Nighantu It has been written in 10 volumes comprising 8 volumes with descriptions of medicinal plants and 2 volumes with descriptions of minerals and animal products. In this work, the first volume of the Chandranighantu has been reviewed that includes total 99 medicinal plants describing synonyms and their properties and actions. The prime peculiarities of this nighantu is addition of local and nepali name and the style of narration of medicinal plants along with very fine handmade colourful sketches of the plants including habitat, root, stem, leaves, fruits, flowers in ints natural colour, clearly differentiating its parts as well as types, which is helpful in proper identification of the plants. This style of description of colourful plants is not found in any other nighantu. This nighantu has found to be taken the basis of pre-existing nighantus such as Dhanwantarinighantu, Rajnighantu, Madanpalnighantu, Kaidev nighantu, Bhavaprakash nighantu and others including lexicons like Amarkosha. Synonyms of plants have been given in different languages like Nepali, Newari, Avadhi, Bhojpuri, Marathi, Bengali, Hindi etc. along with Sanskrit. Conclusion: This nighantu is the evidence of modern era history of medicinal plants use in the Ayurveda. This nighantu is written with the unique style of narration of medicinal plants by synonyms, properties and actions along with colourful sketches. The present critical review recommends scholars, academician, researchers and medicinal plants related experts of recent sciences to explore the hidden knowledge of botany, pharmacognosy, pharmacology and therapeutic uses into gaining deeper perspicuity benefitting the ailing humanity

scholarly journals PHYTOCHEMICAL SCREENING AND PHYSIOCHEMICAL STUDIES ON AERIAL PART OF ACHILLEA MILLEFOLIUM LINN. FOUND IN KASHMIR

2021 ◽  
Vol 14 (2) ◽  
Author(s):  
Suheena Khanday ◽  
Afsahul Kalam ◽  
Ansar Ahmad Ansari ◽  
Aamir Yousuf ◽  
Sajad Salim ◽  
...  
Keyword(s):  
Physicochemical Parameters ◽  
Aerial Part ◽  
Perennial Herb ◽  
Achillea Millefolium ◽  
Western Himalayas ◽  
Phytochemical Screening ◽  
Good Source ◽  
Western Asia ◽  
Phytochemical Studies ◽  
Asteraceae Family

This studyis aimed to evaluate the physicochemical, macroscopic, microscopic and preliminary phytochemical studies of the aerial part of Achillea millefolium L., belonging to the Asteraceae family. It is a perennial herb and is distributed throughout the worldandis native to western Asia and Europe but is also found abundantly in most temperate regions including North America (Anne et al., 2006). Western Himalayas from Kashmir to Kumaon (6000-9000 feet above sea level), also serve as a good source for its production. The plant possesses many important phyto-chemicalslike sesquiterpenes, phenolic compounds, essential oils, etc. The plant has anti-inflammatory, antioxidant, antifungal, antitumor, antiseptic, spasmolytic and hemostatic properties. As there is no detailed standardization work reported on aerial part of Achillea millefolium L., the objective of this study was to work out the physicochemical parameters, macroscopic and microscopic study and preliminary phytochemical constants. The study revealed specific identities for the crude drug which will be useful in identification and to check the adulteration of the raw drug.

scholarly journals Isoquercitrin Ameliorates Cisplatin-Induced Nephrotoxicity Via the Inhibition of Apoptosis, Inflammation, and Oxidative Stress

2020 ◽  
Vol 11 ◽  
Author(s):  
Hao Wang ◽  
Weiwei Xia ◽  
Guangfeng Long ◽  
Zhiyin Pei ◽  
Yuanyuan Li ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Renal Function ◽  
Cell Injury ◽  
Kidney Diseases ◽  
Kidney Injury ◽  
Epithelial Cell Line ◽  
Therapeutic Uses ◽  
And Oxidative Stress

Cisplatin is extensively used and is highly effective in clinical oncology; nevertheless, nephrotoxicity has severely limited its widespread utility. Isoquercitrin (IQC), a natural flavonoid widely found in herbage, is well known and recognized for its antioxidant, anti-inflammatory, and anti-apoptotic properties. However, the potential effects and mechanism of IQC in cisplatin-induced acute kidney diseases remain unknown. In this study, we postulated the potential effects and mechanism of IQC upon cisplatin exposure in vivo and in vitro. For the in vivo study, C57BL/6J mice were pretreated with IQC or saline (50 mg/kg/day) by gavage for 3 days before cisplatin single injection (25 mg/kg). Renal function, apoptosis, inflammation, oxidative stress and p-ERK were measured to evaluate kidney injury. In vitro, mouse proximal tubular cells (mPTCs) and human proximal tubule epithelial cell line (HK2) were pretreated with or without IQC (80 μM for mPTCs and 120 μM for HK2) for 2 h and then co-administrated with cisplatin for another 24 h. Apoptosis, inflammation, ROS and p-ERK of cells were also measured. In vivo, IQC administration strikingly reduced cisplatin-induced nephrotoxicity as evidenced by the improvement in renal function (serum creatinine and blood urea nitrogen), kidney histology (PAS staining), apoptotic molecules (cleaved caspase-3, caspase-8, Bax and Bcl-2), inflammatory cytokines (IL-1β, IL-6, TNF-α, and COX-2), oxidative stress (MDA and total glutathione) and p-ERK. In line with in vivo findings, IQC markedly protected against cisplatin-induced cell injury in mPTCs and HK2 cells. Collectively, these findings demonstrated that IQC administration could significantly protect against cisplatin nephrotoxicity possibly through ameliorating apoptosis, inflammation and oxidative stress accompanied by cross talk with p-ERK. Furthermore, IQC may have potential therapeutic uses in the treatment of cisplatin-induced acute kidney injury.

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